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January 18, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

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January 5, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

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Students Pursue Passions In Honors College Presidential Summer Fellowship Program, Matt Windsor

Browse All News

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Featured Essay: Here Be Hippos, Karen Craigo

Birmingham Poetry Review

pp. 47-52

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2 - Cleared For Travel, University Of Alabama At Birmingham

UAB Magazine

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Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

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Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …

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Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

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The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

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A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

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Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

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Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

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Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

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The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

All ETDs from UAB

Organisms produce chemical defenses to gain a competitive advantage, and to protect themselves from pathogens and predators. There is high inter- and, sometimes, intraspecific diversity in the types and quantities of defensive secondary metabolites. Yet, we do not know much about the mechanisms driving the diversity and its distribution. Macroalgae are important members of ecosystems since they provide living space and are primary producers. To prevent predation, macroalgae make structural or chemical defenses. Chemical defenses in the Antarctic red macroalga Plocamium sp. have extensively been studied. It is widespread along the western Antarctic Peninsula and abundant at sites where it …

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Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Exercise is a powerful behavioral intervention against Central Nervous System (CNS) aging1–3 and plays an essential role in maintaining healthy neurocognitive function and immune metabolism in the aging brain3. We have developed a new transgenic mouse model that moderately over-expresses transcription factor master regulator of proteostasis, Transcription Factor E-B (TFEB), in skeletal muscle (cTFEB;HSACre mice). Despite living sedentary lifestyles, our model of enhanced skeletal muscle proteostasis shows significantly ameliorated proteotoxicity, increased BDNF levels and neurogenesis while improving neurocognitive function and decreasing neuroinflammation in the aging CNS4,5. These neuroprotective effects are markedly reminiscent of those observed in the aging CNS post-exercise6,7, …

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Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …

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The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

All ETDs from UAB

Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a vascular supply is needed to deliver oxygen and nutrients into the increasing mass. Several anti-angiogenic cancer therapies target VEGF and its receptor VEGFR-2, which are major promoters of blood vessel development. Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). Since these therapies focus on the biochemical activation of VEGFR-2 via VEGF ligand binding, we …

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Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller

All ETDs from UAB

Fibromyalgia (FM) is a debilitating chronic pain condition. Its pathophysiology is largely unknown, which has hindered the development of effective treatments. Central sensitization and neuroinflammation have been forwarded as models of FM pathophysiology, both of which indicate the antitussive drug dextromethorphan (DXM) as a potentially effective treatment. DXM is an N-Methyl-D-aspartic acid (NMDA)-receptor antagonist and microglial modulator with anti-neuroinflammatory properties at low doses. It is currently available for clinical use, but has not been tested as a treatment for FM at low dosages. The current study evaluated the effectiveness of DXM in treating FM-associated symptoms of pain, fatigue, cognitive problems, …

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Anti-Abortion Activism And Advances: A Historography, Haley Wells

Vulcan Historical Review

pp. 75-85

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A Case Of Postural Orthostatic Tachycardia Syndrome And Anxiety, Nadia Anabtawi, Clinton Martin, Janaki Nimmagadda, Richard Shelton

UAB Huntsville Research Day - All Presentations

2022 clinical vignette poster

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Looking Past Blindness: Assessing Mental Health In Stargardt Disease, Sebastian A. Schormann, Clinton Martin

UAB Huntsville Research Day - All Presentations

2022 clinical vignette poster

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Tooth Agenesis: Prevalence And Pattern Among Different Ethnicities, Gabrielle Coe

All ETDs from UAB

Tooth agenesis is one of the most common developmental anomalies in humans and is defined as the failure of tooth development or odontogenesis. Prevalence of non-syndromic tooth agenesis has a reported range of 1.6-36.5% and varies by gender, ethnicity, and location. While tooth agenesis is well studied, information within ethnic groups requires further investigation. In this study, dental records of 3033 patients of the UAB School of Dentistry were evaluated to identify and categorize missing teeth by ethnicity and gender. Data analysis was conducted with Chi-square or Fisher’s exact test, with a two-sided significance level of 0.05. An overall prevalence …

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Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins

All ETDs from UAB

The Diamondback Terrapin, Malaclemys terrapin pileata, inhabits saltmarshes in the Northern Gulf of Mexico including along the coast of Alabama. Due to a variety of factors, this species has declined drastically in Alabama, and it is currently designated as a “species of highest conservation concern”. Understanding the ecology of this species is a prerequisite to the recovery of this population. The current thesis addresses the reproductive and foraging ecology of the Diamondback Terrapin in Alabama. This thesis combines the use of classic ecological methodologies with modern technologies. Between April 2019 to July 2022, wild nesting females were caught at a …

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The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron

All ETDs from UAB

A major obstacle to the advancement of our understanding of the metabolically healthy obesity (MHO) phenotype is the inconsistent definition of metabolic health and obesity among studies. A harmonized definition of MHO in adults has been proposed based on the diagnosis of obesity (BMI > 30 k/m2) and meeting the cardio-metabolic criteria for triglycerides, high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), no antihypertensive treatment, fasting blood glucose, and no drug treatment with glucose-lowering agents. In addition, waist circumference can be associated with increased disease risk when WC is >94 cm in men and >80 cm in …

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Clinical Decision-Making: A Survey On The Influence Of Specialty And Experience In Treatment Planning Of Multidisciplinary Cases, Rawan Oueis

All ETDs from UAB

Objective: to evaluate the effect of specialization and experience on treatment planning multidisciplinary cases. Materials and Methods: A survey presenting 7 clinical scenarios and their potential treatment plans was designed and disseminated electronically to five groups of dentists (general dentists, endodontists, prosthodontists, orthodontists, periodontists). 509 responses were collected and analyzed for distribution and levels of agreement. Results: A moderate kappa was found (k=0.4-0.6) between endodontists and periodontists and within endodontists. There was no agreement on the type of restorations that are used between different specialties and within specialties of different years of experience. Conclusion: Specialists and general dentists use a …

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Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady

All ETDs from UAB

KLF2 is an important transcription factor for maintaining vascular homeostasis. Its expression in endothelial cells is triggered by shear stress. The endothelial glycocalyx also plays a role in regulating vascular function, and prior work has shown that glycocalyx expression is affected by shear stress as well. However, the direct link between KLF2 and mechanisms that regulate glycocalyx synthesis has not been established. In the present study, we used human lung microvascular endothelial cells (HLMVECs) to observe changes in glycocalyx expression, barrier function, and thromboinflammation caused by KLF2 overexpression. Lentiviral transduction was the method used for KLF2 overexpression, resulting in a …

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Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

All ETDs from UAB

The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …

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Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang

All ETDs from UAB

Background: The food truck industry in the U.S. has rapidly expanded, with an average growth of 7.9 % from 2017 to 2022. Food truck workers are potentially exposed to harmful airborne contaminants such as particulate matter (PM) and aldehydes produced during cooking process. Kitchen exhaust hoods are designed to capture the cooking emissions, but it is not well understood whether the commercial kitchen exhaust hoods in food trucks are properly, efficiently operated to reduce the workers' exposure to such harmful contaminants. The purpose of the study was to evaluate food truck workers' exposure to respirable particulates generated from cooking process …

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Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker

All ETDs from UAB

Alzheimer’s disease (AD) is the most common cause of dementia in individuals over the age of 65. Of the two hallmark pathologies of AD, tau neurofibrillary tangles (NFTs) correlate more strongly with cognitive decline than do Aβ plaques. NFTs form in the entorhinal cortex (EC) and appear in anatomically connected regions over time as disease progresses. This tau spreading may occur via synaptic connections. Most excitatory synapses occur on dendritic spines, which house the postsynaptic machinery. Spines are actin-rich, plastic structures that change their size and shape in response to synaptic activity in a process that is dependent on actin …

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The Adoption Of New Cancer Drugs In Non-Academic Cancer Centers, Warren M. Smedley

All ETDs from UAB

Advancements in medical knowledge are producing significant improvements in medical technology, developing breakthrough drug therapies, advancing the practice of medicine, and improving outcomes for cancer patients. However, there are delays in getting new and improved therapies incorporated into routine clinical use, depriving cancer patients of valuable and potentially lifesaving treatments. The purpose of this study was to examine the rate of adoption of new cancer drug discoveries into routine clinical practice in non-academic cancer centers. The process of adoption takes a period of time to embrace new therapies, due in part to a prescriber’s need to gain greater comfort with …

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Full-Text Articles in Entire DC Network

January 18, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

January 5, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

Students Pursue Passions In Honors College Presidential Summer Fellowship Program, Matt Windsor

Browse All News

Featured Essay: Here Be Hippos, Karen Craigo

Birmingham Poetry Review

2 - Cleared For Travel, University Of Alabama At Birmingham

UAB Magazine

Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

All ETDs from UAB

Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

All ETDs from UAB

Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller

All ETDs from UAB

Anti-Abortion Activism And Advances: A Historography, Haley Wells

Vulcan Historical Review

A Case Of Postural Orthostatic Tachycardia Syndrome And Anxiety, Nadia Anabtawi, Clinton Martin, Janaki Nimmagadda, Richard Shelton

UAB Huntsville Research Day - All Presentations

Looking Past Blindness: Assessing Mental Health In Stargardt Disease, Sebastian A. Schormann, Clinton Martin

UAB Huntsville Research Day - All Presentations

Tooth Agenesis: Prevalence And Pattern Among Different Ethnicities, Gabrielle Coe

All ETDs from UAB

Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins

All ETDs from UAB

The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron

All ETDs from UAB

Clinical Decision-Making: A Survey On The Influence Of Specialty And Experience In Treatment Planning Of Multidisciplinary Cases, Rawan Oueis

All ETDs from UAB

Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady

All ETDs from UAB

Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

All ETDs from UAB

Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang

All ETDs from UAB

Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker

All ETDs from UAB

The Adoption Of New Cancer Drugs In Non-Academic Cancer Centers, Warren M. Smedley

All ETDs from UAB