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Novel Computational Approaches For Multidimensional Brain Image Analysis, Harish Raviprakash

Electronic Theses and Dissertations, 2020-2023

The overall goal of this dissertation is focused on addressing challenging problems in 1D, 2D/3D and 4D neuroimaging by developing novel algorithms that combine signal processing and machine learning techniques. One of these challenging tasks is the accurate localization of the eloquent language cortex in brain resection pre-surgery patients. This is especially important since inaccurate localization can lead to diminshed functionalities and thus, a poor quality of life for the patient. The first part of this dissertation addresses this problem in the case of drug-resistant epileptic patients. We propose a novel machine learning based algorithm to establish an alternate electrical …

The Troupes Coloniales: A Comparative Analysis Of African American And French Colonial Soldiers In The First World War, Matthew Patsis

Electronic Theses and Dissertations, 2020-2023

This thesis examines the service of African American soldiers during World War I in comparison with the service of French Colonial soldiers from Africa. This thesis argues that African Americans existed as colonial subjects of the American Empire and served as the colonial army of the United States just as soldiers from Africa did for France. The scope of this thesis covers ideologies of race in the United States and France, as well as racial policy and the implementation of racial hierarchy within the French and American armies during World War I. Through comparative analysis, this research reveals the relationship …

Deeper Impressions Of Thomas Nast And Joseph Keppler: Analyzing The Role Of Political Cartoons In The Development And Perceptions Of Late Nineteenth Century Group Images, Timothy Dorsch

Electronic Theses and Dissertations, 2020-2023

This paper analyzes political cartoons from Thomas Nast and Joseph Keppler from the late 1860s through the mid-1880s. It argues that through use of effective symbolism and memorable illustrations, these cartoonists created and popularized caricatures of politicians, laborers, Irish Catholics, African Americans, and women that validated stereotypical views of the late nineteenth century and influenced later historical interpretations of the era. Analyzing the Nast and Keppler cartoons as significant historical resources rather than as interesting illustrations for historical monographs reveals the layers of literacy, social and political thought present in the drawings that the readers of the day would have …

Masters Of The Manipulator? A Species Description And Comparative Genomics Study Of Two New Hyperparasites Of The Zombie Ant Fungus, Brittany Lebert

Electronic Theses and Dissertations, 2020-2023

Fungal hyperparasites have been known to indirectly impact ecosystem composition and disease dynamics by modulating the population size and transmission of their parasite host. In the present study we formally describe two new hyperparasite species that infect the fungus Ophiocordyceps camponoti-floridani, which manipulates the behavior of the Florida carpenter ant. Phylogenetic analyses demonstrate that both fungal hyperparasites are new, distinct species. The unique morphology and phylogenetic placement of one of the species even supports its placement in a new genus, which we have named Niveomyces. Our field data suggests that both new species, Polycephalomyces oviedoensis and Niveomyces ophiocordycipitis, negatively impact …

Naming More Of What We Know: Critical Memoirs & The Ecological Metaphor As A Threshold Concept In Writing, Loren Cooper

Electronic Theses and Dissertations, 2020-2023

"Naming More of What We Know: Critical Memoirs & the Ecological Metaphor as a Threshold Concept in Writing" contributes to the work begun by Adler-Kassner and Wardle to gather and name Writing Studies' body of disciplinary knowledge as "threshold concepts." This thesis answers their call to engage in the ongoing development of threshold concepts by offering an additional critical construct: Writing as ecological. To explicitly acknowledge that writing is ecological is an essential addition to the content of our knowledge because it (1) meets the threshold-concept criteria adapted from Meyer and Land (2003), (2) establishes a codified, embodied, 3-dimensional system …

Molecular And Phenotypic Diversification Of A Cryptic Group Of Terrestrial Frogs From The Southern Andes Of Ecuador, Veronica Urgiles Penafiel

Electronic Theses and Dissertations, 2020-2023

The Ecuadorean Andes sustains one of the most remarkable frog diversifications. In this region, nearly one in three known species of amphibians belong to the Pristimantis genus, which contains the majority of the direct-developing terrestrial frog species. Although efforts are ongoing to understand the diversity of Pristimantis, large regions of the ecosystems they occupy remain understudied, and speciation and diversity of this genus remains poorly understood. Within this context, an interesting taxon with many unresolved questions regarding patterns and process of diversification is the Pristimantis orestes species complex which is distributed across the Paramo landscape and montane forests in the …

Transcendence, William Rincon

Electronic Theses and Dissertations, 2020-2023

Transcendence is a novel that examines masculinity and self-acceptance in the modern era: How do we move on from wrongs done by others and our own mistakes? A coming-of-age novel, Transcendence follows Cassiel, a young man in his mid-twenties, as he searches for his absent father and finds himself in a monastery where monks have strange abilities. He decides to learn meditation and find the source of his unhappiness through trials that test his discipline and faults. With the promise of enlightenment and learning what happened to his long-lost father, Cassiel completes each trial and comes closer to finding the …

Development Of 3d Porous Chitosan-Based Platform For In Vitro Culture, Kailei Xu

Electronic Theses and Dissertations, 2020-2023

Three-dimensional (3D) cell cultures have been widely used in biological research since two-dimensional (2D) cultures have many limitations including alteration of cell morphology, metabolic pathways and gene expression. Therefore, the application of 2D cell cultures in pharmaceutical companies for drug screening causes reproducibility issues in animal studies, which strongly influences the efficiency of drug development. The aim of my studies is to develop 3D cell culture models to better mimic the extracellular matrix (ECM) in tumor microenvironment, not only for deeper understanding of interaction between cells and ECM, but also for the application in drug screening. Three different compositions of …

Novel Roles Of Rip2 In Inflammation And Resolution, Michael Shehat

Electronic Theses and Dissertations, 2020-2023

Receptor-interacting protein 2 (RIP2) is a kinase which mediates signaling downstream of the bacterial peptidoglycan sensors Nucleotide-binding Oligomerization Domain (NOD) 1 and 2. Genetic loss or pharmaceutical inhibition of RIP2 has been shown to be beneficial in multiple inflammatory disease models with the effects largely attributed to reducing pro-inflammatory signaling downstream of peptidoglycan recognition. However, given the widespread expression of this kinase and its reported interactions with numerous other proteins, it is possible that RIP2 has many other unappreciated roles. In this work, we report the involvement of RIP2 in two novel pathways. First, we demonstrate a NOD2 dependent role …

Simulating Medical Isolation: Communicatively Managing Patient And Medical Team Safety, Elizabeth L. Spradley, R. Tyler Spradley

International Crisis and Risk Communication Conference

Reducing hospital acquired or associated infections (HAIs) is a national public health priority. HAIs pose risks to patients, visitors, and medical personnel. To better understand how to communicatively manage safety in medical isolation, data was collected with nursing students simulating medical isolation in a high-fidelity simulation with a medical mannequin with C. difficile. Observations of nursing students and faculty revealed four distinct communication practices: social support, patient education, humor, and storytelling. Conclusions include recommendations to intentionally design these communication practices into high-fidelity medial isolation simulations and scale up these communication practices in routines of safety.

Goodness In Gaming: A Survey On Gamers And Their Altruism, Daniel Amaral

Honors Undergraduate Theses

The psychological inquiry into the effects of videogames and the internet on behavior is still a relatively new field. The question of whether playing violent videogames directly contribute to violent behavior, particularly in reference to its influence in mass shootings, is an important one that needs answers. A plethora of research purportedly shows the negative effects of (violent) videogames, but research showing positive effects, particularly on prosocial behaviors within the virtual world and reality, are less common. If specific videogame preferences are associated with altruistic behaviors, such a finding could elucidate how videogames might contribute to prosocial behavior. In this …

Development Of An Environmental Disposition Scale: A Guide For Fostering Sustainable Behavior, Jady Chen

Honors Undergraduate Theses

Promoting sustainable behavior or environmentally responsible behavior poses challenges because there is no overarching solution for behavior changes. Both surveys and interventions are context specific, meaning behaviors do not necessarily influence other behaviors and the same values, norms, and beliefs do not necessarily translate to the same level of sustainable behavior. Because there are regional differences in ideologies in the United States, a country level approach to encourage sustainable behavior would not be as effective as having interventions that directly correlate with the motivations that encourage environmentally responsible behavior. A survey will be conducted with University of Central Florida undergraduate …

A Model Experiment To Investigate The Possibility Of Glyphosate Contamination In St. Kitts And Nevis, Winston Fu

Honors Undergraduate Theses

Glyphosate is a broad-spectrum herbicide that is used globally to combat the spread of weeds among crops. Not all countries around the world have been using the herbicide. For example, island countries such as Dominica and St. Kitts and Nevis do not use the herbicide on their crops. However, St. Kitts and Nevis imports food and other agricultural products from around the world, leading to the hypothesis that glyphosate is contaminating the soil through those imported products. The aim of this research project was to determine if glyphosate is present in the island country of St. Kitts and Nevis. A …

Investigating The Effect Of Ethanol On Wnt7a And Its Potential Implications In Fetal Alcohol Spectrum Disorder, Erika Lytle

Honors Undergraduate Theses

Fetal Alcohol Spectrum Disorders (FASDs), are caused by maternal alcohol consumption during pregnancy [3]. FASD encompasses a wide variety of cardiac and neural anomalies, while also associated with improper limb development, abnormal craniofacial features, problems within the central nervous system (CNS), and disabilities in learning and communication. Gene-regulating FASDs have not been well studied during the crucial phases of early embryonic development. Genes within the Wnt/Beta-catenin pathway control a vast amount of embryonic developmental processes. Among them is the Wnt7a gene, a significant downstream gene regulator which positively controls neural stem cell proliferation and cardiomyocyte differentiation on a large scale …

Genetic Control Of Arbuscular Mycorrhizal Colonization In Helianthus Annuus, Katherine Stahlhut

Honors Undergraduate Theses

Plant symbiosis with arbuscular mycorrhizal (AM) fungi provides many benefits for plants, including increased nutrient uptake, drought tolerance, and belowground pathogen resistance. In order to have a better understanding of the genetic architecture of mycorrhizal symbiosis, we conducted a genome-wide association study (GWAS) by phenotyping a diversity panel of cultivated sunflower (Helianthus annuus) for root colonization under inoculation with the AM fungus Rhizophagus intraradices. This mapping panel consists of 261 inbred lines that capture approximately 90% of the genetic diversity present in the cultivated sunflower germplasm. Using a mixed linear model approach with a high-density genetic map, we …

Cardiovascular Outcomes In Nonsmokers Exposed To Secondhand Smoke: Results From The National Health And Nutrition Examination Survey (Nhanes) 2015-2016, Suzanne Chaar

Honors Undergraduate Theses

While the adverse health risks associated with smoking have been well-documented, few studies have examined the cardiovascular outcomes associated with secondhand smoking. The purpose of the study was to assess the distributions and association of cardiovascular diseases (CVDs) in nonsmokers exposed to secondhand smoke (SHS). Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2015-2016 cycle. Self-reported smoking status and cotinine levels were used to identify exposure groups (smokers, nonsmokers, and secondhand smokers), and medical history of several cardiovascular diseases such as coronary heart diseases and stroke were also collected via self-report survey. The association between exposure …

The Effect Of Interventions On Radiotherapy-Induced Skin Toxicity: A Systematic Review, Claudia R. Figueroa

Honors Undergraduate Theses

Various studies show a variety of interventions for radiotherapy-induced skin toxicity. Radiotherapy-induced skin toxicity is the most common side effect for women with breast cancer who undergo radiotherapy sessions. Intervention agents include topical creams, barrier films, oral agents, as well as laser therapy. However, despite the variety of intervention agents available, there is still a lack of accepted guidelines to manage radiotherapy-induced skin toxicity. This thesis aims to conduct a systematic review and meta-analysis of published randomized controlled trials with the primary purpose of exploring the available intervention methods to prevent radiotherapy-induced skin toxicity and evaluate the effects of different …

Serial Murder And Media Coverage, Molly Gross

Honors Undergraduate Theses

This study sets out to explore the relationship between news media coverage on serial killers and their behavior. As a result of the lack of previous research on this topic, utilizing past research on a few historically well-known serial killers and news media reports about those serial killers, this study attempts to determine if news media has any effect on a serial killer’s behavior prior to apprehension. After a review of the history of serial murder and the past findings about serial murderers, as well as background on the history of the media coverage of crime, this study will look …

Cultural Institutions' Digital Responses To Covid-19 Temporary Closures, Brittany N. Ryder

Honors Undergraduate Theses

The purpose of the study was to explore what types of digital content cultural institutions implemented during COVID-19 temporary closures and their effects on social media engagement. Existing research identified the role of digital content and social media in cultural institutions, but only in times of normal operations. The study adds to the existing literature by exploring types of digital content implemented, impacts on social media engagement, measures of social media engagement, and future implications in regard to COVID-19 temporary closures.

The study recruited 16 cultural institutions from across the United States to take part in in-depth semi-structured phone interviews …

Viral Stories In Spanish And English: A Qualitative Analysis Of Narrative Perceptions Regarding Infant Immunizations Across Major Ethno-Linguistic Communities, Zeynep H. Elshaer

Honors Undergraduate Theses

The intent of this thesis is to analyze the varying perceptions among Hispanic (Spanish-speaking) and Anglophone communities regarding vaccines and more specifically infant immunization practices, in order to identify common or diverging patterns of communication, information dissemination, and narrative discourse. Currently, medical messaging and health policy is largely formulated without thorough attention to the different ways diverse or minority ethno-linguistic communities may interpret the information, thereby leading to deficiencies in effective communication practices between individuals and healthcare providers or policymakers, and outright opposition between informal and formal public health messaging. This evaluation was conducted in order to broaden the current …

An Analysis Of The Relationship Between Education Assistance Dogs And The Attendance, Verbal Communication Utterances, And Maladaptive Behaviors Of Self-Contained Special Education Students In One Florida School District, Heather Lucas

Electronic Theses and Dissertations, 2020-2023

The purpose of this study was to examine the relationship between the introduction of education assistance dogs (EAD) on the attendance, verbal communication utterances, and maladaptive behaviors of students on behavior intervention plans who were enrolled in self-contained, special education classrooms. Teachers in two elementary classrooms and one middle school classroom gathered data on the three areas of focus. The researcher then utilized a single subject design and corresponding line graphs to represent the data. The results indicated a positive trend in the scores for verbal communication utterances and maladaptive behaviors among targeted students after end introduction of the EAD. …

Getting Lost: The Fungal Hijacking Of Ant Foraging Behavior In Space And Time, Thienthanh Trinh

Electronic Theses and Dissertations, 2020-2023

Many parasites have evolved strategies to exploit host behavior such that it benefits parasite transmission. Ophiocordyceps manipulations of carpenter ant behavior represent an evident example. Manipulated ants are coerced to ascend vegetation and clamp down their mandibles in a stereotypical "death-grip" bite. The fungus then kills the ant, sprouts a stalk and releases infective spores. Research has focused on this ultimate manipulation, leaving the subtler behavioral changes pre-biting largely unexplored. Field and transcriptome data found that the host circadian clocks, olfaction, and communication may be disrupted, suggesting that the fungus is affecting ant foraging activity and effectivity. To test these …

Scalable Communication Frameworks For Multi-Agency Data Sharing, Shafaq Chaudhry

Electronic Theses and Dissertations, 2020-2023

With the rise in frequency and magnitude of natural disasters, there is a need to break down monolithic organizational barriers and engage with community volunteers. This calls for ease of systems interoperability to facilitate communication, data-sharing and scalability of real-time response, essential for crisis communications. We propose two scalable frameworks that enable multi-agency interoperability and real-time data-sharing. The first framework harnesses the power of social media, artificial intelligence, and community volunteers to form an extended rescue-and-response network that alleviates call center burden and augments the finite capacity of dispatch units. Through an "online 9-1-1" service, affected people can request help …

How Artists Can Capture Us: Educating About The Works Of Stephen Sondheim Through Parody, Jarrett Poore

Electronic Theses and Dissertations, 2020-2023

This thesis examined the modern renaissance man and his relationship between musical theatre history and parody; it examined how the modern artist created, produced, and facilitated an original parody in which humor can both influence and enhance an individual's interest in the art form. In the creation and production of The Complete Works of Stephen Sondheim [abridged], I showcased factual insight on one of the most prolific writers of musical theatre and infused it with comedy in order to educate and create appeal for Stephen Sondheim's works, especially those lesser known, to a wider theatrical audience. My two greatest research …

Meroitic Childhood Diet And Weaning At Sai Island, Sudan: A Carbon And Nitrogen Isotopic Study Of Site 8-B-52.B, Brenna Raisor

Electronic Theses and Dissertations, 2020-2023

This research explores the diet and weaning patterns of non-adult individuals from an elite Meroitic (300 BCE – 350 CE) cemetery (8-B-52.B) at Sai Island, Sudan. This was accomplished by conducting stable isotopic analyses of carbon and nitrogen on a sample of 54 individuals. These analyses focused on differences in adult and non-adult diet, non-adult weaning patterns, and intra-elite differences between contemporaneous cemeteries at Sai Island in order to shed light on the patterns of non-adult diet and weaning and the mother-infant dynamic. The non-adult individuals range from 36 weeks gestational age to 16.5 years of age, and the adult …

Playing Disability, Daniel Romano

Electronic Theses and Dissertations, 2020-2023

Disability in performance has a long history, starting with fictional characters such as Shakespeare's Gloucester/Richard, progressing through the freak shows of the early twentieth century, and finally with artists such as Neil Marcus, Mat Fraser and Deaf West Theatre in the past twenty years. Looking to the work of disabled artists, activists, and theorists such as Petra Kuppers and Carrie Sandahl, I will examine the history of both disability in performance and the performance of disability. I will discuss my performance of Garret, a man with muscular dystrophy, in my original play, The Sick Parents Club. Through analysis of what …

Non-Linear Inverse Liquid-Solid Chromatography As A Methodology To Characterize Drug Concentration Losses To Polymeric Materials Used In Body-On-A-Chip Devices For Drug Discovery, Mark Schnepper

Electronic Theses and Dissertations, 2020-2023

Body-on-a-chip and human-on-a-chip systems are currently being used to augment and could eventually replace animal models in drug discovery and basic biological research. However, hydrophobic molecules, especially therapeutic compounds, tend to adsorb to the polymer materials used to create these microfluidic platforms, which may distort the dose-response curves that feed into Pharmacokinetic/Pharmacodynamic (PK/PD) models which translate preclinical data into predictions of clinical outcomes. Adsorption of hydrophobic molecules to these polymer materials needs better characterization. Inverse Liquid-Solid Chromatography paired with a numerical optimization based on the Langmuir model of adsorption was used to characterize the adsorption isotherm parameters of selected drugs …

The Implementation Of An Interdisciplinary Literacy Approach To Examine Effects On Writing Self-Efficacy In A Fourth Grade Classroom, Chelsea Wharin

Electronic Theses and Dissertations, 2020-2023

This qualitative action research examines the effects, if any at all, the implementation of an interdisciplinary literacy unit in a fourth-grade classroom had on students' perceived writing self-efficacy. This study aims to inform the teacher-researcher to make actionable changes to current teaching. Additionally, this study continues the research and discussion surrounding how educators and stakeholders approach instruction. This research required participants to complete a pre-writing self-efficacy survey, participate in an interdisciplinary literacy unit and then complete a post writing self-efficacy survey. The interdisciplinary literacy unit took place during the distance learning environment that was a result of the global pandemic, …

Reconstruction Of Bacterial Strain Genomes From Shotgun Metagenomic Reads, Xin Li

Electronic Theses and Dissertations, 2020-2023

It is necessary to study bacterial strains in environmental samples. The environmental samples are mixed DNA samples collected from the ocean, soil, lake, human body sites, etc. In a natural environment, they provide us new insights into the diversity of our earth. As for bacterial strains on or inside human bodies, to select the proper treatment for diseases caused by bacterial strains, it is critical to identify the corresponding strains and reconstruct their genomes. However, it is a challenge to do so with the DNA from a large number of unknown microbial species mixed together in an environmental sample. The …

Copper/N-Acetylcysteine Coated Iron Oxide Nanoparticles Synthesis, Characterization, And Antimicrobial Activities, Danya Belnour

Electronic Theses and Dissertations, 2020-2023

In recent years, there is a growing interest in developing metal based antimicrobial nanomaterials suitable for agricultural and biomedical applications. For centuries, Copper (Cu) biocide has been used for protecting a wide variety of crops from devastating bacterial and fungal diseases. However, prolonged and aggressive use of Cu led to the development of resistance and accumulation in soil. The latter has been linked to aquatic toxicity due to soil Cu leaching. Furthermore, copper build up in soil causes phytotoxicity and reduces uptake of micronutrient Zn through the root system. In biomedical field, Cu has been historically used as an antimicrobial …