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A Novel In Vitro Multiple-Stress Dormancy Model For Mycobacterium Tuberculosis Generates A Lipid-Loaded, Drug-Tolerant, Dormant Pathogen, Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy Jan 2009

A Novel In Vitro Multiple-Stress Dormancy Model For Mycobacterium Tuberculosis Generates A Lipid-Loaded, Drug-Tolerant, Dormant Pathogen, Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

Background: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dormancy models, using single stress factors, fail to generate a truly dormant Mtb population. An in vitro model that generates truly dormant Mtb cells is needed to elucidate the metabolic requirements that allow Mtb to successfully go through dormancy, identify new drug targets, and to screen drug candidates to discover novel drugs that can kill dormant pathogen. Methodology/Principal Findings: …

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Decorin Is A Novel Antagonistic Ligand Of The Met Receptor, Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T. Owens, David J. Mcquillan, Keith Ireton, Renato V. Iozzo Jan 2009

Decorin Is A Novel Antagonistic Ligand Of The Met Receptor, Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T. Owens, David J. Mcquillan, Keith Ireton, Renato V. Iozzo

Faculty Bibliography 2000s

Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor. Decorin has a complex binding repertoire, thus, we predicted that decorin would modulate the bioactivity of other tyrosine kinase receptors. We discovered that decorin binds directly and with high affinity (K(d) = similar to 1.5 nM) to Met, the receptor for hepatocyte growth factor (HGF). Binding of decorin to Met is efficiently displaced by HGF and less efficiently by internalin B, a bacterial Met ligand. Interaction of decorin with Met induces transient receptor activation, recruitment of the E3 ubiquitin …

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Native Fire Regime As A Reference For Establishing Management Practices, Brean Duncan Jan 2009

Native Fire Regime As A Reference For Establishing Management Practices, Brean Duncan

Electronic Theses and Dissertations

Our understanding of natural fire regimes in human-dominated landscapes is limited. Fire regimes operating in the pyrogenic ecosystems of Florida have been altered by fire suppression and fuel fragmentation. This is especially true of North Merritt Island, Florida, where human impacts have led to an incomplete knowledge of current fire regimes. We know that growing season fires frequently occurred within general return intervals and that many native terrestrial species require fire to remain viable. A 20-year plus period of fire suppression caused structural and compositional changes to vegetation/fuels that led to catastrophic fires and the decline of native species populations …

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Beliefs Of Graduate Students About Unstructured Computer Use In Face-To-Face Classes With Internet Access And Its Influence On Student Recall, Gregory Johnson Jan 2009

Beliefs Of Graduate Students About Unstructured Computer Use In Face-To-Face Classes With Internet Access And Its Influence On Student Recall, Gregory Johnson

Electronic Theses and Dissertations

The use of computers equipped with Internet access by students during face-to-face (F2F) class sessions is perceived as academically beneficial by a growing number of students and faculty members in universities across the United States. Nevertheless, some researchers suggest unstructured computer use detached from the immediate class content may negatively influence student participation, increase distraction levels, minimize recall of recently presented information, and decrease student engagement. This study investigates graduate students' beliefs about computer use with Internet access during graduate face-to-face lecture classes in which computer use is neither mandated nor integrated in the class and the effect of such …

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Automatic Graphics And Game Content Generation Through Evolutionary Computation, Erin Hastings Jan 2009

Automatic Graphics And Game Content Generation Through Evolutionary Computation, Erin Hastings

Electronic Theses and Dissertations

Simulation and game content includes the levels, models, textures, items, and other objects encountered and possessed by players during the game. In most modern video games and simulation software, the set of content shipped with the product is static and unchanging, or at best, randomized within a narrow set of parameters. However, ideally, if game content could be constantly and automatically renewed, players would remain engaged longer in the evolving stream of content. This dissertation introduces three novel technologies that together realize this ambition. (1) The first, NEAT Particles, is an evolutionary method to enable users to quickly and easily …

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Variable Resolution & Dimensional Mapping For 3d Model Optimization, Joseph Venezia Jan 2009

Variable Resolution & Dimensional Mapping For 3d Model Optimization, Joseph Venezia

Electronic Theses and Dissertations

Three-dimensional computer models, especially geospatial architectural data sets, can be visualized in the same way humans experience the world, providing a realistic, interactive experience. Scene familiarization, architectural analysis, scientific visualization, and many other applications would benefit from finely detailed, high resolution, 3D models. Automated methods to construct these 3D models traditionally has produced data sets that are often low fidelity or inaccurate; otherwise, they are initially highly detailed, but are very labor and time intensive to construct. Such data sets are often not practical for common real-time usage and are not easily updated. This thesis proposes Variable Resolution & Dimensional …

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Modeling Scenes And Human Activities In Videos, Arslan Basharat Jan 2009

Modeling Scenes And Human Activities In Videos, Arslan Basharat

Electronic Theses and Dissertations

In this dissertation, we address the problem of understanding human activities in videos by developing a two-pronged approach: coarse level modeling of scene activities and fine level modeling of individual activities. At the coarse level, where the resolution of the video is low, we rely on person tracks. At the fine level, richer features are available to identify different parts of the human body, therefore we rely on the body joint tracks. There are three main goals of this dissertation: (1) identify unusual activities at the coarse level, (2) recognize different activities at the fine level, and (3) predict the …

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Geometric Invariance In The Analysis Of Human Motion In Video Data, Yuping Shen Jan 2009

Geometric Invariance In The Analysis Of Human Motion In Video Data, Yuping Shen

Electronic Theses and Dissertations

Human motion analysis is one of the major problems in computer vision research. It deals with the study of the motion of human body in video data from different aspects, ranging from the tracking of body parts and reconstruction of 3D human body configuration, to higher level of interpretation of human action and activities in image sequences. When human motion is observed through video camera, it is perspectively distorted and may appear totally different from different viewpoints. Therefore it is highly challenging to establish correct relationships between human motions across video sequences with different camera settings. In this work, we …

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"My Dear Mrs. Baskin": Marjorie Kinnan Rawlings And Hamilton Holt, Maurice O'Sullivan Jan 2009

"My Dear Mrs. Baskin": Marjorie Kinnan Rawlings And Hamilton Holt, Maurice O'Sullivan

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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The Rawlings/Holt Correspondence Jan 2009

The Rawlings/Holt Correspondence

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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"Seems Like Bein' Hard Is The Only Way I Kin Stand It": The Softening Of Ma Baxter In Clarence Brown's Adaptation Of The Yearling, Elizabeth Heffelfinger Jan 2009

"Seems Like Bein' Hard Is The Only Way I Kin Stand It": The Softening Of Ma Baxter In Clarence Brown's Adaptation Of The Yearling, Elizabeth Heffelfinger

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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"Storm Fear": The Weather As Wilderness In The Modernist Imagination, Gregory Byrd Jan 2009

"Storm Fear": The Weather As Wilderness In The Modernist Imagination, Gregory Byrd

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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Vol Xvii (2009) Jan 2009

Vol Xvii (2009)

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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Ballcourt Iconography At Caracol, Belize, Patsy Holden Jan 2009

Ballcourt Iconography At Caracol, Belize, Patsy Holden

Electronic Theses and Dissertations

One of the more commonly known aspects of the ancient Maya culture is the ballgame. This ancient ballgame was played by most Mesoamerican cultures on a constructed ballcourt and many major Mesoamerican sites have at least one, if not more than one. Contemporary Mesoamericans still play versions of this ballgame today, but without the use of the ballcourts, questioning the importance and purpose of the ballcourt that is no longer the case today. After over a century of research, scholars have yet to unravel all the cosmological and mythological mysteries of the ballcourt and its purpose to the ancient Maya. …

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A Model Of Treating Hyperfunctional Voice Disorders For School Age Children Within A Serious Gaming Environment, Suzanne King Jan 2009

A Model Of Treating Hyperfunctional Voice Disorders For School Age Children Within A Serious Gaming Environment, Suzanne King

Electronic Theses and Dissertations

The purpose of the present study is to test the feasibility of implementing a video-game based intervention protocol as a means to improve therapy compliance in school age children with hyperfunctional voice disorders. Three levels of modification were made to an existing entertainment software program in order to implement the therapeutic protocol and test compatibility. The third level of modification included a two-phase quasi-experimental single subject design with a school age participant receiving the video game therapy protocol and traditional therapy for equal time. The independent variables for this study included the mode of voice therapy delivery (traditional vs. video …

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The Whole Headlight-Colored Night, Matthew Bryan Jan 2009

The Whole Headlight-Colored Night, Matthew Bryan

Electronic Theses and Dissertations

This collection of short fiction probes the lives of characters trying to make their home in the flat, unchanging landscape of the small towns that make up central Florida. The largely static environment reflects the rigid patterns of behavior and domesticity the characters find themselves so easily falling into. Seemingly ordinary items-a shotgun, a t-shirt, a paper bag-and the small moments that make up everyday life are imbued with significance as men and women painfully aware of their own ordinariness struggle to hold onto those fragile instances of connection, happiness, or even their own self-constructed sense of identity. The struggle …

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Selling Sunshine: How Cypress Gardens Defined Florida, 1935-2004, David Dinocola Jan 2009

Selling Sunshine: How Cypress Gardens Defined Florida, 1935-2004, David Dinocola

Electronic Theses and Dissertations

This thesis examines the relationship between Cypress Gardens and the state of Florida. Specifically, it focuses on how the creator of the park, Dick Pope, created his park after his own idealized vision of the state, and how he then promoted both his park and Florida as one and the same. The growth and later decline of Cypress Gardens follows trends in Florida's growth patterns and shifts in tourism. This study primarily uses a combination of newspaper sources and promotional pictures and other media from the park to explain how Pope attempted to make Cypress Gardens synonymous with Florida. In …

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Taking The Initiative: Exploring The Influence Of Citizen Legislating On Good Goverance In The American States, Kerri Milita Jan 2009

Taking The Initiative: Exploring The Influence Of Citizen Legislating On Good Goverance In The American States, Kerri Milita

Electronic Theses and Dissertations

The citizen legislator is both a controversial and recurring phenomenon of interest in political science research. A longstanding concern for the discipline has been whether or not involvement of the public in the lawmaking process is an asset or a liability to quality governance. This study explores the desirability of citizen legislating in the American states. A four dimensional index is created that includes empirical indicators of "substantive" and "procedural" governance. These indicators include voter turnout, fiscal health, the ideological distance between government and the citizenry, and the diversity of a state's interest group system. The total number of initiatives …

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The Role Of The Internet As A Tool To Aid In U.S. Adult Consumers' Weight Loss, Jaclyn Kirby Jan 2009

The Role Of The Internet As A Tool To Aid In U.S. Adult Consumers' Weight Loss, Jaclyn Kirby

Electronic Theses and Dissertations

This thesis focuses on ways the Internet can positively influence and educate U.S. Americans to become healthier and eventually lose weight. Throughout the past 30 years, the percentage of overweight and obese adults in the U.S. has increased immensely, resulting in a nationwide epidemic (American Association for Public Opinion Research, 2006; Center for Disease Control, 2006; Goodman, 2005; The Obesity Society, 2008). The research question for this thesis is the following: What are the perceptions of U.S. adult consumers regarding the positive influence the Internet has on weight loss? In order to determine the influence of the Internet on U.S. …

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Landcover Change And Population Dynamics Of Florida Scrub-Jays And Florida Grasshopper Sparrows, David Breininger Jan 2009

Landcover Change And Population Dynamics Of Florida Scrub-Jays And Florida Grasshopper Sparrows, David Breininger

Electronic Theses and Dissertations

I confronted empirical habitat data (1994-2004) and population data (1988-2005) with ecological theory on habitat dynamics, recruitment, survival, and dispersal to develop predictive relationships between landcover variation and population dynamics. I focus on Florida Scrub-Jays, although one chapter presents a model for the potential influence of habitat restoration on viability of the Florida Grasshopper Sparrow. Both species are unique to Florida landscapes that are dominated by shrubs and grasses and maintained by frequent fires. Both species are declining, even in protected areas, despite their protected status. I mapped habitat for both species using grid polygon cells to quantify population potential …

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Zinc-Finger Protein Mcpip In Cell Death And Differentiation, Craig Younce Jan 2009

Zinc-Finger Protein Mcpip In Cell Death And Differentiation, Craig Younce

Electronic Theses and Dissertations

Monocyte chemotactic protein-1 (MCP-1) plays a critical role in the development of cardiovascular diseases. How MCP-1 contributes to the development of heart disease is not understood. We present evidence that MCP-1 causes death in cardiac myoblasts, H9c2 by inducing oxidative stress, ER stress and autophagy via a novel Znfinger protein, MCP-1 induced protein (MCPIP). MCPIP expression caused cell death and knockdown of MCPIP, attenuated MCP-1 induced cell death. Expression of MCPIP resulted in induction of iNOS and production of reactive oxygen (ROS). It caused induction of NADPH oxidase subunit phox47 and its translocation to the cytoplasmic membrane. Oxidative stress led …

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Synthesis Of Biocompatible Antioixidant Polymer Coated Cerium Oxide Nanoparticles, Its Oxidase Like Behavior And Cellular Uptake, Atul Asati Jan 2009

Synthesis Of Biocompatible Antioixidant Polymer Coated Cerium Oxide Nanoparticles, Its Oxidase Like Behavior And Cellular Uptake, Atul Asati

Electronic Theses and Dissertations

Cerium oxide nanoparticles have been widely used for various applications such as catalytic converters for automobile exhaust, ultraviolet absorber, and electrolyte in fuel cells. Most recently, cerium oxide nanoparticles (nanoceria) have been employed as potent free-radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. These properties of cerium oxide nanoparticles can open new vistas in medicine and biotechnology. The present study utilizes the water-based-wet-chemical method to synthesize biocompatible,stable and highly monodisperse polymer coated cerium oxide nanoparticles. Polymer coated cerium oxide nanoparticles possess all the characteristics of the uncoated cerium oxide nanoparticles. These nanoparticles were found to be effective as pH-dependent antioxidant …

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Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication, John Rumsey Jan 2009

Tissue Engineered Myelination And The Stretch Reflex Arc Sensory Circuit: Defined Medium Formulation, Interface Design And Microfabrication, John Rumsey

Electronic Theses and Dissertations

The overall focus of this research project was to develop an in vitro tissue-engineered system that accurately reproduced the physiology of the sensory elements of the stretch reflex arc as well as engineer the myelination of neurons in the systems. In order to achieve this goal we hypothesized that myelinating culture systems, intrafusal muscle fibers and the sensory circuit of the stretch reflex arc could be bioengineered using serum-free medium formulations, growth substrate interface design and microfabrication technology. The monosynaptic stretch reflex arc is formed by a direct synapse between motoneurons and sensory neurons and is one of the fundamental …

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Determinants Of Chloroplast Gene Expression And Applications Of Chloroplast Transformation In Lactuca Sativa And Nicotiana Tabacum, Tracey Ruhlman Jan 2009

Determinants Of Chloroplast Gene Expression And Applications Of Chloroplast Transformation In Lactuca Sativa And Nicotiana Tabacum, Tracey Ruhlman

Electronic Theses and Dissertations

Genetic modification of plastids in the model plant tobacco (Nicotiana tabacum) has demonstrated that numerous foreign gene products can accumulate to high levels in this setting. Plastid biotechnology is maturing to encompass the improvement of food and feed species and the production of biopharmaceutical proteins for oral delivery necessitating development of stable transplastomic edible plants. In the interest of establishing an edible platform we have investigated the use of native and foreign regulatory elements in relation to foreign gene expression in plastids. Multiple sequence alignments of intergenic regions for 20 species of angiosperm showed that despite 95% identity in the …

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Tourists' Attitudes Toward The Use Of Animals In Tourist Attractions: An Empirical Investigation, Amir Shani Jan 2009

Tourists' Attitudes Toward The Use Of Animals In Tourist Attractions: An Empirical Investigation, Amir Shani

Electronic Theses and Dissertations

From time immemorial human beings have utilized animals for various needs and purposes, which led societies to debate the justification for using animals and to reflect on the way in which animals are treated. These concerns have also resulted in various contemporary studies aimed to reveal interest groups'--as well as the general publics'--views and opinions on the issues under dispute. Nevertheless, despite the considerable incorporation of animals in entertainment and leisure venues, only limited efforts have been geared towards exploring the ethical aspects of using animals in these initiatives. This lack of attention is especially evident in the tourism literature, …

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Content And Citation Analysis Of Interdesciplinary Humanities Textbooks Within A Framework Of Curriculum Theory, Julie Guidera Jan 2009

Content And Citation Analysis Of Interdesciplinary Humanities Textbooks Within A Framework Of Curriculum Theory, Julie Guidera

Electronic Theses and Dissertations

The purpose of this dissertation was to analyze the content of textbooks used in undergraduate survey courses in interdisciplinary humanities to understand the content of the curriculum and how an author's viewpoint shapes the product. By enumerating the texts and images authors and their publishers used to illustrate 20th century culture and the transition into the 21st century, the analysis generated a description of the range of perspectives from traditional to postmodern found in six sampled textbooks. Textbook content provided chronological data, while authors' source citations established identity properties of the works' contributors. Through a ranking system of authors' treatment …

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The Anatomy Of A Production: The Analysis Of The Directorial Journey Mounting "Steel Magnolias" For The Stage, Aradhana Tiwar Jan 2009

The Anatomy Of A Production: The Analysis Of The Directorial Journey Mounting "Steel Magnolias" For The Stage, Aradhana Tiwar

Electronic Theses and Dissertations

This study is based on the Vine Theater Company's production of "Steel Magnolias" performed in March of 2007 at the Garden Theater in Winter Park Florida, directed by Aradhana Tiwari. This document examines the directorial journey from vision to the stage. Specifically it will explore a.) The dynamics of the production process from a directorial lens. b.) Interpreting Harling's text for design and performance c.) The development of an artistic aesthetic through collaboration. In May of 2007, I mounted a production of "Steel Magnolias" for the Orlando International Fringe Festival. The show was performed in the Universal, a thrust space …

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Like A Woman: Playing The Homosexual As Truth In Kiss Of The Spider Womana, Michael Beaman Jan 2009

Like A Woman: Playing The Homosexual As Truth In Kiss Of The Spider Womana, Michael Beaman

Electronic Theses and Dissertations

Identity, who we are, is at the core of every human being, thus at the core of every character from every play. How the character identifies his self through gender and sexual identity will shape both physical and emotional choices that an actor will make through the rehearsal process. As an actor, it is absolutely imperative to resist the urge to pass judgment on the characters we portray. As more characters in modern drama are openly gay, there is an increasing urge for an actor to fall into campy stereotypes. Through a performance of the role of Molina in Manuel …

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Machinal: A Sourcebook For The Actress Playing "Young Women", Brittney Rentschler Jan 2009

Machinal: A Sourcebook For The Actress Playing "Young Women", Brittney Rentschler

Electronic Theses and Dissertations

This thesis will document four phases of my rehearsal process/performance while portraying the role of Helen in Sophie Treadwell's Machinal. The first phase of the project will be researching and analyzing historical material on: Sophie Treadwell (the playwright) Ruth Snyder (the murderess upon whom the character of Helen is based), and the actual murder that occurred in the 1920's. The second phase that will be documented is a character analysis. I will take each episode and divide it into the following sections: given circumstances, what is said about the character by the playwright, by others, or by herself, objectives, tactics, …

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X: The Rise And Fall Of An Asylum Star (A Journey Of Two Actresses), Erika Wilhite Jan 2009

X: The Rise And Fall Of An Asylum Star (A Journey Of Two Actresses), Erika Wilhite

Electronic Theses and Dissertations

The performance of X: The Rise and Fall of an Asylum Star, in conjunction with my thesis document, investigates the dichotomy of fantasy and reality for a performer. I compare the creative and emotional journey of Augustine, a young woman hospitalized for hysteria, to my own journey as an actress. Augustine was also performer, for her doctors led her in public demonstrations of the symptoms of hysteria. Her "talent" for hysteria earned her notoriety and celebrity. She was coached and directed from her doctors to enhance her demonstrations. As a result, the validity and authenticity of her state was questionable. …

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