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University of Alabama at Birmingham

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The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan Jan 2021

The Role Of Cd38 In Anti-Tumor Immunity And Tumor Immune Evasion, Panpan Yuan

All ETDs from UAB

CD38 is a multifunctional protein that is expressed in many immune cells, modulating NAD metabolism, inflammation and oxidative stress. Recent studies suggest that CD38 is also implicated in tumor immunosuppression. However, the role of CD38 in anti-tumor immunity and tumor immune evasion, and mechanisms involved, are still unclear. We hypothesized that CD38 expression by immune cells constricts T cell-mediated anti-tumor immune responses and promotes tumor cell immune evasion. We investigated whether mice lacking CD38 (CD38-/-) had impaired tumor growth in subcutaneous, intraperitoneal and intravenous syngeneic tumor models. CD38-/- mice showed no difference in subcutaneous B16 melanoma tumor growth and pulmonary …


Disparities, Telemedicine, And Covid-19: Rhetorical Approaches To Health And Medicine For Positive Behavior Change In Older African American Women, Audrey S. Wrenn Jan 2021

Disparities, Telemedicine, And Covid-19: Rhetorical Approaches To Health And Medicine For Positive Behavior Change In Older African American Women, Audrey S. Wrenn

All ETDs from UAB

Overlapping exigencies experienced during the COVID-19 pandemic illustrate the need for adaptable and flexible public health responses that include cultural perspectives and lived experiences of specific groups. The rhetoric surrounding COVID-19 has proven to be multifocal because of the social and environmental experiences occurring simultaneously. Americans experienced periods of civil unrest, unequitable health care, overall lifestyle changes, and an immediate shift to telehealth use as the pandemic unfolded. This research examines telehealth engagement during the pandemic among African American (AA) women ages 75 and older to indicate the benefits and challenges to patient care in a virtual environment and from …


Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming Jan 2021

Experience-Dependent Plasticitiy Of Functional Connectivity In Human Visual Cortex Following Central Vision Loss, Leland Lanelle Fleming

All ETDs from UAB

The human brain is shaped by a dynamic interplay between innate factors and life experiences. Neuroscience has long grappled with understanding this relationship, particularly with regard to how changes in experience impact the brain during adulthood. This question is especially important in the context of macular degeneration, a disease that causes significant visual impairment and drastically alters day-to-day visual experiences for individuals afflicted by the disease. Specifically, people with macular degeneration lose the ability to use vision in the center of the visual field, the region of the retina with the highest spatial resolution. Subsequently, these individuals must rely on …


The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon Jan 2021

The Impact Of Blimp1 On Etreg Stability And The Tumor Microenvironment, Michael Dixon

All ETDs from UAB

CD4+ Foxp3+ regulatory T (Treg) cells are responsible for maintaining immunological homeostasis and self-tolerance through the regulation of immune responses against foreign and self-antigens, and they comprise both central Treg and effector Treg (eTreg) subsets. Because of their ability to suppress potent immune responses, eTreg cells expressing the transcription factor Blimp1 are frequently recruited to the tumor microenvironment (TME) to suppress anti-tumor responses by tumor infiltrating effector cells. Here, we demonstrate in murine transplantable tumor models that Blimp1 is required for intratumoral eTreg stability and that loss of Blimp1 by intratumoral eTreg cells results in their reduced suppressive activity and …


How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary Jan 2021

How Inflammation, High-Density Lipoproteins, And Genes Affect The Relationship Between Apol1 And Kidney Outcomes, Ninad S. Chaudhary

All ETDs from UAB

Over the past decade, the discovery of novel genetic loci on chromosome 22q, apolipoprotein-L1 (APOL1), has given insights into the racial differences in kidney outcomes at the population level. APOL1 risk alleles are unique to African ancestry and confer increased susceptibility to end-stage kidney disease (ESKD) especially among individuals without diabetes. However, the diseases do not occur in all who inherit these alleles. Current efforts are driven towards identifying the factors that can interact with APOL1 in the development of kidney diseases. This dissertation investigated whether the association between APOL1 and kidney outcomes is affected by inflammatory markers (AIM1), high-density …


Darley-Usmar Named Senior Associate Dean For Research Compliance And Administration, Jessica Martindale Dec 2020

Darley-Usmar Named Senior Associate Dean For Research Compliance And Administration, Jessica Martindale

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No abstract provided.


Debunking The Myths About The Covid-19 Vaccine, Staff Dec 2020

Debunking The Myths About The Covid-19 Vaccine, Staff

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No abstract provided.


Singh Receives $7.6 Million In Research Funding For Rheumatoid Arthritis Study, Alicia Rohan Dec 2020

Singh Receives $7.6 Million In Research Funding For Rheumatoid Arthritis Study, Alicia Rohan

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No abstract provided.


Uab To Provide First Vaccine Doses To Front Line And Clinical Staff, Ems And Other Birmingham-Area Hospitals, Tyler Greer Dec 2020

Uab To Provide First Vaccine Doses To Front Line And Clinical Staff, Ems And Other Birmingham-Area Hospitals, Tyler Greer

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No abstract provided.


Prdm16 Suppresses Hif-Targeted Gene Expression In Kidney Cancer, Mary Ashley Canevaro Dec 2020

Prdm16 Suppresses Hif-Targeted Gene Expression In Kidney Cancer, Mary Ashley Canevaro

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No abstract provided.


Dutta Named Chair Of Department Of Genetics, Jessica Martindale Dec 2020

Dutta Named Chair Of Department Of Genetics, Jessica Martindale

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No abstract provided.


Reductive Stress In Neuroblastoma Cells Aggregates Protein And Impairs Neurogenesis, Jeff Hansen Dec 2020

Reductive Stress In Neuroblastoma Cells Aggregates Protein And Impairs Neurogenesis, Jeff Hansen

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No abstract provided.


Tended By Blazers, These Uab Gardens Plots Grow Produce For The Food-Insecure On Campus, Haley Herfurth Dec 2020

Tended By Blazers, These Uab Gardens Plots Grow Produce For The Food-Insecure On Campus, Haley Herfurth

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No abstract provided.


Sigma Xi Honor Society At Uab Awarded Honorable Mention For Chapter Program Of Excellence, Brianna Hoge Dec 2020

Sigma Xi Honor Society At Uab Awarded Honorable Mention For Chapter Program Of Excellence, Brianna Hoge

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No abstract provided.


New Activity Found For Chd7, A Protein Factor Vital In Embryonic Development, Jeff Hansen Dec 2020

New Activity Found For Chd7, A Protein Factor Vital In Embryonic Development, Jeff Hansen

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No abstract provided.


Institutional Research Core Program Adds New Cores; Creates Major Growth In Program, Mary Ashley Canevaro Nov 2020

Institutional Research Core Program Adds New Cores; Creates Major Growth In Program, Mary Ashley Canevaro

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No abstract provided.


Birmingham-Based Uab Spinoff Will Develop Treatments For Cardio-Pulmonary Diseases, Jeff Hansen Nov 2020

Birmingham-Based Uab Spinoff Will Develop Treatments For Cardio-Pulmonary Diseases, Jeff Hansen

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No abstract provided.


Two Uab Students Awarded Clinton Global Initiative University Seed Funding, Staff Nov 2020

Two Uab Students Awarded Clinton Global Initiative University Seed Funding, Staff

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No abstract provided.


Research, Training At Uab Are Improving The Lives Of America's Heroes, Matt Windsor Nov 2020

Research, Training At Uab Are Improving The Lives Of America's Heroes, Matt Windsor

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No abstract provided.


Uab Names Assistant Dean For Biomedical Programs, Alicia Rohan Nov 2020

Uab Names Assistant Dean For Biomedical Programs, Alicia Rohan

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No abstract provided.


Gavin Named Assistant Dean For Undergraduate Biomedical Programs, Jessica Martindale Nov 2020

Gavin Named Assistant Dean For Undergraduate Biomedical Programs, Jessica Martindale

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No abstract provided.


Interdisciplinary Work Highlighted At Covid-19 Research Symposium, Jeff Hansen Oct 2020

Interdisciplinary Work Highlighted At Covid-19 Research Symposium, Jeff Hansen

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No abstract provided.


Covid-19 Research Symposium Engages Over 2k Participants; Highlights Outstanding Research At Uab, Mary Ashley Canevaro Oct 2020

Covid-19 Research Symposium Engages Over 2k Participants; Highlights Outstanding Research At Uab, Mary Ashley Canevaro

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No abstract provided.


Microbial Strains Show Individualized Patterns Of Stability In The Developing Infant Gut, Jeff Hansen Oct 2020

Microbial Strains Show Individualized Patterns Of Stability In The Developing Infant Gut, Jeff Hansen

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No abstract provided.


Faculty Honored At 2020 Argus Awards Ceremony, Joy Marsch Oct 2020

Faculty Honored At 2020 Argus Awards Ceremony, Joy Marsch

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No abstract provided.


Uab Computer Science Professor Receives National Science Foundation Grant For Collaborative Research, Staff Oct 2020

Uab Computer Science Professor Receives National Science Foundation Grant For Collaborative Research, Staff

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No abstract provided.


Weinmann Selected As Chair Of Nih Cellular And Molecular Immunology - B Study Section, Joy Marsch Oct 2020

Weinmann Selected As Chair Of Nih Cellular And Molecular Immunology - B Study Section, Joy Marsch

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No abstract provided.


23 Honored With Endowed Chair Or Professorship In The School Of Medicine, Mary Ashley Canevaro Oct 2020

23 Honored With Endowed Chair Or Professorship In The School Of Medicine, Mary Ashley Canevaro

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No abstract provided.


Your Zip Code Is A Risk Factor For Covid-19: Study Will Identify Where Testing, Therapies Are Needed Most, Matt Windsor Oct 2020

Your Zip Code Is A Risk Factor For Covid-19: Study Will Identify Where Testing, Therapies Are Needed Most, Matt Windsor

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No abstract provided.


Nih Funds Core Center For Childhood Cystic Kidney Disease At Uab, Alicia Rohan Oct 2020

Nih Funds Core Center For Childhood Cystic Kidney Disease At Uab, Alicia Rohan

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No abstract provided.