Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 2341 - 2370 of 6508

Full-Text Articles in Entire DC Network

Leukemia Stem Cell Markers And Inv(16) In Acute Myeloid Leukemia, Jason Legrand Jan 2016

Leukemia Stem Cell Markers And Inv(16) In Acute Myeloid Leukemia, Jason Legrand

All ETDs from UAB

Although greater than 85% of inv(16) acute myeloid leukemia patients are able to achieve first complete remission after anthracycline- and cytarabine-based therapy, only about 60% of patients survive the disease long-term due to relapsed disease or treatment-related mortality. Multiple studies have shown that acute myeloid leukemia is composed of heterogeneous populations of leukemic clones that can exhibit a wide degree of genetic, epigenetic, and functional diversity, accounting for different outcomes in response to therapy. Genomic analysis of leukemic clones in paired diagnostic and relapse samples of acute myeloid leukemia has shown that all relapses stem from surviving leukemic or ancestral …


Three-Dimensional Age-Related Changes Of The Adult Male Face, Catherine Haynie Haynie Jan 2016

Three-Dimensional Age-Related Changes Of The Adult Male Face, Catherine Haynie Haynie

All ETDs from UAB

Objectives: The adult population is a fast growing subgroup of orthodontic practices. The facial soft tissues of adults are different from adolescents, and there is significant sexual dimorphism in the aging of facial soft tissue. It is imperative for the orthodontist to understand how aging effects the soft tissues of the face, and to know how male and females differ in this process. The objectives of this study include: 1.) Identification of trends in facial aging among a Caucasian male and African American male sample utilizing three-dimensional surface imaging technology. 2.) Comparison of the aging effects between the Caucasian and …


The Use Of An Open-Label Placebo To Treat Cancer-Related Fatigue In Cancer Survivors, Theresa Walker Hoenemeyer Jan 2016

The Use Of An Open-Label Placebo To Treat Cancer-Related Fatigue In Cancer Survivors, Theresa Walker Hoenemeyer

All ETDs from UAB

Background: A placebo is an inert substance (e.g., sugar pill) or procedure (e.g., sham surgery) that should confer no beneficial effects. Nonetheless, typically, 30-50% of those randomized to placebos report significant benefits. New studies indicate that the use of disclosed or open-label placebos reduces self-reported symptoms among patients with irritable bowel syndrome, migraine attacks, and major depression. Methods: The investigator conducted a 7-week pilot study to evaluate the feasibility and effects of an open-labeled administration of placebo pills on patient-reported clinical and psychosocial outcomes among cancer survivors seeking relief from cancer-related fatigue. The specific aims of this study were to: …


Astrocyte Morphology And Cell Number In Rett Syndrome, Kenneth Taylor Holt Jan 2016

Astrocyte Morphology And Cell Number In Rett Syndrome, Kenneth Taylor Holt

All ETDs from UAB

Rett Syndrome (RTT) is an X-linked neurodevelopmental disorder caused by a mutation in the transcriptional regulator methyl CPG binding protein 2 (MECP2) gene that affects 1 in 10,000 female live births annually. RTT patients experience seemingly normal development for the first 12-18 months of life; this period of normal development is followed by developmental regression. The symptoms of Rett syndrome include severe cognitive deficits, seizures, loss of ambulation and gross motor skills, breathing abnormalities, hand stereotopies and gastrointestinal dysmotility. The basic science research for this disorder has focused almost exclusively on neuronal mechanisms, leaving limited understating of the role of …


The Effect Of Proinflammatory Cytokines On Thioredoxin-Interacting Protein In Pancreatic Beta-Cells, Kyunghee Hong Jan 2016

The Effect Of Proinflammatory Cytokines On Thioredoxin-Interacting Protein In Pancreatic Beta-Cells, Kyunghee Hong

All ETDs from UAB

Pro-inflammatory cytokines, such as Interleukin (IL)-1β, Tumor necrosis factors (TNF) α, and Interferon (IFN)γ, have been implicated as critical mediators of β-cell destruction in diabetes. In addition, although a combination of these three cytokines has been used to mimic the inflammatory conditions of type 1 diabetes in vitro, the mechanisms underlying the effect are not fully understood. Previously, we discovered Thioredoxin-interacting protein (TXNIP) as a key regulator of glucotoxicity-induced β-cell apoptosis and β-cell dysfunction, while deletion of TXNIP prevented type 1 (T1D) and type 2 diabetes (T2D). However, the effects of proinflammatory cytokines on the regulation of TXNIP have not …


Race Effects Of Perceived Weight Status And Its Relationship With Unmet Health Care Need, Sarah B. Rutland Jan 2016

Race Effects Of Perceived Weight Status And Its Relationship With Unmet Health Care Need, Sarah B. Rutland

All ETDs from UAB

This study (n=9,630) evaluates the influence of race on the relationship between perceived weight status (PWS) and obtaining health care when a respondent thought care was needed (unmet need) among young adults (age 24-34) using Wave IV of the National Longitudinal Study of Adolescent to Adult Health. Using the framework of fundamental cause, I assume that health disparities between groups is due to unequal distribution of resources between those groups that enables a group with more resources, such as wealth or race privilege, to access and support better health outcomes. I focus on race, and specifically racism, as a resource …


Sustainable Construction With Green Compressed Earth Block (Gceb), Marwan Mostafa Jan 2016

Sustainable Construction With Green Compressed Earth Block (Gceb), Marwan Mostafa

All ETDs from UAB

orthogonal predictors.


Exploring The Lived Experience Of Young African American Breast Cancer Survivorship To Inform The Adaptation Of A Psychoeducational Intervention: Y-Ambient, Timiya S. Nolan Jan 2016

Exploring The Lived Experience Of Young African American Breast Cancer Survivorship To Inform The Adaptation Of A Psychoeducational Intervention: Y-Ambient, Timiya S. Nolan

All ETDs from UAB

In the United States, 26,393 young women (≤ 45 years) will be diagnosed with breast cancer in 2016. Though survival rates are improving, there are health disparities among young African American women when compared to young Caucasians (e.g., poorer quality of life). Despite recommendations to provide targeted evidence-based survivorship care, there are about 23,000 young African American breast cancer survivors (YAABCS) in Alabama, Louisiana, and Mississippi for whom this care does not exist. Few studies have examined survivorship experiences and/or tested intervention efficacy among this group. Further study is warranted to understand the experiences of YAABCS and adapt targeted interventions …


Stem Students Help Reinvent The Teacher, Staff Dec 2015

Stem Students Help Reinvent The Teacher, Staff

Browse All News

No abstract provided.


Uab's Undiagnosed Diseases Program Gives Answers Where There Were None, Staff Dec 2015

Uab's Undiagnosed Diseases Program Gives Answers Where There Were None, Staff

Browse All News

No abstract provided.


From Eastside Birmingham To The Cori Supercomputer At Lawrence Berkeley National Laboratory - Uab Graduation 2015, Jeff Hansen Dec 2015

From Eastside Birmingham To The Cori Supercomputer At Lawrence Berkeley National Laboratory - Uab Graduation 2015, Jeff Hansen

Browse All News

No abstract provided.


Galin To Direct Clinical Skills Center In The School Of Medicine, Kendra Carter Dec 2015

Galin To Direct Clinical Skills Center In The School Of Medicine, Kendra Carter

Browse All News

No abstract provided.


Strategic Investments Will Boost Uab Research And Economic Development, Jeff Hansen Dec 2015

Strategic Investments Will Boost Uab Research And Economic Development, Jeff Hansen

Browse All News

No abstract provided.


Uab Commencement Ceremonies And Doctoral Hooding Dec. 12, Shannon Thomason Dec 2015

Uab Commencement Ceremonies And Doctoral Hooding Dec. 12, Shannon Thomason

Browse All News

No abstract provided.


Uab Senior Luke Mcclintock First-Round Finalist For Highly Competitive Hertz Fellowship, Staff Nov 2015

Uab Senior Luke Mcclintock First-Round Finalist For Highly Competitive Hertz Fellowship, Staff

Browse All News

No abstract provided.


Study Finds Genetic Risk Factor Can Lead To Hyperinflammatory Disorder, Death After Viral Infection, Staff Nov 2015

Study Finds Genetic Risk Factor Can Lead To Hyperinflammatory Disorder, Death After Viral Infection, Staff

Browse All News

No abstract provided.


Trial Combining Exercise And A Drug May Help Seniors Muscle Up, Alicia Rohan Nov 2015

Trial Combining Exercise And A Drug May Help Seniors Muscle Up, Alicia Rohan

Browse All News

No abstract provided.


U.S. Biomedical Postdoctoral Fellow Numbers Decline, Uab Researcher Finds, Jeff Hansen Nov 2015

U.S. Biomedical Postdoctoral Fellow Numbers Decline, Uab Researcher Finds, Jeff Hansen

Browse All News

No abstract provided.


Uab Researchers Seek Friedreich's Ataxia Biomarkers, Jeff Hansen Nov 2015

Uab Researchers Seek Friedreich's Ataxia Biomarkers, Jeff Hansen

Browse All News

No abstract provided.


U.S. Biomedical Postdoctoral Fellow Numbers Decline, Uab Researcher Finds, Jeff Hansen Nov 2015

U.S. Biomedical Postdoctoral Fellow Numbers Decline, Uab Researcher Finds, Jeff Hansen

Browse All News

No abstract provided.


Uab Faculty Lead Acr Team To Develop New Guidelines For Rheumatoid Arthritis, Alicia Rohan Nov 2015

Uab Faculty Lead Acr Team To Develop New Guidelines For Rheumatoid Arthritis, Alicia Rohan

Browse All News

No abstract provided.


Landmark Blood Pressure Study, Published Today By Nejm, Confirms Benefits Of Lower Blood Pressure, Staff Nov 2015

Landmark Blood Pressure Study, Published Today By Nejm, Confirms Benefits Of Lower Blood Pressure, Staff

Browse All News

No abstract provided.


Uab Researchers Seek Friedreich's Ataxia Biomarkers, Jeff Hansen Nov 2015

Uab Researchers Seek Friedreich's Ataxia Biomarkers, Jeff Hansen

Browse All News

No abstract provided.


Female Sex Hormone May Save Injured Soldiers On The Battlefield, Jeff Hansen Oct 2015

Female Sex Hormone May Save Injured Soldiers On The Battlefield, Jeff Hansen

Browse All News

No abstract provided.


Shrimp May Grow Faster, Bigger, Healthier And Tastier On Sea Urchin Droppings Diet, Staff Oct 2015

Shrimp May Grow Faster, Bigger, Healthier And Tastier On Sea Urchin Droppings Diet, Staff

Browse All News

No abstract provided.


Pursuing Links Between Inflammation And Parkinson's, In Lab And Clinic, Jeff Hansen Oct 2015

Pursuing Links Between Inflammation And Parkinson's, In Lab And Clinic, Jeff Hansen

Browse All News

No abstract provided.


Uab-Hudsonalpha Center For Genomic Medicine Awards First Pilot Grants, Alicia Rohan Oct 2015

Uab-Hudsonalpha Center For Genomic Medicine Awards First Pilot Grants, Alicia Rohan

Browse All News

No abstract provided.


Uab-Hudsonalpha Center For Genomic Medicine Awards First Pilot Grants, Sara Davies Oct 2015

Uab-Hudsonalpha Center For Genomic Medicine Awards First Pilot Grants, Sara Davies

Browse All News

No abstract provided.


Uab Study Finds Possible Frontline Therapy For Older Patients With Hodgkin Lymphoma, Staff Oct 2015

Uab Study Finds Possible Frontline Therapy For Older Patients With Hodgkin Lymphoma, Staff

Browse All News

No abstract provided.


Uab Study Finds Possible Frontline Therapy For Older Patients With Hodgkin Lymphoma, Beena Thannickal Oct 2015

Uab Study Finds Possible Frontline Therapy For Older Patients With Hodgkin Lymphoma, Beena Thannickal

Browse All News

No abstract provided.