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University of Alabama at Birmingham

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Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu Jan 2006

Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu

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Increased levels of protein-associated O-linked N-acetylglucosamine (O-GlcNAc) have been correlated with increased tolerance to stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, increased the tolerance of the heart to ischemia and reperfusion (I/R). Hearts from male rats were isolated and perfused with Krebs-Henseliet buffer containing 5mM glucose, and global, no-flow ischemia was induced for 20min followed by 60 min reperfusion. 20 min pre-treatment with 10 mM glucosamine, which enters the HBP directly, significantly improved functional recovery and decreased cardiac Troponin I release …

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Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li Jan 2006

Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li

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Gli family members-mediated continuous Hedgehog (Hh) pathway activity plays a role in the growth of a number of human cancers, including the common malignancy of skin, basal cell carcinoma (BCC), and other highly aggressive tumor types. However, the mechanism by which Gli proteins act to promote the outgrowth of cancer in response to stimulation of Hh signaling is poorly understood. Identified as zinc finger transcriptional factors, the Gli family of proteins has been shown to be involved in multiple cellular processes through activating its target genes. Therefore, to study the function of Gli target genes is important for our understanding …

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Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu Jan 2006

Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu

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Notch1 and KLF4 function in the specification of epithelial cell fates, and each can act as a context-dependent oncogene or tumor suppressor. We report that KLF4 directly regulates transcription of Notch1 and that cleavage of full-length Notch1 to the active intracellular form, N1IC, is necessary for transformation by KLF4. Paradoxically, KLF4 suppresses canonical Notch1-CSL signaling by up-regulating Hairless, an antagonist of this pathway. Dominant-negative inhibitors of the canonical Notch1 signaling pathway do not block transformation of epithelial cells by KLF4, while they greatly reduce the efficiency of transformation by N1IC. Thus, N1IC can transform cells by two distinct mechanisms: the …

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The Influence Of Retroviral Codon Usage On The Acquisition Of The Trna Used To Prime Reverse Transcription, Matthew T. Palmer Jan 2006

The Influence Of Retroviral Codon Usage On The Acquisition Of The Trna Used To Prime Reverse Transcription, Matthew T. Palmer

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An essential step in retrovirus replication is the conversion of the genomic-length viral RNA into a DNA copy, a reaction which is catalyzed by reverse transcriptase and primed by a host cell tRNA. The nearly continuous association of tRNA with the various components of translation, as well as the severely limited time in which a tRNA molecule spends in an uncharged state, constitute seemingly formidable barriers to the acquisition and use of host cell tRNA as primers. The mechanism by which retroviruses acquire this implausible primer are unknown. Naturally occurring isolates of most retrovirus species show a conserved use of …

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Intestinal Peptides And Ethnic Differences In Insulin Secretion, Paul B. Higgins Jan 2006

Intestinal Peptides And Ethnic Differences In Insulin Secretion, Paul B. Higgins

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African Americans (AA) exhibit greater insulin responses following either an oral or intravenous glucose challenge relative to their European American (EA) counterparts. The etiology of this difference is not fully understood nor has it been confirmed with a more physiologically relevant mixed meal. Insulin secretion is regulated by a variety of factors. Significant among these are the enteric peptides glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The role of the incretin system in the ethnic differences in post challenge insulinemia has received little attention. Hence, the purpose of the study was two-fold. First, determine whether AA have higher fasting …

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Surface Reconstruction Using Gamma Shapes, Ying Sun Jan 2006

Surface Reconstruction Using Gamma Shapes, Ying Sun

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Surface reconstruction from a set of sample points is important in many applications, including computer graphics, reverse engineering, computer vision and medical imaging. In this dissertation, several surface reconstruction techniques are investigated and the Alpha Shapes method is studied in detail. A new method, called Gamma Shapes, is introduced and implemented for reconstructing surfaces from a set of unorganized sample points. The Alpha Shapes method requires that the data point set be uniformly sampled in order to reconstruct an acceptable surface. Gamma Shapes method is an extension of the Alpha Shapes method with the advantage that the Gamma Shapes method …

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Molecular Regulation Of Neural Stem Cell Apoptosis., Rizwan S. Akhtar Jan 2006

Molecular Regulation Of Neural Stem Cell Apoptosis., Rizwan S. Akhtar

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No abstract provided.

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Role Of Growth Factor Receptor Tyrosine Kinases And Downstream Signaling Kinases In Cancer Cell Phenotypes., Norman Robert Estes Jan 2006

Role Of Growth Factor Receptor Tyrosine Kinases And Downstream Signaling Kinases In Cancer Cell Phenotypes., Norman Robert Estes

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No abstract provided.

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Development, Validation, And Use Of A Novel [2-Carbon-13] Uracil Breath Test To Detect Dihydropyrimidine Dehydrogenase Deficiency., Lori K. Mattison Jan 2006

Development, Validation, And Use Of A Novel [2-Carbon-13] Uracil Breath Test To Detect Dihydropyrimidine Dehydrogenase Deficiency., Lori K. Mattison

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No abstract provided.

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Nutrient Intakes, Body Fat, Eating Attitudes, And Exercise Habits Of Collegiate Female Athletes Involved In A Sport Emphasizing Leanness Compared To A Sport Not Emphasizing Leanness., Nancy E. Miller Jan 2006

Nutrient Intakes, Body Fat, Eating Attitudes, And Exercise Habits Of Collegiate Female Athletes Involved In A Sport Emphasizing Leanness Compared To A Sport Not Emphasizing Leanness., Nancy E. Miller

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No abstract provided.

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Capsid -Membrane Interactions In Mason -Pfizer Monkey Virus Budding., Elizabeth Heather Stansell Jan 2006

Capsid -Membrane Interactions In Mason -Pfizer Monkey Virus Budding., Elizabeth Heather Stansell

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No abstract provided.

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Identification And Characterization Of The O-Glcnaczyme: A Multienzyme Complex Regulating O-Glcnac Modification., Thomas R. Whisenhunt Jan 2006

Identification And Characterization Of The O-Glcnaczyme: A Multienzyme Complex Regulating O-Glcnac Modification., Thomas R. Whisenhunt

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No abstract provided.

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Racial Disparities In Breast Cancer Treatment In Alabama., Julie Lynn Worthington Jan 2006

Racial Disparities In Breast Cancer Treatment In Alabama., Julie Lynn Worthington

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No abstract provided.

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O-Glcnac In Development., Damon Brian Bowe Jan 2006

O-Glcnac In Development., Damon Brian Bowe

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No abstract provided.

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Embedded Clustering Systems With Biological Data Mining Applications., Yonghui Chen Jan 2006

Embedded Clustering Systems With Biological Data Mining Applications., Yonghui Chen

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No abstract provided.

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Acculturation And Leisure Time Physical Activity Among Racially And Ethnically Diverse Women From Nhanes Iii, 1988€“1994., Ronnesia B. Gaskins Jan 2006

Acculturation And Leisure Time Physical Activity Among Racially And Ethnically Diverse Women From Nhanes Iii, 1988€“1994., Ronnesia B. Gaskins

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No abstract provided.

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Determination Of Dietary Protein, Carbohydrate, And Lipid Requirements For The Sea Urchin Lytechinus Variegatus Fed Semi-Purified Feeds., Hugh S. Hammer Jan 2006

Determination Of Dietary Protein, Carbohydrate, And Lipid Requirements For The Sea Urchin Lytechinus Variegatus Fed Semi-Purified Feeds., Hugh S. Hammer

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No abstract provided.

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The Role Of Parasocial Interaction In An Entertainment -Education Radio Soap Opera For Physical Activity And Self -Efficacy: A Concurrent Triangulation Mixed Methods Approach., Yoko Kawamura Jan 2006

The Role Of Parasocial Interaction In An Entertainment -Education Radio Soap Opera For Physical Activity And Self -Efficacy: A Concurrent Triangulation Mixed Methods Approach., Yoko Kawamura

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No abstract provided.

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Recognition Memory Of The Human Face: A Magnetoencephalography Study., Dongwook Lee Jan 2006

Recognition Memory Of The Human Face: A Magnetoencephalography Study., Dongwook Lee

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No abstract provided.

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An Examination Of Sexual Risk Behaviors And Future Time Perspective Among African American Female Juvenile Detainees., Kimberly D. Leeks Jan 2006

An Examination Of Sexual Risk Behaviors And Future Time Perspective Among African American Female Juvenile Detainees., Kimberly D. Leeks

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No abstract provided.

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Effects Of Psychological Stress And Cytokine Genes On Humoral Immune Response To Tetanus Toxoid Adsorbed In Family Caregivers Of Alzheimer's Disease Patients., Jian Li Jan 2006

Effects Of Psychological Stress And Cytokine Genes On Humoral Immune Response To Tetanus Toxoid Adsorbed In Family Caregivers Of Alzheimer's Disease Patients., Jian Li

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No abstract provided.

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Adenosine Kinase From Mycobacterium Tuberculosis., Mary C. Long Jan 2006

Adenosine Kinase From Mycobacterium Tuberculosis., Mary C. Long

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No abstract provided.

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Brms1 Suppresses Breast Cancer Metastasis To Multiple Organs., Pushkar A. Phadke Jan 2006

Brms1 Suppresses Breast Cancer Metastasis To Multiple Organs., Pushkar A. Phadke

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No abstract provided.

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Assessment Of Health Knowledge Among College Freshmen Students At The Hashemite University In Jordan., Moayad Abdullah Metlaq Wahsheh Jan 2006

Assessment Of Health Knowledge Among College Freshmen Students At The Hashemite University In Jordan., Moayad Abdullah Metlaq Wahsheh

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No abstract provided.

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The Impact Of Sense Of Coherence And Coping On Quality Of Life, Endocrine Reactivity And Natural Killer Cell Activity In Breast Cancer Survivors., Sheryl A. Ebert Jan 2006

The Impact Of Sense Of Coherence And Coping On Quality Of Life, Endocrine Reactivity And Natural Killer Cell Activity In Breast Cancer Survivors., Sheryl A. Ebert

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No abstract provided.

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A Geographic Study Of Childhood Cancers Near Hazardous Waste Sites In Florida., Gregory D. Kearney Jan 2006

A Geographic Study Of Childhood Cancers Near Hazardous Waste Sites In Florida., Gregory D. Kearney

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No abstract provided.

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Conserved Locus Control Region Sequences Controlling Beta-Globin Gene Expression In Mice., Andrea A. Svendsen Jan 2006

Conserved Locus Control Region Sequences Controlling Beta-Globin Gene Expression In Mice., Andrea A. Svendsen

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No abstract provided.

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Differential Homeostatic Supercoil Regulation In Escherichia Coli And Salmonella Enterica Serovar Typhimurium., Milton Keith Champion Jan 2006

Differential Homeostatic Supercoil Regulation In Escherichia Coli And Salmonella Enterica Serovar Typhimurium., Milton Keith Champion

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No abstract provided.

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The Role Of Lymphocyte Derived Growth Hormone In Cells Of The Immune System., John Thomas Farmer Jan 2006

The Role Of Lymphocyte Derived Growth Hormone In Cells Of The Immune System., John Thomas Farmer

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No abstract provided.

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Hope, Self -Efficacy, And Functional Recovery After Knee And Hip Replacement., Shannon Maureen Hartley Jan 2006

Hope, Self -Efficacy, And Functional Recovery After Knee And Hip Replacement., Shannon Maureen Hartley

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No abstract provided.

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