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An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee Jan 2012

An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee

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Pre-diabetes is a major contributor to increased morbidity and mortality in the US. Without proper and timely intervention the majority of individuals with pre-diabetes will develop Type 2 diabetes. African Americans (AA) and people living in the Stroke Belt have increased odds of developing pre-diabetes compared to Whites and people living outside the Stroke Belt. While several covariates have been identified as contributors to the increased odds of pre-diabetes there is little consensus on which covariates may be responsible for the disparities of pre-diabetes. The reasons for disparities in pre-diabetes are complex and require further investigation. This study explored the …

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The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand Jan 2012

The Role Of Cd11c+ Cells In Response To Ozone, Jeffrey David Brand

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Environmental ozone exposure remains a major public health concern with over one-third of the United States population experiencing unhealthful levels. Epidemiological studies indicate exposure increases morbidity in those with pre-existing disease such as asthma, though the biological mechanisms underlying this phenomenon remain elusive. CD11c+ cells within the respiratory tract include dendritic cells (DCs), which are the most efficient antigen presenters and play major roles controlling immune responses. In addition, DCs are thought necessary for asthma pathogenesis and exacerbation. Therefore the link between ozone associated asthma morbidity may be DCs. We hypothesize ozone exposure may site specifically alter DC phenotypes, numbers, …

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Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix Jan 2012

Discovery And Characterization Of Streptococcus Pneumoniae Serotype 11e Reveals A Novel Model Of Serotype Evolution, Juan Jose Calix

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The facultative pathogen Streptococcus pneumoniae is capable of producing a polysaccharide (PS) capsule that prevents bacterial recognition and clearance by the host immune system. Over 90 antigenically distinct capsule serotypes have been identified. Because anti-capsule antibodies can mediate bacterial clearance, capsule diversity is critical to S. pneumoniae survival. However, the mechanisms of capsule evolution remain unclear. Due to the complex interaction of capsule synthesis (cps) genes, it is commonly thought that pneumococcal serotypes evolve once and that all clinically relevant serotypes are genetically derived from a single founding clone. In this dissertation we demonstrate a novel mechanism of capsule evolution …

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Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa Jan 2012

Identification, Molecular Cloning And Characterization Of Transmitted/Founder Hiv-1 Subtype A, D And Ad Viruses And Envelope Glycoproteins, Joshua Baalwa

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A precise molecular identification of transmitted/founder (T/F) HIV-1 genomes responsible for productive infection in humans can be an enabling strategy for elucidating mechanisms of virus transmission, immunopathogenesis and prevention. Previously, we reported a single genome sequencing approach, which when combined with a mathematical model of early random virus diversification, allowed for an unambiguous identification of T/F HIV-1 subtype B and C envelope (env) genes. Here, we apply this method to the identification and molecular cloning of full-length HIV-1 genomes and env genes of the less well-studied, but nonetheless important, HIV-1 subtypes A and D. Twelve subtype A (n=5), D (n=5) …

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Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles Jan 2012

Examination Of Urban High School Dropouts With High Self-Efficacy: A Phenomenological Study, Ronald Bayles

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The purpose of this study was to explore the lived experience of urban students in Central Alabama with high self-efficacy who have dropped out of school to pursue a GED. This study: (a) provided a platform that gave voice to students to share their lived experience as they made the decision to drop out of high school, (b) identified the character traits of students with high self-efficacy, and (c) revealed the essence of what motivated students to move to resilience after appearing to give up. A qualitative research design was used. The phenomenological approach provided the opportunity for participants to …

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Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette Jan 2012

Sonication Treatment Of Diesel Fuel Laden Sump Water, Roxanne E. Bessette

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Diesel engines are the work horses of industry and transportation. Pervasive diesel fuel use impacts stormwater, by increasing petroleum releases to surface waters. Sump containment of diesel-adulterated stormwater commonly keeps diesel from contacting surface waters. Once contained, the quandary lies in effective stormwater treatment that allows discharges within the local watershed. On-site treatment of diesel sump water ordinarily involves gravity oil-water separation technologies. These technologies' treatment times range from hours to days. Commonly, they cannot meet National Pollution Discharge Elimination System (NPDES) stormwater discharge standards for oil and grease because they best remove `free' oil not commonly occurring emulsions. Oil-water …

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Understanding The Mechanisms Underlying Pgc-1Α-Mediated Regulation Of Interneuron-Specific Genes, Ashruta Patel Jan 2012

Understanding The Mechanisms Underlying Pgc-1Α-Mediated Regulation Of Interneuron-Specific Genes, Ashruta Patel

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The expression of parvalbumin (Pvalb), a calcium buffering protein expressed in subsets of inhibitory neurons throughout the brain, is reduced in numerous psychiatric and neurological disorders, yet little is known about its transcriptional regulation. Previous work from the Cowell Lab has shown that the expression of Pvalb and other interneuron-specific genes in the mouse brain is dependent on the transcriptional coactivator peroxisome proliferator activated receptor coactivator 1α (PGC-1α ) and that overexpression of PGC-1α in neuroblastoma cells is sufficient to robustly induce Pvalb. The Cowell Lab determined that expression of Pvalb requires a region upstream of the human Pvalb transcription …

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A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger Jan 2012

A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger

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Parkinson's Disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Gene multiplication of alpha-synuclein causes an autosomal dominant inheritance pattern of PD. A mouse model overexpressing alpha-synuclein demonstrates some of the phenotype seen in PD. In a microarray of these mice, a downregulation of angiogenin was observed prior to symptom onset, demonstrating a potential link of angiogenin to pathology in this model. Angiogenin has also been associated with the onset of Amyotrophic Lateral Sclerosis (ALS), and is neuroprotective in models of ALS through activation of the Akt …

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The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein Jan 2012

The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein

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In recent years, hydrogen sulfide (H2S) has been identified as a ubiquitous cell signaling molecule. In addition to its diverse physiological roles, H2S has emerged as a possible drug therapy, with a wide range of applications. Along with cytoprotective effects in pathological states such as ischemia-reperfusion injury, H2S has been shown to decrease aerobic metabolism in a reversible manner. This dissertation is focused on exploring H2S-induced hypometabolism and the implications therein for human health and disease. We have shown that rats exposed to 80 ppm H2S gas in combination with low oxygen (10.5% O2) for 6 hr exhibit decreases in …

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Examination Of Bafilomycin And Atp6v0c As Putative Mediators Of App Clearance In A Pre-Clinical Model Of Alzheimer's Disease, Charles Alan Taylor Jan 2012

Examination Of Bafilomycin And Atp6v0c As Putative Mediators Of App Clearance In A Pre-Clinical Model Of Alzheimer's Disease, Charles Alan Taylor

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Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and the most common form of dementia. Fundamental hallmarks of AD include progressive hippocampal neuron death, neurofibrillary tangles associated with tau deposits, and accumulation of amyloid plaques containing amyloid beta (Aß), a cleavage product derived from amyloid precursor protein (APP). Deficits in the clearance of APP, due to lysosomal dysfunction for instance, result in the accumulation of APP C-terminal fragments (APP-CTFs) and toxic species of Aß (Aß40-42) (1). Defective lysosomal proteolysis represents a mechanism that may contribute to AD pathologies, including protein aggregation and neuronal cell death. Therefore the lysosome represents an …

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The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor Jan 2012

The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor

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THE IMPACT OF COMMUNITY HEALTH CENTERS ON PROSTATE CANCER SCREENING BEHAVIORS OF AFRICAN AMERICAN MALES: A MIXED METHODS STUDY MICHAEL C. TAYLOR UAB SCHOOL OF PUBLIC HEALTH DEPARTMENT OF HEALTH BEHAVIOR ABSTRACT Federally qualified community health centers have a significant impact upon uninsured and low income populations in the United States by providing low cost primary care and preventive services. The purpose of this mixed methods study was to determine the impact of community health centers (CHCs) on African American males' prostate cancer screening behavior in a major Southern city. A sequential explanatory mixed method model was used to assess …

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Surviving Stem: Mentoring, Self-Effiacay And Career Intentions Of Female Graduate Students In Science, Technology, Engineering, And Math, Elizabeth Allyne Yost Jan 2012

Surviving Stem: Mentoring, Self-Effiacay And Career Intentions Of Female Graduate Students In Science, Technology, Engineering, And Math, Elizabeth Allyne Yost

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The state of women in STEM (Science, Technology, Engineering, and Math) is not equitable to that of their male counterparts. While great strides have been taken in the last few years, many areas of STEM are still unable to draw equitable numbers of women into the academy. One way to encourage women to enter in and remain in the academy is through mentoring. Through mentoring, women are able to see that a career path is possible for them and better learn how to navigate the structure of the academy. Mentoring has also been shown to increase self-efficacy, which the Social …

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Serotonin Signaling In Angiogenesis, Ali Zamani Jan 2012

Serotonin Signaling In Angiogenesis, Ali Zamani

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Serotonin (5-hydroxytryptamine, 5-HT) is a well-known "happy" neurotransmitter. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed class of antidepressant medications to raise the serotonin level in the brain. However, the majority of serotonin in the human body is present outside of the brain and stored in platelets in blood circulation. Blood coagulation is a common feature of malignant solid tumors and leads to significant serotonin release from activated platelets into tumor environment. Due to the unique feature of platelet in lacking nucleus, the impact of platelet and serotonin on cancer progression has been overlooked by studies focusing on cancer …

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Exploring Health Disparities For Children In The City Of Milwaukee, Mark Edwin Anderson Jan 2012

Exploring Health Disparities For Children In The City Of Milwaukee, Mark Edwin Anderson

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This study investigated whether school-based oral health programs as a public policy intervention increased dental sealant applications among children from low-income families and minorities in public schools in inner city Milwaukee. By using a difference-in-differences analysis, we examined pre-post time frames, 2001-2003 and 2008-2009, to determine sealant application usage in public schools in nine inner city Milwaukee zip codes after the intervention of a public policy initiative to expand school-based oral health programs with the expressed intent of increasing placement of dental sealants in children at high risk for dental decay and disease. Results of a binary logistic regression revealed …

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Finding A Cure For Venezuelan Equine Encephalitis Virus (Veev) Infection: The Search For The Antiviral Genes And Vaccine Development., Svetlana Atasheva Jan 2012

Finding A Cure For Venezuelan Equine Encephalitis Virus (Veev) Infection: The Search For The Antiviral Genes And Vaccine Development., Svetlana Atasheva

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Venezuelan equine encephalitis virus (VEEV) is a re-emerging virus that causes a severe and often fatal disease in equids and humans. To date, despite a continuous public health threat, no vaccines or antiviral drugs against VEEV infection have been developed for human use. In this study we took advantage of accumulated knowledge of capsid protein function in viral replication, assembly and virus-host interactions. Besides being an integral part of the virion, capsid protein is the major determinant of VEEV pathogenesis. This protein is cytotoxic and induces cellular transcriptional shutoff as a countermeasure to the cellular antiviral response. We introduced targeted …

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Methylxanthine-Induced Neuroprotection In Neural Stem Cells, Stacy I. Ejem Jan 2012

Methylxanthine-Induced Neuroprotection In Neural Stem Cells, Stacy I. Ejem

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Neonatal brain injury is a significant health concern of premature low birth weight babies that often leads to devastating developmental complications. Many of these babies do not survive and those that survive could end up with social and mental disorders. Premature babies are susceptible to brain injury due to their unique and underdeveloped anatomy. The insufficiency of the neonatal defense and antioxidant system prevents the body from buffering against ROS, causing oxidative stress. Adenosine, known as a modulator of cerebral blood flow, has been shown to be neuroprotective; it prevents excessive neuronal firing. However, depending on the cell type and …

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Novel Device To Quantify The Mechanical Properties Of Electrospun Nanofibers, Timothy John Fee Jan 2012

Novel Device To Quantify The Mechanical Properties Of Electrospun Nanofibers, Timothy John Fee

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Electrospun biomaterials are gaining popularity as scaffolding for engineered tissues. These fibrous scaffolds of natural or synthetic polymers can mimic the nano-scale properties of the natural extra-cellular matrix. It is becoming clear that the mechanical deformation of any electrospun matrix plays an important role in cell signaling. However, electrospun biomaterials have inherently complex geometries due to the random deposition of fibers during the electrospinning process. This complex fiber geometry complicates any attempt at quantifying forces exerted on adherent cells during electrospun matrix deformation. In order to quantify the mechanical properties of arrays of individual electrospun fibers in physiological conditions, a …

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Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd Jan 2012

Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd

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The ocular lens functions to focus light coming into the eye onto the retina. Lens development begins in utero, and continues over an individual's lifetime. Lens fiber cells and their proteins are only synthesized once and have no repair mechanisms, so they remain for an individual's lifetime. The α-crystallins, the most abundant lens proteins, act as chaperones to keep damaged/unfolded proteins in-solution. Cataract disease is associated with protein damage, leading to a light scattering opacity. It has been suggested that truncation of αA-crystallin leads to a loss of chaperone function. Cataract disease is the leading cause of blindness in the …

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Functional Collaboration Between Igf-1 Receptor And Growth Hormone Signaling Pathway, Yujun Gan Jan 2012

Functional Collaboration Between Igf-1 Receptor And Growth Hormone Signaling Pathway, Yujun Gan

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GH receptor (GHR) binds GH in its extracellular domain (ECD) to activate the GHR-associated cytoplasmic tyrosine kinase, JAK2. IGF-1 binds IGF-1R, a disulfide-linked heterotetramer with tyrosine kinase activity in its intracellular domain (ICD). Classically, IGF-1 is a GH effector in a “linear” GH→GHR→IGF-1→IGF-1R pathway. Our recent studies suggest IGF-1R also subserves GH signaling in several novel ways: 1) GH induces a GHR-JAK2-IGF-1R complex, whose formation is independent of tyrosine phosphorylation of any of the partners; 2) Cotreatment with IGF-1 augments acute GH signaling; 3) deletion of IGF-1R in primary osteoblasts or human prostate cancer cells blunts acute GH signaling. In …

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Parental Influences On Driving Behavior In Adolescents With Attention Deficit Hyperactivity Disorder, Annie Artiga Garner Jan 2012

Parental Influences On Driving Behavior In Adolescents With Attention Deficit Hyperactivity Disorder, Annie Artiga Garner

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Drivers with attention-deficit/hyperactivity disorder (ADHD) are approximately six times more likely to become involved in a motor vehicle crash (MVC) than drivers without the disorder. Moreover, adolescent drivers with ADHD are likely at greater risk because their attention regulation difficulties are exacerbated by their driving inexperience. Research has primarily focused on the impact of ADHD on driving outcomes among adults. Thus, there is little literature assessing the role of parents in influencing driving outcomes of adolescents with ADHD. The present study was conducted to examine the impact of parenting practices during middle adolescence on the driving outcomes of adolescents with …

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Regulation Of Neuronal Cell Death By Bh3-Only Proteins, Arindam P. Ghosh Jan 2012

Regulation Of Neuronal Cell Death By Bh3-Only Proteins, Arindam P. Ghosh

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Apoptosis in metazoan organisms plays critical roles in normal development, tissue homeostasis and immunity, and its disturbed regulation leads to many pathological states, including cancer, autoimmunity, infection and degenerative disorders. Apoptosis can be triggered by the engagement of `death receptors' of the tumor necrosis factor receptor family on the cell surface or by diverse intracellular signals that act upon the BCL2 (B-cell CLL/lymphoma 2) protein family, which controls the integrity of the mitochondrial outer membrane through the complex interactions of family members. Both the pathways lead to cellular demolition by dedicated proteases termed caspases. Different BH3-only proteins (or combinations of …

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Modulation Of Morpho-Functional Characteristics Of Astrocytes Using Chemically-Functionalized Water-Soluble Single-Walled Carbon Nanotubes, Manoj K. Gottipati Jan 2012

Modulation Of Morpho-Functional Characteristics Of Astrocytes Using Chemically-Functionalized Water-Soluble Single-Walled Carbon Nanotubes, Manoj K. Gottipati

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In this thesis, I report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.

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Becoming Scholars: Examining The Link Between Moral Problem-Solving And Academic Authorship Practices In Future Educational Leaders In One Southern State, Jennifer L. Greer Jan 2012

Becoming Scholars: Examining The Link Between Moral Problem-Solving And Academic Authorship Practices In Future Educational Leaders In One Southern State, Jennifer L. Greer

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The public expects its educational leaders - from instructional leaders and principals to college administrators and deans - to be moral exemplars. Nowhere is moral behavior more central to the central mission of teaching and learning than in the realm of academic integrity, where decisions are made daily about grading, testing, promotion, admissions, placement, and awards. Moral problem solving, one essential and teachable component of moral behavior, has been studied in teachers and, to a lesser extent, principals. Yet little empirical research has been conducted on moral problem solving, or reasoning, among educational leadership graduate students in training for positions …

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Predictors Of Vaginal Douching Behavior And Sexual Risk Taking Among A Population Of Women In The South: The Influence Of Sexual Concurrency And Partner Incarceration, Keri J. Griffin Jan 2012

Predictors Of Vaginal Douching Behavior And Sexual Risk Taking Among A Population Of Women In The South: The Influence Of Sexual Concurrency And Partner Incarceration, Keri J. Griffin

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In the United States, adolescent women between the ages of 14 and 19 are estimated to bear the largest burden of sexually transmitted infections. Left untreated, these infections have the potential to result in several adverse reproductive health outcomes. Sexually risky behaviors, including early sexual initiation, sexual partner concurrency, and the use of vaginal douche products increase the risk for the contraction of sexually transmitted infections. Further, having a sexual relationship with a male partner who is known to have other partners or a history of contact with the justice system might put a woman at additional risk. Utilizing a …

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Analysis Of Abundance And Biodiversity Of Mosquitoes And Their Epidemiological Implications In Three Urban Neighborhoods In The Southeastern United States, Erick Xavier Caamano Jan 2012

Analysis Of Abundance And Biodiversity Of Mosquitoes And Their Epidemiological Implications In Three Urban Neighborhoods In The Southeastern United States, Erick Xavier Caamano

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Birmingham, Alabama has experienced several mosquito-borne epidemics, including Saint Louis encephalitis (SLE) and West Nile virus (WNV). Despite the outbreak of these diseases, the city lacks a mosquito surveillance program that would assist in vector control efforts. In order to assess the possible advantages of implementing a surveillance system for the city, three neighborhoods were chosen for surveys based on the fact that past epidemics have been concentrated in these areas. During the two surveillance years, 2009 had more abundance of mosquitoes and more species variability than the 2010 season. Overall, as abundance of mosquitoes increased in a particular site, …

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Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable And Hybrid Composite Resins, Qinyue Cai Jan 2012

Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable And Hybrid Composite Resins, Qinyue Cai

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Dental composites are used for a variety of applications in dentistry today. Dental composites are composed of a resin matrix containing a blend of Bis-GMA (bis-phenol A-glycidyldimethacrylate) or urethane dimethacrylate (UDMA) along with TEGDMA (tetraethylglycidylmethacrylate). Exhaustive researches has been conducted in recent years to improve physical and mechanical properties of resin-based dental composites, since the existing resin-filler systems may not be suitable for long term applications in large as well as high stress restorations. Nanofillers reinforced composite resins have shown promising results. Silica-based nanoparticles and clusters are blended with larger-sized fillers and are available commercially for restoring large posterior restorations. …

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Postpartum Health Outcomes Of Male Partners: The Paternity Role, Carrie Ann Betcher Jan 2012

Postpartum Health Outcomes Of Male Partners: The Paternity Role, Carrie Ann Betcher

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The purpose of this study was to investigate how assuming a paternal role for the first time affects the mental and physical health of males, and identify the key characteristics of the paternal role. The characteristics deemed most important by first-time fathers were providing love (51.3%), being a teacher (19.9%), participating in childcare responsibilities (11.8%), providing financially (9.6%), providing protection (3.7%), and being an authority figure (3.7%). Conversely, 21.1% of fathers stated financial obligations were not important, and 18.7% of fathers deemed participating in childcare not important. All fathers within this study self-reported being at least moderately active in their …

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Schizophrenia And Vergence Eye Movements, Mark S. Bolding Jan 2012

Schizophrenia And Vergence Eye Movements, Mark S. Bolding

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Background: Compared to healthy controls (HC), patients with schizophrenia (SZ) have lower smooth pursuit gain and have been reported as having a higher prevalence of convergence insufficiency. To date, however, there have been no reports on vergence tracking gain in such patients. Therefore, we investigated both static and dynamic vergence behavior in healthy controls and patients with schizophrenia. Methods: Eye movements were recorded in multiple tasks including antisaccades, triangular waveform smooth pursuit at multiple frequencies, and triangular waveform vergence tracking of a real target at multiple frequencies. Eye position data were collected at 500 Hz using a binocular video eye …

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Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn Jan 2012

Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn

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Bacteriophage can mediate the transfer of unrelated mobile genetic elements (MGE) from a carrier bacterial cell to the susceptible population around it. This transfer results in the spread of virulence or other accessory genes encoded on the MGE. During viral particle assembly, the MGE can discourage the formation of viable bacteriophage progeny by limiting the size of the particles to those large enough to encapsidate the MGE, but too small to fit the complete bacteriophage genome which is three times larger. Here, I present models for size determination by an external scaffolding protein which is independent of and dominant over …

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Physical Activity Barriers Following Traumatic Brain Injury: A Cognitive Mapping Study, Anna De Joya Jan 2012

Physical Activity Barriers Following Traumatic Brain Injury: A Cognitive Mapping Study, Anna De Joya

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Background: Despite the strong evidence indicating the benefits of regular physical activity (PA) for health and functioning, individuals with a traumatic brain injury (TBI) do not engage in PA at levels consistent with public health recommendations. To eliminate the health disparities and promote PA in this population, the barriers unique to individuals with TBI should be identified by different stakeholders to establish effective health promotion programs that have sustainable outcomes. There is limited evidence to guide the development and delivery of effective PA interventions in the TBI field. Objectives: The specific aims of this study are: 1) to identify the …

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