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Efficacy Of Spirulina (Arthrospira Platensis) Utilization In Broiler Diets, Garrett James Mullenix Dec 2021

Efficacy Of Spirulina (Arthrospira Platensis) Utilization In Broiler Diets, Garrett James Mullenix

Graduate Theses and Dissertations

Spirulina (Arthrospira platensis) is a cyanobacteria microalgae that has potential as an animal feed ingredient. Five experiments were conducted to further assess its ability to serve as a protein source in broiler diets. Experiment 1 consisted of an amino acid digestibility and apparent metabolizable energy assay. The results indicated that the standardized ileal amino acid levels of spirulina are comparable with typical soybean meal. Experiment 2 assessed the performance and processing parameters of broilers fed 10% spirulina in low crude protein diets, using published digestibility coefficients. Spirulina inclusion improved footpad quality and increased redness and yellowness of the breast, skin …


Divergent Selection For Water Conversion Ratio In Broiler Populations, Joseph Hiltz Dec 2021

Divergent Selection For Water Conversion Ratio In Broiler Populations, Joseph Hiltz

Graduate Theses and Dissertations

Water scarcity is a global reality and with the anticipated population growth, freshwater resources will be further strained to meet both human needs and agriculture applications. To ensure a water sustainable and food secure future, all aspects of agriculture must become more efficient. Two strategies were explored. The potential of improving water efficiency in broilers was examined. The first strategy was to develop a more efficient and accurate method for measuring water consumption/inputs in agriculture. To date, water measuring technology has lacked the necessary sophistication to assure accuracy and repeatability of low flow water usage.

After establishing a low flow …


Evaluation Of Nitrous Oxide Emissions From Furrow-Irrigated Rice On A Silt-Loam Soil In Arkansas, Jordan M. Slayden Dec 2021

Evaluation Of Nitrous Oxide Emissions From Furrow-Irrigated Rice On A Silt-Loam Soil In Arkansas, Jordan M. Slayden

Graduate Theses and Dissertations

As the number one rice (Oryza sativa)-producing state in the United States, Arkansas also ranks fourth as the largest user of groundwater. Recently, due to the development of drought- resistant hybrid cultivars, the furrow-irrigated rice production system has become an increasingly popular alternative to traditional flood-irrigated production with respect to conserving groundwater and maintaining yield. However, other environmental parameters, like greenhouse gas emissions, specifically nitrous oxide (N2O), have yet to be evaluated under furrow-irrigated rice. The objectives of this study were to i) evaluate the effects of site position (i.e., up-, mid-, and down-slope) and tillage treatment [i.e., conventional tillage …


In The Line Of Duty - A Documentary Film About Davis Duty And His Seeing Eye Dog, Paulina Sobczak Dec 2021

In The Line Of Duty - A Documentary Film About Davis Duty And His Seeing Eye Dog, Paulina Sobczak

Graduate Theses and Dissertations

“In the Line of Duty” is a documentary film about Jeff Davis Duty, a man from a small town in Arkansas, who lost his sight at the age of five. He is the oldest Seeing Eye dog user in the world. At the age of 22, he was awarded a Fulbright Scholarship at the London School of Economics in England, as the first Fulbright Scholar with disability. Duty achieved great success in his career as a lawyer, leading a fulfilling and enjoyable life. The documentary film’s storytelling focuses on Duty’s life from his childhood to current times and presents all …


The Same River Twice, Claire Remy Pincumbe Dec 2021

The Same River Twice, Claire Remy Pincumbe

Graduate Theses and Dissertations

This thesis is a portion of a novel written during my time at the University of Arkansas.


Body Mass And Body Condition Variation Of Mallards (Anas Platyrhynchos) Within And Among Winters Within The Lower Mississippi Alluvial Valley, John Thompson Veon Dec 2021

Body Mass And Body Condition Variation Of Mallards (Anas Platyrhynchos) Within And Among Winters Within The Lower Mississippi Alluvial Valley, John Thompson Veon

Graduate Theses and Dissertations

Most North American waterfowl overwinter in southern North America before migrating back to breeding grounds in the northern US and Canada. These species face the challenge of needing to maintain or increase their body mass during an environmentally difficult winter period. Successful body mass maintenance during the winter period has major ramifications not only for their winter survival but for their fitness across the entire year. Recent research in Europe and the western United States suggests that the body mass of mallards (Anas platyrhynchos) has increased from the late 1960s to early 2000s. However, the factors responsible for increases in …


Genome-Wide Analyses Of Genomic Variation Regulating Differential Stress Responses In Japanese Quail, Steven Anthony Shumaker Dec 2021

Genome-Wide Analyses Of Genomic Variation Regulating Differential Stress Responses In Japanese Quail, Steven Anthony Shumaker

Graduate Theses and Dissertations

As consumer demands for poultry grow, producers work to improve bird productivity in both meat and egg production. This endeavor is multifaceted, as many different factors play a part in influencing the productivity of birds, including environmental conditions, overall health, and genetic potential. One aspect controlled for in all aspects of poultry production optimization is stress management. Mitigation of stress is of primary concern to producers, as improper stress management can have many deleterious effects on chickens. Stress management requires an understanding of poultry stress responses and their physiological mechanisms, which can be more deeply understood through genomic analysis. Chapter …


Optimization Of Nitrogen Removal Rate In One-Stage Reactor Through Partial Nitrification Anammox Process During Direct Treatment Of Poultry Litter Wastewater, Yiting Xiao Dec 2021

Optimization Of Nitrogen Removal Rate In One-Stage Reactor Through Partial Nitrification Anammox Process During Direct Treatment Of Poultry Litter Wastewater, Yiting Xiao

Graduate Theses and Dissertations

Anammox is an increasingly common process used for the treatment of reject water and even mainstream wastewater due to its low oxygen demand. However, anammox is not commonly utilized in the direct treatment of poultry litter because of the high organic content, which would inhibit the anammox process. Thus, this project is aimed at optimizing the nitrogen removal rate through partial nitrification anammox process (PN/A) to treat synthetic poultry litter wastewater. Nitrogen removal efficiencies will therefore be improved through optimizing the combination of three operating parameters including hydraulic retention time (HRT), dissolved oxygen (DO) concentration, and carbon to nitrogen (C/N) …


Reducing Dietary Crude Protein: Characterization Of Branched-Chain Amino Acid Antagonism In Modern Broiler Chickens, Craig William Maynard Dec 2021

Reducing Dietary Crude Protein: Characterization Of Branched-Chain Amino Acid Antagonism In Modern Broiler Chickens, Craig William Maynard

Graduate Theses and Dissertations

Reducing the crude protein content of broiler diets while maintaining performance has been a primary research area in nutrition. During the late 20th century, the bulk of this research has involved supplementing broiler diets with feed-grade amino acids and proving the economic benefits of their additions. To date, widespread adoption of feed-grade amino acids is limited to methionine, lysine, threonine, and to some extent valine. With valine and isoleucine gaining prevalence in commercial formulation, classic data on the antagonisms associated with the branched-chain amino acids has returned to the forefront of practical broiler nutrition research. Therefore, a series of 23 …


Precise Nitrogen Recommendations Improve Economic And Environmental Outcomes In Arkansas Rice Production, Cristin Roberts Dec 2021

Precise Nitrogen Recommendations Improve Economic And Environmental Outcomes In Arkansas Rice Production, Cristin Roberts

Graduate Theses and Dissertations

Soil testing has become an increasingly important tool in making agronomically efficient production management decisions. N-STaR is a N test used in rice production and is unique in its ability to selectively quantify soil organic-N compounds which are readily mineralizable for plant N uptake and contribute to growth and yield. This study uses historical (2002–2018) adoption rates of N-STaR, which is funded through Rice Checkoff funds, to calculate the total cost savings from N-STaR adoption. These cost savings alone would be the “typical” benefits used in a benefit-cost ratio of a public ally funded research program like N-STaR. However, we …


Sensitivity Of Soybean And Rice To Dicamba, Owen Wesley France Dec 2021

Sensitivity Of Soybean And Rice To Dicamba, Owen Wesley France

Graduate Theses and Dissertations

Although the integration of dicamba as a postemergence (POST) herbicide has proven useful in controlling many herbicide-resistant weeds, its damage to soybean at low rates, such as supplied by drift and volatility, has been well-documented. Injury to other crops, such as rice, from off-target movement of dicamba and other commonly used herbicides, such as glyphosate, may also occur. Practical options for mitigating injury and yield loss to soybean and other crops from dicamba off-target movement could prove beneficial if dicamba continues to be used during summer months. Experiments were conducted to determine the effects of multiple agricultural practices, including cultivar …


Adapting Animals: Nineteenth-Century British Literature, Science, And Media, Kristen Layne Figgins Dec 2021

Adapting Animals: Nineteenth-Century British Literature, Science, And Media, Kristen Layne Figgins

Graduate Theses and Dissertations

In the nineteenth century, Charles Darwin and other proponents of evolutionary theory provided a theoretical framework for discussing the question of humanity’s place in the world. These nascent theories emphasized the shared animal nature of humans and the nonhuman creatures who had once occupied a distinctly lower place on the chain of being. My dissertation addresses the question of how nineteenth-century scientific attitudes about animals were reflected in the literature of the period. By examining culture-texts from the nineteenth century, it is clear that literature was an active participant in extending scientific knowledge, often by playing with the blending categorical …


New Titanate Bioceramic Nanomaterials For Drug Delivery And Controlled Release, Seaab Imad Sahib Dec 2021

New Titanate Bioceramic Nanomaterials For Drug Delivery And Controlled Release, Seaab Imad Sahib

Graduate Theses and Dissertations

Nanomaterials have attracted much attention for biomedical applications due to their unique characteristics that are proven to be potential in cell sensing, drug delivery, biological membrane penetration, biocompatibility, and tissue adhesion. The outcomes of this dissertation presented in chapter III-V mainly discuss new approaches in drug delivery, cellular uptake improvement, and neuronal regeneration and protection using a well-optimized titanium-based nanomaterial. In particular, Chapter III summarizes the impact of two different versions of the titanate nanowires on ameliorating the delivery of the antimicrobial and anticancer drug in vitro. Those drugs were loaded on the surface of the fabricated nanowires and characterized …


Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello Dec 2021

Investigating Effects Of Microenvironmental Stress On Cell Metabolism Using Multiphoton Imaging, Lisa Rebello

Graduate Theses and Dissertations

Resistance to therapy in cancer is a major cause of poor prognosis in patients. Tumor hypoxia plays an active role in mediating treatment resistance and has been linked to metastases and metastatic potential in cancer. Our research focused on three objectives: i) To understand metabolic effects of chronic and intermittent hypoxia in murine breast cancer cells and its affiliation with metastatic potential ii) To identify the metabolic changes associated with radiation therapy in a panel of radiosensitive and radioresistant human head and neck cancer cells and iii) to monitor the changes in cell metabolism associated with gain of treatment resistance. …


Enzymatic Degradation Of Microcystin-Lr By Microcystinase (Mlra), Faisal Alqhtani Dec 2021

Enzymatic Degradation Of Microcystin-Lr By Microcystinase (Mlra), Faisal Alqhtani

Graduate Theses and Dissertations

Microcystin-LR (MC-LR) is affecting the water supply worldwide. Hence, a way to eliminate this toxin is an essential target. In this study, successful cloning of the mlrA gene and producing MlrA enzyme that can degrade the cyclic MC-LR to linearized MC-LR was done. MlrA protein was expressed in Escherichia coli BL-21 (E. coli). Also, enhancing the MlrA yield by adding nickel to LB media was a success in producing more MlrA enzyme from the same volume. Even though the enzyme showed no activity after adding Ni, the enzyme was expressed at a higher yield. Furthermore, it was to investigate adding …


Winter Cover Crop Mixes: Effects On Strip-Tilled Plasticulture And No-Till Watermelon Production In Arkansas, Alden Neil Hotz Dec 2021

Winter Cover Crop Mixes: Effects On Strip-Tilled Plasticulture And No-Till Watermelon Production In Arkansas, Alden Neil Hotz

Graduate Theses and Dissertations

Watermelon, Citrullus lanatus (Thunb.) Matsum. & Nakai, producers in Arkansas grow watermelons in either plasticulture or bare-ground systems. Both systems can benefit from the use of winter cover crops for weed control and to supply nitrogen (N) to the watermelon crop. Currently, the use of cover crops in watermelon production in AR is mostly limited to either cereal rye (Secale cereale L.) or winter wheat (Triticum aestivum L). The objective of this research is to evaluate the potential benefits of growing a mix of a legume and grass cover crops before watermelon production in both a strip-till plasticulture and a …


Invited Review: Lessons From The Covid-19 Pandemic For Food Supply Chains, John D. Anderson, James L. Mitchell, Joshua G. Maples Dec 2021

Invited Review: Lessons From The Covid-19 Pandemic For Food Supply Chains, John D. Anderson, James L. Mitchell, Joshua G. Maples

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Purpose

Some of the biggest economic disruptions from the COVID-19 pandemic were experienced in food supply chains, particularly in the protein sector. This article examines these protein-sector supply-chain shocks, exploring the nature and causes of the market disruptions during the pandemic, evaluating the effects of these shocks from an economic perspective, and discussing potential market and policy responses that could mitigate the adverse effects of similar events in the future.

Sources

A variety of sources contemporary to the pandemic were surveyed to document pandemic effects on meat and poultry supply chains. The implications of pandemic effects for supply chain participants …


Rice Quality And Its Impacts On Food Security And Sustainability In Bangladesh, Indrani Saha, Alvaro Durand-Morat, Lawton Lanier Nalley, Mohammad Jahangir Alam, Rodolfo M. Nayga Jr. Dec 2021

Rice Quality And Its Impacts On Food Security And Sustainability In Bangladesh, Indrani Saha, Alvaro Durand-Morat, Lawton Lanier Nalley, Mohammad Jahangir Alam, Rodolfo M. Nayga Jr.

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Rice market efficiency is important for food security in countries where rice is a staple. We assess the impact of rice quality on rice prices, food security, and environmental sustainability in Bangladesh. We find that while price varies as expected for most quality attributes, it is unaffected by a broken percentage below 24.9 percent. This reveals a potential inefficiency, considering the average 5 percent broken rate observed in the market. An increase in the broken rate of milled rice within the limits supported by our findings can, ceteris paribus, increase rice rations by 4.66 million a year, or conversely, …


Effects Of Extrinsic And Intrinsic Factors On Meat Quality And Muscle Biology Of Livestock, Yongjie Wang Dec 2021

Effects Of Extrinsic And Intrinsic Factors On Meat Quality And Muscle Biology Of Livestock, Yongjie Wang

Graduate Theses and Dissertations

In order to improve the meat quality of livestock, intrinsic and extrinsic factors that impact meat quality have been studied for a long time to optimize production quality. Nutrition, breed, and environment are the three most common factors to improve meat quality and muscle growth. The objective of this thesis is to perform a horizontal comparison of the effects of crude protein levels, breeds, and topsoil on the growth performance, muscle development, and meat quality of livestock, and also a longitudinal analysis using RNA-seq, RT-qPCR, and Western-blot to investigate the changes in genes and proteins related to muscle growth, and …


Comparing Organic And Conventional Yield Responses To Climate Variations, Joost Wilken Meyer Dec 2021

Comparing Organic And Conventional Yield Responses To Climate Variations, Joost Wilken Meyer

Graduate Theses and Dissertations

This thesis compares the responses of organic yields and conventional yields towards climate variations. To achieve this objective, weather variables such as growing season weather conditions (average temperature, precipitation, cloud cover, relative humidity, drought index), weather anomalies, the occurrence of severe or extreme droughts and excessive rainfalls, are combined with 23 data sets gathered from previous studies that compare organic and conventional yields from the same location and time periods. To narrow the scope, the thesis focuses on soybean, maize, and wheat production in Europe and North America. Study-level fixed-effects models are used to control for any time-invariant factors such …


Crispr Gene Editing Drivers, Barriers And Prospects: A Comparative Study Among Plant Scientists Globally, Adriaan Johannes De Lange Dec 2021

Crispr Gene Editing Drivers, Barriers And Prospects: A Comparative Study Among Plant Scientists Globally, Adriaan Johannes De Lange

Graduate Theses and Dissertations

The introduction of CRISPR gene editing into food crops has potential to contribute to food security and sustainable food production globally. To date, most scientific studies have focused on consumer perception of CRISPR gene edited foods or the potential benefits and risks of the CRISPR technology and none have focused on the perceptions of plant scientists concerning CRISPR gene editing. This study aimed to explore the investments, functions, barriers, benefits for specific crops and beneficiaries of CRISPR gene editing according to plant scientists, by distributing an online survey in which 1,040 plant scientists active across six continents and in both …


Dissonance Between Christian Beliefs And Eating Habits In The South, Karli Dianne Stringer Dec 2021

Dissonance Between Christian Beliefs And Eating Habits In The South, Karli Dianne Stringer

Graduate Theses and Dissertations

The purpose of this qualitative study was to initiate understanding of how obesity in the South is still so prevalent even though the majority of inhabitants subscribe to a faith that discourages unhealthy lifestyles. Furthermore, the information presented in this research sought to fill the knowledge gap for communicators and educators concerning the dissonance between Christianity in the South and the unhealthy eating habits of Southerners. Grounded in the Cognitive Dissonance Theory, this study comprised of a semi-structured interview route in which Protestant evangelical Christians in the South (N = 11) participated in a descriptive study conducted by a committee …


Identification Of Phosphorous Loading Point Source Facilities To 303(D) Listed Nutrient Impaired Waters Through Watershed Delineation Using Arcgis For Life Cycle Assessment Applications, John Zimmerman Dec 2021

Identification Of Phosphorous Loading Point Source Facilities To 303(D) Listed Nutrient Impaired Waters Through Watershed Delineation Using Arcgis For Life Cycle Assessment Applications, John Zimmerman

Chemical Engineering Undergraduate Honors Theses

The work done for this project is part of a larger “life cycle assessment (LCA) of novel electrochemical phosphorus recovery technology at the wastewater treatment plant and U.S. watershed scales” (Morrissey 2019). The goal of that LCA is to determine “environmental impacts of implementing electrochemical struvite recovery at the wastewater treatment plant, U.S watershed, and global scales” (Morrissey 2019). This project’s goal is to identify locations deemed more sensitive to eutrophication impacts. The results will be used as part of the life cycle inventory (LCI) accounting for geographically explicit phosphorus flows. The waters identified as impaired were sourced from the …


How Are Agricultural Research Projects Conceiving Innovation? An Assessment Of The European Union Multi-Actor Projects, Samuel Brea Martinez-Collado Dec 2021

How Are Agricultural Research Projects Conceiving Innovation? An Assessment Of The European Union Multi-Actor Projects, Samuel Brea Martinez-Collado

Graduate Theses and Dissertations

Horizon research programs are the European Union’s lighthouse for innovation and research concerning the agri-food chain, the management of natural resources, and the bioeconomy. Their innovation strategy approach is one that pursues the practical application of the research via the collaboration of all actors involved. Such strategy is the reflection of a Multi-Actor Approach as their procedure to enhance innovation. This paper presents the main trends and directions 101 Multi-Actor Projects (MAPs) are following on said approach towards innovation. The analysis is based on the use of well-defined “pathways” and “measures” proposed in the Guidelines for Evaluation of Innovation in …


Northern Bobwhite Occupancy Patterns On Multiple Spatial Scales Across Arkansas, Ellery V. Lassiter, Marcus Asher, Grace Christie, Connor Gale, Andrhea Massey, Cody Massery, Christopher R. Middaugh, John T. Veon, Brett A. Degregorio Dec 2021

Northern Bobwhite Occupancy Patterns On Multiple Spatial Scales Across Arkansas, Ellery V. Lassiter, Marcus Asher, Grace Christie, Connor Gale, Andrhea Massey, Cody Massery, Christopher R. Middaugh, John T. Veon, Brett A. Degregorio

Biological Sciences Faculty Publications and Presentations

Northern bobwhite Colinus virginianus populations have been rapidly declining in the eastern, central, and southern United States for decades. Land use change and an incompatibility between northern bobwhite resource needs and human land use practices have driven declines. Here, we applied occupancy analyses on two spatial scales (state level and ecoregion level) to more than 5,000 northern bobwhite surveys conducted over 6 y across the entire state of Arkansas to explore patterns in occupancy and land use variables, and to identify priority areas for management and conservation. At the state level, northern bobwhite occupied 29% of sites and northern bobwhite …


Review: Physiological Growth Trend Of Current Meat Broilers And Dietary Protein And Energy Management Approaches For Sustainable Broiler Production, P. Maharjan, D. A. Martinez, J. Weil, N. Suesuttajit, C. Umberson, G. Mullenix, K. M. Hilton, A. Beitia, C. N. Coon Dec 2021

Review: Physiological Growth Trend Of Current Meat Broilers And Dietary Protein And Energy Management Approaches For Sustainable Broiler Production, P. Maharjan, D. A. Martinez, J. Weil, N. Suesuttajit, C. Umberson, G. Mullenix, K. M. Hilton, A. Beitia, C. N. Coon

Poultry Science Faculty Publications and Presentations

The food production system needs to be sustainable including poultry sector to feed the increasing global population. An accepted economical and environmental approach of broiler production is to produce larger broilers faster while using less feed. Broiler production is aimed at producing consumable meat and meat products. The global broiler meat market has evolved over the years with increasing selection pressure shifted toward attaining yield characteristics for increased cut-up parts such as breast and thighs. There is a shift toward a big bird market in the U.S. with approximately 70% of the broiler meat produced from large birds (>2.72 …


An Assessment Of The Neurovascular Structures Of The Trigeminal Nerve And Their Relationship To Diet In Primates, Caitlin Yoakum Dec 2021

An Assessment Of The Neurovascular Structures Of The Trigeminal Nerve And Their Relationship To Diet In Primates, Caitlin Yoakum

Graduate Theses and Dissertations

The inferior alveolar nerve (IAN) enters the mandible via the mental foramen, supplies nervous sensation to the mandibular teeth as it travels through the mandibular canal, and exits the mandibular foramen to send information to the brain to maintain chewing cycles and protect the teeth from damage. Although bony canals and foramina have been shown to form around soft-tissue structures, there are some examples (e.g., the hypoglossal nerve/canal) where the nervous structures do not comprise most of the canal/foramina space. It is important to know the size of nerves because it has been established that larger nerves convey more information …


Canine Microwear In Relation To Diet In Sumatran Primates And African Great Apes, Putu Pujiantari Dec 2021

Canine Microwear In Relation To Diet In Sumatran Primates And African Great Apes, Putu Pujiantari

Graduate Theses and Dissertations

This thesis considers canine microwear in relation to diet in five Sumatran primates (Pongo abelii, Hylobates lar, Hylobates agilis, Presbytis thomasi, and Macaca fascicularis) and two African great apes (Pan paniscus and Pan troglodytes schweinfurthii) using both microwear texture analysis and microwear feature analysis techniques. Statistical results for texture analysis show that there are significant differences in scale of maximum and heterogeneity. This indicates that some species have large pits on their canine surfaces, having these dominated by deep features at coarse scale yet have a slight microwear heterogeneity. For feature analysis, all variables show statistically significant variation. Variance in …


The Electrification Of The Kitchen: On The Energy Consumption Of Common Electric Cooking Appliances, Hozen Ricchie Rose Asok Rose Dec 2021

The Electrification Of The Kitchen: On The Energy Consumption Of Common Electric Cooking Appliances, Hozen Ricchie Rose Asok Rose

Graduate Theses and Dissertations

In developed countries, electricity has been gaining popularity as a source of energy for meal preparation. Utilizing electricity produced from renewable resources along with efficient electrical cooking appliances could result in sustainable clean cooking. The first objective of this research was to study the efficiency of common electrical cooking appliances—namely induction, resistance plate, resistance coil, infrared, and electric pot— by the water boiling test and the simmering test. The induction and electric pot were observed as the most efficient devices for the water boiling test. For simmering, which mimics many cooking processes, the electric pot and resistance coil were the …


Mitochondrial Aberrations During The Progression Of Disuse Atrophy Differentially Affect Male And Female Mice, Megan E. Rosa-Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene Dec 2021

Mitochondrial Aberrations During The Progression Of Disuse Atrophy Differentially Affect Male And Female Mice, Megan E. Rosa-Caldwell, Seongkyun Lim, Wesley S. Haynie, Jacob L. Brown, David E. Lee, Kirsten R. Dunlap, Lisa T. Jansen, Tyrone A. Washington, Michael P. Wiggs, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Background

Disuse decreases muscle size and is predictive of mortality across multiple pathologies. Detriments to mitochondrial function are hypothesized to underlie disuse-induced muscle atrophy. Little data exist on early mechanisms contributing to onset of these pathologies, nor is it known how they differ between sexes. The purpose of this study was to examine differential and conserved responses to mitochondrial quality control in male and female mice during the development and progression of disuse-induced atrophy.

Methods

One hundred C57BL/6J mice (50 male and 50 female) were hindlimb unloaded to induce disuse atrophy for 0 (con), 24, 48, 72, or 168 h. …