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Articles 4291 - 4320 of 6508
Full-Text Articles in Entire DC Network
Understanding The Molecular Mechanism Of Eukaryotic Translation Termination: Functional Analysis Of Ribosomal Rna And Eukaryotic Release Factor One, Hua Fan-Minogue
Understanding The Molecular Mechanism Of Eukaryotic Translation Termination: Functional Analysis Of Ribosomal Rna And Eukaryotic Release Factor One, Hua Fan-Minogue
All ETDs from UAB
No abstract provided.
Novel Immunomodulatory Oligonucleotides For Cancer Therapy, Elizabeth R. Rayburn
Novel Immunomodulatory Oligonucleotides For Cancer Therapy, Elizabeth R. Rayburn
All ETDs from UAB
No abstract provided.
Proteomic Discovery Of Genistein Action In The Rat Mammary Gland., Craig Rowell
Proteomic Discovery Of Genistein Action In The Rat Mammary Gland., Craig Rowell
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No abstract provided.
The Design And Synthesis Of Anti Bacterial Inhibitors Of Nad Synthetase, Whitney Beysselance Moro
The Design And Synthesis Of Anti Bacterial Inhibitors Of Nad Synthetase, Whitney Beysselance Moro
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No abstract provided.
Vitamin A And Retinoic Acid In Neonatal Hyperoxic Lung Injury, Masheika James
Vitamin A And Retinoic Acid In Neonatal Hyperoxic Lung Injury, Masheika James
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No abstract provided.
Regulation Of Ho-1 And Its Role In Angiogenesis, Jessy Deshane
Regulation Of Ho-1 And Its Role In Angiogenesis, Jessy Deshane
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Ischemic tissue and organ dysfunction occur in a variety of cardiovascular diseases. The hypoxic environment created during ischemic injury activates cytoprotective genes, of which heme oxygenase-1 (HO-1) is of great interest. This microsomal inducible enzyme is involved in the homeostasis of prooxidant heme, which is released from heme proteins upon injury. HO-1 responds to a variety of oxidative stress associated stimuli. HO-1 expression has been implicated as a protective response in diverse disease states which has been attributed to the beneficial properties of the by products iron, carbon monoxide and biliverdin/bilirubin. Regulation of expression of HO-1 is also significant, as …
O -Glcnac Modification In Muscle Development, Ping Huang
O -Glcnac Modification In Muscle Development, Ping Huang
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O-glycosylation, a type of posttranslational modification, is abundant and dynamic in the cell, yet its function in cell signaling and destiny regulation is far from known. This study examines the effects of O-glycosylation on muscle differentiation and metabolism, and the potential mechanism behind the effects: proteasome blockade. Proteasome action is required for muscle differentiation. We previously have shown that O-GlcNAc modification of the 19S cap of the proteasome can inhibit the proteolytic function of this organelle. By changing O-GlcNAc modification levels and proteasome function independently in C2C12 skeletal myoblasts, we have found that myoblast differentiation is largely dependent on both. …
Parallels In Trna Primer Acquisiton By Lentiviruses, Maureen C. Kelly
Parallels In Trna Primer Acquisiton By Lentiviruses, Maureen C. Kelly
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No abstract provided.
Transportation Infrastructure Resilience And Disaster Preparedness Education In Alabama, Stephanie Victoria Watson
Transportation Infrastructure Resilience And Disaster Preparedness Education In Alabama, Stephanie Victoria Watson
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No abstract provided.
The Role Of The Hypoxia-Inducible Factor Pathway In Bone Development And Repair, Ying Wang
The Role Of The Hypoxia-Inducible Factor Pathway In Bone Development And Repair, Ying Wang
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No abstract provided.
An Architecture Framework For Composite Services With Process-Personalization, Rajani Shankar Sadasivam
An Architecture Framework For Composite Services With Process-Personalization, Rajani Shankar Sadasivam
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No abstract provided.
Exposure To Airborne Asbestos In Jamaican Hospitals, Henroy P. Scarlett
Exposure To Airborne Asbestos In Jamaican Hospitals, Henroy P. Scarlett
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No abstract provided.
Elucidating The Role Of Nephrono Phthisis Proteins Utilizing Caenorhabditis Elegans As A Model, Marlene Elizabeth Winkelbauer
Elucidating The Role Of Nephrono Phthisis Proteins Utilizing Caenorhabditis Elegans As A Model, Marlene Elizabeth Winkelbauer
All ETDs from UAB
No abstract provided.
X-Ray Crystal Structures Of Yeast Heat Shock Proteins And Mitochondrial Outer Membrane Translocon Member Tom70p, Yunkun Wu
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No abstract provided.
Differences Between Estimated And Actual Caloric Intake, William E. Coggin
Differences Between Estimated And Actual Caloric Intake, William E. Coggin
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No abstract provided.
Sex Steroid And Growth Factor Expression In Prostates Of Transgenic Mice Exposed To Dietary Polyphenols, Leah Cook
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No abstract provided.
The Role Of The Primary Cilium In Energy And Glucose Metabolism, James Robert Davenport
The Role Of The Primary Cilium In Energy And Glucose Metabolism, James Robert Davenport
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No abstract provided.
Transit Operations Under Emergency Conditions, Amar S. Chaukar
Transit Operations Under Emergency Conditions, Amar S. Chaukar
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The events of September 11th and the recent terrorist attacks on transit systems around the world have increased interest in protection and emergency preparedness for the transit systems. Emergency preparedness planning for transit systems is necessary to prevent distractions and effectively respond to major man-made or natural disasters. In this thesis a large-scale dynamic simulation/assignment model was developed and used to evaluate the impact of emergency conditions on transit operations in the Birmingham, AL, area. The Birmingham regional model was developed using the Visual Interactive System for Transport Algorithms. After the base model was tested and calibrated, a major traffic …
Ca 2+ /Calmodulin-Dependent Protein Kinase Ii Regulates The Growth Of Human Osteosarcoma Cells In Vivo, Hyeran Choo
Ca 2+ /Calmodulin-Dependent Protein Kinase Ii Regulates The Growth Of Human Osteosarcoma Cells In Vivo, Hyeran Choo
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Osteosarcoma is the most predominant primary bone cancer among pediatric patients. The pathogenesis and mechanism of osteosarcoma, however, as yet remains unclear. This study investigated the hypothesis that Ca2+/calmodulin-dependent protein kinase II (CaMK II), activated by Ca2+ and its intracellular receptor, calmodulin, plays a critical role in the growth of human osteosarcoma cells. The inhibition of CaMK II with its pharmacologic antagonist KN-93 was used to investigate the role of CaMK II in the growth of human osteosarcoma cells because our preliminary data showed that =-CaMK II is expressed in several human osteosarcoma cell lines. To examine the in vivo …
Isolation And Characterization Of Human Periodontal Ligament Stem Cells, Isabel C. Gay
Isolation And Characterization Of Human Periodontal Ligament Stem Cells, Isabel C. Gay
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The periodontal ligament (PDL) is thought to include progenitor cells capable of forming fibroblasts, osteoblasts and cementoblasts. However, characterization of PDL stem cell populations (SC) remains undetermined due in part, to the diversity of cell types that conform to the periodontal apparatus. Objective: To isolate and characterize PDLSC and assess their pluripotent capabilities to differentiate into bone, cartilage and adipose cell types. Methods: PDL was scraped from human teeth, enzymatically digested, and cells stained for STRO- 1 (SC marker) using fluorescent immunohistochemistry. Positive cells were FACS sorted and expanded in culture. Human bone marrow SC (BMSC) served as a positive …
The Influence Of Insulin On Lipolysis In African American And Caucasian Prepubertal, Premenopausal, And Postmenopausal Females, Laura Lee T Goree
The Influence Of Insulin On Lipolysis In African American And Caucasian Prepubertal, Premenopausal, And Postmenopausal Females, Laura Lee T Goree
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African Americans, compared to Caucasians, may have chronically suppressed free fatty acid (FFA) mobilization due to basal and postprandial hyperinsulinemia. The pur-pose of this study was to determine if lower FFA among African Americans are due to higher insulin concentration and if this ethnic difference in FFA, beta cell function, and insulin suppression of FFA declines with age. Subjects who qualified underwent a fre-quently-sampled intravenous glucose tolerance test (FSIGT) for determination of insulin sensitivity (Si) and the acute insulin response to glucose (AIRg). Body composition and fat distribution were assessed with dual-energy x-ray absorptiometry (DXA) and com-puted tomography (CT), respectively. …
Determinants That Confer Stop Codon Specificity To Tetrahymena Thermophila Erf1, Cara Hope Heath
Determinants That Confer Stop Codon Specificity To Tetrahymena Thermophila Erf1, Cara Hope Heath
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In eukaryotes, translation termination is a process which is initiated by the presence of a stop codon in the A site of the ribosome and mediated by the binding of a release factor (eRF1). In most eukaryotes, any one of three stop codons UGA, UAG, or UAA, is required for the binding of eRF1. However some organisms, such as the ciliates, have diverged from this universal coding. In one type of ciliate species, Tetrahymena thermophila, UAA and UAG are no longer recognized as stop codons and now both encode a glutamine residue. It was previously thought that domain 1 of …
Mesofauna Associated With The Subtropical/Tropical Marine Sponge Amphimedon Viridis : Are Faunal Associations Likely To Provide Refuge From Fish Predation Due To Physical Or Chemical Feeding Deterrent Properties Of This Sponge?, Jonathan Huang
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Sessile benthic marine organisms such as sponges are frequently colonized by a wide diversity of invertebrates. The present study focused on a quantitative analysis of the mesofauna associated with the common subtropical/tropical sponge Amphimedon viridis and explored several criteria for the basis for this mesofauna-sponge relationship. Specimens of Amphimedon viridis were hand-collected individually in bags from both Saint Joseph Bay, Florida Panhandle, and Sugar Loaf Key, Florida Keys between April - November 2006. Quantitative analyses of sponge surfaces and interiors revealed that the most common sponge-associated group was comprised of amphipods, followed by polychaetes and tenaid crustaceans. 35 percent of …
Verbal Agression In Military Communication: Genetics Vs. Environment, Scott Gregory Johnson
Verbal Agression In Military Communication: Genetics Vs. Environment, Scott Gregory Johnson
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A content analysis was done on various studies involving hormonal effects on verbal and physical aggression in animals ranging from “old world monkeys” to humans in order to prove that genetics is responsible for verbal aggressiveness used by military personnel in the contemporary operating environment. The prevailing belief set is that the military is more aggressive than other social and vocational groups. The analysis shows that military members do not differ in neurophysiology from other groups and species. Only studies on animals with human-like limbic systems were used. The analy-sis includes discussions on the evolution of the use of pure …
The Effect Of Dietary Selenium On Weight Gain And Gonad Production In The Sea Urchin Lytechinus Variegatus, Warren T. Jones
The Effect Of Dietary Selenium On Weight Gain And Gonad Production In The Sea Urchin Lytechinus Variegatus, Warren T. Jones
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Small Lytechinus variegatus were collected in October 2004 from Port St. Joseph Peninsula State Park, FL (30° N, 85.5° W) and transported to the Texas A&M Shrimp Mariculture Facility in Port Aransas, TX. Subadult sea urchins were held individually in 25 cm x 10 cm diameter cylindrical cages and were fed semi-purified formulated feeds containing 0.55, 1.1, or 2.4 mg Se/kg feed for 12 weeks (n = 16 individuals per feed treatment, 13.67 ± 0.20 SE g initial wet weight, 30.12 ± 0.15 SE mm diameter; 32 ± 2 ppt salinity and 22 ± 1 C). Sea urchins were weighed …
Outcome Assessment On Skeletal Stability After Rigid External Distraction Osteogenesis In Cleft Lip And Palate Patients, Julio Enrique Tabarini
Outcome Assessment On Skeletal Stability After Rigid External Distraction Osteogenesis In Cleft Lip And Palate Patients, Julio Enrique Tabarini
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Purpose: Distraction osteogenesis (DO) using an external distraction device in the correction of maxillary hypoplasia (MH) in cleft lip and palate patients has been shown to be an effective and stable technique. The purpose of this study is to determine the outcome of skeletal stability for this procedure using the Rigid External Distraction (RED) System in patients with cleft lip and palate (CLP). Materials and methods: Twenty CLP patients with moderate to severe maxillary hypoplasia were treated between June 2000 and June 2006. Their average age at the time of the surgery was 12.6 years. DO was started after a …
Design Of A Service-Oriented Dashboard, Gayathri Sundar
Design Of A Service-Oriented Dashboard, Gayathri Sundar
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Service-Oriented Enterprises are currently focused on offering enhanced user experiences to customers, employees, and enterprise partners who use the enterprise’s software applications. A better user experience is delivered through the presentation of services and business processes to the user in a composite manner, and by facilitating a better user-application interaction for the user. Our experience with the bioinformatics domain helped us to see that although existing models of enterprise portals offer an integrated environment to present applications and enterprise resources, they are not sufficient to address certain complex user-application interactions. In this thesis, we present a design for a Service-Oriented …
Vitamin D Receptor Deficiency And Postnatal Tooth Formation, Xueming Zhang
Vitamin D Receptor Deficiency And Postnatal Tooth Formation, Xueming Zhang
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The reduction of caries is one of the major objectives of Healthy People 2010 (USDHHS, 2000). For individuals at risk for caries, early identification and interception before the occurrence of the disease are crucial to preventing the cariogenesis. However, host genetic variants that compromise the mineralization of dental enamel and dentin are unclear. The vdr mutation has been reported to be associated with bone loss. Therefore, it is likely that vitamin D resistance may affect dental enamel and dentin formation. The objective of this study was to investigate the effects of VDR deficiency on postnatal tooth formation in a vdr …
Predictors Of Indoor Dust Mite And Cockroach Levels, J Mark Brooks
Predictors Of Indoor Dust Mite And Cockroach Levels, J Mark Brooks
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Exposures to dust mite and cockroach indoor allergens are important environmental risk factors in allergic sensitization and the development and exacerbation of asthma. To determine the relationship of indoor allergen levels and residence characteristics, dust samples were collected from indoor surfaces in residences in the Birmingham, Alabama area. The dust samples were analyzed for specific dust mite (Der p 1 and Der f 1) and cockroach (Bla g 1) antigens, the results of which were used to represent the level of indoor allergen present in each residence. The presence, and in some cases the degree, of potential allergen-predicting characteristics of …
Coupling Selection Of The Hiv- 1 Trna Primer Used For Reverse Transcription With Viral Translation And Encapsidation, Uros V. Djekic
Coupling Selection Of The Hiv- 1 Trna Primer Used For Reverse Transcription With Viral Translation And Encapsidation, Uros V. Djekic
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HIV-1 belongs to the Retroviridae family. A hallmark of retroviral replication is the process of reverse transcription. Viral reverse transcriptase requires placement of a cellular tRNA primer onto the primer binding site (PBS) in order to initiate conversion of the viral RNA genome into a double stranded DNA copy. Mutation of the HIV-1 PBS forces the virus to utilize the non-cognate primer. Even though extensive studies have been done over the past 15 years, the mechanism of HIV-1 primer selection has yet to be completely elucidated. HIV-1 captures free tRNA during a yet undefined step in viral replication. However, our …