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Transdiagnostic Symptom Clusters Among Idiopathic Pain And Fatigue Disorders, Chloe Lisette Jones Jan 2023

Transdiagnostic Symptom Clusters Among Idiopathic Pain And Fatigue Disorders, Chloe Lisette Jones

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Background: There are no established etiologies, biomarkers, or approved treatments for myalgicencephalomyelitis/chronic fatigue syndrome (ME/CFS). It is thought that the ME/CFS criteria may be diagnosing individuals within a spectrum of different disease states, or even different diseases. There likely exist shared mechanisms across idiopathic pain and fatigue disorders, and diverse mechanisms underneath each individual diagnosis. The need to compare ME/CFS to similar, overlapping, and distinct disorders is a critical element in progressing our understanding of idiopathic pain and fatigue. Methods: A total of 2,731 comprehensive medical history and symptom reports were collected from respondents across the globe with a variety …

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The Critical Period Of Long-Term Plasticity In Adult-Born Granule Cells Is Mediated By T-Type Calcium Channels, William Michael Kennedy Jan 2023

The Critical Period Of Long-Term Plasticity In Adult-Born Granule Cells Is Mediated By T-Type Calcium Channels, William Michael Kennedy

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Neurogenesis occurs in the dentate gyrus of adult rodents leading to a heterogeneous population of dentate granule cells (GCs) in the granule cell layer. Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that contributes to their role in dentate gyrus function. Various mechanisms have been proposed to underlie the critical period of plasticity, including minimal GABAergic synaptic inhibition, robust NMDAR2B currents, and high intrinsic excitability conferred by T-type Ca2+ channels. In this collection of work, we investigate the critical period for long-term potentiation (LTP) in 4–6-week-old abGCs. We conclude that GABAergic inhibition regulates LTP in 4-week-old …

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Physiology And Energetics Of Resilient Coral-Dinoflagellate Communities, Elise F. Keister Jan 2023

Physiology And Energetics Of Resilient Coral-Dinoflagellate Communities, Elise F. Keister

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Despite coral reefs declining globally, thermally resilient coral-dinoflagellate communities have been identified, providing insight into how corals can inhabit warmer environments. These corals are able to better resist and recover from thermal stress events compared to adjacent, offshore conspecifics that are found in habitats that have cooler temperatures. To better understand the physiological traits that make corals resilient, I measured the initial tissue biomass and energy reserves of eight coral species. These corals were collected from both warm-water nearshore habitats and offshore reefs with milder temperatures in Palau, Micronesia. Despite contrasting environments, coral tissue similarities between these populations were striking, …

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Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan Jan 2023

Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan

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The gain of function of nuclear factor erythroid 2 like 2 (Nrf2), in the absence of oxidative stress (or toxic insults), its pathophysiology arising from the endoplasmic reticulum and exercise intervention to mitigate the pathology are the focal point of this dissertation. Nrf2, when constitutively expressed, has been previously associated with cardiomyopathy. Chapter II investigated the hypothesis that cardiac-specific expression of Nrf2 (mNrf2-TG) would establish a pro-reductive state and trigger adaptive cardiac remodeling by enhancing the basal antioxidant defense. Through RNA profiling and imaging techniques, the study underscored that while acute preconditioning might prove advantageous against oxidative stress, prolonged pro-reductive …

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Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler Jan 2023

Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler

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Play, especially social play, is crucial to child development and impacts their cognitive, socioemotional, and motor growth. Children with an autism spectrum disorder (ASD) have social and motor impairments that act as barriers to their access to these critical social play opportunities. Those who are able to overcome these barriers through therapy have been shown to have better physical and mental outcomes. Unfortunately, the COVID-19 pandemic restricted social play opportunities for all children and disproportionately impacted children with ASD, further widening developmental gaps between them and their non-autistic peers. The development of the COVID-19 vaccine and its availability to children …

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Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow Jan 2023

Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow

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Lower respiratory infections are the primary cause of infectious death among the elderly. One reason for this is ‘inflamm-aging,’ a chronic low-grade inflammatory state that develops with advanced age. Pertinently, our group has shown increases in TNF levels to be responsible for age-dependent macrophage dysfunction (ADMD) and, in turn, enhanced susceptibility to Streptococcus pneumoniae, the leading cause of community-acquired pneumonia. The underlying molecular mechanisms responsible, however, remain unclear. Following adoptive transfer of alveolar macrophages (AM) from aged (18+ months) or young (3-6 month) mice into young mice, followed by infection with S. pneumoniae, we found that aged AM were sufficient …

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Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Christopher Livelo Jan 2023

Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Christopher Livelo

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Obesity is a global epidemic that affects countless numbers of people caused by genetic and environmental factors including circadian disruption, which poses significant health risks to skeletal muscle physiology and other tissues. While a feeding fasting intervention known as time-restricted feeding (TRF) has been shown to mitigate obesity-related muscle dysfunction, the underlying mechanisms remain a subject of investigation. In this study, we delve into potential mechanisms underlying TRF's protective effects on muscle physiology in the context of diet- and genetic-induced obesity using Drosophila models. Our findings reveal that TRF triggers the upregulation of key genes involved in glycine production (Sardh …

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The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith Jan 2023

The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith

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This research evaluates the effectiveness of a Specialized Cardiac Catheterization Laboratory Shielding Device (SCCLSD) compared to traditional shielding methods in reducing occupational exposure to scattered x-rays, contributing to the ongoing enhancement of radiation safety in the cardiac catheterization laboratory (CCL) setting. The upper component of the SCCLSD comprises a mobile, transparent barrier with lead-equivalent malleable drapes designed to conform to the patient's body contours. It is height-adjustable, creating a protective shield against scatter radiation generated during CCL procedures. The lower portion of the SCCLSD replaces traditional lead-lined drapes, extending further down the table and incorporating additional shielding for staff protection.An …

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The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain Jan 2023

The Impact Of Diabetes On At-Fault Motor Vehicle Collisions In Older Adults: Visual Function, Medication, And Crash Characteristics, Thomas A. Swain

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Older drivers represent one of the fastest growing age groups of drivers in the United States. Crash risk among older adults, who have the highest prevalence of vision impairment, has been shown to be related to worse visual function. Diabetes mellitus is a chronic health condition affecting more than 23.1 million Americans, and one in three have pre-diabetes. Persons with diabetes are at increased risk of conditions which cause vision loss. Research indicates those with diabetes have higher rates of MVCs. Despite the increased MVC risk among each of these groups, work has yet to evaluate if diabetes modifies the …

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Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy Jan 2023

Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy

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Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 15 months. Poor patient survival is, in part, caused by a stem-like and therapy-resistant population of brain tumor initiating cells (BTICs). BTICs are plastic, with the capacity to overcome oxidative damage. Guanosine triphosphate cyclohydrolase I (GCH1), a rate limiting enzyme in the de novo synthesis of the redox cofactor, tetrahydrobiopterin (BH4), was previously identified as a significant regulator of oxidative stress in BTICs. Reducing oxidative damage in the form of lipid peroxidation is imperative for GBM growth: lipid metabolism is required for the …

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The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams Jan 2023

The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams

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Young adults transitioning to adulthood from economically disadvantaged backgrounds may experience physical, cognitive, and socio-emotional challenges. Resources and opportunities available during this transition can significantly impact their ability to integrate into society. The impact of economic disadvantage on the well-being of youth transitioning to adulthood remains understudied. The purpose of this study was to understand how economic disadvantage influenced the well-being of youth transitioning into adulthood. This project used longitudinal data from the Panel Study of Income Dynamics (PSID) and its supplements: the Child Development Supplement (CDS) and the Transition into Adulthood Supplement (TAS). Hypothesis one results revealed that young …

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Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles Jan 2023

Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles

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Manganese (Mn) has the potential to be an important element in biomedical research as different isotopes of Mn have the characteristics to be used for both positron emission tomography (PET) and magnetic resonance imaging (MRI). Manganese(II) (55Mn) is paramagnetic which makes it useful as a contrast agent in T1-weighted magnetic resonance imaging (MRI). Mn as a radiotracer provides excellent sensitivity for studying 55Mn, but only Manganese-52 (52Mn) met the criteria for this research. 52Mn has a half-life (t1/2 = 5.591 days) that was long enough to optimize purification, chemistry and examine timepoints over several days. 52Mn decays by positron emission …

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Development And Evaluation Of A Nanomatrix Coated Stent Using A Vascular Sheet With Atherosclerosis Model, Xixi Zhang Jan 2023

Development And Evaluation Of A Nanomatrix Coated Stent Using A Vascular Sheet With Atherosclerosis Model, Xixi Zhang

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While cardiovascular stent technology has considerable advances, there are hurdles to overcome due to the dysfunctional stented arteries which fail to maintain vascular homeostasis. Current stent designs ignored the significance of promoting functional artery healing (pro-healing). Therefore, we developed a pro-healing nanomatrix coating for stent. Previous studies investigated its effect on individual vascular cell type. In natural artery, there are multiple vascular cell types that strongly affect stent performance. Thus, an in vitro vascular double-layer (VDL) system was used to observe stent effects on different vascular cell types. And the pro-healing ability and mechanism of the nanomatrix coated stent were …

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A Cold Plasma-Enabled Reduction Process For The Fabrication Of Metallic Nanostructures Onto Polymeric Biomaterials, Gerardo Hernández Moreno Jan 2023

A Cold Plasma-Enabled Reduction Process For The Fabrication Of Metallic Nanostructures Onto Polymeric Biomaterials, Gerardo Hernández Moreno

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The design and manufacture of novel materials has served as the bedrock for tissue engineering and regenerative medicine. There exists a need for more biocompatible implantable materials in the biomedical device space. The approach to developing biomaterials fit for biomedical devices has been focused on decreasing overall physiological interaction with the local environment. However, the development of more biomechanically favorable materials has placed an emphasis on designing materials that display biomimetic and biomechanical properties resembling that of the host tissue at the implant site. As biomaterials engineering has progressed, the race to find materials that interact at the nano- and …

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Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao Jan 2023

Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao

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The HIV care continuum is a public health model that outlines the steps or stages people with HIV go through from diagnosis to achieving and maintaining viral suppression. Retention in care, a key component of the HIV care continuum, is critical in achieving good health outcomes for people with HIV (PWH) and preventing HIV transmission. Consistent HIV care is essential for the health of PWH as a part of retention in care. De-spite no standard measure for retention in care to PWH, the missed (no-show) vis-its/appointments is one of the most commonly used methods for evaluating retention in HIV care. …

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An Exploration Of The Mental Health Experiences Of Young Women With Diminished Ovarian Reserve, Brittany M. Woods Jan 2023

An Exploration Of The Mental Health Experiences Of Young Women With Diminished Ovarian Reserve, Brittany M. Woods

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Infertility is a reproductive disease resulting in the inability to conceive. One in six individuals will experience infertility in their lifetime. Diminished ovarian reserve (DOR) reduces the quantity and/or quality of a female's oocyte pool and is a known cause of infertility. Although this occurs during normal ovarian aging in the late 30s and early 40s, DOR can also impact younger women, increasing their risk for psychological distress from an unexpected diagnosis. The purpose of this dissertation is to develop a deeper understanding of the mental health experiences of young women with DOR through the generation of three manuscripts. Manuscript …

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Effects Of Dietary R, S-1, 3-Butanediol Diacetoacetate On Components Of Energy Balance And Hepatic Health, Kelsey A. Rushing Jan 2023

Effects Of Dietary R, S-1, 3-Butanediol Diacetoacetate On Components Of Energy Balance And Hepatic Health, Kelsey A. Rushing

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Objective: Exogenous ketone administration presents a possible treatment strategy for obesity and obesity-related diseases. The exogenous ketone ester, R,S-1,3-butanediol diacetoacetate (BD-AcAc2) decreases adiposity and hepatic steatosis in high-fat dietinduced obese mice. In our previous work, carbohydrate energy was removed and replaced with the ketone ester to produce isocaloric diets. The current investigation aimed to determine whether BD-AcAc2 decreases markers of hepatic steatosis and inflammation in lean mice on a high-fat, high-sugar (HFHS) diet without removing carbohydrate energy. Methods: Sixteen 11-week-old male C57BL/6J mice were randomized to one of two groups for 9 weeks (n = 8 per group): 1) Control …

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Understanding The Dual Role Of The Oncolytic Viruses And Natural Killer Cells In Targeting Neuroblastoma, Colin Harrington Quinn Jan 2023

Understanding The Dual Role Of The Oncolytic Viruses And Natural Killer Cells In Targeting Neuroblastoma, Colin Harrington Quinn

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Pediatric cancer is the leading cause of death by disease in children, and neuroblastoma accounts for roughly 15% of pediatric cancer related deaths. Neuroblastoma is a malignancy of neural crest origin and develops in the ganglia of the peripheral nervous system, most commonly arising in the adrenal glands. Advancements in therapy have significantly improved outcomes for children with low-risk neuroblastoma but for those with high-risk refractory, or relapsed disease, survival outcomes remain dismal and intervention with toxic chemotherapeutics often result in long term morbidities. The need for improved therapies for this patient population is dire. Immunotherapies offer a novel approach …

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Plasticity Characteristics Of Cxcr5+ Cd4+ T Memory Cells And Cxcr5- Non-Tfh Memory Cells, Ching-En Lee Jan 2023

Plasticity Characteristics Of Cxcr5+ Cd4+ T Memory Cells And Cxcr5- Non-Tfh Memory Cells, Ching-En Lee

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iv ability to differentiate into CXCR5- and CXCR5+ effector cells between the CCR7- and CCR7+ CXCR5+ CD4+ T memory cells, between WT and μMT CXCR5+ CD4+ T memory cells, as well as between Bcl6- and Bcl6+ CXCR5- non-Tfh memory cells. This finding did not support the hypothesis that the heterogeneous characteristics within CXCR5- non-Tfh memory cells and CXCR5+ CD4+ T memory cells significantly affect their abilities to differentiate into CXCR5- and CXCR5+ effector cells during recall responses.

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Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones Jan 2023

Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones

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Kidney disease is the tenth-leading cause of death in the United States (US). There are significant racial disparities within kidney disease: African Americans (AAs) have the highest rates of CKD and carry a four-fold higher risk of developing end-stage renal disease (ESRD). They are also less likely to undergo kidney transplants, and among those who do, are more likely to experience graft rejection. Additionally, until 2021, kidney function equations were shown to underestimate the severity of kidney disease in AA due to the use of race coefficients. Among all populations, genetic and epigenetic factors contribute to kidney disease. However, AAs …

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Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap Jan 2023

Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap

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Heterozygous loss of function mutations in the progranulin gene cause frontotemporal dementia, characterized by deficits in social behavior, language comprehension and motor function. Almost every frontotemporal dementia-related progranulin mutation is loss of function and results in progranulin haploinsufficiency. For this reason, progranulin replacement is a conceptually straightforward therapeutic strategy for patients with frontotemporal dementia caused by progranulin mutations. Here, we outline progranulin biology, progranulin deficient mouse models of frontotemporal dementia and preclinical interventions centered around increasing brain progranulin levels. We have demonstrated that blocking the progranulin C-terminus, which harbors the sortilin binding site, improves the cross-correctional capacity of neurotropic progranulin …

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Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring Jan 2023

Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring

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Pancreatic Neuroendocrine Tumors (PNETs) are highly heterogeneous neoplasms arising from the hormone-secreting cells of the endocrine pancreas. PNETs are broadly categorized as functional and non-functional based on the presence of symptoms associated with hormone secretion, which occurs in approximately 30% of cases. While functional tumors are all considered for resection because of these symptoms and their associated sequelae, non-functional tumors > 2cm are currently resected based on increased risk of developing metastatic disease. However, this criterion is based on data from predominantly White patients. Recent studies have shown that Black patients have much higher rates of lymph node metastatic disease at …

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Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis Jan 2023

Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis

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Climate change, waste management crises, and global pandemics emphasize the need for a thriving science, technology, engineering, and mathematics (STEM) workforce, and one of the jobs of STEM educators is to provide meaningful educational experiences that engage STEM students in scientific practices, broaden their worldview, and prepare them for a future career in the scientific field. Undergraduate research experiences have been shown to benefit STEM students, but few students can participate, especially at early stages in their undergraduate studies. To broaden participation in undergraduate research, an honors general chemistry laboratory course was converted into a course-based undergraduate research experience (CURE) …

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Inkjet-Printed Reseroir Computing Network For In Situ Sensor Predictions, Steven D. Gardner Jan 2023

Inkjet-Printed Reseroir Computing Network For In Situ Sensor Predictions, Steven D. Gardner

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The technological achievements made with silicon-based transistors have led to nearly all the computing seen today, complete with benefits such as maximized operating speeds, parallel/tensor processing, minimized power overhead, etc. The silicon electronics industry is foundational to scientific progression with its profound impact on modeling, simulations, and fast/reliable computing. However, silicon-based transistors have evolved to meet their physical limitations and have saturated fields of innovation. New fields in computing outside of silicon-based methods have emerged as exotic materials enter the research domain. The suite of super-performing materials like Graphene, Carbon Nanotubes, and Molybdenum Disulfide have chaotic, non-linear behaviors that make …

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Modular Regulation And Function Of The Polypyrimidine Tract Binding Protein 1 (Ptbp1), Christine Carico Jan 2023

Modular Regulation And Function Of The Polypyrimidine Tract Binding Protein 1 (Ptbp1), Christine Carico

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RNA binding proteins (RBPs) are critical regulators of gene expression as they are responsible for the chaperoning and processing of every nascent RNA transcript. Many studies have investigated mechanisms of specificity of RBP function and have identified factors such as cell-specific expression of RBPs and differential preferences for RNA secondary structure. However, RBPs are often multi-domain proteins that contain repeats of various RNA binding domains (e.g., RNA recognition motif) and little work in the genomic era of transcriptomic interrogation has been done to define the contribution of individual domains to the overall protein function. Polypyrimidine tract binding protein 1 (PTBP1) …

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Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun Jan 2023

Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun

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Older adults with human immunodeficiency virus (HIV) experience a high prevalence of chronic obstructive pulmonary disease (COPD). Considering having either HIV or COPD is related to worse health outcomes in older adults, aging with both HIV and COPD may synergistically and negatively affect the health outcomes of older people with HIV (PWH) and comorbid COPD. The purpose of this dissertation was to explore the aging of PWH with COPD. This purpose was accomplished through three articles: 1) an adaptation of a gerontological model investigating what is known about the aging of PWH and people with COPD and extrapolating that to …

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Impact Of Streptococcus Parasanguinis-Generated Reactive Nitrogen Species On Pseudomonas Aeruginosa Virulence And The Host Response, Joshua J. Baty Jan 2023

Impact Of Streptococcus Parasanguinis-Generated Reactive Nitrogen Species On Pseudomonas Aeruginosa Virulence And The Host Response, Joshua J. Baty

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Streptococcus parasanguinis is an oral commensal bacterium that produces hydrogen peroxide. Hydrogen peroxide can react with endogenous molecules such as nitrite to form reactive nitrogen intermediates (RNI). These S. parasanguinis-mediated RNI have been shown to inhibit oral pathogens such as Streptococcus mutans, Enterococcus faecalis, and Aggregatibacter actinomycetemcomitans. As such, S. parasanguinis plays a protective role in the oral microbial ecosystem by antagonizing and preventing colonization by oral pathogens. In addition to being an important organism for the health of the oral cavity, S. parasanguinis has also been associated with improved outcomes for people with cystic fibrosis. There are two explanations …

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Exploring The Regulatory Mechanisms Of Ire1 Signaling In Biotic And Abiotic Stress Responses In Arabidopsis, Taiaba Afrin Jan 2023

Exploring The Regulatory Mechanisms Of Ire1 Signaling In Biotic And Abiotic Stress Responses In Arabidopsis, Taiaba Afrin

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Given their immobility, plants have various survival strategies, including the critical ability to recognize and respond to stressors. Exposure to different environmental and intracellular signals triggers significant modifications in stress response regulators' expression. These changes often occur in the endoplasmic reticulum (ER), where a rise in protein synthesis can overwhelm the system, accumulating misfolded proteins and activating a mechanism known as the unfolded protein response (UPR). UPR is a complex regulatory network with three primary branches in eukaryotic systems. The IRE1-mediated pathway is the most conserved among UPR signaling branches. In Arabidopsis, IRE1 splices bZIP60 mRNA and produces a functional …

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Gain Of Keratinized Muscosa Around Dental Implants Using A Combination Of Strip Gingival Graft And Acellular Dermal Matrix - A Prospective Case Study, Louai Haddad Jan 2023

Gain Of Keratinized Muscosa Around Dental Implants Using A Combination Of Strip Gingival Graft And Acellular Dermal Matrix - A Prospective Case Study, Louai Haddad

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Several surgical techniques have been described to increase keratinized tissue (KT) around implants and teeth. Despite various methods, the bulk of evidence reported that the use of keratinized autogenous graft (i.e., Free Gingival Grafts (FGG)), harvested from the patient’s palate, remained the gold standard in soft tissue augmentation procedures and provided more predictable results. However, soft tissue autograft supply can be limited, and its harvesting is associated by increased patient morbidity. Several clinical studies have demonstrated the effectiveness of using allogenic soft tissue grafts such as Acellular Dermal Matrix Allograft (ADMA) instead of FGG to augment keratinized tissue (KT). This …

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Pharmacologic Proteasome Activators Ameliorate Alzheimer's-Like Pathology In Ad Fly Models, Mehar Bano Jan 2023

Pharmacologic Proteasome Activators Ameliorate Alzheimer's-Like Pathology In Ad Fly Models, Mehar Bano

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The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays a critical role in nervous system processes. This includes the maintenance of cellular homeostasis in neurons (1). It also includes synaptic efficacy and plasticity as well as protein turnover, presynaptic vesicle transport, and neuronal protesostasis. Proteasome function is impaired as a consequence of aging, which is aggravated by conditions like Alzheimer's Disease and Related-Dementias (AD, ADRD) (2). According to earlier work from our lab the proteasome is critical to how quickly AD progresses. In Drosophila, human cells, and …

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