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Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Pereira, Rupesh Kariyat May 2025

Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Pereira, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Biochar is a charcoal-like substance made by the pyrolysis of organic material from agricultural and forestry waste. While biochar is well documented for altering soil physicochemical conditions, few studies have investigated its possible effects on the management of arthropod pests. Tobacco hornworm (Manduca sexta) and fall armyworm (Spodoptera frugiperda, FAW) are specialist and generalist insect herbivores respectively, that can cause significant defoliation in natural and agricultural ecosystems. In this study, we examined whether walnut shell biochar can affect growth and development of these herbivores. Specifically, we investigated how biochar influences parameters such as mass gain, length of pupation, pupal mass, …


Contributors, Diamond Line Editors May 2025

Contributors, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.


Diamond Line - Spring 2025, Diamond Line Editors May 2025

Diamond Line - Spring 2025, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.


This Land Is Your Land, This Land Is My Land: The Keys To Unlocking Eight Million Acres Of Checkerboarded Public Land, Dalton Springer May 2025

This Land Is Your Land, This Land Is My Land: The Keys To Unlocking Eight Million Acres Of Checkerboarded Public Land, Dalton Springer

Arkansas Law Review

The term “checkerboarded land” has become associated with alternating public and private square-mile lots in Western states such as Wyoming, Colorado, Washington, Idaho, Montana, Utah, Nevada, and Arizona. In the mid-19th century, the United States was in the throes of Manifest Destiny. President Abraham Lincoln signed the 1862 Pacific Railway Act which aimed to connect the eastern United States with the newly acquired western territories by developing the Transcontinental Railroad. As an incentive for building the rail line, the federal government granted the even-numbered one-square-mile sections of land to the railroad companies, while retaining the odd-numbered one-square-mile sections for itself. …


A History Of Omics Discoveries Reveals The Correlates And Mechanisms Of Loading-Induced Hypertrophy In Adult Skeletal Muscle. 2024 Camps Young Investigator Award Invited Review, Toby L. Chambers, Kevin A. Murach May 2025

A History Of Omics Discoveries Reveals The Correlates And Mechanisms Of Loading-Induced Hypertrophy In Adult Skeletal Muscle. 2024 Camps Young Investigator Award Invited Review, Toby L. Chambers, Kevin A. Murach

Health, Human Performance and Recreation Faculty Publications and Presentations

Since the early 2000s, omics approaches to study skeletal muscle hypertrophy consequent to loading (e.g., resistance exercise) have expanded dramatically. Beginning with genomics and transcriptomics, there are now omics datasets from hypertrophying skeletal muscle spanning methylomics, proteomics, and phosphoproteomics, with further integration of single cell/nucleus-specific omics, among others. The purpose of this review is to explore the history of leveraging omics to enable understanding and discovery with respect to loading-induced hypertrophy in adult skeletal muscle. We elaborate on key historical and contemporary studies and findings, highlight specific examples where omics discoveries led to a mechanistic understanding of skeletal muscle growth, …


The Relationship Between Food Allergies And Intolerances And The Development Of Disordered Eating Patterns, Lucy M. Scholma May 2025

The Relationship Between Food Allergies And Intolerances And The Development Of Disordered Eating Patterns, Lucy M. Scholma

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Food allergies and food intolerances are becoming an increasingly more prevalent issue in the Unites States. To mitigate adverse reactions, these individuals often eliminate food or food groups from their diets and the ramifications of these lifestyle changes may result in disordered eating patterns. In regard to food allergies and intolerances and eating disorders, it is reasonable to suggest that the overlapping lifestyle choices and physical, social, and emotional ramifications may lead to a correlation between the two phenomena. This study explores the relationship between food allergic and food intolerant individuals and disordered eating habits among college students. Survey results …


The Effects Of Incubation Humidity On Broiler Chicks, Claire Caples May 2025

The Effects Of Incubation Humidity On Broiler Chicks, Claire Caples

Animal Science Undergraduate Honors Theses

Leg health issues are a welfare problem in commercial broiler chickens and an economic issue for the broiler industry. Broilers exhibiting leg abnormalities show altered gait, reduced ability to access resources, and increased lameness incidence. These leg health issues can result from many animal and environmental factors during incubation and post-hatch. Incubation strategies may contribute to the development of leg health issues, and recent research has increased focus on incubation factors affecting embryonic development and health and welfare post-hatch. Thus, the objective of this study was to evaluate the effect of high (80%), low (55%), and ideal (65%) humidity on …


Developing Protective Measures To Reduce The Incidence Of Bacterial-Induced Chondronecrosis With Osteomyelitis In Broiler Chickens, Alexa L. Thomas May 2025

Developing Protective Measures To Reduce The Incidence Of Bacterial-Induced Chondronecrosis With Osteomyelitis In Broiler Chickens, Alexa L. Thomas

Animal Science Undergraduate Honors Theses

Bacterial Chondronecrosis with Osteomyelitis (BCO) lameness is a significant animal welfare and food safety issue affecting the commercial broiler industry in the United States and worldwide. Bacteria can translocate from the respiratory system and/or the gastrointestinal tract into the bloodstream, eventually settling in bone microfractures leading to necrosis and BCO lameness.

This study evaluated the effects of Probiotic 1 and Probiotic 2 on the incidence of BCO lameness in broiler chickens. Probiotic 1 was applied as a spray on Day 1-old chicks, while Probiotic 2 was administered prophylactically (orally in feed) from Day 1 to Day 56. Birds were assigned …


The Utilization And Deterioration Of Travertine In Classical, Baroque, And Fascist Architecture: A Case Study From Rome, Italy, Kaitlyn V. Fitzgerald May 2025

The Utilization And Deterioration Of Travertine In Classical, Baroque, And Fascist Architecture: A Case Study From Rome, Italy, Kaitlyn V. Fitzgerald

Graduate Theses and Dissertations

Travertine limestone has formed the resilient backbone of Roman architecture for over two millennia and across several cultural periods. This study identified the leading causes of travertine decay in Rome across Ancient, Baroque, and Fascist periods in order to efficiently prioritize conservation and restoration efforts across the city. The methodology developed here can then be utilized in other urban settings. Rome’s iconic landmarks such as the Flavian Amphitheater, St. Peter’s Basilica, and the Spanish Steps all owe their existence to this local limestone. High rates of urbanization now dictate how architectural travertine interacts with its surrounding environments and landscapes. Grand …


Assessing The Recall Of Traffic Safety Campaigns In Arkansas, Pratik Babu Pokharel May 2025

Assessing The Recall Of Traffic Safety Campaigns In Arkansas, Pratik Babu Pokharel

Graduate Theses and Dissertations

This study estimates the degree to which drivers recall traffic safety campaigns based on sociodemographic characteristics including driving frequency, vehicle type, education, income, age, household composition, race, and gender. Traffic safety campaigns are efforts to educate, persuade, and inspire individuals to adjust their attitudes and behaviors for improved road safety, utilizing planned communications over a set time period. They aim to encourage safe driving using slogans shown on television, radio, social media, billboards, and variable message signs. Two years of a mail-based survey conducted in Arkansas were used to estimate binary logistic regression models for each of four safety campaigns. …


An Analytical Evaluation Of Economic Geography Within Maine And Its Resource Industries: 1600 To Present, Maureen Mantooth May 2025

An Analytical Evaluation Of Economic Geography Within Maine And Its Resource Industries: 1600 To Present, Maureen Mantooth

Graduate Theses and Dissertations

Resource peripheries represent a fringe area within economic geography, originating from the core-periphery theory developed by Friedmann and Miller. This concept has evolved to address global and regional contexts, referring to marginalized regions that rely heavily on the extraction and export of natural resources. By studying these regions, we gain a deeper understanding of critical components in global economic systems. This dissertation focuses on Maine as a case study of a resource periphery, using the framework proposed by Hayter et al. (2003) within the broader regional contexts of New England and the United States. Key factors explored include resource exploitation, …


Using Scaffolding, Gamification, And Self Awareness To Create Responsive Ux/Ui In Cad Software To Nurture Metacognition In Novice Users, Obed Ibrahim Gonzalez May 2025

Using Scaffolding, Gamification, And Self Awareness To Create Responsive Ux/Ui In Cad Software To Nurture Metacognition In Novice Users, Obed Ibrahim Gonzalez

Graduate Theses and Dissertations

Computer-aided Design (CAD) software represents a significant shift from manual and analog design processes to digital workflows, offering substantial utility, accuracy, and productivity benefits. However, CAD software often presents a steep learning curve, particularly for novice users who are new to the software or possess only basic knowledge. Traditional CAD curricula have predominantly focused on technical problem-solving—teaching tools and systems—while often neglecting strategic knowledge that encompasses reflection, planning, and refining, which are essential components of metacognition. Metacognition is crucial for transforming novices into experts who use fewer and more complex commands, employ sophisticated planning, and achieve their goals more efficiently. …


A Living House Never Stands Still, Holly Rose Kranker May 2025

A Living House Never Stands Still, Holly Rose Kranker

Graduate Theses and Dissertations

A Living House Never Stands Still is an exhibition that explores the interplay between place, memory, and the suspension of time through diverse mediums and materials. I engage with seemingly mundane objects, interpreting them through a non-linear, dream-like, and irrational framework to unearth latent connections across time–past, present, and future. Central to these explorations is the concept of home—not merely as a physical location, but as an evolving entity. Home is a sacred space for me.

My recent studio reflections are focused on the lifecycle of objects, the emotional responses they evoke, and how these cycles emulate the human body …


Adult Effects And Affects: Dialogic Reflections And Theoretical Analysis Of Systemic Led Education, Early Childhood Education, And Art Education, Katherine Galaz May 2025

Adult Effects And Affects: Dialogic Reflections And Theoretical Analysis Of Systemic Led Education, Early Childhood Education, And Art Education, Katherine Galaz

Graduate Theses and Dissertations

Through self-exploration, reflexive dialogue, and literature review I look to the grey areas, contradictions, and margins of hegemonic educational practices. I highlight the ways in which the standard of education is structured in opposition to how children seek to understand and make sense of the world. In my analysis of early childhood settings and art education under the umbrella of the U.S. education system, I approach historical antecedents involving colonialism and systemic injustice. Within the field of art education, I specifically look at the artistic and imaginative ways that children resist societal norms in early childhood education. As such, I …


Characterizing The Medial Forebrain Bundle In Adolescents With Anhedonic Depression, Tina Nguyen May 2025

Characterizing The Medial Forebrain Bundle In Adolescents With Anhedonic Depression, Tina Nguyen

Biological Sciences Undergraduate Honors Theses

Adolescent depression has quickly grown in prevalence, yet the underlying neuropathology remains poorly understood. Anhedonia–the diminished ability to experience pleasure–is a core symptom of melancholic depression. Early identification of biomarkers associated with anhedonic depression could help mitigate the severity of the disorder by enhancing treatment efficacy. Blunted functionality of the nucleus accumbens (NAcc), the reward center of the brain, and abnormal dopaminergic activity in the ventral tegmental area (VTA) have both been linked to depression. Furthermore, glutamatergic input from the hypothalamus modulates the VTA which in turn, downregulates dopamine release in the NAcc. However, there is limited evidence supporting that …


Assessing The Prevalence Of Ehrlichia Spp. In Ticks Associated With Canids In Arkansas, Eva J. Berryhill May 2025

Assessing The Prevalence Of Ehrlichia Spp. In Ticks Associated With Canids In Arkansas, Eva J. Berryhill

Animal Science Undergraduate Honors Theses

Canine ehrlichiosis is a disease that is commonly seen in dogs. In previous studies, the southeastern part of the United States has been identified as an area of high prevalence. Arkansas was included in the region where the prevalence is high. Changes in climate, household income, and tick population were identified as factors contributing to this high prevalence. Canine ehrlichiosis is caused by three Ehrlichia spp., which are E. canis, E. ewingii, and E. chaffeensis. Ticks are responsible for transmitting the disease, specifically R. sanguineus, D. variabilis, and A. americanum. For this study, the goal was to determine the prevalence …


Utilizing 16s Ribosomal Rna Sequencing To Identify Bacterial Species Colonizing Lame Birds With Bacterial Chondronecrosis With Osteomyelitis, Kara Hoover May 2025

Utilizing 16s Ribosomal Rna Sequencing To Identify Bacterial Species Colonizing Lame Birds With Bacterial Chondronecrosis With Osteomyelitis, Kara Hoover

Animal Science Undergraduate Honors Theses

Broiler chicken lameness has become prevalent in recent years due to high growth rates in broilerchickens. Bacterial chondronecrosis with osteomyelitis (BCO), the main cause of lameness, is characterized by necrosis of femoral and tibial heads in affected birds. Heavier birds are more susceptible to mechanical stress in these regions, which results in microfractures, leading to lameness. BCO lameness poses huge financial pressure to the poultry industry, as 14-50% of flocks can become affected during outbreaks. The purpose of this experiment was to identify bacterial species present in birds with BCO lameness. A total of 1,560 chicks were randomly distributed into …


The Effect Of 1,25-Dihydroxyvitamin D3 Supplementation On Humoral Immunity Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Bailey Herberger May 2025

The Effect Of 1,25-Dihydroxyvitamin D3 Supplementation On Humoral Immunity Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Bailey Herberger

Animal Science Undergraduate Honors Theses

Bacterial chondronecrosis with osteomyelitis (BCO) lameness, the most predominant locomotive illness in fast-growing broilers, causes substantial animal well-being issues and affects broiler production, leading to huge financial losses. Several strategies, including feed supplementations using organic trace minerals, vitamin D, probiotics, and prebiotics, have been utilized to alleviate BCO lameness incidences in broiler chickens. Previous studies have indicated that feeding an additive of Panbonis®-G-1,25(OH)2D3 from Solanum glaucophyllum containing 1 µg/kg G-1,25(OH)2D3 to broilers for the first 28 days of their production cycle reduced BCO lameness by more than 50%. In this study, we …


Effects Of Intradermal Injections Of Lipopolysaccharide On The Local And Systemic Acute Inflammatory Responses In Turkeys, Delaney F. Roberts May 2025

Effects Of Intradermal Injections Of Lipopolysaccharide On The Local And Systemic Acute Inflammatory Responses In Turkeys, Delaney F. Roberts

Poultry Science Undergraduate Honors Theses

In chickens, the growing feather (GF) pulp has been established as a cutaneous bioassay to monitor and assess tissue/cellular immune activities in response to intradermal (i.d.) injections of test materials. The objective of this pilot study was to determine the suitability of the GF bioassay in turkeys by examining the acute inflammatory responses initiated by i.d. GF-pulp injections of lipopolysaccharide (LPS). For this, three, 5-wk-old turkey poults were used. Two poults had 8 GFs injected (10 μL/GF) with low (L)-LPS (0.1 μg/GF) and 8 GFs with high (H)-LPS (1 μg/GF), while a third poult had 8 GFs injected with endotoxin-free …


Decoding Oncology-Focused Biotechnology Firms: Lifecycle Analysis And Predictive Insights For Valuation From A Junior Associate's Perspective, Kesav P. Chandrasekhar May 2025

Decoding Oncology-Focused Biotechnology Firms: Lifecycle Analysis And Predictive Insights For Valuation From A Junior Associate's Perspective, Kesav P. Chandrasekhar

Finance Undergraduate Honors Theses

Oncology-focused biotechnology firms present unique valuation challenges due to high R&D costs, long development timelines, and uncertain clinical outcomes. This thesis addresses such challenges by integrating the clinical development lifecycle with financial valuation models to provide predictive insights into company value. A structured framework is developed that primarily focuses on stage-specific probabilities of success (PoS) for drug candidates and their impact on firm valuation, embedded in techniques such sum-of-the-parts (SOTP) analysis. By quantitatively linking clinical trial phases and likelihoods of approval to cash flow projections, the model enables a more realistic, risk-adjusted estimation of a biotech firm's worth. Through lifecycle …


The Effect Of Administered Animal-Assisted Therapy On University Students' Anxiety And Stress, Chloe Penton May 2025

The Effect Of Administered Animal-Assisted Therapy On University Students' Anxiety And Stress, Chloe Penton

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Abstract

Purpose: The purpose of this research study is to evaluate the effects of animal-assisted therapy (AAT) on undergraduate student anxiety and stress, comparing the effectiveness between an individual AAT session to a group study session without AAT. Animal-assisted therapy is a type of canine therapy that may be a helpful tool to decrease student test anxiety, and potentially, a meaningful stress-reducing intervention for university students. Our results sought to examine differences in traditional study practices vs the use of AAT prior to exams, and support or refute animal-assisted therapy as a low-cost, minimal-risk, effective solution for undergraduate student anxiety. …


Inflammatory Response In Ucd200/206 Scleroderma-Prone Chickens To Intradermal Injection Of Silikon 1000, Katee L. Johnson May 2025

Inflammatory Response In Ucd200/206 Scleroderma-Prone Chickens To Intradermal Injection Of Silikon 1000, Katee L. Johnson

Animal Science Undergraduate Honors Theses

Intradermal injections of silicone materials have resulted in chronic inflammation and fibrotic reactions in some individuals. The UCD200/206 line of chickens is characterized by spontaneous development of scleroderma/systemic sclerosis (SSc), a fibrotic autoimmune disease. This longitudinal study examined the cellular inflammatory activity initiated by SILIKON 1000 (a silicone product used as a filler in human skin) at the site of intradermal (i.d.) injection and in the peripheral blood in the SSc-prone UCD 200/206 (UCD) chickens and healthy White Leghorn (WL) controls. Specifically, the pulps of growing feathers (GFs) were i.d. injected with SILIKON or endotoxin-free, sterile PBS (8 and 3 …


The Effect Of 1,25-Dihydroxyvitamin D3 Supplementation On Humoral Immunity Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Bailey Herberger May 2025

The Effect Of 1,25-Dihydroxyvitamin D3 Supplementation On Humoral Immunity Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Bailey Herberger

Animal Science Undergraduate Honors Theses

Bacterial chondronecrosis with osteomyelitis (BCO) lameness, the most predominant locomotive illness in fast-growing broilers, causes substantial animal well-being issues and affects broiler production, leading to huge financial losses. Several strategies, including feed supplementations using organic trace minerals, vitamin D, probiotics, and prebiotics, have been utilized to alleviate BCO lameness incidences in broiler chickens. Previous studies have indicated that feeding an additive of Panbonis®-G-1,25(OH)2D3 from Solanum glaucophyllum containing 1 µg/kg G-1,25(OH)2D3 to broilers for the first 28 days of their production cycle reduced BCO lameness by more than 50%. In this study, we …


Influence Of Gossypol From Cottonseed Meal Fed To Pregnant Sows On Seminiferous Tubule Diameters In Male Offspring, Elizabeth Callaway May 2025

Influence Of Gossypol From Cottonseed Meal Fed To Pregnant Sows On Seminiferous Tubule Diameters In Male Offspring, Elizabeth Callaway

Animal Science Undergraduate Honors Theses

Feral swine were first brought to the United States in the 1500s as a source of food and have been reported as an invasive species since then without an efficient method of population control. Ongoing research indicates that the total cost of the damage this species has caused estimates to around 1.5 billion dollars each year (USDA, 2023). Gossypol is a phenolic compound found in the cotton plant and can be administered in the form of cottonseed meal (CSM). Gossypol has been associated with reduced fertility in various species (Randel et al., 1992). Pregnant sows were fed cottonseed meal to …


Creative Brief For Wk Kellogg's Co, Sarah K. Johnson May 2025

Creative Brief For Wk Kellogg's Co, Sarah K. Johnson

Marketing Undergraduate Honors Theses

In recent years, cereal, the once classic and essential breakfast food has been losing its market share and overall sales in the breakfast category. WK Kellogg’s cereal brands include Frosted Flakes, Froot Loops, Frosted Mini Wheats, Special K, Rice Krispies, Raisin Bran, Corn Flakes, and more, yet their sales have been falling. They now face a challenge, as consumers become more cost and health conscious, how can cereal be made fun again? What ways can they engage with new audiences and further excite current customers? After conducting research, I have developed a creative brief and strategic pitch that include solutions …


Livestock Risk Protection Basis Risk For Feeder Cattle, Bryce Anderson May 2025

Livestock Risk Protection Basis Risk For Feeder Cattle, Bryce Anderson

Graduate Theses and Dissertations

Recent government subsidies make livestock risk protection (LRP) insurance an affordable price risk management tool for many U.S. cattle producers. LRP insurance triggers a loss when the Chicago Mercantile Exchange (CME) Feeder Cattle Index falls below the selected coverage price. The CME Feeder Cattle Index is a 7-day weighted average of feeder cattle prices in 12 states. This paper determines if LRP policy holders who produce feeder cattle in states whose feeder cattle prices are not included in the CME Feeder Cattle Index are exposed to excess basis risk. To do this, we use a hedonic regression model to determine …


Calming Music As An Emotion Regulation Technique In Response To A Traumatic Sexual Assault Narrative, Mia A. Iandolo May 2025

Calming Music As An Emotion Regulation Technique In Response To A Traumatic Sexual Assault Narrative, Mia A. Iandolo

Psychological Science Undergraduate Honors Theses

Experiencing a sexual assault often results in lasting psychological trauma that inhibits the person’s ability to function, so coping strategies are needed to reduce those symptoms. This study was done to understand the effect of listening to calming music (vs silence) on both anxiety levels and memory recall following the description of a sexual assault. It was hypothesized that listening to calming music would decrease both anxiety and memory levels in a manner that the association between music and memory would be at least partially mediated by anxiety levels. Participants (N=99; 68% female; 84% White; 87% heterosexual) came …


Functional Consequences Of Lysine Acetylation Of Phosphofructokinase Isozymes, Xinyu Lin, Nour Fatema, Qinglei Gan, Chenguang Fan May 2025

Functional Consequences Of Lysine Acetylation Of Phosphofructokinase Isozymes, Xinyu Lin, Nour Fatema, Qinglei Gan, Chenguang Fan

Chemistry & Biochemistry Faculty Publications and Presentations

Phosphofructokinase (Pfk) catalyzes the phosphorylation of fructose 6-phosphate and is a key regulatory point in the glycolysis pathway. Multiple lysine residues in both Pfk isozymes, PfkA and PfkB, have been identified to be acetylated in Escherichia coli by proteomic studies, but no studies have been implemented to further characterize these acetylation events. To investigate the role of Pfk acetylation, the genetic code expansion strategy was used to generate homogeneously acetylated Pfk variants at target lysine sites that have been reported to be acetylated in nature. We found that acetylation of K309 of PfkA and K27 of PfkB decreased PfK enzyme …


Sports Betting, The Gateway Drug To A Gambling Addiction: A Study Of The Implications Of Sports Gambling On Societal Well-Being And Its Effects On The Younger Generation, Ellison Lewis May 2025

Sports Betting, The Gateway Drug To A Gambling Addiction: A Study Of The Implications Of Sports Gambling On Societal Well-Being And Its Effects On The Younger Generation, Ellison Lewis

Marketing Undergraduate Honors Theses

Introduction

It is everywhere you turn. In recent years we have seen unprecedented growth in the advertising, activities, and addiction of gambling. To put it into perspective “the AGA reported that total revenue from land-based casino games, sports betting and iGaming reached $66.52 billion for the calendar year, a 10% gain from the previous record set in 2022.” Of that, $10.92 billion came from sports betting specifically which was a 44.5% increase from the prior year (Reynolds, 2024). Factors contributing to the rise include the increase in gambling advertisements, the legalization of sports betting, and the removal of environmental barriers …


Leveraging Natural Variation In Yeast To Understand Susceptibility Differences In Parkinson’S Disease, Julio Andres Molina Pineda May 2025

Leveraging Natural Variation In Yeast To Understand Susceptibility Differences In Parkinson’S Disease, Julio Andres Molina Pineda

Graduate Theses and Dissertations

Parkinson’s Disease (PD) is a neurodegenerative disorder that causes countless suffering around the world. Both forms, familial and sporadic, have been associated with the misfolding and cytotoxicity of α-synuclein, an otherwise non-pathogenic protein suspected to have various roles in the normal maintenance of the central nervous system. Model organisms have emerged as great vessels to uncover the cellular and molecular mechanisms that shape α-syn biology, and great strides have been made to understand it. Yet, it is still unclear why some individuals are affected by α-syn toxicity, while others not so much. Since it’s extremely complicated to study and probe …