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Articles 1501 - 1530 of 6508
Full-Text Articles in Entire DC Network
Kidney-Resident Macrophages - A Role For Healing During Acute Kidney Injury?, Staff
Kidney-Resident Macrophages - A Role For Healing During Acute Kidney Injury?, Staff
Browse All News
No abstract provided.
Leading Researcher Returns To Discuss Origins Of Human Aids And Malaria At Uab's Darwin Day, Staff
Leading Researcher Returns To Discuss Origins Of Human Aids And Malaria At Uab's Darwin Day, Staff
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No abstract provided.
Faculty Save Students $1.1 Million On Course Materials, Haley Herfurth
Faculty Save Students $1.1 Million On Course Materials, Haley Herfurth
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No abstract provided.
Researchers Discover New Biomarker For Age-Related Macular Degeneration, Staff
Researchers Discover New Biomarker For Age-Related Macular Degeneration, Staff
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No abstract provided.
New Master's Degree In Anatomy Offered, And Classes Begin In June, Staff
New Master's Degree In Anatomy Offered, And Classes Begin In June, Staff
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No abstract provided.
Vision Scientists Publish Findings Of Lipid Impact In The Mechanism Of Dry Eye Disease, Staff
Vision Scientists Publish Findings Of Lipid Impact In The Mechanism Of Dry Eye Disease, Staff
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No abstract provided.
Activated Pmn Exosomes Are Pathogenic Entities That Cause Destruction In The Copd Lung, Staff
Activated Pmn Exosomes Are Pathogenic Entities That Cause Destruction In The Copd Lung, Staff
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No abstract provided.
Obesity Surgery Leads To Emergence Of New Microbial Strains In The Human Fecal Community, Jeff Hansen
Obesity Surgery Leads To Emergence Of New Microbial Strains In The Human Fecal Community, Jeff Hansen
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No abstract provided.
Nad+ Depletion Triggers Programmed Cell Death To Kill Macrophages Infected With Mycobacterium Tuberculosis, Brit Blalock
Nad+ Depletion Triggers Programmed Cell Death To Kill Macrophages Infected With Mycobacterium Tuberculosis, Brit Blalock
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No abstract provided.
Uab Outsources Its Revenue-Producing Antibodies To The Birmingham Company Southernbiotech, Staff
Uab Outsources Its Revenue-Producing Antibodies To The Birmingham Company Southernbiotech, Staff
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No abstract provided.
Award-Winning Scientist Joins The Nature Conservancy's "Can We Talk Climate" Campaign, Staff
Award-Winning Scientist Joins The Nature Conservancy's "Can We Talk Climate" Campaign, Staff
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No abstract provided.
Birmingham Poetry Review 46 (End Matter), Birmingham Poetry Review Staff
Birmingham Poetry Review 46 (End Matter), Birmingham Poetry Review Staff
Birmingham Poetry Review
pp. 287-309
Space City, Joshua Gottlieb-Miller
Diary Of Our Fatal Illness, Susannah B. Mintz
Uab Magazine - Summer 2019, University Of Alabama At Birmingham
Uab Magazine - Summer 2019, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Uab Magazine - Fall 2019/Winter 2020, University Of Alabama At Birmingham
Uab Magazine - Fall 2019/Winter 2020, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Section 1: Materials & Design, Ectc Coordinating Committee
Section 1: Materials & Design, Ectc Coordinating Committee
Early Career Technical Journal (ECTJ)
Proceedings of the 19th Annual Early Career Technical Conference, November 2-3, 2019. School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama; pp. 1-21
Proceedings Of The 19th Annual Early Career Technical Conference (Complete Issue), Ectc Coordinating Committee
Proceedings Of The 19th Annual Early Career Technical Conference (Complete Issue), Ectc Coordinating Committee
Early Career Technical Journal (ECTJ)
Proceedings of the 19th Annual Early Career Technical Conference, November 2-3, 2019. School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama
On The Design And Development Of A Monolithic Compliant Gripper And Serial Closed Loop Chain Mechanism, Martin Garcia, Ayse Tekes
On The Design And Development Of A Monolithic Compliant Gripper And Serial Closed Loop Chain Mechanism, Martin Garcia, Ayse Tekes
Early Career Technical Journal (ECTJ)
Section 1: Materials & Design; pp. 16-21
A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le
A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le
All ETDs from UAB
Membrane proteins belonging to the ATP-Binding Cassette (ABC) superfamily are responsible for transporting substrates into or out of cells. ABC transporters, such as P-glycoprotein (Pgp/ABCB1) defend cells by the active efflux of many chemically diverse cytotoxic compounds. The ABC protein, CFTR/ABCC7, is a passive chloride ion channel that provides fluid homeostasis. Pgp and CFTR of are high clinical interest since mutations in CFTR can result in Cystic Fibrosis (CF) and upregulation of Pgp in tumor cells can result in multidrug resistance (MDR). There has been a major effort to develop clinical drugs to treat CF by either repairing defects in …
The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed
The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed
All ETDs from UAB
About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …
Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry
Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry
All ETDs from UAB
The “gold standard” of bone grafting materials is autograft. Unfortunately, autogenous bone must first be harvested from the patient, leading to complications such as donor site morbidity. Because of this, many surgeons rely on non-autogenous bone grafting materials. While these grafts are more available than autogenous bone, they require extensive processing which significantly reduces their osteoinductivity. Therefore, there is substantial interest in finding ways to add osteoinductive molecules to these grafts. Previously, our lab has focused on utilizing molecules derived from bone morphogenetic protein 2 (BMP2) with an attached hydroxyapatite-binding domain (polyglutamate) to anchor them onto bone grafting materials. Previous …
Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin
All ETDs from UAB
A growing body of studies highlights that many adult diseases and health disparities in late-life are rooted in childhood adversities. However, there is little research that examines how social stratification processes structure the inequality in early-life stress exposure, and the effects of stress exposure on health outcomes may vary based on the intersections of social stratification categories. Drawing on an integrated framework of the life course stress process and intersectionality theory, this study examines the patterns in childhood adverse experiences (ACEs) by race/ethnicity and gender and how race/ethnicity, gender, and adult socioeconomic status (SES) combine to modify the effects of …
Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka
Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka
All ETDs from UAB
Modern medicine employs many drugs in its disease treatment methods. This is because they provide the best permanent solutions to complicated ailments. However the usefulness of these drugs is mitigated by several factors, namely that of specific release. Common drug delivery mechanisms lack the specificity needed to ensure that release is limited to the diseased area, which can lead to unnecessary side effects. By utilizing medical imaging, both drug delivery devices and physiology can be observed by physicians, which can greatly increase the specificity of drug delivery. Specifically, utilizing a very inert medical imaging modality, such as ultrasound, guarantees minimum …
O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman
O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman
All ETDs from UAB
Post translational modification of proteins plays a crucial role in regulating their function, and the role of one such modification, termed O-GlcNAcylation, is understudied. O-GlcNAcylation involves the dynamic cycle of adding and removing an O-linked N-acetylglucosamine (O-GlcNAc) by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which are highly expressed in the hippocampus. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. We have shown that acute and selective increase in O-GlcNAcylation of AMPAR GluA2 subunits underlies expression of a novel form of LTD at CA3-CA1 synapses (O-GlcNAc LTD), as well …
Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford
Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford
All ETDs from UAB
Even the most effective and widely used drugs in modern disease treatment can be compromised by low bioavailability and off-target damage which leads to detrimental side effects. Polymeric drug carriers have been developing in recent times with the aim of rendering the therapeutic cargo inert and protecting it from the body’s natural defense mechanisms until arrival at the target site, upon which a specific stimulus will cause the drug to release from the carrier locally. To this end, antioxidant capability in drug carriers can help mediate the cascade of reactive oxygen species that meet injected materials and, in doing so, …
Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black
Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black
All ETDs from UAB
The kidneys are complex, multi-faceted organs that are responsible for regulatory processes, such as fluid homeostasis, hormone production, blood pressure regulation, and systemic toxin removal. Sudden disruption of these processes by acute kidney injury (AKI) causes rapid decline in renal function as well as significant morbidity and mortality. AKI is a significant clinical concern, affecting up to 13.3 million people globally each year and has the propensity to progress to chronic kidney disease (CKD), though the mechanism remains undefined. One reason for this is due to the lack of understanding of models used to study both AKI and CKD, hindering …
An Ex Vivo Model Of Neuroendocrine Tumors: A Net Gain, Brendon R. Herring
An Ex Vivo Model Of Neuroendocrine Tumors: A Net Gain, Brendon R. Herring
All ETDs from UAB
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that originate in a diverse array of anatomical locations and have widely variable clinical presentations and responses to treatment. Patient-derived xenografts and cell lines are valuable models of tumor biology and for testing personalized therapeutics on tumors prior to their administration to patients. However, as PDX models and cell lines for neuroendocrine tumors are lacking in both number and validity, we have developed a 3D flow perfusion polydimethylsiloxane (PDMS) bioreactor model for the purpose of culturing patient derived NETs. The goal of this thesis is to determine the ability to use …
We Never Considered Teaching: A Critical Narrative Of African American Stem Majors’ Identity As Stem Educators, Paulette Georgina Evans
We Never Considered Teaching: A Critical Narrative Of African American Stem Majors’ Identity As Stem Educators, Paulette Georgina Evans
All ETDs from UAB
The need to diversify and retain non-White STEM teachers in the educator workforce has brought to surface the need to more deeply understand why non-White educators choose teaching as a profession and, equally as important, why they choose to stay. Although there is literature documenting the shortages of African American teachers including how African Americans can be recruited and retained, there is a need to look more closely at how African American undergraduate STEM majors who are in innovative teacher preparation programs articulate their affinity to teaching. The following critical narrative study focuses on how pre-service non-White teachers, particularly African …
St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty
St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty
All ETDs from UAB
ST6Gal-I adds α2-6 sialic acids to select N-glycosylated cell surface receptors, thereby modulating receptor function and intracellular signaling. ST6Gal-I is upregulated in various carcinomas and confers cancer stem cell (CSC) properties evidenced by tumorspheroid growth, chemoresistance and tumor initiating potential. In pancreatic ductal adenocarcinoma (PDAC), ST6Gal-I conferred gemcitabine resistance by abrogating DNA damage and altering expression levels of gemcitabine metabolism genes. Further, ST6Gal-I promoted resistance to chronic gemcitabine treatment. Additionally, metastatic clones of a PDAC cell line had increased ST6Gal-I expression and ST6Gal-I knockdown enhanced gemcitabine sensitivity. To investigate the physiological consequences of ST6Gal-I in PDAC, murine models were used. …