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Articles 3151 - 3180 of 6508
Full-Text Articles in Entire DC Network
Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid
Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid
All ETDs from UAB
Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …
Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts
Characterization Of Emergent Spatial-Temporal Orders In Transcription Regulatory Networks Using Phase Locking Analysis, Herbert Keith Roberts
All ETDs from UAB
The study of gene regulatory networks (GRNs) is paramount for continued breakthroughs in understanding the genetic architecture of life and how alterations thereof contribute to disease. The complex spatio-temporal orders within GRNs are studied primarily through the modeling of time-course gene expression data. Recently, gene expression profiling technology has improved greatly in regards to accuracy and resolution, enabling novel methodology development and characterization of GRNs. Many methods have been utilized to model GRNs from gene expression data (correlational measures, time-warping, coherence, and/or causality, etc). In this study, we propose a new approach based on phase locking analysis that compliments existing …
Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf
Commensal Microbiota And Its Impact On Health And Autoimmune Diabetets, Kyle James Wolf
All ETDs from UAB
Environmental exposures such as diet, use of antibiotics, and lifestyle have significant impact on the health of an individual. One mechanism that acts as a major pathway in these environmental exposures is the role intestinal commensal microbiota play in both metabolic and immunological responses. Metabolic pathways are altered through changes in metabolites provided by commensal microbiota; alterations in microbial make-up can have drastic impacts on metabolic function. Similarly, the development and maturation of the immune system is dependent on the intestinal microbes to induce tolerance and act as both an immune modulator as well as a barrier against pathogens. We …
A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang
A Study Of Multi-Group And Multivariate Tests Of Equivalence With Application To Microarray And, Celeste Yang
All ETDs from UAB
In this dissertation we have adapted two multi-group equivalence tests to be performed on high-dimensional data. The F and Range test for multi-group equivalence were applied to the public microarray dataset GSE11291 to detect equivalently expressed genes. They were also evaluated in terms of type I error and power using single gene simulation and a high-dimension simulation. The F test has higher power than the Range for the same simulated data and parameter settings, in the single gene simulations. The power of the two tests is similar in the high-dimension simulation. The multi-group equivalence tests that were applied to the …
Characterization Of The Mumps Virus Replicase, Robert Marsden Cox
Characterization Of The Mumps Virus Replicase, Robert Marsden Cox
All ETDs from UAB
Negative strand RNA viruses (NSV) are unique because their nucleocapsids are used directly as the template for both transcription and replication. The viral genomic RNA is coated by the nucleoprotein (N) for the entirety of the NSV replication cycle. The viral polymerase, which is composed of the L and P proteins, can only recognize encapsidated RNA as the template for RNA synthesis. Our previous studies have solved the EM structure of the MuV N-RNA complex at 25Å . This structure revealed how the nucleocapsid is assembled and provides an initial model for examining how the viral polymerase may recognize the …
Using A Mixed Methods Sequential Design To Identify Factors Associated With African American Mothers' Intention To Vaccinate Their Daughters Aged 9 To 12 For Hpv With A Purpose Of Informing A Culturally-Relevant, Theory-Based Intervention, Jennifer Cunningham
All ETDs from UAB
The purpose of this sequential, explanatory mixed methods research study was to understand what factors influenced African American maternal intentions to get their daughters aged 9 years to 12 years vaccinated in Alabama. In the first, quantitative phase of the study, the research questions focused on identifying the predictive power of eleven variables, representing selected factors associated with maternal intentions to vaccinate their daughters. The data were collected via a self-developed instrument that used a mixed mode survey design that was web-based (N = 14) and paper-based (N = 228). Participant demographics were analyzed using descriptive statistics. A binary, logistic …
Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar
Sulindac Sulfide Amide As A Novel Agent For The Prevention And Treatment Of Lung Cancer, Evrim Gurpinar
All ETDs from UAB
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from cyclooxygenase (COX) inhibition limit their use in cancer prevention. We recently described a N,N-dimethylethyl amine derivative of SS, sulindac sulfide amide (SSA), that does not inhibit COX-1 or -2, yet displays potent tumor cell growth inhibitory activity. Here, we studied the basis for the growth inhibitory effects of SSA on human lung adenocarcinoma cell lines and evaluated its preclinical pharmacology. SSA potently inhibited the growth of lung tumor cells with IC50 values of 2-5 μ compared with 44-52 …
The Effects Of Sleep Restriction On Adolescents' Pedestrian Safety, Aaron Leah Davis
The Effects Of Sleep Restriction On Adolescents' Pedestrian Safety, Aaron Leah Davis
All ETDs from UAB
Introduction. Over 8,000 American adolescents ages 14 and 15 require medical attention due to pedestrian injury annually. Psychosocial factors contributing to pedestrian safety include reaction time, impulsivity, risk-taking, attention, and decision-making. These characteristics are also influenced by sleep restriction. Adolescents require 8.5 hours of uninterrupted sleep each night. Despite requiring more sleep than other children, adolescents often do not obtain adequate sleep due to delayed circadian, academic demands, extracurricular activities, media use, and minimal parental supervision. This combination of factors may place adolescents at risk for pedestrian injury. Method. This study investigated whether sleep restriction reduces adolescents' pedestrian safety. Using …
Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell
Clinical Consequences Of Micrornas In Colorectal Cancer, Liselle C. Bovell
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Colorectal cancer (CRC) is a heterogeneous disease, and factors such as tumor location, the environment, genetics, and ethnic differences, can influence its development and progression. Over the last few decades, overall CRC mortality rates have declined; however, racial disparities in mortality rates have increased. The discovery of biomarkers that focus on identifying individual differences based on confounders such as tumor stage and patient race/ethnicity is needed, for such biomarkers can lead to development of personalized therapeutic approaches to target these molecules. MicroRNAs (miRNAs) are a class of small molecules that regulate genes at the post-transcriptional level. Altered miRNA expression levels …
Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs
Therapeutic Potential Of Genetically-Engineered Mesenchymal Stem Cells In Multiple Myeloma, Jerome T. Higgs
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ABSTRACT Multiple Myeloma (MM) remains the second most common hematologic malig-nancy occurring in adults, which primarily affects the skeletal system causing severe bone destruction, spinal cord compression and hypercalcemia. Current therapies, which include chemotherapy, radiotherapy, autologouos stem cell transplantation and in some cases surgery, have extended the median survival between 3 and 10 years. However, MM is still incurable and therefore improving current therapies or developing newer ones to reduce the burden of osteolytic damage and extend survival rate will be highly beneficial for patient management. The long-term goal of this study is to develop a novel therapeutic approach to …
Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj
Regulation Of Glioma Cell Migration And Proliferation By A Non-Selective Cation Channel., Arun Kumar Rooj
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Two of the most striking features of brain tumors are their unusual ability to robustly proliferate and migrate in the brain. Previous results from our laboratory suggest that glioma cells express a non-selective cation channel that is composed of Epithelial Sodium Channel (ENaC) and Acid Sensing Ion Channel (ASIC) subunits. We hypothesize that this glioma specific current regulates glioma cell migration and proliferation by modulating an intracellular signaling pathway. To test our hypothesis, we have attenuated this cationic conductance by either pharmacological blockers (psalmotoxin-1 and benzamil), or by knocking down expression of a particular subunit of this cross-clade ion channel …
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
Determinant Of G-Chain Mediated Fc Receptor Signaling, Spandan Shah
All ETDs from UAB
Fc receptors provide an interface between humoral immunity and cellular immunity by binding to the Fc portion of immunoglobulin and mediating effector functions. Cells expressing Fc receptors play a major role in immune complex clearance via phagocytosis, leading to a context dependent pro- or anti-inflammatory environment. Signaling by multi-chain Fc receptor complexes, including FcgRI, FcgRIII, FceRI and FcaRI is mediated by the ITAM-containing common FceRIg (g-chain) subunit. However, despite the use of a common g-chain, different Fc receptor complexes elicit specific cellular programs, suggesting additional layers of regulation of tyrosine based signaling by g-chain. We hypothesized that the unique g-chain …
Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson
Neuropathological Alterations In Alzheimer's Disease: An Up Close Look At Sympathetic Sprouting, Amy Renee Nelson
All ETDs from UAB
Pathological hallmarks of AD include neurofibrillary tau tangles, amyloid beta (Abeta) accumulation and cholinergic degeneration. Cholinergic degeneration can be mimicked in rats by lesioning cholinergic neurons in medial septum. Hippocampal cholinergic denervation disrupts retrograde transport of nerve growth factor (NGF), leading to its accumulation, which subsequently triggers sprouting of noradrenergic sympathetic fibers from the superior cervical ganglia into hippocampus. Dr. McMahon's lab previously reported that coincident with this sprouting, there is an increase in cholinergic innervation that correlates with a recovery of M1 muscarinic receptor dependent plasticity at CA3-CA1 synapses and visual cortex. These findings suggest that noradrenergic sympathetic sprouting …
Psychology Award Given To, Then Named For, Neuroscience Major, Jim Bakken
Psychology Award Given To, Then Named For, Neuroscience Major, Jim Bakken
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No abstract provided.
December 7, 2012 Ereporter, University Of Alabama At Birmingham
December 7, 2012 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
December 5, 2012 Greenmail, University Of Alabama At Birmingham
December 5, 2012 Greenmail, University Of Alabama At Birmingham
GreenMail (student newsletter through 2024)
No abstract provided.
Uab Doctors Share Fitness And Exercise Advice For The Middle-Aged Man, Alicia Rohan
Uab Doctors Share Fitness And Exercise Advice For The Middle-Aged Man, Alicia Rohan
Browse All News
No abstract provided.
Uab Researcher Named Aaas Fellow, Jim Bakken
Uab Researcher Receives Lifetime Achievement Award, Jim Bakken
Uab Researcher Receives Lifetime Achievement Award, Jim Bakken
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No abstract provided.
Uab Senior Wins Cultural Experiences Abroad Scholarship, Jim Bakken
Uab Senior Wins Cultural Experiences Abroad Scholarship, Jim Bakken
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No abstract provided.
Genetic Defense Mechanism May Offer Biological Clue To Racial Disparities In Kidney Disease, Jim Bakken
Genetic Defense Mechanism May Offer Biological Clue To Racial Disparities In Kidney Disease, Jim Bakken
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No abstract provided.
Genetic Defense Mechanism May Offer Biological Clue To Racial Disparities In Kidney Disease, Greg Williams
Genetic Defense Mechanism May Offer Biological Clue To Racial Disparities In Kidney Disease, Greg Williams
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No abstract provided.
Grow Your Own Food: Uab May Offer Garden Plots On Campus, Jim Bakken
Grow Your Own Food: Uab May Offer Garden Plots On Campus, Jim Bakken
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No abstract provided.
Jiang And Etikala Named Mr. And Ms. Uab 2012, Shannon Thomason
Jiang And Etikala Named Mr. And Ms. Uab 2012, Shannon Thomason
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No abstract provided.
October 3, 2012 Greenmail, University Of Alabama At Birmingham
October 3, 2012 Greenmail, University Of Alabama At Birmingham
GreenMail (student newsletter through 2024)
No abstract provided.
New Group Enables Students To Help Each Other With Career Aspirations, Jim Bakken
New Group Enables Students To Help Each Other With Career Aspirations, Jim Bakken
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No abstract provided.
Mr. And Ms. Uab 2012 Scholarship Finalists Announced, Shannon Thomason
Mr. And Ms. Uab 2012 Scholarship Finalists Announced, Shannon Thomason
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No abstract provided.
Uab Announces Robert Palazzo As College Of Arts & Sciences' Interim Dean, Jim Bakken
Uab Announces Robert Palazzo As College Of Arts & Sciences' Interim Dean, Jim Bakken
Browse All News
No abstract provided.
September 26, 2012 Greenmail, University Of Alabama At Birmingham
September 26, 2012 Greenmail, University Of Alabama At Birmingham
GreenMail (student newsletter through 2024)
No abstract provided.
Uab Researcher Wins Grant To Study Gene Networks And Longevity, Jim Bakken
Uab Researcher Wins Grant To Study Gene Networks And Longevity, Jim Bakken
Browse All News
No abstract provided.