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Glutamate Excitotoxicity In Epilepsy And Ischemia, Mangala Meenakshi Soundarapandian Jan 2007

Glutamate Excitotoxicity In Epilepsy And Ischemia, Mangala Meenakshi Soundarapandian

Electronic Theses and Dissertations

'Excitotoxicity' represents the excitatory amino acid mediated degeneration of neurons. Glutamate is the major excitatory neurotransmitter in the brain. Glutamate excitotoxicity has been implicated in a number of neurodegenerative disorders like Stroke, Epilepsy, Alzheimer's disease and traumatic brain injury. This neurotoxicity is summed up by the 'glutamate hypothesis' which describes the cause of neuronal cell death as an excessive release of glutamate causing over excitation of the glutamate receptors and subsequent increase in influx of calcium leading to cell death. An effort to counteract this neurotoxicity has lead to the development of glutamate receptor antagonists that can effectively serve as …

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In Search Of: Stories From The Ones Left Behind, Mayra Lizzette Velez Jan 2007

In Search Of: Stories From The Ones Left Behind, Mayra Lizzette Velez

Electronic Theses and Dissertations

In Search Of: Stories from the Ones Left Behind introduces five young women-- June, Leila, Kiss, Marianne, and Alma-- who struggle to impede loved ones from abandoning them. One woman confronts her worst fears when she finds out about her husband's affair with a mutual friend; one comes to terms with her sister's poor lifestyle choices; another copes with her mother's sudden marriage; and yet another figures out that in order to keep her fiance, she must be willing to take on responsibilities foreign to her. And then there is the story of Alma, a contemplative but naive seventeen-year-old girl …

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Lim Kinase 1 Modulates Expression Of Matrix Metalloproteinases And Associates With Gamma-Tubulin: Dual Role In Invasion And Mito, Tenekua Tapia Jan 2007

Lim Kinase 1 Modulates Expression Of Matrix Metalloproteinases And Associates With Gamma-Tubulin: Dual Role In Invasion And Mito, Tenekua Tapia

Electronic Theses and Dissertations

LIM kinase 1 (LIMK1) is a unique dual specificity serine/threonine kinase containing two N-terminal LIM domains in tandem, a PDZ domain and a C-terminal catalytic domain. LIMK1 is involved in modulation of actin cytoskeleton through inactivating phosphorylation of the ADF (actin depolymerization factor) family protein cofilin. Recent studies have shown that LIMK1 is upregulated in breast and prostate cancer cells and tissues, promotes metastasis in animals and induces acquisition of an invasive phenotype when ectopically expressed in benign prostate epithelial (BPH) cells. Furthermore, overexpression of LIMK1 was associated with altered sub cellular localization of the membrane type 1 matrix metalloprotease …

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The Round Barn, Susan Elizabeth Fallows Jan 2007

The Round Barn, Susan Elizabeth Fallows

Electronic Theses and Dissertations

The Round Barn is a novel in two parts that tells the story of two Iowa farm families during the period 1915 to 1929, a volatile time in the history of the American farm. The first part of the novel tells the story of Joe Marshall, a young man in conflict with his hard-working farmer father. At sixteen-years-old, Joe must choose whether to leave the farm to pursue his own desires or to stay where he is needed to help keep his financially strapped family afloat. Part two of the novel focuses on Mae Allinson, a woman in her early …

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Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman Jan 2007

Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman

Electronic Theses and Dissertations

Retrocyclin RC-101, a θ-defensin with lectin-like properties, potently inhibits infection by many HIV-1 subtypes by binding to the heptad repeat (HR)-2 region of gp41 and preventing six-helix bundle formation. In the present study, we used in silico computational exploration to identify residues of HR2 that interacted with RC-101 and then analyzed the HIV-1 Sequence Database at LANL for residue variations in the HR1 and HR2 segments that could plausibly impart in vivo resistance. Docking RC-101 to gp41 peptides in silico confirmed its strong preference for HR2 over HR1, and implicated residues crucial for its ability to bind HR2. We mutagenized …

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The Effects Of Trivalent Arsenicals And Thioredoxin Reductase Inhibitors On Selenium Metabolism In Lung Cell Culture Models, Sarah Ryann Talbot Jan 2007

The Effects Of Trivalent Arsenicals And Thioredoxin Reductase Inhibitors On Selenium Metabolism In Lung Cell Culture Models, Sarah Ryann Talbot

Electronic Theses and Dissertations

Arsenic exposure, through various routes, is associated with the development of cancer of the skin, lung, liver, kidney, and bladder. Treatment of cells in culture with trivalent arsenicals has been shown to increase reactive oxygen species (ROS). In particular, monomethylarsonous acid (MMAIII), a trivalent metabolite of arsenite, is highly cytotoxic and possibly carcinogenic. Three trivalent arsenicals; arsenite, arsenic trioxide (ATO), and MMAIII, are also known inhibitors of the selenoprotein thioredoxin reductase (TrxR). Selenium, an essential micronutrient in mammals, is needed in the form of selenocysteine for activity of this enzyme and other selenoproteins. TrxR is part of a key component …

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Tourist Trap: On Being Raised In Award-Winning Sand, Catherine Jane Carson Jan 2007

Tourist Trap: On Being Raised In Award-Winning Sand, Catherine Jane Carson

Electronic Theses and Dissertations

The literary essays in this collection explore the relationships between mind, body, and environment as the narrator explores Orlando, her beachfront hometown of Sarasota, and other "tourist traps." The traditional and experimental essays here question how residents make popular vacation destinations their own and how much trust one can put in strangers, neighbors, city planners, theme-park designers, and lovers. Dance floors, hybrid bikes, flying elephants, swing sets, and swimming pools fill these pages. Worries spiral like disco lights on dance floors, and cultural forces press down with the constant pressure of pedal strokes. With the embodiment of place comes connection …

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Modeling And Partitioning The Nucleotide Evolutionary Process For Phylogenetic And Comparative Genomic Inference, Todd Castoe Jan 2007

Modeling And Partitioning The Nucleotide Evolutionary Process For Phylogenetic And Comparative Genomic Inference, Todd Castoe

Electronic Theses and Dissertations

The transformation of genomic data into functionally relevant information about the composition of biological systems hinges critically on the field of computational genome biology, at the core of which lies comparative genomics. The aim of comparative genomics is to extract meaningful functional information from the differences and similarities observed across genomes of different organisms. We develop and test a novel framework for applying complex models of nucleotide evolution to solve phylogenetic and comparative genomic problems, and demonstrate that these techniques are crucial for accurate comparative evolutionary inferences. Additionally, we conduct an exploratory study using vertebrate mitochondrial genomes as a model …

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University Of Central Florida Libraries, Annual Report 2006-2007, Ucf Libraries Jan 2007

University Of Central Florida Libraries, Annual Report 2006-2007, Ucf Libraries

Libraries' Documents

No abstract provided.

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The Wind Shuffled The Palm Fronds Like New Money: George Garrett's Florida, Casey Clabough Jan 2007

The Wind Shuffled The Palm Fronds Like New Money: George Garrett's Florida, Casey Clabough

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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Identification And Suitability Of A Non-Anthropomorphic Meta-Language Framework In Military Applications, Gilbert Cardona Jan 2007

Identification And Suitability Of A Non-Anthropomorphic Meta-Language Framework In Military Applications, Gilbert Cardona

Electronic Theses and Dissertations

Humans carry mental models concerning the behaviors, looks, and operation of products, tools, and items used in their daily lives. When these items do not fit a user's conceptual model confusion and inefficiency occur. There are four basic types of mental models based on interactive activities: 1) instructing, 2) conversing, 3) manipulating and navigating, and 4) exploring and browsing. This thesis will focus on the conversing conceptual model and its application to communications between human-agent teams to best fit a user's mental model for that communication. A non-anthropomorphic framework does not exist for use in military applications such as; target …

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Spacecraft Loads Predictionvia Sensitivity Analysis And Optimization, Tom Braswell Jan 2007

Spacecraft Loads Predictionvia Sensitivity Analysis And Optimization, Tom Braswell

Electronic Theses and Dissertations

Discrepancies between the predicted responses of a finite element analysis (FEA) and reference data from test results arise for many reasons. Some are due to measurement errors, such as inaccurate sensors, noise in the acquisition system or environmental effects. Some are due to analyst errors precipitated by a lack of familiarity with the modeling or solver software. Still others are introduced by uncertainty in the governing physical relations (linear versus non-linear behavior), boundary conditions or the element material/geometrical properties. It is the uncertainty effects introduced by this last group that this study seeks to redress. The objective is the obtainment …

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Signal Processing Of An Ecg Signal In The Presence Of A Strong Static Magnetic Field, Aditya Gupta Jan 2007

Signal Processing Of An Ecg Signal In The Presence Of A Strong Static Magnetic Field, Aditya Gupta

Electronic Theses and Dissertations

This dissertation addresses the problem of elevation of the T wave of an electrocardiogram (ECG) signal in the magnetic resonance imaging (MRI). In the MRI, due to the strong static magnetic field the interaction of the blood flow with this strong magnetic field induces a voltage in the body. This voltage appears as a superimposition at the locus of the T wave of the ECG signal. This looses important information required by the doctors to interpret the ST segment of the ECG and detect diseases such as myocardial infarction. This dissertation aims at finding a solution to the problem of …

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Learning Human Behavior From Observation For Gaming Applications, Christopher Moriarty Jan 2007

Learning Human Behavior From Observation For Gaming Applications, Christopher Moriarty

Electronic Theses and Dissertations

The gaming industry has reached a point where improving graphics has only a small effect on how much a player will enjoy a game. One focus has turned to adding more humanlike characteristics into computer game agents. Machine learning techniques are being used scarcely in games, although they do offer powerful means for creating humanlike behaviors in agents. The first person shooter (FPS), Quake 2, is an open source game that offers a multi-agent environment to create game agents (bots) in. This work attempts to combine neural networks with a modeling paradigm known as context based reasoning (CxBR) to create …

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Fate Of Nitrogen And Phosphorus Species From A Black And Goldtm Nugget Mix In A Laboratoy Column Simulated Septic Tank Drainfiel, Timir Shah Jan 2007

Fate Of Nitrogen And Phosphorus Species From A Black And Goldtm Nugget Mix In A Laboratoy Column Simulated Septic Tank Drainfiel, Timir Shah

Electronic Theses and Dissertations

The presence of nitrates and phosphorus in ground water is a worldwide problem. A septic tank with drainfield that is conventionally designed does not typically remove nitrogen in the form of nitrates. The main risks are in "Blue baby" syndrome and suspected carcinogenic effect of nitrates on humans and the nutrient enrichment of receiving waters. In some areas nitrate and phosphorus removal are essentially required. Thus the information in this report concentrates on using media in the drainfield for the removal of nitrogen and phosphorus. Extensive work has been conducted in the past few decades in order to find suitable …

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Image-Space Approach To Real-Time Realistic Rendering, Musawir Shah Jan 2007

Image-Space Approach To Real-Time Realistic Rendering, Musawir Shah

Electronic Theses and Dissertations

One of the main goals of computer graphics is the fast synthesis of photorealistic image of virtual 3D scenes. The work presented in this thesis addresses this goal of speed and realism. In real-time realistic rendering, we encounter certain problems that are difficult to solve in the traditional 3-dimensional geometric space. We show that using an image-space approach can provide effective solutions to these problems. Unlike geometric space algorithms that operate on 3D primitives such as points, edges, and polygons, image-space algorithms operate on 2D snapshot images of the 3D geometric data. Operating in image-space effectively decouples the geometric complexity …

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Biostability In Drinking Water Distribution Systems In A Changing Water Quality Environment Using Corrosion Inhibitors, Bingjie Zhao Jan 2007

Biostability In Drinking Water Distribution Systems In A Changing Water Quality Environment Using Corrosion Inhibitors, Bingjie Zhao

Electronic Theses and Dissertations

In this study, the bacterial growth dynamics of 14 pilot drinking water distribution systems were studied in order to observe water quality changes due to corrosion inhibitor addition. Empirical models were developed to quantity the effect of inhibitor type and dose on bacterial growth (biofilm and bulk water). Water and pipe coupon samples were taken and examined during the experiments. The coupons were exposed to drinking water at approximately 20°C for at least 5 weeks to allow the formation of a measurable quasi- steady-state biofilm. Bulk water samples were taken every week. In this study, two simple but practical empirical …

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Fluvial Geomorphologic And Hydrodynamic Assessment In The Tidal Portion Of The Lower Rio Grande River, Us-Mexico Borderland, A. Ernest, B. Bokhim, N. B. Chang, I. J. Huang Jan 2007

Fluvial Geomorphologic And Hydrodynamic Assessment In The Tidal Portion Of The Lower Rio Grande River, Us-Mexico Borderland, A. Ernest, B. Bokhim, N. B. Chang, I. J. Huang

Faculty Bibliography 2000s

With fast population growth and economic development in the US-Mexico Borderland, water diversion and usages has reduced the flow substantially in the Low Rio Grande River (LRGR). Tidal portion of the LRGR has posed an environmental drought issue since 1993 and the channel clogged with the invasion of non-native plants also causes environmental problems. As a result of the intensity of these natural and manmade factors, the Rio Grande stopped flowing to the sea in February 2001. The flows were reduced to a point that they were unable to push out the sand deposited at the mouth. Geomorphologic evolution in …

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Impact Of Trivalent Arsenicals On Selenoprotein Synthesis, Denis Ganyc, Sarah Talbot, Fanta Konate, Sarah Jackson, Brian Schanen, William Cullen, William T. Self Jan 2007

Impact Of Trivalent Arsenicals On Selenoprotein Synthesis, Denis Ganyc, Sarah Talbot, Fanta Konate, Sarah Jackson, Brian Schanen, William Cullen, William T. Self

Faculty Bibliography 2000s

BACKGROUND: Exposure to arsenic has been associated with development of skin, lung, bladder, liver, and kidney cancer. Recent evidence suggests that an increase in oxidative stress in cells treated with arsenicals represents the molecular mechanism behind arsenic-induced carcinogenesis. Selenium, in the form of selenocysteine, is necessary for the activity of several enzymes with a role in defense against reactive oxygen species. A mutual sparing effect between arsenic and selenium has been shown in animal studies when both metalloids are present in high concentrations. OBJECTIVES: To determine whether changes in selenoprotein synthesis may be an underlying mechanism behind arsenic-induced carcinogenesis, we …

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Dune Vegetation Fertilization By Nesting Sea Turtles, Laura B. Hannan, James D. Roth, Llewellyn M. Ehrhart, John F. Weishampel Jan 2007

Dune Vegetation Fertilization By Nesting Sea Turtles, Laura B. Hannan, James D. Roth, Llewellyn M. Ehrhart, John F. Weishampel

Faculty Bibliography 2000s

Sea turtle nesting presents a potential pathway to subsidize nutrient-poor dune ecosystems, which provide the nesting habitat for sea turtles. To assess whether this positive feedback between dune plants and turtle nests exists, we measured N concentration and delta N-15 values in dune soils, leaves from a common dune plant ( sea oats [Uniola paniculata]), and addled eggs of loggerhead (Caretta caretta) and green turtles ( Chelonia mydas) across a nesting gradient ( 200 - 1050 nests/km) along a 40.5-km stretch of beach in east central Florida, USA. The delta N-15 levels were higher in loggerhead than green turtle eggs, …

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Modified Beckmann-Kirchhoff Scattering Model For Rough Surfaces With Large Incident And Scattering Angles, James E. Harvey, Andrey Krywonos, Cynthia L. Vernold Jan 2007

Modified Beckmann-Kirchhoff Scattering Model For Rough Surfaces With Large Incident And Scattering Angles, James E. Harvey, Andrey Krywonos, Cynthia L. Vernold

Faculty Bibliography 2000s

Surface scattering effects are merely diffraction phenomena resulting from random phase variations induced on the reflected wave-front by microtopographic surface features. The Rayleigh-Rice and Beckmann-Kirchhoff theories are commonly used to predict surface scattering behavior. However, the Rayleigh-Rice vector perturbation theory is limited to smooth surfaces, and the classical Beckmann-Kirchhoff theory contains a paraxial assumption that confines its applicability to small incident and scattering angles. The recent development of a linear systems formulation of nonparaxial scalar diffraction phenomena, indicating that diffracted radiance is a fundamental quantity predicted by scalar diffraction theory, has led to a reexamination of the classical Beckmann-Kirchhoff scattering …

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Gene Expression And The Evolution Of Phenotypic Diversity In Social Wasps, Eric A. Hoffman, Michael Ad Goodisman Jan 2007

Gene Expression And The Evolution Of Phenotypic Diversity In Social Wasps, Eric A. Hoffman, Michael Ad Goodisman

Faculty Bibliography 2000s

Background: Organisms are capable of developing different phenotypes by altering the genes they express. This phenotypic plasticity provides a means for species to respond effectively to environmental conditions. One of the most dramatic examples of phenotypic plasticity occurs in the highly social hymenopteran insects ( ants, social bees, and social wasps), where distinct castes and sexes all arise from the same genes. To elucidate how variation in patterns of gene expression affects phenotypic variation, we conducted a study to simultaneously address the influence of developmental stage, sex, and caste on patterns of gene expression in Vespula wasps. Furthermore, we compared …

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Individual Identification Of Polar Bears By Whisker Spot Patterns, Carlos Anderson Jan 2007

Individual Identification Of Polar Bears By Whisker Spot Patterns, Carlos Anderson

Electronic Theses and Dissertations

Many types of ecological studies require identification of individual animals. I developed and evaluated an automated identification system for polar bears (Ursus maritimus) based on their whisker spot patterns. First, I measured the reliability of using whisker spot patterns for identification from polar bear photographs taken in western Hudson Bay. This analysis involved estimating the complexity of each whisker spot pattern in terms of its information content. I found that 98% of patterns contained enough information to be reliable, and this result varied little among three different observers. Based on these results, I implemented a computer-aided identification system for polar …

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Modeling Free Chlorine And Chloramine Decay In A Pilot Distribution System, Jorge Miguel Arevalo Jan 2007

Modeling Free Chlorine And Chloramine Decay In A Pilot Distribution System, Jorge Miguel Arevalo

Electronic Theses and Dissertations

The purpose of this study was to identify the effect that water quality, pipe material, pipe size, flow conditions and the use of corrosion inhibitors would have on the rate of free chlorine and chloramine decay in distribution systems. Empirical models were developed to predict the disinfectant residual concentration with time based on the parameters that affected it. Different water treatment processes were used to treat groundwater and surface water to obtain 7 types of finished waters with a wide range of water quality characteristics. The groundwater was treated either by conventional treatment by aeration (G1) or softening (G2) or …

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The Illusion Of Art: My Amalgamation Of Illustration And Contemporary Art, Victor Davila Jan 2007

The Illusion Of Art: My Amalgamation Of Illustration And Contemporary Art, Victor Davila

Electronic Theses and Dissertations

Drawing on archetypical aspects of human characteristics and personalities, I create images that illustrate our connection to memory, media, and culture. My work is informed by pop culture, including television, movies, cartoons and comic books as it relates to characters in our own physical world and society. The grid is used to represent both childhood games and the frames of a comic strip, where each panel equals an exact moment of time.

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Adaptive Technomythography: The Apotheosis Of Machine And Development Of Legend In A System Of Dynamic Technology, Roger Wolf Jan 2007

Adaptive Technomythography: The Apotheosis Of Machine And Development Of Legend In A System Of Dynamic Technology, Roger Wolf

Electronic Theses and Dissertations

Human beings will effectively deify any suitably complex system that cannot be explained through basic haptic interaction. Our culture loves technology. These days it seems we need it to feel whole. In an effort to explore the development of mythology and modular aesthetic in a technological age I have designed and constructed a number of interactive robotic 'organisms' to engage in arbitrary movement in geometric enclosures. Through observation and dialog I seek to assess the extent to which people assign human characteristics to the random and oft times aberrant mechanical behavior. To supplement this endeavor, a fictional astrological system that …

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Kaho'olawe:A Case Study Of A Movement And The Media In Reclaiming A Hawaiian Island, Danielle Pedro Jan 2007

Kaho'olawe:A Case Study Of A Movement And The Media In Reclaiming A Hawaiian Island, Danielle Pedro

Electronic Theses and Dissertations

The reclaiming of land can provide for heated controversy between communities. The controversy at the outset may seem simple, but is actually quite complex involving hegemonic factors such as social, political, and economic influence. One such factor is the media. This research examines media coverage via framing in a battle between the United States Navy and the Hawaiian people to claim ownership of a Hawaiian island named Kaho'olawe. This research analyzes 519 newspaper articles from two Hawaiian newspapers--The Honolulu Star Bulletin and The Honolulu Advertiser--over a seven-year period. Six framing devices--advocate, economic, environment, Hawaiian, military, and political--are devised and implemented. …

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12th Annual Joseph C. Andrews Mentoring Breakfast, February 15, 2007, Black Faculty And Staff Association Jan 2007

12th Annual Joseph C. Andrews Mentoring Breakfast, February 15, 2007, Black Faculty And Staff Association

BFSA Collection - Mentoring Breakfast Materials

No abstract provided.

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The Relationship Between The Basic Skills Proficiency Of Counselor Education Master's Level Students And Client Outcome, Lorie Welsh Jan 2007

The Relationship Between The Basic Skills Proficiency Of Counselor Education Master's Level Students And Client Outcome, Lorie Welsh

Electronic Theses and Dissertations

A review of literature on the history of psychology and counseling revealed a limited amount of research on counselor education training programs, specifically basic skills versus client outcome. The purpose of this study was to investigate the relationship between counselor educator student's basic skills and the effects these skills had on client outcome. By way of a multiple regression, two independent variables, the Global Scale for Rating Helper Responses (GSRR) and the Counselor Skills and Professional Behavior Scale (CSPBS) were analyzed in relation to the Outcome Questionnaire (OQ-45.2). Results indicated that there was no statistical significance between basic skills and …

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Trophic Status Of A Small Mammal Assemblage On Cape Canaveral Air Force Station With An Emphasis On Peromyscus Polionotus Niveiv, Megan Keserauskis Jan 2007

Trophic Status Of A Small Mammal Assemblage On Cape Canaveral Air Force Station With An Emphasis On Peromyscus Polionotus Niveiv, Megan Keserauskis

Electronic Theses and Dissertations

Successful translocation of a listed species into an area of previous occupation requires knowledge of the habitat needs. The presence of the necessary food items is critical to the successful establishment of a new population; this information is unknown for Peromyscus polionotus niveiventris, the southeastern beach mouse, a threatened subspecies on the east coast of Florida. I used fecal and stable isotope analysis to determine the diet of this subspecies at Cape Canaveral Air Force Station, Brevard County, Florida, between the autumn of 2003 and the spring of 2005. Six trapping grids were established, three in the dune/swale and three …

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