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Cross-Talk Of Retinoic Acid And Adrenergic Hormone Signaling May Influence Development Of Cardiac Conduction And Rhythmicity In Utero, Sabikha Alam May 2011

Cross-Talk Of Retinoic Acid And Adrenergic Hormone Signaling May Influence Development Of Cardiac Conduction And Rhythmicity In Utero, Sabikha Alam

HIM 1990-2015

Stress hormones, adrenaline and noradrenaline, have been shown to be critical for heart development. Mice lacking dopamine greek lower case letter beta]-hydroxylase (Dbh), an enzyme responsible for synthesis of these adrenergic hormones, die during mid-gestation due to cardiac failure. Prior research showed that adrenergic cells are found within the electrical conduction system of the heart, and adrenergic deficiency leads to slowed cardiac conduction during embryogenesis. Microarray analysis of wild-type (Dbh+/+) and knockout (Dbh-/-) mouse hearts revealed significant differences in expression of retinoic acid (RA) signaling genes. RA signaling has also been shown to be critical for heart development. These data …

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Analysis Of The Repair Of Topoisomerase Ii Dna Damage, Eric D. Goldstein May 2011

Analysis Of The Repair Of Topoisomerase Ii Dna Damage, Eric D. Goldstein

HIM 1990-2015

A large number of anti-cancer chemotherapeutics target DNA topoisomerases. Etoposide is a specific topoisomerase II poison which causes reversible double strand DNA breaks. The focus of this project is to analyze the repair of DNA damage induced by etoposide.. Double strand DNA break repair is mediated by through either non-homologous end joining (NHEJ) or homologous recombination. NHEJ repairs through direct ligation of a double stranded break while homologous recombination utilizes a homologous template to recover the wild type sequence. A reporter cassette, RYDR-GFP, has been stably integrated into HeLa cells. This reporter contains an ultra-high affinity topoisomerase II cleavage site …

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Effectiveness Of Nonpharmacological Techniques For Procedural Analgesia In The Neonatal Intensive Care Unit, Lauren E. Flaherty May 2011

Effectiveness Of Nonpharmacological Techniques For Procedural Analgesia In The Neonatal Intensive Care Unit, Lauren E. Flaherty

HIM 1990-2015

The purpose of this thesis is to provide a critical analysis of research findings about nonpharmacological techniques used independently of pharmacological techniques to prevent or reduce procedural pain for infants in the neonatal intensive care unit (NICU). A synthesis of the current research related to nonpharmacological pain relief techniques for infants was conducted for this thesis. Nonpharmacological interventions reviewed in this study include: Kangaroo Care, swaddling, facilitated tucking, positioning, music, non-nutritive sucking and sucrose. An interdisciplinary review of the research was performed using the interdisciplinary databases Cumulative Index of Nursing and Allied Health, PubMED, and PsychINFO. Inclusion criteria for this …

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The Effect Of Chemical Fragrances On Child Health And Development, Katie L. Gilton May 2011

The Effect Of Chemical Fragrances On Child Health And Development, Katie L. Gilton

HIM 1990-2015

The American public is bombarded with chemically fragranced products every day, typically in combination with each other. These products can include cosmetics, perfumes, detergents, air fresheners, soaps, and deodorants. Contained in these fragranced products are chemicals that can be harmful to child health and development. Many articles have been published examining the chemicals found in fragranced products and the effects that these chemicals can have on the human body. This integrated literature review examines empirical evidence related to the health and safety of particular chemicals used in these products. Nurses need to be aware of the actual and potential harms …

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An Exploration Of Materials For Music Integration In Elementary Science Education, Nicole Jennet Mills May 2011

An Exploration Of Materials For Music Integration In Elementary Science Education, Nicole Jennet Mills

HIM 1990-2015

Strong educators always look for different ways to excite and enthrall their students in the curriculum. The field of science education often loses student interest due to the complexities and vocabulary found in the scientific realm. Incorporating music into the classroom has shown positive results as a way to integrate student learning and a different way of facilitating students in the learning process (Brewer, 1992; Davies, 200). Resources for implementing the integration of music and science exist throughout the Internet in a variety of mediums. This study looks at the availability of said resources and the concepts they cover, for …

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On Rights A Defense And Analysis Of Rights Through Natural Law, Ramon E. Lopez May 2011

On Rights A Defense And Analysis Of Rights Through Natural Law, Ramon E. Lopez

HIM 1990-2015

One of the central questions in political theory deals with the nature of rights. What sorts of rights do people possess? How are these rights justified? How ought these rights be reflected and related when seen in political, economic, and social institutions? Following the publication of John Rawls' A Theory of Justice (1971) and Robert Nozick's Anarchy, State, and Utopia (1974), rights have once again returned to dominate much of contemporary political theory. However, natural law, which was the historical basis of the early Enlightenment theories of rights, is no longer the primary system appealed to when discussing rights. In …

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Paul Verhoeven, Media Manipulation, And Hyper-Reality, Emmanuel William Malchiodi May 2011

Paul Verhoeven, Media Manipulation, And Hyper-Reality, Emmanuel William Malchiodi

HIM 1990-2015

Does the individual really matter in the post-modern world, brimming with countless signs and signifiers? My main objective in this writing is to demonstrate how this happens in Verhoeven's films, exploring his central themes and subtext and doing what science fiction does: hold a mirror up to the contemporary world and critique it, asking whether our species' current trajectory is beneficial or hazardous.; Dutch director Paul Verhoeven is a polarizing figure. Although many of his American made films have received considerable praise and financial success, he has been lambasted on countless occasions for his gratuitous use of sex, violence, and …

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Plant-Made Oral Vaccines Evaluation Of Capsules, James Stewart New May 2011

Plant-Made Oral Vaccines Evaluation Of Capsules, James Stewart New

HIM 1990-2015

Antigen expression through the Chloroplast Transformation Technology (CTT) produces bioencapsulated subunit-vaccines, capable of eliciting immune responses when delivered orally. Considerable challenges to effective plant-based vaccines are the normalization of dosage and preservation of accumulated antigen, which is complicated by variable high water content and protease activity. This study critically examines the efficacy of lyophilization in dehydrating plant-tissues and preserving plant-derived antigens with vaccine potential. Lyophilization was optimized through gravimetric analysis using lettuce expressing Protective Antigen (PA) of Bacillus anthracis (LS-HPAG) and the human autoantigen Proinsulin (Pins) fused to Cholera toxin subunit B (LS-CTB-Pins). Lyophilization for 48-hours was sufficient treatment to …

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Examining The Magic Tree House Series For Historical Accuracy And Educational Implications, Nina Washington May 2011

Examining The Magic Tree House Series For Historical Accuracy And Educational Implications, Nina Washington

HIM 1990-2015

Often teachers are faced with the challenge of teaching more content with less time and resources. The use of trade books within the content areas allows teachers to integrate multiple skills in one lesson. The Magic Tree House series has been popular with students and teachers on the elementary level. Using books such as these would be a good way for teachers to use their allotted time to teach all of the content that they are accountable for. This thesis will explore the historical accuracy and educational connections within the Magic Tree House series by Mary Pope Osborne. The purpose …

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Nursing Interventions In The Care Of Patients Undergoing Induced Hypothermia, Angela D. Zimmerman May 2011

Nursing Interventions In The Care Of Patients Undergoing Induced Hypothermia, Angela D. Zimmerman

HIM 1990-2015

Use of induced hypothermia for the purpose of lowering intracranial pressure and preserving neuronal function has increased as research data reveals a trend of positive outcomes in patients treated with this therapy. Recently induced hypothermia following cardiac arrest due to ventricular fibrillation has been deemed successful. Current research has expanded to evaluate the effectiveness of induced hypothermia as a treatment modality for severe stroke and head trauma. In spite of its efficacy, complications exist with this treatment modality. The purpose of this literature review is to examine potential complications secondary to induced hypothermia and highlight the nurse's role in managing …

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Using Young Adult Literature To Teach The Classics A Study On Pairing Young Adult Novels With The Classic Works In Secondary English Classrooms, Deanna Lynn Velazquez May 2011

Using Young Adult Literature To Teach The Classics A Study On Pairing Young Adult Novels With The Classic Works In Secondary English Classrooms, Deanna Lynn Velazquez

HIM 1990-2015

Young adult literature is a genre of literature that is often overlooked. Adolescents would greatly benefit from reading young adult novels, academically and also for enjoyment. Educators are not using young adult literature as often as they should in the classrooms as a tool, due to strict curricula. However, young adult literature is a perfect tool for aiding with comprehension of the classic works. Pairing certain young adult books with classics would help adolescents understand the classic novel, but also assist in intriguing the student enough to pick up both books. After an online survey given to nine Seminole County …

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It’S Okay To Be Gay…: A Librarian’S Journey To Acceptance And Activism, Jason D. Phillips May 2011

It’S Okay To Be Gay…: A Librarian’S Journey To Acceptance And Activism, Jason D. Phillips

Faculty Scholarship and Creative Works

This chapter presents the deeply personal and professional journey of Jason D. Phillips, an academic librarian, as he navigates the challenges of embracing his identity as a gay man within the conservative environments of Southern academia. Beginning with a facetious reflection that library school "made him gay," Phillips recounts how his education and early professional experiences became transformative, offering acceptance, community, and the impetus to come out. His story unfolds across pivotal moments—from confronting internalized homophobia and grappling with visibility in conservative workplaces, to finding mentorship, building GLBT library collections, and becoming an advocate for inclusion and intellectual freedom. Phillips …

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Passive Underground Drainfield For Septic Tank Nutrient Removal Using Functionalized Green Filtration Media, Martin Wanielista, Ni-Bin Chang, Ammarin Makkeasorn Apr 2011

Passive Underground Drainfield For Septic Tank Nutrient Removal Using Functionalized Green Filtration Media, Martin Wanielista, Ni-Bin Chang, Ammarin Makkeasorn

UCF Patents

Methods, systems and compositions for a green sorption media for bioretention soil amendments in drainfields for on-site waste water systems filled with the green sorption media to foster an anaerobic or anoxic environment saturated. The green sorption media includes one or more recycled materials, including tire crumb, sawdust, orange peel, coconut husks, leaf compost, oyster shell, soy bean hulls and one or more naturally occuring materials including peat, sands, zeolites, and clay. The wastewater filtration system for a passive drainfield includes the green sorption material mixture, a cell including baffled compartments and a riser, the cell filled with green sorption …

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Sandspur, Vol 117, No 25, April 14, 2011, Rollins College Apr 2011

Sandspur, Vol 117, No 25, April 14, 2011, Rollins College

The Rollins Sandspur

Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.

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Sandspur, Vol 117, No 22, March 24, 2011, Rollins College Mar 2011

Sandspur, Vol 117, No 22, March 24, 2011, Rollins College

The Rollins Sandspur

Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.

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Targeting Of Mkrni For Identifying Cancer Treatment Agents, Mark Muller, In Chung, Mi Kang, Jun Kim, Tae Lee, Sue Oh, Sun Park Mar 2011

Targeting Of Mkrni For Identifying Cancer Treatment Agents, Mark Muller, In Chung, Mi Kang, Jun Kim, Tae Lee, Sue Oh, Sun Park

UCF Patents

The molecular chaperone Hsp90 binds specifically to hTERT and is required for assembly of active telomerase activity. We show that disruption of Hsp90 function gy geldanamycin efficient ubiquitination and proteasome-mediated degradation of hTERT.

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Tissue Substitutes Comprising Stem Cells And Reduced Ceria, Kiminobu Sugaya, Petya Georgieva, Stephanie Merchant, Sudipta Seal, Manny Vrotsos Feb 2011

Tissue Substitutes Comprising Stem Cells And Reduced Ceria, Kiminobu Sugaya, Petya Georgieva, Stephanie Merchant, Sudipta Seal, Manny Vrotsos

UCF Patents

A biocompatible composite includes a solid biocompatible material and stem cells attached thereto. The biocomposite provides a stable interface with endogenous tissue and the implanted composition resulting in accelerated repair to damaged bones and tissues. A method of repairing bone includes the steps of obtaining live stem cells from a patient to be treated or a haplotype matched donor and culturing the stem cells with a biocompatible material. The stem cells attach to a surface of the biocompatible material to form a biocompatible composite. The biocompatible composite is positioned in proximity to bone to be treated, wherein said stem cell …

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A Solid Phase Assay For Topoisomerase I Interfacial Poisons And Catalytic Inhibitors, Vidusha Cyril Jan 2011

A Solid Phase Assay For Topoisomerase I Interfacial Poisons And Catalytic Inhibitors, Vidusha Cyril

Electronic Theses and Dissertations

We report a mechanism based screening technique to rapidly identify eukaryotic topoisomerase I targeting agents. The method is based on genetic tagging of topoisomerase I to immobilize the enzyme on a solid surface in a microtiter well format. DNA is added to the wells and retained DNA is detected by Picogreen fluorescence. Compounds that result in an increase in Picogreen staining represent potential topoisomerase interfacial poisons while those that reduce fluorescence report catalytic inhibitors; therefore, the solid phase assay represents a „bimodal‟ readout that reveals mechanisms of action. The method has been demonstrated to work with known interfacial poisons and …

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Fish From Afar Marine Resource Use At Caracol, Belize, Smith Petra Cunningham Jan 2011

Fish From Afar Marine Resource Use At Caracol, Belize, Smith Petra Cunningham

Electronic Theses and Dissertations

The ancient Maya had strong ties to the sea. The trade, transportation and use of marine resources were important not only to coastal Maya communities, but also to the heavily populated cities that lay many miles inland. A review of zooarchaeological evidence recovered from excavations at the inland site of Caracol, Belize suggests that the inhabitants imported marine fish for food, marine shell for working into trade items, and sharks teeth and stingray spines for ritual use. This thesis examines the manner in which fish and other marine resources were used, procured and transported from the coast to the site …

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Beyond The Battlefield, Gary A. Seymour Jan 2011

Beyond The Battlefield, Gary A. Seymour

Electronic Theses and Dissertations

I am exhibiting several drawings, paintings, and sculptures representing a visual record of my creative research into, and my handling of, snails. Although I depict snails and their environment in a loose representational style, I have begun to incorporate digital drawing to enhance my art in a mixed media approach. I have created illustrative images of a forest floor as I imagine it would look to a snail in a giant, menacing world. Close-up images of grass become unusual jungle scenes, and my once tiny snails achieve a measure of control in this fanciful world. The inspiration for my art …

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Identification Of Factors Influencing The Commission Of Burglaries, Mustafa Donmez Jan 2011

Identification Of Factors Influencing The Commission Of Burglaries, Mustafa Donmez

Electronic Theses and Dissertations

As in many countries, burglary is a very serious crime in Turkey. Scientific methods and techniques are needed to solve complex burglary cases. This study is completed in the Bursa Police context since they classified many crime data conducive to scientific studies under a project called BEMTAP. The main purpose of this study is to examine the factors influencing the commission of burglaries, using an epid-criminological perspective. It can be argued that factors leading to the commission of a crime are important for formulating preventive strategies in the community. In this study, the contributing factors are categorized into three main …

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University Of Central Florida Factbook 2010-2011, University Of Central Florida Jan 2011

University Of Central Florida Factbook 2010-2011, University Of Central Florida

Historical Fact Book and Enrollment

Historical fact book and enrollment data for the University of Central Florida.

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Making Visual Noise, Deborah Starr Leitch Jan 2011

Making Visual Noise, Deborah Starr Leitch

Electronic Theses and Dissertations

Focusing on the combination of multi-cultural and historical influences from my personal life experiences, my creations of odd juxtapositions of space, complex pattern and new iconography in my paintings, reveal more than merely a representational image to a viewer. Although my subjects may vary from the anonymous to media celebrity, it is their relationship to me that influences the creation of my static animation and visual noise.

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An Evaluation Study Of The Effectiveness Of Using A Reaction-Based Process For Hydrazine Waste Remediation, Cristina M. Oropeza Jan 2011

An Evaluation Study Of The Effectiveness Of Using A Reaction-Based Process For Hydrazine Waste Remediation, Cristina M. Oropeza

Electronic Theses and Dissertations

Hydrazine (HZ) and monomethylhydrazine (MMH) are used extensively as hypergolic propellants at Kennedy Space Center. These highly reactive fuels are considered highly toxic, and potentially carcinogenic. Consequently, the transport, handling, and disposal of hydrazines is strictly regulated to protect personnel and the environment. Currently, KSC generates large volumes of hydrazine-laden wastewater for disposal. This waste is contained and shipped on public highways for subsequent disposal by incineration presenting a potentially catastrophic threat to the environment and the general public in the event of an accidental release. Other existing remediation methods include oxidative and reductive pathways as well as biodegradation in …

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Gore's Science The Kairos Of An Inconvenient Truth And The Implications For Science Writing, Carolyn M. Glasshoff Jan 2011

Gore's Science The Kairos Of An Inconvenient Truth And The Implications For Science Writing, Carolyn M. Glasshoff

Electronic Theses and Dissertations

Modern Americans are exposed to scientific and technical information on a daily basis that urges them to react as well as learn about new ideas. The popular science writing that circulates this information must be portrayed in a way that makes it easy for lay people to understand complicated ideas while at the same time remaining complex enough to convince readers that the information is reliable, accurate, and worth learning. In making decisions about how to accomplish this balancing act, science writers make decisions that influence the audience's opinion about new scientific ideas, how easily the audience will accept or …

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I Thought You Were Someone Else, Maria Milazzo Jan 2011

I Thought You Were Someone Else, Maria Milazzo

Electronic Theses and Dissertations

I Thought You Were Someone Else deals with violence, family, love, art, and gender. The author examines these issues as well as what makes a creative work fiction or nonfiction by creating a multi-genre collection of seven short fiction stories and five short nonfiction pieces. Fictional stories feature protagonists similar to the author and protagonists who could be considered completely different from the author. Nevertheless, the protagonists in these pieces, whether they are real or fictitious, all experience grand realizations concerning their identity and surroundings. Essentially, they realize they are not who they thought they were. A young boy realizes …

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Adaptive Responses Of Branchial Morphology To Hypoxia In The Neotropical Electric Fish Genus Brachyhypopomus, Leilani B. Pathak Jan 2011

Adaptive Responses Of Branchial Morphology To Hypoxia In The Neotropical Electric Fish Genus Brachyhypopomus, Leilani B. Pathak

Electronic Theses and Dissertations

Many tropical aquatic environments worldwide are characterized by intermittent or prolonged hypoxia (low dissolved oxygen). Nevertheless, many tropical freshwater fishes are able to inhabit these challenging environments via a range of morphological, physiological and behavioral adaptations. Brachyhypopomus is a diverse genus of weakly electric fishes represented by 28 known species distributed from Panama to Argentina. 17 species are restricted to permanently normoxic habitats (blackwater rivers and terra firme streams), eight species are restricted to seasonally or perennially hypoxic habitats (whitewater floodplains of large tropical rivers or permanent swampy habitats), and three species are eurytopic (occur in both seasonally hypoxic and …

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Mechanisms Of Alpha]-Synuclein-Induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal Jan 2011

Mechanisms Of Alpha]-Synuclein-Induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting one million Americans. Despite its social and economic impact, the pathological cascades that lead to neuron dysfunction and degeneration in PD are poorly understood. Endoplasmic reticulum (ER) stress has been implicated as an initiator or contributing factor in neurodegenerative diseases including PD. The ER is an organelle central to protein folding and intracellular Ca2+ homeostasis. Perturbations of these functions result in ER stress and upregulation of ER stress proteins, of which some have been implicated in counteracting ER stress-induced cell death. The mechanisms that lead to ER stress and how ER …

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More Of John D. Macdonald's Brood, Cal Branche Jan 2011

More Of John D. Macdonald's Brood, Cal Branche

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

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Identification Of Fabrics Likely To Collect And Disperse Fel D 1, Mary Janice Jones Jan 2011

Identification Of Fabrics Likely To Collect And Disperse Fel D 1, Mary Janice Jones

Electronic Theses and Dissertations

Individuals sensitive to domestic cat allergen Fel d 1 experience a variety of symptoms including eye irritation, respiratory irritation, asthma, and severe respiratory distress. Fel d 1 is a protein produced in the saliva and on the skin of domestic cats. Previous studies have demonstrated that Fel d 1 adheres to clothing, upholstery, and human hair and has been found in non-cat environments in levels high enough to cause allergic reactions in sensitive individuals. In a general sense, two very different approaches have been adopted to study Fel d 1. One area of the literature focuses on the molecular biology …

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