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Multidisciplinary Approach To Research: An Interview With Dr. Bradley Newcomer, Toral Patel

Inquiro (undergraduate research journal)

pp. 96-97

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Uab's 2009 Goldwater Representatives, Shweta Patel

Inquiro (undergraduate research journal)

p. 97

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Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby

All ETDs from UAB

cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …

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Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang

All ETDs from UAB

The fight against cancer has generated wide interest in understanding the genetic mechanisms behind the disease. One group of oncogenes – transcription factors – offers many opportunities for treatment or prevention. Among these transcription factors is KLF4, which functions in post-mitotic epithelial cells to promote differentiation. KLF4 has tumorigenic activity in both in vitro and in vivo models. In analyzing transcripts that were induced by KLF4, we noted the induction of multiple nuclear receptors, including retinoid receptors. Retinoids are well-established as chemopreventive agents, but the mechanisms by which they act to prevent cancer remain unclear. Previous studies have shown that …

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Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom

All ETDs from UAB

Neurogenesis is a crucial process for development, plasticity, and regenerative capacity of the developing and adult brain. Impairment of neurogenesis has been implicated in the etiology of psychiatric disorders. Although substantial studies have shown that therapeutic interventions enhance neurogenesis, much less is known about what factors impair neurogenesis. Thus, the present work examined if glycogen synthase kinase-3 (GSK3) has a role in impaired neurogenesis, focusing on apoptosis and proliferation of neural precursor cells (NPCs). This investigation found that GSK3 promotes apoptotic signaling in cultured NPCs subjected to two insults, trophic factor withdrawal and genotoxic stress. Both stimuli activated GSK3, Bax, …

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Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews

All ETDs from UAB

eimer’s disease (AD) is a progressive neurodegenerative disorder characterized by two major pathophysiological hallmarks, beta-amyloid (A��) plaques and tau tangles. In AD and other tau associated neurodegenerative disorders, termed tauopathies, a critical role in promoting neuronal degeneration has been demonstrated for hyperphosphorylated forms of tau. Recent findings suggest that cleavage of tau in the carboxyl-terminal region (Asp421) may also promote deleterious effects of tau on neuronal health. In the first half of my study, the relationship between Asp421 cleaved tau and a common AD associated stressor (endoplasmic reticulum [ER] stress) was investigated using an inducible cortical neuronal model. Cells expressing …

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Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena

All ETDs from UAB

Rapid bone loss occurs during prolonged periods of weightlessness experienced by astronauts during spaceflights which leads to osteopenia and increased fracture risk upon return to earth. Spaceflight studies have shown that the bone loss occurs as a result of both a decrease in bone formation and an increase in bone resorption, however, the molecular mechanisms still need to be elucidated. Previous studies from our laboratory and other groups have indicated that modeled microgravity leads to inhibition of osteoblastogenesis and a stimulation of adipogenesis of human mesenchymal stem cells in osteogenic medium which is most likely mediated by a decrease in …

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Non-Shared Familial Environment As A Determinant Of Discordant Patterns Of Disordered Eating Behaviors Among Sibling Pairs In A Family, Suparna Bagchi

All ETDs from UAB

Worldwide 15-40% of adolescents practice Disordered Eating Behavior (DEB). This study examined DEB development and the role of 1) shared familial factors among sibling pairs; and 2) non-shared familial experiences among discordant sibling pairs adjusted for individual and shared familial factors. The "National Longitudinal Study of Adolescent Health" data on 3274 adolescents were analyzed. The sample contained: twins (n=952), full siblings (n=1434), half siblings (n=418), and biologically not-related siblings (n=470). Multivariable regression analysis examined familial factors associated with DEB in the overall sample and sibling pair types. Adolescents engaging in DEB (~16%) were more likely to be white females with …

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Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck

All ETDs from UAB

Unlike antigen-specific alpha beta-T cells, gamma delta-T cells can recognize and lyse cancerous cells rapidly upon encounter in a manner that does not require the recognition of tumor-specific antigens. Given the well-documented capacity of gamma delta-T cells to innately kill malignant cells, efforts are now underway to exploit the antitumor properties of gamma delta-T cells for clinical purposes. Here, we present for the first time preclinical in vivo mouse models of gamma delta-T cell-based immunotherapy directed against breast cancer. These studies were explicitly designed to approximate clinical situations in which adoptively-transferred gamma delta-T cells would be employed therapeutically against breast …

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Identification Of New Strategies For The Treatment Of Glioblastoma Multiforme Utilizing A Pharmacogenomic Approach: Genetic Profiles Associated With Patient Prognosis And Outcome To Capecitabine Treatment, Jessica Marie Grunda

All ETDs from UAB

Glioblastoma multiforme (GBM) is the most lethal form of primary brain neoplasm with average patient survival between 9 and 15 months even with the most aggressive treatment modalities. Unfortunately, this poor outcome has not appreciably changed in the past 50 years emphasizing the lack of traditional `trial and error' methods in identifying an efficacious treatment for GBM. Pharmacogenomics is greatly impacting cancer research through the development of personalized medicine and rationally designed treatment paradigms for the development of more efficacious and less toxic treatment modalities. The main objective of this research was to utilize a pharmacogenomic approach to identify new …

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Identification Of The Function Of Rv0194 In Mycobacterium Tuberculosis, Rachel Philpott

All ETDs from UAB

No abstract provided.

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The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler

All ETDs from UAB

Members of the ß2-integrin family of adhesion molecules, CD11a, CD11b, and CD11c, have all been shown to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). CD11d had yet to be studied in demyelinating disease and its functions remained unclear. We report here that CD11d is the only member of the ß2-integrin family of adhesion molecules that fails to protect against the development of EAE. Surprisingly, the EAE studies suggested that CD11a, CD11b, and CD11c were all contributing to T cell activity during disease development by mechanisms beyond the migration of these cells into the CNS. However, the …

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Monosodium L-Glutamate Exposure Adversely Affects Early Development In The Sea Urchin Lytechinus Variegatus, Dorothy B. Moseley

All ETDs from UAB

No abstract provided.

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Mechanism Of Centaurin Alpha -1 Control Of Neuronal Differentiation, Donna Monique Hill

All ETDs from UAB

No abstract provided.

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Hitler's Baby Farms: The Lebensborn Project, John C. Faulkner

Vulcan Historical Review

pp. 28-52

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An Interview With James Ward, Department Of Mathematics, Ashruta Patel

Inquiro (undergraduate research journal)

p. 23

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“I Talk To God But The Sky Is Empty:” W.B. Yeats’S Influence On Sylvia Plath’S Renunciation Of Christianity, Rachel Leigh Anderson

All ETDs from UAB

No abstract provided.

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Bone Properties Surrounding Ha-Coated Custom Osseous Integrated Dental Implants, Maribel Ibañez Baker

All ETDs from UAB

No abstract provided.

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A Comparison Of Two Soft Tissue Gingivectomy Techniques, James R. Durham

All ETDs from UAB

No abstract provided.

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A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty

All ETDs from UAB

No abstract provided.

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A Comparison Of Allogenous Bone Graft Versus Particulate Autogenous Bone Graft To Gain Increase In Vertical And Horizontal Dimension Prior To Implant Placement. A Human Clinical Study., Elfa Gudmundsdottir

All ETDs from UAB

No abstract provided.

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Development And Application Of A Technique To Measure Soft Tissue Changes Following Noncarious Cervical Lesion Restorations, Prabhavathi Jampani

All ETDs from UAB

No abstract provided.

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Effects Of Cyclic Strain On Tgf-Ss1 Activation And Phenotype Modulation The Aortic Valve Interstitial Cells, Michael P. Nilo

All ETDs from UAB

No abstract provided.

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Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther

All ETDs from UAB

Maintenance of immune homeostasis involves a balance between T cell effector responses to antigen stimulus and reciprocal downregulation of this response through peripheral tolerance mechanisms. Upon exposure to pathogen, cytokine production and signaling serve to tightly coordinate cell-mediated clearance of antigen followed by contraction of the immune response. Interkeukin-2 (IL-2) is a type I family cytokine critical for expansion of activated T cells in vitro and enhancement of T cell memory responses in vivo. Deficiency of IL-2 in vivo also revealed a critical role for IL-2 in immune tolerance through the maintenance of T regulatory cell populations (Treg) in peripheral …

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The Significance Of Heavy Chain Cdr3 Diversity In The Antibody Response To Polysaccharides, Tamer Mahmoud

All ETDs from UAB

An understanding of the molecular mechanisms involved in the generation of protective antibody responses to polysaccharides associated with pathogenic microorganisms is of importance for improving vaccine design. The heavy chain third complementarity-determining region (HCDR3) of an antibody molecule is at the center of its antigen-binding site and plays a determinative role in antigen recognition. The goal of this dissertation was to investigate the role of HCDR3 diversity and composition on the antibody response to the polysaccharide α 1→3 Dextran (DEX). In the first study, we investigated the role of TdT, a DNA polymerase that plays a major role in generating …

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The Acute Onset Of Insulin Resistance In Adipose Tissue Following Trauma And Hemorrhage, Vanessa L. Williams

All ETDs from UAB

Insulin resistance and hyperglycemia are common findings in patients following acute illnesses or injuries, such as surgical trauma, thermal injury, infection, hemorrhage, and sepsis. Insulin has three main target tissues: liver, skeletal muscle, and adipose tissue. Insulin resistance in the liver results in an increase in gluconeogenesis. In skeletal muscle, insulin resistance causes a decrease in insulin-stimulated glucose uptake. However, little is known about the contribution that adipose tissue makes to the insulin resistant state. The goals of the research presented in this dissertation were to: 1) determine whether insulin resistance developed in adipose tissue following acute trauma and hemorrhage; …

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Analysis Of Cystic Kidney Disease-Related Genes In Caenorhabditis Elegans, Corey L. Williams

All ETDs from UAB

Cilia are evolutionarily conserved, membrane-bound, microtubule-based organelles found on a diverse array of cell types in eukaryotic organisms. Inherited diseases of cilia protein dysfunction include Nephronophthisis (NPHP), Joubert Syndrome (JBTS), Meckel-Gruber Syndrome (MKS), and Bardet-Biedl Syndrome (BBS). Important insight in the basic cell biological functions of BBS and NPHP proteins has been gained from analysis in the nematode Caenorhabditis elegans. My goal in this dissertation was to model MKS protein function in cilia biology utilizing the powerful genetic malleability of C. elegans. mks-1 and mks-3, the C. elegans homologs of two MKS-associated proteins in humans, were selected for this analysis. …

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Modification Of Adenovirus Capsid Proteins For Gene Therapy Applications, Yizhe Tang

All ETDs from UAB

Adenovirus (Ad) is the most commonly used viral vector in gene therapy applications to date for a broad range of diseases. Although Ad-based viral vectors have many advantages in a variety of gene therapy designs, the commonly used adenoviral vectors have several key shortcomings. Those shortcomings include (1) inefficient transduction in cell types devoid of Ad’s native receptors and the incapability of gene delivery to targets behind physical barriers; (2) restricted accessibility to the central nerve system due to the existence of the blood-brain barrier (BBB); (3) lack of a useful strategy and platform to generate multi-functionality displaying Ad vectors …

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Axonal Trafficking Of Bmp Signals In Drosophilia Motoneurons, Rebecca Burt Smith

All ETDs from UAB

The Drosophila Bone Morphogenetic Protein (BMP) Glass bottom boat (Gbb) is a ligand for the BMP type II receptor, Wishful thinking (Wit). Mutations in either of these proteins impair synaptic growth at the neuromuscular junction (NMJ). Gbb is a retrograde signal (from target to innervating neuron) that is essential for proper NMJ development and function. Tissue-specific rescue of pathway mutants and immunolocalization experiments indicate that the receptor-ligand interaction occurs at the NMJ, and results in the nuclear accumulation of the phosphorylated form of the transcription factor Mad, indicating that retrograde transport along the axon is critical for pathway activation. We …

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The Essential Role Of Macrophages And Tlr Signaling In The Host Response To Mycoplasma Pneumoniae, Jen-Feng Lai

All ETDs from UAB

Several reports have suggested that Mycoplasma pneumoniae (Mp) can contribute importantly to the expression of symptoms in asthmatic human subjects. As a foundation for understanding the interactions between Mp and asthma susceptibility, we first studied the mechanisms by which the host normally eliminated Mp. Mice were inoculated with 4x106 Mp intranasally. Twenty-four hours after inoculation with Mp, subpopulations of CD11b+ macrophages/monocytes had been recruited into the lungs. The clearance of Mp was impaired both in macrophage-depleted and in macrophage-deficient mice. Furthermore, mice deficient in MyD88, a major adaptor for TLR signaling, showed dramatically defective clearance of Mp, associated with reduced …

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Full-Text Articles in Entire DC Network

Multidisciplinary Approach To Research: An Interview With Dr. Bradley Newcomer, Toral Patel

Inquiro (undergraduate research journal)

Uab's 2009 Goldwater Representatives, Shweta Patel

Inquiro (undergraduate research journal)

Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby

All ETDs from UAB

Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang

All ETDs from UAB

Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom

All ETDs from UAB

Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews

All ETDs from UAB

Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena

All ETDs from UAB

Non-Shared Familial Environment As A Determinant Of Discordant Patterns Of Disordered Eating Behaviors Among Sibling Pairs In A Family, Suparna Bagchi

All ETDs from UAB

Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck

All ETDs from UAB

Identification Of New Strategies For The Treatment Of Glioblastoma Multiforme Utilizing A Pharmacogenomic Approach: Genetic Profiles Associated With Patient Prognosis And Outcome To Capecitabine Treatment, Jessica Marie Grunda

All ETDs from UAB

Identification Of The Function Of Rv0194 In Mycobacterium Tuberculosis, Rachel Philpott

All ETDs from UAB

The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler

All ETDs from UAB

Monosodium L-Glutamate Exposure Adversely Affects Early Development In The Sea Urchin Lytechinus Variegatus, Dorothy B. Moseley

All ETDs from UAB

Mechanism Of Centaurin Alpha -1 Control Of Neuronal Differentiation, Donna Monique Hill

All ETDs from UAB

Hitler's Baby Farms: The Lebensborn Project, John C. Faulkner

Vulcan Historical Review

An Interview With James Ward, Department Of Mathematics, Ashruta Patel

Inquiro (undergraduate research journal)

“I Talk To God But The Sky Is Empty:” W.B. Yeats’S Influence On Sylvia Plath’S Renunciation Of Christianity, Rachel Leigh Anderson

All ETDs from UAB

Bone Properties Surrounding Ha-Coated Custom Osseous Integrated Dental Implants, Maribel Ibañez Baker

All ETDs from UAB

A Comparison Of Two Soft Tissue Gingivectomy Techniques, James R. Durham

All ETDs from UAB

A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty

All ETDs from UAB

A Comparison Of Allogenous Bone Graft Versus Particulate Autogenous Bone Graft To Gain Increase In Vertical And Horizontal Dimension Prior To Implant Placement. A Human Clinical Study., Elfa Gudmundsdottir

All ETDs from UAB

Development And Application Of A Technique To Measure Soft Tissue Changes Following Noncarious Cervical Lesion Restorations, Prabhavathi Jampani

All ETDs from UAB

Effects Of Cyclic Strain On Tgf-Ss1 Activation And Phenotype Modulation The Aortic Valve Interstitial Cells, Michael P. Nilo

All ETDs from UAB

Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther

All ETDs from UAB

The Significance Of Heavy Chain Cdr3 Diversity In The Antibody Response To Polysaccharides, Tamer Mahmoud

All ETDs from UAB

The Acute Onset Of Insulin Resistance In Adipose Tissue Following Trauma And Hemorrhage, Vanessa L. Williams

All ETDs from UAB

Analysis Of Cystic Kidney Disease-Related Genes In Caenorhabditis Elegans, Corey L. Williams

All ETDs from UAB

Modification Of Adenovirus Capsid Proteins For Gene Therapy Applications, Yizhe Tang

All ETDs from UAB

Axonal Trafficking Of Bmp Signals In Drosophilia Motoneurons, Rebecca Burt Smith

All ETDs from UAB

The Essential Role Of Macrophages And Tlr Signaling In The Host Response To Mycoplasma Pneumoniae, Jen-Feng Lai

All ETDs from UAB