Digital Commons Network^™

Social Support As An Effect Modifier Of The Assocation Between Drug-Use Related Stigma And History Of Substance Use During Pregnancy Among Women Who Use Unprescribed Opioids In New York City: A Cross-Sectional Study, Isabelle C. Lynch

Graduate Studies Theses and Dissertations 2026

Substance use and misuse among women who are pregnant is a growing public health concern in the United States. Overdose deaths are now a leading cause of death among pregnant and postpartum women, and neonatal abstinence syndrome rates have increased to 23 per 1000 births. A barrier addressing substance use among these women is social stigma, which in part is driven by punitive drug policies that criminalize substance use during pregnancy and societal gender roles and norms surrounding women’s substance use. Social support, including emotional, instrumental, and informational support, can serve to mitigate the negative impacts of stigma on health …

Viral Dynamics Across Managed And Wild Pollinators: Integrating Immunity, Ecology, And Community Structure, Allison Malay

Graduate Studies Theses and Dissertations 2026

Managed honey bees (Apis mellifera) are critical agricultural pollinators, yet colonies continue to experience persistently high losses across North America and Europe. These declines are driven by interacting stressors, including parasites, pathogens, nutrition, and landscape context. Viral pathogens are key contributors to colony morbidity and mortality, but the processes governing variation in viral prevalence, load, and host response remain incompletely understood. This dissertation investigates how viral dynamics in honey bees emerge from interactions among host immunity, colony condition, environmental context, and pollinator community structure. By integrating measures of viral prevalence, viral load, and immune gene expression across multiple …

Characterization And Experimental Study Of Ammonia-Hydrogen Flames Inside A Toroidal Jet-Stirred Reactor At Atmospheric Conditions, Oli Marquez Valenzuela

Graduate Studies Theses and Dissertations 2026

Due to rising concerns about global surface temperatures and carbon emissions, there has been an increased interest in studying alternative fuels. Ammonia and hydrogen are fuels with the potential to replace general biofuels, hydrocarbons, and sustainable aviation fuels, as they do not contain any carbon, eliminating carbon emissions. However, they are both difficult to work with. Hydrogen has great combustion characteristics such as low ignition energy, high flame speed and lower heating value. However, it is volatile and difficult to store, requiring it to be compressed to high pressure or cooled to incredibly low temperatures. Ammonia can be used as …

Cell Type-Specific Fatty Acid Signalling And Its Sex Dependence, Emeline Masterson

Graduate Studies Theses and Dissertations 2026

Dietary fat is a highly palatable, energy-dense nutrient whose oral detection powerfully shapes ingestion patterns and metabolic outcomes. Despite clear behavioral and physiological evidence that fat can evoke distinct taste signals, the cellular and molecular mechanisms underlying its transduction remain poorly understood. A critical gap exists in our understanding of the cell-type-specific molecular pathways and how these signals are modulated by hormonal status. This dissertation delineates estrogen-dependent plasticity in FA transduction within the peripheral taste system, revealing coordinated, sex and cell-type-specific modulation of these pathways. To understand the missing mechanisms, FA-evoked responses were compared in Type II cells from wild-type …

Ignition Delay Time Measurements Of Natural Gas/Ammonia Mixtures At Gas Turbine Operating Conditions, Zachary A. Morris

Graduate Studies Theses and Dissertations 2026

Natural Gas/Ammonia (NG/NH₃) fuel blends are a promising route to reduce CO₂ emissions from gas turbines while leveraging existing NG infrastructure, but their autoignition behavior at elevated pressures is not yet well constrained. This work reports high-pressure shock tube ignition delay time (IDT) measurements for NG/NH₃/Air mixtures at gas turbine-relevant conditions. Experiments were performed at pressures of 5, 10, and 25 bar, temperatures from 1500 to 2100 K, with equivalence ratios of Φ = 1.0, 1.2, and 1.4, and argon-diluted fuel compositions spanning pure NH₃ to NG-rich blends. Experiments were carried out in two …

The Intersection Of Abuse, Child Welfare, And The Law For Intimate Partner Violence Survivors: Gender Violence As An Antagonistic Social Force, Julio Montanez

Graduate Studies Theses and Dissertations 2026

Intimate partner violence (IPV)—as gender violence—pits children’s civil rights and women’s civil liberties against each other. To explore this phenomenon, the current work features five (5) studies that aim to understand the systemic consequences of IPV and child maltreatment for victims and survivors of both types of abuse.

• Study 1 is a qualitative-deductive study featuring a directed content analysis of news media pertaining to a trial court case on lethal child maltreatment and IPV.
• Study 2 is a qualitative-inductive study featuring a feminist critical discourse analysis of trial court data on lethal child maltreatment and IPV.
• Study 3 is a …

Exploring The Role Of Hes4 During Retroviral Infection, Raphael Opoku

Graduate Studies Theses and Dissertations 2026

Human immunodeficiency virus (HIV) infection disrupts immune homeostasis and impairs antiviral defenses, partly by compromising natural killer (NK) cell activity, with simian immunodeficiency virus (SIV) infection in rhesus macaques serving as a valuable model to investigate these mechanisms. This research examines the regulatory role of HES4 and its isoforms in NK cell function during retroviral infection, with particular focus on how Notch signaling–dependent regulation of HES4 shapes NK effector responses. HES4, a downstream effector of the Notch signaling pathway, encodes transcriptional repressors central to immune cell differentiation, yet its contribution to NK cell biology remains poorly understood. Using molecular and …

Magic In The Margins: A Painter's Ode To Love, Loss, And Laughter, Angelina B. Palmisano

Graduate Studies Theses and Dissertations 2026

In art, there lives a gift of transcendence with power to transport the viewer into another realm of thought and imagination beyond the limitations of our physical world. This thesis, Magic in the Margins: A Painter’s Ode to Love, Loss, and Laughter, is an exploration of the ways art can serve as both sanctuary and vessel for storytelling. Satire is used to criticize vices, and subtle humor is my tool to resonate serious content necessary for authentic self-reflection. I am investigating how to use painting as a means to make deeply intimate and visceral connections. Each canvas exploring the innermost, …

Source Credibility And Chatbots: How Design Factors Impact Chatbot Effectiveness, Kristen M. Schmidt

Graduate Studies Theses and Dissertations 2026

Source credibility theory states that the more credible a source appears to be, the more likely one is to believe both true and untrue information from it. In the modern day, misinformation is considered a major problem, particularly with virtual communication, meaning it is essential to study what factors influence a system’s source credibility. Virtual agents are a particularly relevant subject of study given that their source credibility can be impacted by both technological and social factors. Across three experiments, this dissertation utilized a novel chatbot interaction design to test how varying design factors would impact a chatbot’s source credibility …

Tl;Dr (Too Long; Didn't Read): Examining The Assessment And Causes Of Careless Responding Within Experimental Vignette Studies, David L. Sexton Jr.

Graduate Studies Theses and Dissertations 2026

Careless responding occurs when participants answer survey items without considering their content and poses a serious threat to data quality. However, while past research has examined its deleterious effects on both survey and low-stakes cognitive ability measures, little research has focused on careless responding in experimental vignette methodology (EVM) research. EVM studies require participants to attend to one or more experimental vignettes, which are carefully crafted written scenarios designed to manipulate a focal variable across conditions. However, if participants are careless in attending to study vignettes, they may not be exposed to the researchers’ intended experimental manipulations, thereby precluding them …

Building Eden Where We Can, Ireland Thomas

Graduate Studies Theses and Dissertations 2026

Building Eden Where We Can is a nonfiction memoir told in vignettes that come together to build a wider story. Through these vignettes, we are shown a narrator who is simultaneously surviving an abusive family, navigating a rare diagnosis, and coming to terms with their queerness. By braiding narratives and maintaining these various threads, this collection examines the intersections of sickness and religion, tradition and freedom, as well as fear and love. The lattermost dichotomy is represented in the narrator’s ultimate choice to leave behind a life of fear in the mother figure’s safe cage. In exchange, they receive a …

Interactions Of Complement With Paramyxovirus Persistently Infected Cells, Nasser N. Yousef

Graduate Studies Theses and Dissertations 2026

Persistent RNA virus infections (PI) are often characterized by extended viral shedding and maintained cycles of inflammation. We have an incomplete understanding of interactions between exogenous and cell intrinsic Complement (C') factors and paramyxovirus PI cells. Parainfluenza virus 5 (PIV5) acute infected (AI) cells can be recognized and lysed by exogenous C’ factors, but PI cells become resistant to C’-mediated lysis. We hypothesized that the relative sensitivity of AI and PI cells to C’ lysis is correlated with viral glycoprotein expression on the surface of cells. PI cells display lower levels of viral glycoprotein expression compared to AI cells. Pharmacological …

Charge Transport Modeling Of Multifunctional Molecular Transistors, Romena Akter

Graduate Studies Theses and Dissertations 2026

Distinguishing between the current–voltage characteristic curves associated with different transport mechanisms in a molecular electronic device and an artifact arising from device-level disorder is a central challenge in the study of molecular electronics. Characterizing these mechanisms and connecting them qualitatively to molecular-level orbital alignment, electrode coupling, voltage division, energetic disorder, and reorganization energy requires not only experimental data but also a rigorous theoretical framework for extracting physically meaningful parameters from measured transfer characteristics. This dissertation addresses this challenge in Chapters 2, 3, and 4 by developing and applying four complementary transport models —Simmons tunneling, single-level Landauer, Marcus hopping, and McConnell …

Fgf19 As A Colorectal Cancer Serum Biomarker And Fgfr4 As A Mediator Of Anti-Her2 Resistance In Breast Cancer, Jordan Beardsley

Graduate Studies Theses and Dissertations 2026

The fibroblast growth factor 19 (FGF19)-fibroblast growth factor receptor 4 (FGFR4) signaling pathway regulates hepatic metabolism, bile acid (BA) synthesis, and hepatocyte proliferation. This signaling axis also is implicated in promoting tumor progression, therapeutic resistance, and metastasis in certain cancers.

In colorectal cancer (CRC) there is a critical need for non-invasive biomarkers for disease detection and monitoring. We identified FGF19 as a candidate CRC serum marker through meta-transcriptomics and found FGF19 to be expressed and secreted by CRC cell lines. Tumor-derived FGF19 was detectable in mouse serum at levels correlating with tumor volume in a subcutaneous xenograft model. RNA sequencing …

Vaccine Hesitancy In Arabic Discourse: A Multi-Method Social Media Study, Nada Dimashkieh Chehab

Graduate Studies Theses and Dissertations 2026

Vaccine hesitancy — the state of uncertainty about vaccination — poses global public health challenges, undermining efforts to prevent infectious diseases. It is also a contextual phenomenon, shaped by social and political forces. While survey-based research on vaccine hesitancy is abundant both globally and in the Arab world, humanities-oriented approaches using discourse analysis remain limited especially in Arabic on social media: some have tracked trends on Twitter, but virtually none have done so on Facebook. This dissertation addresses these gaps through a multimethod design combining Textual and Trend Analyses and Critical Discourse Study. It examines vaccine-related trends and discourses among …

Pioglitazone Uncouples Macrophage Inflammatory Signaling From Epithelial Oxidative Stress During Map Infection Mimicking Crohn’S Disease Treatment, Sabera Akter Bushra

Graduate Studies Theses and Dissertations 2026

Crohn’s disease (CD) is a chronic inflammatory bowel disease characterized by intestinal inflammation, epithelial barrier dysfunction, and abnormal immune signaling. CD pathophysiology is increasingly linked to Mycobacterium avium subspecies paratuberculosis (MAP) infection, which increases chronic macrophage activation and the production of inflammatory mediators that lead to epithelial damage. Among these mediators, CXCL10, TNF-α, and IL-6 contribute in inflammation, while NOX-1 and SERPINE-1 indicate epithelial oxidative stress and damage. Despite the role of macrophage-epithelial interaction in CD, selective pharmaceutical regulation of this axis remains unclear. Pioglitazone, an FDA-approved PPARγ agonist used for type 2 diabetes, is an appealing repurposing candidate, given …

Ex Vivo Sensitivity Assays With Molecular Validation To Guide Preclinical Drug Selection For Schwann Cell Tumors, Ethan W. Hass

Graduate Studies Theses and Dissertations 2026

Schwann cells are the glial cell of the peripheral nervous system. They are dependent on receptor tyrosine kinase-mediated RAS signaling, cell matrix adhesion, and cell-cell contact to proliferate during nerve development and repair. These pathways become deregulated with loss of function of the merlin tumor suppressor encoded by NF2, leading to benign tumors called schwannomas. Patients with NF2-related schwannomatosis (NF2-SWN) develop bilateral vestibular schwannomas that cause hearing loss, tinnitus, and death from brainstem compression if untreated. Severe NF2-SWN causes multiple spinal and peripheral schwannomas and neuropathic pain. Schwannomas require careful monitoring, trial and error use of repurposed anti-cancer …

Cultivating Workplace Happiness In Technology Workers, Cherie A. Herrin

Graduate Studies Theses and Dissertations 2026

Technology workers are central to the innovation and performance of modern organizations and retaining them is a persistent challenge for modern organizations. One important aspect of retention in many contexts is Workplace Happiness, which has been argued to improve worker performance and reduce turnover; however, there is little empirical evidence of the effectiveness of these interventions for technology workers. This dissertation develops a model in which two affective states, Workplace Happiness and Workplace Distress, mediate the relationships between six socio-technical work conditions and two behavioral outcomes: Turnover Intent and Work Execution (i.e., self-rated work performance and quality). A systematic literature …

Investigating The Anti-Apoptotic Properties Of The N-Terminus Of The Chlamydia Trachomatis Effector Tarp, Kasey S. Jordan

Graduate Studies Theses and Dissertations 2026

As the most prevalent bacterial STI in the United States and leading cause of infection-related blindness worldwide, the obligate intracellular bacteria, Chlamydia trachomatis (Ct), poses a significant threat to public health. As an obligate intracellular bacteria, invasion of the host cell is a crucial step in Chlamydia’s developmental cycle. To drive invasion, Ct injects prepackaged effectors into the host cell using a T3SS. An early Chlamydial effector, translocated actin recruiting phosphoprotein, or Tarp, interacts with host cell actin to promote invasion, mediated via Tarp’s C-terminal region. Although the function of Tarp’s C-terminus is well defined, the Tarp’s N-terminus …

Teledentistry: A Path To Minimize Emergency Department Dependency For Dental Issues, Aishwarya Joshi

Graduate Studies Theses and Dissertations 2026

Teledentistry has been promoted as a strategy to minimize emergency department (ED) visits for non-traumatic dental conditions (NTDCs). However, it remains unclear whether structural readiness or temporary policy expansion drives sustained reductions in reliance on the ED. This study integrates Andersen’s Behavioral Model of Health Services Use and Diffusion of Innovation (DOI) theory to examine determinants of Medicaid NTDC ED utilization and Tele-dentistry adoption.

Andersen’s model posits that utilization is shaped by predisposing, enabling, and need factors, whereas DOI theory emphasizes structural attributes that influence adoption, including relative advantage, compatibility, complexity, trialability, and observability. Combining these frameworks allows for a …

The Odyssey Of Emotion Regulation In Extremis: How Challenges Lead To Team States Through Regulation And Psychological Safety In Ice, Andres Kaosaar

Graduate Studies Theses and Dissertations 2026

Isolated, confined, and extreme (ICE) teams experience challenges that require continuous emotional adaptation. Although emotion regulation (ER) has been recognized as critical for functioning in these contexts, little is known about how specific challenges shape regulatory responses, how team climate influences those responses, and how individual regulation accumulates into team-level outcomes. This dissertation develops and tests a multilevel framework linking challenge exposure, perceived psychological safety, individual ER, team emotions, and team viability in space analog environments. Data were collected from 36 crews (N = 184) participating in two-week missions at two space analog stations, yielding 2,577 daily observations and …

Internalized Shame, Self-Focused Attention, And Post-Event Processing In Everyday Social Anxiety, Wooje Lee

Graduate Studies Theses and Dissertations 2026

The purpose of this study was to investigate how emotional processes, represented by internalized shame and daily shame (from the emotion-focused therapy model), and cognitive processes, represented by self-focused attention and post-event processing (from cognitive-behavioral models), operate on a daily basis to contribute to social anxiety. Data collected from a sample of 39 individuals with high social anxiety via an online survey and daily diaries was analyzed using multilevel path analysis. The results showed that, at the within-person level, daily shame experienced during an important social interaction influenced self-focused attention during that same interaction and subsequent post-event processing, which in …

High School Teachers' Perceptions And Experiences Of Legislative Changes: An Interpretative Phenomenological Analysis, Marie Lewis

Graduate Studies Theses and Dissertations 2026

The purpose of this interpretative phenomenological analysis was to explore the perceptions and experiences of high school English Language Arts teachers in one public school district in the state of Florida as they navigated educational legislation that has been implemented over the last five years. The study interviewed ten experienced high school ELA teachers who had taught for more than five years in Florida’s public school system. One semi-structured interview was conducted along with brief follow-ups to share thematic statements with the participants. This study also included a document analysis of HB 1467 and HB 1069 as well as the …

The Diversity Of Flavivirus Antibody Dependent Enhancement (Ade) Profiles From A Pediatric Cohort In Mexico, Maiesha Samiha Mahmood

Graduate Studies Theses and Dissertations 2026

The Aedes mosquito-borne flaviviruses Zika (ZIKV) and dengue (DENV-1-4) cause an estimated 400 million annual infections globally and pose an increasing threat to public health. Typically, individuals infected with ZIKV or a DENV serotype generate neutralizing serotype-specific antibodies and non-neutralizing, cross-reactive antibodies that bind multiple flaviviruses. Upon secondary heterotypic infection, pre-existing antibodies can either protect or exacerbate disease through antibody dependent enhancement (ADE). ADE occurs when non- or sub-neutralizing concentrations of cross-reactive antibodies facilitate viral uptake into FcγR-bearing myeloid cells, enabling infection of otherwise non-permissive cells and driving severe disease. To date, ADE has not been characterized at a population …

Development Of The Simultaneous Alcohol And Cannabis Use Expectancy Questionnaire (Sac-Eq), Shane D. Marohnic

Graduate Studies Theses and Dissertations 2026

Background: Simultaneous alcohol and cannabis use (SAC/SAM), defined as using alcohol and cannabis at the same time so that their effects overlap, has been identified as a hazardous form of polysubstance use. Expectancies are a causal mechanism and can be changed with predictable reductions in substance use and associated consequences, yet only one measure has been developed to assess expectancies related to SAC. Due to limitations of the existing measure, this study sought to create a more comprehensive SAC expectancy scale. Method: Three phases of participants (Phase 1, N = 493; Phase 2, n = 4; Phase 3, n …

Comics In The Classroom: Social Science Teachers' Lived Experiences With Comic Art In Instruction, Robert W. Mcintosh

Graduate Studies Theses and Dissertations 2026

This qualitative descriptive phenomenological study explored secondary social science teachers’ lived experiences with comic art in classroom instruction. Existing research suggests that comic art, including comic books and graphic novels, can support student engagement, content understanding, visual literacy, and critical thinking; however, less is known about how teachers experience and make decisions about using comic art in social science education. Framed by Technological Pedagogical Content Knowledge and Social Cognitive Theory, the study treated comic art as a representational instructional technology and examined how teacher confidence and the context of their experience shaped its use. Data were collected through semi-structured interviews …

Human-Centered Governance Of Climate Resilience: Integrating Sustainability, Equity, And Mental Health, Chelcee A. Pangerl

Graduate Studies Theses and Dissertations 2026

This dissertation examines how sustainability and resilience are defined, implemented, and experienced across three levels of climate governance: household perception, community experience, and federal policy. Climate resilience is often evaluated through infrastructure performance, emissions targets, restoration timelines, and preparedness systems, yet these measures do not fully capture how residents experience uncertainty, support, equity, and mental health. To address this gap, the dissertation develops and applies the Integrated Policy Framework for Sustainability and Resilience (IPFSR). IPFSR organizes six domains into three functional categories: policy outcomes, human-centered dimensions, and implementation mechanisms. Sustainability and operational/physical resilience are treated as policy outcomes; mental health …

Perspectives Of Poetry: Peering Into Poetry And Aphasia, Kristian M. Perez

Graduate Studies Theses and Dissertations 2026

People with aphasia often experience significant barriers to communication, emotional expression, and participation in meaningful life activities following stroke or neurological injury. Although poetry and creative expression have been explored in broader therapeutic contexts, limited research has examined how people with aphasia perceive poetry. The purpose of this qualitative study was to explore the perspectives of people with aphasia regarding definitions of poetry, level of interest in poetry and the factors influencing said interest. Semi-structured interviews were conducted with adults with aphasia recruited through convenience sampling. Participants responded to questions before and after exposure to the poem Trust by Mark …

Discrete Element Modeling Of Granular Soils: Critical State Behavior Applied To Impact Pile Driving, Esteban Patino Marin

Graduate Studies Theses and Dissertations 2026

This thesis investigates the use of the Discrete Element Method (DEM) to study two complementary aspects of granular soil mechanics: critical state behavior of granular materials and dynamic response of driven piles in sand, both of which are governed by the same particle-scale mechanisms of dilation, contraction, and fabric evolution.

The first examines the critical state behavior and fabric anisotropy of granular soils through DEM simulations of direct shear, direct simple shear, and true triaxial tests. Sphere-cluster particles representative of a uniform sand are used in two assemblages of approximately twenty-five thousand and one hundred twenty-five thousand spheres to evaluate …

Performing The Digital Identity: A Media Discourse Analysis Of Online Identity Construction, Dalya Qasem

Graduate Studies Theses and Dissertations 2026

This dissertation investigates how news media construct narratives about TikTok and its role in shaping digital identity. While existing scholarship has examined issues such as privacy, marketing, and entertainment, less attention has been given to how identity is represented, negotiated, and understood within public discourse. Using Critical Discourse Analysis (CDA) combined with computational text analysis through Voyant Tools, this study analyzes a corpus of 111 news articles published between 2020 and 2025 that explicitly reference TikTok and identity. The analysis identifies prominent keywords, topics, and rhetorical patterns across media texts. Furthermore, the research demonstrates a critical analysis of popular understandings …