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Articles 2221 - 2250 of 6508
Full-Text Articles in Entire DC Network
United States Presidential Primaries: What You Need To Know About Each Candidate's Views On Health Care Policy And Prescription Drugs, Alicia Rohan
Browse All News
No abstract provided.
Uab Continues To Be A Powerhouse In Cardiovascular Research, Adam Pope
Uab Continues To Be A Powerhouse In Cardiovascular Research, Adam Pope
Browse All News
No abstract provided.
Salmonella Expert Presents At 28th Bertram Marx Lecture At Uab, Staff
Salmonella Expert Presents At 28th Bertram Marx Lecture At Uab, Staff
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No abstract provided.
Mitophagy In Macrophages Is A Key Step Toward Pulmonary Fibrosis, Jeff Hansen
Mitophagy In Macrophages Is A Key Step Toward Pulmonary Fibrosis, Jeff Hansen
Browse All News
No abstract provided.
Uab Students Propose Innovative Solutions To Global Issues At Clinton Global Initiative University, Tyler Greer
Uab Students Propose Innovative Solutions To Global Issues At Clinton Global Initiative University, Tyler Greer
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No abstract provided.
Mitophagy In Macrophages Is A Key Step Toward Pulmonary Fibrosis, Jeff Hansen
Mitophagy In Macrophages Is A Key Step Toward Pulmonary Fibrosis, Jeff Hansen
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No abstract provided.
Are Zoo Elephants Too Fat, Too Skinny Or Just Right?, Adam Pope
Are Zoo Elephants Too Fat, Too Skinny Or Just Right?, Adam Pope
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No abstract provided.
World-Renowned Geneticist To Speak At 2016 Bertram M. Marx Lectureship, Ella Robinson
World-Renowned Geneticist To Speak At 2016 Bertram M. Marx Lectureship, Ella Robinson
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No abstract provided.
Changes In Shape And 'Squishiness' Can Help Drug-Containing Microcapsules Reach Tumors, Jeff Hansen
Changes In Shape And 'Squishiness' Can Help Drug-Containing Microcapsules Reach Tumors, Jeff Hansen
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No abstract provided.
Regards Data Show Diabetics Who Use Verapamil Have Lower Glucose Levels, Tyler Greer
Regards Data Show Diabetics Who Use Verapamil Have Lower Glucose Levels, Tyler Greer
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No abstract provided.
Bedwell Named Interim Chair Of Biochemistry, Kendra Carter
Bedwell Named Interim Chair Of Biochemistry, Kendra Carter
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No abstract provided.
Frans De Waal Named Recipient Of 2016 Ireland Distinguished Visiting Scholar Award, Staff
Frans De Waal Named Recipient Of 2016 Ireland Distinguished Visiting Scholar Award, Staff
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No abstract provided.
2016 Darwin Day Commemorates Charles Darwin's Birthday, Showcases Scientific Research, Staff
2016 Darwin Day Commemorates Charles Darwin's Birthday, Showcases Scientific Research, Staff
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No abstract provided.
John Kearney Named An American Association Of Immunologists Career Award Recipient, Jeff Hansen
John Kearney Named An American Association Of Immunologists Career Award Recipient, Jeff Hansen
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No abstract provided.
How Obesity Makes Memory Go Bad, Jeff Hansen
Two Department Of Medicine Professors Elected To Asci, Carolyn Walsh
Two Department Of Medicine Professors Elected To Asci, Carolyn Walsh
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No abstract provided.
John Kearney Named An American Association Of Immunologists Career Award Recipient, Jeff Hansen
John Kearney Named An American Association Of Immunologists Career Award Recipient, Jeff Hansen
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No abstract provided.
New Faculty Recruits To Lead Nuclear, Molecular Imaging In The Department Of Radiology, Liann Cates
New Faculty Recruits To Lead Nuclear, Molecular Imaging In The Department Of Radiology, Liann Cates
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No abstract provided.
Five Junior Faculty Named The 2016 Pittman Scholars, Uab Heersink School Of Medicine News
Five Junior Faculty Named The 2016 Pittman Scholars, Uab Heersink School Of Medicine News
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No abstract provided.
Series Of Aging Seminars Launches At Uab, Staff
Yoder Appointed Interim Chair Department Of Cell, Developmental And Integrative Biology, Uab Heersink School Of Medicine News
Yoder Appointed Interim Chair Department Of Cell, Developmental And Integrative Biology, Uab Heersink School Of Medicine News
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No abstract provided.
Uab Magazine - Fall 2016, University Of Alabama At Birmingham
Uab Magazine - Fall 2016, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Tried And Blue: The Unionist Origins Of Alabama’S Blue Spot, David Henslee
Tried And Blue: The Unionist Origins Of Alabama’S Blue Spot, David Henslee
Vulcan Historical Review
pp. 90-103
Uab Magazine - Spring 2016, University Of Alabama At Birmingham
Uab Magazine - Spring 2016, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Interplay Between Her2, Parp1, And Nf-Κb In Breast Cancer: Potential Therapeutic Implications, Monicka Ewa Wielgos
Interplay Between Her2, Parp1, And Nf-Κb In Breast Cancer: Potential Therapeutic Implications, Monicka Ewa Wielgos
All ETDs from UAB
We previously reported that HER2+ breast cancers are susceptible to Poly (ADP-Ribose) polymerase inhibitors (PARPi) alone, agents that are efficacious against homologous recombination (HR) deficient tumors. However, this phenomenon was determined to be independent of a HR repair deficiency but rather due to suppression of NF-κB activity and signaling by PARP inhibition. Further, HER2 overexpression itself was necessary and sufficient to confer this susceptibility. Interestingly, PARP1 and phosphorylated RelA/p65 (NF-κB) levels were found to be elevated in human HER2+ breast cancers compared to luminal breast cancers. These data suggest a possible interplay between HER2, PARP1, and NF-κB, and how this …
The Role Of Glutamate In Immune Cell Infiltration And Excitotoxic Mechanisms In Autoimmune Demyelination, Kirsten Scarlett Evonuk
The Role Of Glutamate In Immune Cell Infiltration And Excitotoxic Mechanisms In Autoimmune Demyelination, Kirsten Scarlett Evonuk
All ETDs from UAB
Multiple sclerosis is the most common neurological disorder in young adults. Current treatments modulate the immune system, but no treatments prevent central nervous system damage. Inflammation occurs even during disease remission, contributing to ongoing damage and resulting in disease progression. The lack of neuroprotective treatments despite continued inflammatory onslaught in the central nervous system indicates the need for therapeutic discovery in this area. One potential therapeutic target is glutamate, whose dysregulation in multiple sclerosis has been implicated in excitotoxic cellular death. Herein we describe the roles of glutamate in multiple sclerosis and explore the blockade of a source of excitotoxic …
Epigenetic Dysregulation In Levodopa-Induced Dyskinesia, David Anthony Figge
Epigenetic Dysregulation In Levodopa-Induced Dyskinesia, David Anthony Figge
All ETDs from UAB
Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (L-DOPA) exposure in Parkinson disease (PD) patients. LID is characterized by a “priming effect”, whereby initial administrations of L-DOPA trigger a sensitized biochemical and transcriptional response upon subsequent administrations of L-DOPA. In neurons, transcriptional regulation through dynamic changes to epigenetic modifications, including DNA methylation and histone acetylation, have been shown pivotal to many long-term behavioral modifications; however, their role in LID has been minimally explored. Using a rodent model, we show LID development leads to the aberrant expression of DNA demethylating enzymes and locus-specific changes to DNA …
Differential Effects Of Short-Term Morphine Treatment On Brain Volumes Of Men And Women With Low Back Pain, Kelsey Campbell
Differential Effects Of Short-Term Morphine Treatment On Brain Volumes Of Men And Women With Low Back Pain, Kelsey Campbell
All ETDs from UAB
Objective: Long- and short-term opioid use is associated with morphological changes in the human brain. Opioids have analgesic and adverse effects, including addiction, that differently impact men and women. The current study aimed to investigate whether differences exist between men and women in gray matter volume changes after acute morphine treatment for chronic low back pain. Methods: This study analyzed data from 27 chronic low back pain patients (17 men, 10 women) who were treated with oral morphine over a period of 30 days. High-resolution structural images were acquired immediately before and after morphine treatment. Images were compared using voxel …
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
All ETDs from UAB
It is known that the vacuolar ATPase has a number of functions related to tumor growth and progression such as involvement in drug resistance, pH regulation, autophagy, and lysosomal acid protease activation, as well as invasion and metastasis. Here we specifically describe the role of ATP6v1c1 in murine and human models of breast cancer. ATP6v1c1 is the dominant isoform of the coordinating subunit (ATP6v1c) involved in the assembly of the vacuolar ATPase complex which plays a key role in cancer growth and progression. We also describe how ATP6v1c1 knockdown impairs tumor nutrient signaling through mTORC1 and tumor cell proliferation, by …
Section 1: Bio-Medical/Bioengineering, Ectc Coordinating Committee
Section 1: Bio-Medical/Bioengineering, Ectc Coordinating Committee
Early Career Technical Journal (ECTJ)
Proceedings of the 16th Annual Early Career Technical Conference, November 5, 2016. School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama; pp. 1-30