Digital Commons Network^™

June 16, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Role Of Mitochondrial And Lysosomal Damage In Neurotoxicity From Parkinson 'S-Related Environmental Exposures, Neda Ilieva

ETDs from 2020-2029

Parkinson's disease (PD) is a progressive motor neurodegenerative disorder with a predominantly idiopathic etiology. More recently, however, the contribution of exogenous risk factors such as environmental contaminants has become of interest. Some endogenous genetic risk factors have been well characterized, but the mechanisms by which exogenous insults, such as environmental contaminants, drive dopaminergic neurodegeneration remain incompletely understood. This dissertation will address how environmental contaminants converge on mitochondrial and lysosomal dysfunction to activate parallel neurotoxic signaling pathways, with a focus on the LRRK2 kinase and the cGAS-STING innate immune pathway. Chapter 2 demonstrates that pharmacological inhibition of LRRK2 kinase activity protects …

June 12, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Celebrate America's 250th With Free Fourth Of July Concert From Uab Summer Band, Shannon Thomason

Browse All News

No abstract provided.

Emotion Work In Emergency Communication Workers: A Mixed-Methods Analysis On Well-Being, Katherine Luann Sweeney

ETDs from 2020-2029

Emergency communication workers play a vital role in public safety and healthcare, but they are frequently an overlooked population when studying well-being. With a survey sample size of N=336, and an interview sample size of N=24, this dissertation utilizes a mixed-methods approach to explore what kind of factors influence dispatcher well-being. The mixed-methods findings lead to three important outcomes. First, there are detrimental consequences of shift work on dispatchers’ overall health. Second, dispatchers report high levels of emotional exhaustion, stress, and trauma exposure. The qualitative findings suggest that the rewards associated with helping people outweigh the mental health consequences. Lastly, …

June 10, 2026 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

June 9, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

June 5, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Targeting Inflammatory And Growth Signaling Pathways In Breast Cancer Through Diet, Microbiome, And Metabolite Interactions, Brittany Lorraine Witt

ETDs from 2020-2029

Breast cancer (BC) accounts for 1 in 3 (or 30%) of all new female cancers each year and is the most common malignant cancer in women in the United States. Since the 1990s, there has been a 44% decrease in BC, but there is still a significant gap between certain groups in terms of mortality rates. Black women have a higher mortality rate and risk for triple-negative breast cancer (TNBC). This may be due to social (inadequate access to health care facilities, insurance, or completion of therapy) and biological (genetic mutations, tumor characteristics, or comorbidity) factors between races and other …

The Malaugh Operations And The Quadratic Invariant Gaps Of $\Si_4^C$, Forrest M. Hilton

ETDs from 2020-2029

Connected Julia sets of polynomials generally correspond to laminations, sets of chords of the unit disc that reflect the dynamics of the Julia set. If the circle is measured in revolutions and the polynomials studied are of degree $d$, then the dynamics on the lamination is given by the covering map $\sigma_d(t) := td \pmod 1$ where chords are mapped by their end points. Every lamination has at least one laminational invariant set, which is loosely an invariant complementary component of the lamination. That set has a significant impact on the shape of the Julia set. James Malaugh showed how …

The Relationship Between The Environment And Pollution With Surgical Outcomes And Disparities, Wendelyn Marie Oslock

ETDs from 2020-2029

Air pollution exposure has been linked to many surgically managed diseases and adverse health events that occur in the postoperative period. Despite this, the impact of air pollution on postoperative recovery is poorly understood. This knowledge gap may be one of the underlying mechanisms for persistent disparities in surgical outcomes. Previous studies have found racial and economic disparities in air pollution exposure. These same communities have been shown to experience worse surgical outcomes. The goal of this thesis is to explore if exposure to air pollution impacts surgical outcomes and determine if disparities in socioeconomic factors impact this relationship. The …

Predictors And Outcomes Of Reading Intervention Success In Autistic Children: Memory And Brain Connectivity, Meagan Elizabeth Beckerson

ETDs from 2020-2029

Reading comprehension is a complex skill that relies on linguistic and cognitive abilities, including executive control processes. Creating a cohesive representation of text involves maintaining visual and verbal information in short term memory (STM) and using executive control skills to integrate information, apply it to questions, and draw inferences. Many autistic children demonstrate strong individual word reading (decoding) but poor comprehension, resulting in a discrepant reading profile. The role of STM and executive control—along with the underlying neural systems that support these processes—in reading comprehension and response to intervention has not been examined in autistic children with this profile. The …

Distribution, Abundance And Habitat Utilization Of Sea Turtles In The Northern Gulf Of Mexico, With An Emphasis On Coastal Mississippi, Theresa Rose Madrigal

ETDs from 2020-2029

The Gulf of Mexico represents important habitat for a variety of sea turtle species. This includes habitats for the various life history stages ranging from the oceanic stage of hatchling and post-hatchling turtles, neritic subadults, to the adult foraging and reproduc-tive stages. In contrast to many areas of the Gulf of Mexico, there has been a limited amount of data reported on sea turtle nesting as well as sea turtle foraging and develop-mental habitat in the north central Gulf of Mexico. This thesis includes two studies which investigate the importance of the coastal areas of Mississippi as sea turtle habitat. …

June 3, 2026 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.

Novel Oral Fluid Drug Screening Device Evaluation, Sarah Jenkins

ETDs from 2020-2029

Oral fluid (OF) has been determined comparable to blood while being a more accurate specimen to reflect recent use than urine. OF roadside testing devices utilize the ease of access and toxicological information provided by OF. These devices are designed to be used as a roadside screening device that can detect the presence of drugs. In 2018, Alabama was the first state in America to implement a comprehensive state OF drug testing program for screening and laboratory testing. At the current moment, there are five approved devices for use in Alabama. Part of the development of the program involved evaluating …

Applying Signal Detection Theory Using Evofinder To A 10-Consecutively Manufactured Barrel Study That Included Damaged Bullets, Ruheen Firoz Charania

ETDs from 2020-2029

The science of firearm and tool mark identification is based on the premise that no two tools produce the same microscopic detail and the tool that made the marks can be distinguished from all others. Based on the AFTE Theory of Identification, firearms comparisons can be classified as Identification, Elimination, Inconclusive, or Unsuitable for examination, with inconclusive indicating insufficient individual characteristics to support identification or exclusion. Error rates in firearm examinations are typically calculated by counting how often examiners make false-positive and false-negative conclusions relative to known ground truth, but inconclusive decisions complicate these calculations because they neither support nor …

June 2, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Lesson Plan For Dataone Lifecycle’S “Describe” Stage Using Historical Data From The Alabama Insane Hospital Annual Report (Aihar) Collection, Marla Hertz, Tricia Martone

Libraries Professional Work

This activity will teach the value of documentation in research data management using real data from Alabama mental institutions. During the Describe stage of data management, the why, who, what, when, where, and how of the data is provided to improve the interpretation and reuse of research data. This lesson includes options to complete the activity in an analog or digital fashion and is appropriate for undergraduate students and up.

Learning outcomes:

• Learners will be able to articulate the value of documentation in data creation and sharing.
• Learners will be able to construct a data README to describe their data …

Impact Of Institutional Expected Practice Guidelines On Oral And Long-Acting Intravenous Antibiotic Use For Serious Bacterial Infections, William Bradford

ETDs from 2020-2029

Expected practice interventions are a type of antimicrobial stewardship intervention in which local guidelines regarding antimicrobial prescribing are developed and released at an institutional level to establish an institutional standard of care. An expected practice intervention to encourage use of oral and long-acting IV (PO/LAIV) antibiotics for serious infections was performed at the University of Alabama at Birmingham Hospitals in November of 2022. We conducted a quasi-experimental pre/post study using a difference in differences approach to evaluate the effect of these guidelines on a primary outcome of length of stay (LOS) and secondary outcomes of inpatient antibiotic days, 3-month readmission, …

Mapping Structural Mistrust In Medicine, Ashleigh Allgood

ETDs from 2020-2029

Much of the existing literature treats mistrust as resistance or noncompliance. A structural perspective reverses that logic. It views mistrust as a reflection of institutional behavior rather than individual belief. When systems repeatedly fail to protect or repair harm, withdrawal becomes a reasonable and protective response. Structural mistrust represents both an adaptation to inequality and a cumulative record of institutional unreliability. This dissertation develops and tests a theory of structural mistrust as a collective orientation that links institutional design to individual behavior and perceived health. It makes three contributions. First, it conceptualizes structural mistrust as a product of state institutions …

Investigating The Effects Of Increased O-Glcnaylation On Pathology In Alzheimer’S Disease, Melissa Louise Garcia

ETDs from 2020-2029

Alzheimer’s disease (AD) is currently the 7th leading cause of death, with few treatment options. It is known that AD pathology begins 20-30 years before clinical symptoms manifest. Some of the earliest pathological changes occur in glial cells of the hippocampus, causing them to become chronically reactive, as well as the accumulation of Amyloid-β (Aβ) in the hippocampus and hyperphosphorylated Tau (pTau) in the locus coeruleus, resulting in dysfunction of the noradrenergic (NA) system. Preclinical studies have shown promise in the abilities of the post-translational modification O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc is a tightly regulated reversible enzymatic modification controlled by the …

The Impact Of Economic Stability On Diagnostic Timing Of Autism Spectrum Disorder In Children, Leslie Box Simms

ETDs from 2020-2029

Diagnosis of neurodevelopmental delays in children, including autism spectrum disorder, is an often lengthy and burdensome process, potentially placing children with economic instability at risk for diagnostic delay. The first aim of this dissertation was to explore the impact of economic stability on diagnostic timing of autism spectrum disorder via a scoping review of the literature. Papers were summarized by study design, data sourcing, handling of variables, statistical methodology, and the effect of economic stability factors on diagnostic timing of autism. Income and healthcare insurance were the most frequently employed measures of economic stability, with transportation, housing, and food security …

What If?, Jennifer Love

ETDs from 2020-2029

WHAT IF? JENNIFER LOVE MASTER OF ARTS IN ENGLISH – CREATIVE WRITING ABSTRACT What If? is a contemporary romance novel set in Birmingham, AL and Manhattan, NY. The story follows ex high school sweethearts, Liyah Mason and Max Thomas, who broke up shortly after their graduation. One night, while at the same restaurant, Max and Liyah reconnect. Their reconnection results in Liyah’s boyfriend, Owen, breaking up with her. Feeling the need for a reset, Liyah goes to New York. Due to a career ending injury, Max’s career as a major league baseball player is cut short. In the midst of …

Aging Like A Pro: Altering Health Behavior Motivation Through Community Education Programs, Susan Eva Fox-Rosellini

ETDs from 2020-2029

ABSTRACT Population aging presents significant public health challenges, particularly in preventing cognitive decline and maintaining functional independence among older adults. Today in the United States, the National Institutes of Health (NIH) estimates that about 40% of people aged 65 or older have age-associated memory issues. That number is expected to more than double by 2060. Community-based education programs can represent a scalable strategy to influence behavior modification that may be linked to successful cognitive aging. This dissertation evaluated the Aging Like A Pro (ALP) community education program that focused on key aspects of health: sleep, mindfulness, nutrition, and fitness, encouraging …

The American Revolution As America’S Civil War: Rethinking National Transformation, 1776-1877, Lucille Harlow

ETDs from 2020-2029

This thesis reinterprets the American Revolution by examining it not solely as a colonial rebellion against British authority but as a conflict that unfolded within American society itself. Long before independence was declared, political authority in British North America had already begun to fracture. Imperial institutions weakened, while revolutionary committees, militias, and local associations asserted competing claims to legitimacy. Rather than emerging from a unified population rising together in common purpose, the Revolution developed within communities already strained by suspicion, surveillance, and contested allegiance. Drawing on soldiers’ diaries and memoirs, including those of John Adlum, Jeremiah Greenman, Joseph Plumb Martin, …

Elucidating The Role Of The Rnf20 Histone Modifier In Pancreatic Beta Cells, Tanya Hans Pierre

ETDs from 2020-2029

Diabetes is defined as a loss of functional beta cell mass. It is classically categorized into Type 1 Diabetes (T1D), immune-mediated beta cell destruction and Type 2 Diabetes, which is characterized by whole body insulin resistance alongside beta cell dysregulation. The incidence of diabetes worldwide has risen annually. Despite the presence of therapeutic interventions, diabetes’ heterogeneity can prompt ineffective glycemic control and the development of diabetes-associated comorbidities. For that reason, new approaches to glycemic control for individuals with diabetes are required. One approach to restore glucose homeostasis is beta cell replacement therapy, in which stem cells are programmed into beta-like …

Exploring Medical Mistrust In A Higher Education Context: A Mixed Methods Study, Kiera Denise Walker

ETDs from 2020-2029

Medical mistrust, a type of institutional distrust, has been identified as a social determinant of health and a barrier to utilization of healthcare services. It has been negatively associated with preventive disease screenings, vaccine hesitancy, medication adherence, organ donation, research participation, and overall lower healthcare satisfaction. This can result in a widening of health disparities, an increase in prevalence of preventable diseases, and negative health outcomes despite accessibility to healthcare. The purpose of this study is to assess how medical mistrust manifests across the higher education context and explore what factors contribute to its existence among this population. An explanatory …

Emotion In Absence: Omission, World War I, And Masculine Vulnerability In Ernest Hemingway's In Our Time, Anna Murph

ETDs from 2020-2029

This thesis analyzes Ernest Hemingway’s depictions of male-male and male-female relationships in his collection of short stories, In Our Time. By comparing heterosexual and homosocial relationships, I explore how Hemingway’s depictions of male bonds are not only unique due to his famed terseness but also rooted in shared understanding, prompting a reconsideration of how male bonds are interpreted textually. I consider Hemingway’s use of omission and focus on how his minimalistic style lends to a reading of male-male relationships as more emotionally intimate than heterosexual relationships. When analyzing omission and relational dynamics through concepts such as gesture, touch, identity, and …

Characterizing The Role Of The Paraventricular Nucleus Of The Thalamus D2r+ Neurons In Interoceptive Predictions, Briana Machen

ETDs from 2020-2029

Interoceptive predictions are internal models through which the brain anticipates future bodily states based on past experiences and environmental cues. Under healthy conditions, these predictions allow organisms to anticipate physiological needs and proactively adjust behavior to maintain homeostasis. When these processes become dysregulated, however, environmental cues can trigger maladaptive physiological responses. Although interoceptive prediction is increasingly recognized as a key mechanism underlying adaptive behavior, the neuronal circuits responsible for generating these predictions remain poorly understood. The paraventricular nucleus of the thalamus (PVT) receives convergent inputs from brain regions involved in processing both interoceptive signals and exteroceptive cues, positioning it to …

The Association Of Motherhood And Maternal-Related Life Events And Cardiovascular-Related Health, Disease Events, And Mortality, Taishayla Mckitt

ETDs from 2020-2029

More than 40% of U.S. women have cardiovascular disease (CVD), and nearly half have at least one major risk factor. Sparse evidence exists related to the role of childrearing (regardless of prior pregnancy) on CVD. A recent literature review highlighted the influence of reproduction on CVD and health and identified opportunities for advancement. At present, it has yet to be discovered from prospective epidemiologic studies the extent to which parenting and maternal events have influence on cardiovascular health and clinical events. It has been demonstrated that parous women have greater prevalence of cardiovascular risk factors (e.g., short sleep duration and …