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Analysis Of The Mechanical, Microstructural, And Biocompatibility Properties Of Novel Magnesium-Based Hybrid Nanocomposite Materials For Orthopedic Applications, Thomas H. Mcgehee

Biomedical Engineering Undergraduate Honors Theses

Bone fractures and complete joint replacements are becoming more common, primarily because of accidents and age-related issues. Conventional solutions to treat these orthopedic injuries involve inert metal alloys to correct bone fractures until the healing process is complete, where a secondary revision surgery is then required to remove the implant. Issues regularly associated with these solutions include stress shielding, bone resorption, infection, inflammation, and implant loosening. Magnesium (Mg)-based nanocomposites offer promising potential as an alternative to commonly used metal alloys because of their favorable mechanical properties and biocompatibility. A particularly advantageous property of Mg is its natural biodegradation in vivo, …

Justification For The Biological Foundation Of Methane On Mars: Methanogens’ Capacity To Metabolize On Montmorillonite Clay And Basalt, Ashley Ezeldin

Biological Sciences Undergraduate Honors Theses

The possibility of extraterrestrial life, particularly on Mars, remains a compelling question in astrobiology. Mars' harsh atmospheric conditions, dominated by carbon dioxide and extreme cold, prevent the survival of aerobic species. However, it still leaves the possibility of methanogens, an anaerobic species that can survive in extreme conditions, to inhabit this planet. Due to the discovery of methane on Mars, it is possible that methanogens may live and grow in the subsurface of this planet.

For this experiment, basalt and montmorillonite clay were chosen as substrates because they are believed to be found in the composition of Mars's subsurface. Methane, …

Characterizing The Medial Forebrain Bundle In Adolescents With Anhedonic Depression, Tina Nguyen

Biological Sciences Undergraduate Honors Theses

Adolescent depression has quickly grown in prevalence, yet the underlying neuropathology remains poorly understood. Anhedonia–the diminished ability to experience pleasure–is a core symptom of melancholic depression. Early identification of biomarkers associated with anhedonic depression could help mitigate the severity of the disorder by enhancing treatment efficacy. Blunted functionality of the nucleus accumbens (NAcc), the reward center of the brain, and abnormal dopaminergic activity in the ventral tegmental area (VTA) have both been linked to depression. Furthermore, glutamatergic input from the hypothalamus modulates the VTA which in turn, downregulates dopamine release in the NAcc. However, there is limited evidence supporting that …

The Effect Protein Supplementation On Waist-To-Hip Ratio, Bmi, Lipid Profile, And Resting Energy Expenditure In Postmenopausal Women, Caleb Flores

Biological Sciences Undergraduate Honors Theses

Postmenopausal women are a growing and at risk population that face increased risk for adverse changes in body composition, lipid profile, and overall cardiometabolic health due to hormonal changes associated with aging. Over 40% of postmenopausal women have obesity, which can be linked not just aging but the menopausal transition. Because of the negative effects of menopause on cardiometabolic, research into dietary interventions to combat these effects are needed. High-protein diets have shown promise in mitigating these effects, but sufficient research has not been done to determine the effects on postmenopausal women. This study aimed to evaluate the effects of …

Assessment Of Nitrogen Source Utilization During Nitrogen Fixation And Nitrogenase Regulation By Methanosarcina Acetivorans, Avery Carter

Biological Sciences Undergraduate Honors Theses

Nitrogen is a crucial element in biomolecules such as proteins and DNA, essential for all cellular life. Biological nitrogen fixation, a process utilized by certain bacteria and archaea, reduces dinitrogen (N₂) to ammonia (NH₃), enabling growth in the absence of fixed nitrogen sources like NH₃. This process is driven by the metalloenzyme nitrogenase, which catalyzes the reaction: N₂ + 16ATP + 8e⁻ + 8H⁺ → 2NH₃ + H₂ + 16ADP + 16Pi. Due to its high energy demand, nitrogenase production and activity are tightly regulated. Among archaea, nitrogenase is found exclusively in methanogens, where its regulation remains poorly understood. We …

Assessing Language Skills Of Children Within The Head Start Program Using Language Sampling Analysis, Lynley Bowen

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Fluency disorders, including stuttering and cluttering, disrupt one’s natural rate of speech and can cause implications for one’s emotional well-being. This study explores the relationship between language factors and stuttered events in preschool-age children by analyzing a spontaneous language sample using two transcription software programs, CLAN and SALT. A language sample was collected from a child enrolled in a local Head Start program and was transcribed and analyzed using the software programs. Results from CLAN’s KIDEVAL and FLUCALC features offered analysis of the child’s language profile, as well as SALT’s standards measure report feature. This study highlights the importance of …

Activity-Based Protein Profiling On Nucleophilic Amino Acid Residues With Pyrocarbonates, James Van Horn

Chemistry & Biochemistry Undergraduate Honors Theses

The complexity of the proteome requires strategies that efficiently characterize protein functions. Activity-Based Protein Profiling (ABPP) is a method that identifies enzyme activity by targeting key catalytic residues. This study focused on histidine, a residue involved in enzymatic catalysis, metal coordination, and protein-protein interactions. Despite its importance, histidine-specific chemical probes are limited due to its variable reactivity. This work developed and characterized a histidine-specific probe using a pyrocarbonate-based mechanism. Singleresidue assays confirmed selective reactivity of the probe with histidine over other nucleophilic amino acids. Further testing on enzymatic proteins and lysed cell proteomes showed that the probe modified histidine residues …

Molecular Insights: Advances In Single Molecule And Single Particle Detection For Analysis Of Chemical, Physical, And Biological Phenomena, James Ethan Batey

Chemistry & Biochemistry Undergraduate Honors Theses

This thesis is focused on recent advancements made in the field of chemical imaging, optical microscopy, and recent developments that have improved spatial, temporal, or spectral resolution or have made certain techniques more accessible and cost effective for their wider adoption. This thesis is organized based on the systems of interest we studied with each new technique. Although, it is important to note that many of the methods here can be used with a multitude of systems even if not explicitly mentioned. The first chapter of this thesis will discuss the current state of chemical imaging, common terminology, and important …

Usage Of Natural Language Processing And Deep-Learning Techniques On Thematic Apperception Tests To Predict Big Five Personality Traits, Blayten Jones

Electrical Engineering and Computer Science Undergraduate Honors Theses

The usage of personality as a method of behavioral prediction and outcomes of success has grown considerably over the last few decades. This project explores predicting user personality profiles via the Big Five personality index through the integration of advanced natural language processing techniques as well as neural networks. Using a dataset provided by Dr. James W. Pennebaker, participants analyze an image—formally referred to as a thematic apperception test—and write a thorough paragraph describing the details. This free-form text, along with their personality test results, is captured in a structured dataset. Many deep-learning and machine learning models have been used …

Synthetic Dataset Generator To Assist In Training Of Multilayer Perceptron Based Neural Network, Megan Leach

Electrical Engineering and Computer Science Undergraduate Honors Theses

Synthetic dataset generation attempts to solve the issue of needing large datasets to train models and observe behaviors in both a cost and time effective way. This project aims to highlight the value of synthetic data creation and how it was useful when training a neural network model by creating a synthetic dataset generator for a specific model in order to evaluate its behavior in difference scenarios. The model that was used in this project was created to select high-quality papers while maximizing the diversity of authors based on race, gender, and country characteristics, essentially mimicking a review process. The …

Evaluating Ai As A Design Tool In Architectural Workflows: Exploring Its Effectiveness In Addressing Design Problems And Integrating Into Studio Processes, Seth S. Cutlip

Architecture Undergraduate Honors Theses

This paper examines the integration of AI imaging tools into traditional analog workflows within architecture studios. This looks specifically at the early conceptual design phase and examines, through a research through design approach, how AI imaging tools like Comfyui and Krita can support ideation, material exploration, and spatial composition. This approach will be remaking design exercises from a prior architectural studio, the study critically evaluates the effectiveness of AI tools in addressing design problems, enhancing workflow efficiency, and supporting creative agency. The findings show both the generative potential and the limitations of these AI imaging tools. This emphasizes the need …

Quantifying Freshwater Salinization Impacts On Nitrate Removal Via Denitrification In Urban Streams, Brynnen Beck

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

As the urban world expands, the construction of impervious surfaces increases erosion and runoff into nearby streams. Urbanization also adds waste from human activity into the environment. One of these wastes is runoff from road salt application in winter months, which can increase stream salinization and interfere with other important ecological processes, such as denitrification. Therefore, the objective of this study was to compare nitrate removal via denitrification between two urban streams to understand the role of road salts in freshwater salinization. We compared conductivity measurements between the streams to see how background conductivity (a proxy for salinity) influences resilience …

Personalized Model Of Cardiac Fibroblast Signaling Using Patient-Specific Data, Elizabeth A. Schuler

Chemical Engineering Undergraduate Honors Theses

Heart disease is the leading cause of death worldwide for both men and women, and cardiac fibroblasts are critical to heart form and function. Essential roles of cardiac fibroblasts include cell-cell communication, cell-cell signaling, and synthesizing and degrading the extracellular matrix (ECM), which controls structural support and tissue repair of the heart. Abnormal fibroblast signaling can lead to negative impacts, including fibrosis, impaired heart function, and inflammation. A computational model of cardiac fibroblast signaling on Netflux and MATLAB software was adapted and utilized to determine the effect of patient-specific levels of cytokines, hormones, growth factors, peptides, and membrane tension on …

Multifunctional Pvdf Ionogels With Magnetic Nanoparticles For Electroactive And Magnetic Actuation, Alfredo Carrillo Valverde

Chemical Engineering Undergraduate Honors Theses

The fast development of compact and multifunctional electronics has driven interest in smart materials capable of responding to multiple stimuli. Ionogels, polymers that have been swollen with ionic liquids (IL), offer several favorable electrochemical and thermal properties due to their intrinsic ion conductivity, wide electrochemical window, non-flammability, and high thermal stability. However, their poor mechanical properties (e.g., modulus and strength) limit their use in applications. In this work, multifunctional PVDF ionogel composites were made by blending magnetically responsive iron oxide nanoparticles (Fe₃O₄ MNPs) into the polymer matrix. The influence of MNP concentration (9-21 wt%) on composition, ionic …

Over-Imitation In Adolescents With Autism Compared With Typically Developing Peers: An Expanded Literature Review, Elizabeth Floeck

Communication Disorders and Occupational Therapy Undergraduate Honors Theses

Abstract

Background:

Over-imitation, the act of imitating both relevant and irrelevant actions, is a behavior commonly found in human learning and social development. It is often observed in typically developing (TD) children and is believed to play a role in both social and learning development. While the exact motivations behind over-imitation remain a mystery, over-imitation appears to be a socially motivated behavior. Children may over-imitate when they know certain actions are unnecessary, suggesting this behavior stems from social acceptance and norms. In individuals with autism spectrum disorder (ASD), social and communicative behaviors are drastically different from TD individuals. In individuals …

Decoding Oncology-Focused Biotechnology Firms: Lifecycle Analysis And Predictive Insights For Valuation From A Junior Associate's Perspective, Kesav P. Chandrasekhar

Finance Undergraduate Honors Theses

Oncology-focused biotechnology firms present unique valuation challenges due to high R&D costs, long development timelines, and uncertain clinical outcomes. This thesis addresses such challenges by integrating the clinical development lifecycle with financial valuation models to provide predictive insights into company value. A structured framework is developed that primarily focuses on stage-specific probabilities of success (PoS) for drug candidates and their impact on firm valuation, embedded in techniques such sum-of-the-parts (SOTP) analysis. By quantitatively linking clinical trial phases and likelihoods of approval to cash flow projections, the model enables a more realistic, risk-adjusted estimation of a biotech firm's worth. Through lifecycle …

Dental Microwear Of Miocene Primates From The Carpathian Basin, Rudabánya, Hungary, Anna K. Wilcox

Biological Sciences Undergraduate Honors Theses

This study reconstructs and compares the dietary habits of the late Miocene primates Anapithecus hernyaki and Rudapithecus hungaricus by analyzing dental microwear patterns on fossilized teeth recovered from Rudabánya, Hungary. Previous research suggested that these sympatric species were both primarily frugivores but were unable to separate them by diet. However, earlier studies were limited by smaller sample sizes and less advanced methodologies. This study used an expanded sample and modern microwear texture analysis techniques to compare molar and incisor microwear patterns between the two species. Results revealed that Rudapithecus molars exhibited higher complexity compared to Anapithecus molar complexity, suggesting a …

Phosphatase Activity And Structure Of The Spoiie Protein In Clostridioides Difficile, Kathryn Wootten

Biological Sciences Undergraduate Honors Theses

Clostridioides difficile is a major cause of severe gastrointestinal infections and diseases, particularly in healthcare settings. Because of its ability to produce infectious endospores by sporulation, the protein SpoIIE, which is known to play a role in the regulation of this process, is being explored as a potential therapeutic target. In order to gain better insight into the structure and function of this protein, a concentrated and purified sample of the protein must be obtained. The goal of this study was to determine the conditions that would yield the highest amount of SpoIIE. The density of the cultures of bacteria …

Identifying Novel Molecular Targets To Induce Ferroptosis In Drug-Tolerant Cancer Cells Through Computational Modeling, Haris J. Rana

Biological Sciences Undergraduate Honors Theses

Ferroptosis is an iron-dependent, reactive oxygen species (ROS)-driven form of regulated cell death in which the cell membrane is degraded by lipid peroxidation. It is regulated by multiple enzymes, such as glutathione peroxidase 4 (GPX4), which prevents membrane degradation by reducing lipid peroxides and protecting cells from oxidative damage. When inhibitors like RSL3 target GPX4, lipid peroxides build up, and toxic ROS compromises membrane integrity. Traditional anticancer treatments, such as most chemotherapies, aim to eliminate tumor cells by damaging DNA and triggering apoptosis. However, resistance to apoptosis is a “hallmark of cancer,” often resulting in treatment failure. As a distinct …

Structural Stability Of Fgf1-Fgf2 Dimer Established Via Salt Bridges With Mutation K296q, Ashleigh Letterman

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast Growth Factors (FGFs) are a family of cell-signaling proteins. FGF, specifically the FGF-1 subfamily, which contains FGF-1 and FGF-2, is important in several biological functions such as wound healing, cell proliferation, and angiogenesis. FGF-1 has cell proliferation properties and FGF-2 has angiogenic properties. These FGFs have great potential for wound-healing therapy medications...

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Examining The Effects Of Quercetin On Phenotypic Characteristics Of Human Mesenchymal Stem Cells, Thomas M. Needy

Biomedical Engineering Undergraduate Honors Theses

Introduction A significant obstacle to mesenchymal stem cell (MSC) potency and therapeutic utility is in vitro senescence, an irreversible cessation of replication associated with age-related complications. Senolytic drugs, such as quercetin, may be helpful in selectively culling senescent cells while leaving non-senescent cells unaffected, thereby increasing potency of high-passage MSCs.

Methods The phenotypic, genotypic, and immunomodulatory effects of quercetin were assessed using in vitro models. Senescent cells, created through repeated subculturing of MSCs in vitro, and non-senescent cells were treated with 10 μM quercetin, differentiated into osteocytes, adipocytes, and chondrocytes, and analyzed to observe the effect of quercetin.

Results Quercetin …

Flexible Microelectrode-Based Impedance Immunosensor For Rapid Detection Of E. Coli O157:H7, Sonatan Kumar Biswas

Graduate Theses and Dissertations

Abstract Food contamination poses a significant threat to public health, the economy, and human health worldwide, occurring at any stage of the food supply chain, from farm to fork. Escherichia coli 0157:H7, recognized as one of the principal causes of foodborne illness, poses a considerable risk to food safety. The primary objective of this investigation is to devise a flexible microelectrode-based immunosensor capable of swiftly identifying E. coli O157:H7 cells without the need for incubation in a pure culture environment. In the development of the biosensor, the gold electrode (composed of 50% Au) underwent an initial coating process involving 2-aminoethanethiol/cysteamine, …

Shaping Minds, Shaping Future: Analyzing K-12 Climate Change Education Policy Preferences In Arkansas, Nataliia Borozdina

Graduate Theses and Dissertations

Climate change education in K-12 public schools is a highly debated and divisive policy issue, particularly in politically conservative states such as Arkansas, where ideological divisions often dominate and shape public attitudes and policy preferences. This dissertation examines the attitudes, preferences, and behavioral intentions of three key stakeholder groups, namely the policy elites, general public, and educators toward climate change education policies in K-12 public schools in the state of Arkansas. While political party affiliation is an important factor, this study explores a more nuanced relationship by considering the interplay of Cultural Theory, risk perception, trust in government, climate change …

Atomic Level Characterization For The Transport Cycle Conformational Pathways Of Multidrug Resistance Protein 1 (Mrp1), Samuel Wamwere Mwatha

Graduate Theses and Dissertations

The multidrug resistance-associated protein 1 (MRP1/ABCC1) is an ATP-binding cassette (ABC) transporter that mediates the cellular efflux of endogenous and xenobiotic substrates, including therapeutic drugs. Its overexpression is a major contributor to multidrug resistance in cancer, which tends to result in negative clinical results. Even with considerable progress made in structural biology, the intricate details of how membrane lipid composition affects the conformational changes and functional switches of MRP1 still lack explanation.

This thesis employs long-timescale, all-atom molecular dynamics (MD) simulations to study the influence of various lipids on MRP1 lipid bilayer environments. Both inward-facing and outward-facing conformations of MRP1 …

Exploring 2slgbtqia+ Parenting In Northwest Arkansas, Bailey Mason

Graduate Theses and Dissertations

Since the U.S. Census Bureau first published data on “same-sex” households in 2011, research has repeatedly indicated the majority of 2SLGBTQIA+ parents (here on referred to as “queer parents”) reside outside of major cities in heavily populated regions of the country. However, due to widespread metronormative narratives about the queer experience, the experiences of queer parents in less-populated regions are rarely studied. This qualitative study explores the lived experiences of queer parents in Northwest Arkansas, a region of the politically and religiously conservative Southern U.S. with areas both urban and rural. Applying grounded theory and drawing from queer theory to …

Using Deep Learning And Two-Photon Excitation Fluorescence Microscopy To Predict Breast Cancer Recurrence And Response To Chemotherapy, Nicholas Powell

Graduate Theses and Dissertations

Accurate prediction of breast cancer recurrence plays a critical role in guiding treatment decisions, particularly regarding the use of systemic therapy for patients. While genomic assays such as the Oncotype DX Recurrence Score offer valuable prognostic information, they are limited in accessibility and application. The work presented in this thesis explores an imaging-based approach for the prediction of breast cancer recurrence that combines multiphoton microscopy (MPM) with deep learning to classify individual breast cancer biopsy samples by risk of recurrence. Genomic differences in tumors with different recurrence potentials may translate to distinct optical and structural information that can be captured …

Fish Cultivation In Fallow Season Rice Fields: Effects On Landscape Methane Emissions, Samuel Carroll

Graduate Theses and Dissertations

Co-cultivation of aquatic animals and rice in the same field is a fairly common practice in various parts of the world, with a number of well-established agro-ecological benefits, such as decreasing the need for chemical pesticides and fertilizers, increasing soil organic matter, and reducing the land area needed for agricultural production. One area of environmental concern in rice production is greenhouse gas emissions. Rice production contributes about 10% of global anthropogenic methane (CH₄) emissions. Currently around 27.5% of Arkansas rice fields are flooded in the winter, which can increase CH₄ emissions in the fallow season by 45% …

What's Love Got To Do With It? A Content Analysis Of Romantic Depictions In Tween Television Programming, Laura Workman

Graduate Theses and Dissertations

In the streaming era of entertainment, television programming is available at the touch of a fingertip to any pre-adolescent tween (those between the ages of 8-13) with a smartphone. Previous content analyses have examined romantic relationship content on television programming in a limited manner, covering mostly teen shows and sexual behavior, rather than tween shows and romantic relationship behavior. And so, despite the fact that tweens tend to use media as a socializing agent for learning acceptable romantic relationship norms, not much is known about how television programs likely watched by this age demographic are depicting romantic relationships. Therefore, it …

Electrochemically Precipitated Struvite Effects On Extractable Soil Nutrients, Owen Collins

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

Struvite recovery from wastewater streams may provide an alternative to traditional fertilizer-phosphorus (P) sources, while also providing the benefit of reducing nitrogen and P loads in wastewater effluent and reducing effects of eutrophication in surface waters. Limited research has been conducted to assess the effects of struvite fertilization on concentrations of soil micronutrients and potassium (K) compared to other traditional fertilizer-P sources in historically agricultural soils. The objective of this study was to assess the effects of fertilizer-P source (i.e., synthetically produced electrochemically precipitated struvite [ECST], chemically precipitated struvite [CPST], monoammonium phosphate [MAP], diammonium phosphate [DAP], triple superphosphate [TSP], rock …

Inflammatory Response In Ucd200/206 Scleroderma-Prone Chickens To Intradermal Injection Of Silikon 1000, Katee L. Johnson

Animal Science Undergraduate Honors Theses

Intradermal injections of silicone materials have resulted in chronic inflammation and fibrotic reactions in some individuals. The UCD200/206 line of chickens is characterized by spontaneous development of scleroderma/systemic sclerosis (SSc), a fibrotic autoimmune disease. This longitudinal study examined the cellular inflammatory activity initiated by SILIKON 1000 (a silicone product used as a filler in human skin) at the site of intradermal (i.d.) injection and in the peripheral blood in the SSc-prone UCD 200/206 (UCD) chickens and healthy White Leghorn (WL) controls. Specifically, the pulps of growing feathers (GFs) were i.d. injected with SILIKON or endotoxin-free, sterile PBS (8 and 3 …