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In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi Jan 2025

In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi

All ETDs from UAB

After the Berlin Conference of 1884-1885, the Great Powers of Europe, including the newly-born German Empire, greatly expanded their influence and colonial possessions in Africa, with colonies in East Asia and the South Pacific quickly following suit. The German Empire, like its contemporaries, engaged with medicine as a necessary part of its colonial endeavors in order to keep both its native laborers and European settlers healthy. Using documents from the German Bundesarchiv (Federal Archive), including official reports made to the German Colonial Office and documenting of formally conducted expeditions, as well as the writings of colonial doctors, this research examines …

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"The Association Between Serious Psychological Distress And Life Satisfaction Among U.S Adults With Hypertension", Kellen Michael Lenz Jan 2025

"The Association Between Serious Psychological Distress And Life Satisfaction Among U.S Adults With Hypertension", Kellen Michael Lenz

All ETDs from UAB

Purpose: Given the observed link between psychosocial and physical health outcomes, this study investigates the association between serious psychological distress and life satisfaction among U.S adults with hypertension. Methods: A cross-sectional study using 2021 National Health Interview Survey data among U.S adults was conducted to investigate the association between serious psychological distress and hypertension and assess the role of life satisfaction in modifying this relationship. Hypertension (diagnosed, undiagnosed), serious psychological distress (≥ 13 on the Kessler 6 nonspecific distress scale), and life satisfaction (Very satisfied, Satisfied, Dissatisfied, Very dissatisfied) were self-reported by participants. Ordinal logistic regression was used to investigate …

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Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller Jan 2025

Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller

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Maternal immune activation (MIA) refers to the occurrence of an inflammatory immune response during any stage of pregnancy. This manifests as the upregulation of proinflammatory cytokines and can be caused by air pollution, obesity, or viral infection. When this occurs during the first trimester in humans, it increases the offspring’s susceptibility to developing neuropsychiatric disorders such as autism (ASD) and schizophrenia (SZ), in males more commonly than females. In addition to behavioral manifestations of neuropsychiatric disorders, metabolic syndrome (MetS) is a common comorbidity, defined as the co-occurrence of three or more symptoms including but not limited to hyperlipidemia, hypertension, and …

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Reducing Stress: The Role Of The Rcl Operon In Bacterial Stress Response To Hypothiocyanite, Julia Meredith Jan 2025

Reducing Stress: The Role Of The Rcl Operon In Bacterial Stress Response To Hypothiocyanite, Julia Meredith

All ETDs from UAB

The human immune system utilizes a variety of weapons against bacterial communities within the body, which allow it to control the overall microbial population. Understanding how some bacterial species are able to better deal with and survive damage by the immune system while others are not, can help us elucidate the complex relationship between us and our microbiome. One tool that immune cells use for microbial control is the potent oxidant hypothiocyanite/hypothiocyanous acid (-OSCN/HOSCN). The response mounted by Escherichia coli and other bacterial species in order to survive damage caused by HOSCN is the focus of this dissertation. In the …

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Therapeutic Implications Of Fractionated Radiotherapy And Marcks’ Regulation Of Tunneling Nanotubes In Glioblastoma, Lauren Catherine Nassour-Caswell Jan 2025

Therapeutic Implications Of Fractionated Radiotherapy And Marcks’ Regulation Of Tunneling Nanotubes In Glioblastoma, Lauren Catherine Nassour-Caswell

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Glioblastoma (GBM) is the most common primary brain malignancy in adults and the gradual development of treatment resistance prevents patients from achieving remission. A primary objective in the field is to devise strategies to overcome this. We predicted this could be achieved by improving existing therapies, creating better models to study GBM, and by identifying a potential therapeutic target. Fractionated radiotherapy (RT) has been used in GBM standard of care for over a century but does not account for GBM heterogeneity. We first hypothesized that in silico mathematical modeling would be a useful tool for cytotoxicity prediction. While this model …

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Investigating Risk Of Suboptimal Hiv Treatment Outcomes (Treatment Failure And Disengagement) Among Pregnant And Postpartum Women Living With Hiv, Kevin Owuor Jan 2025

Investigating Risk Of Suboptimal Hiv Treatment Outcomes (Treatment Failure And Disengagement) Among Pregnant And Postpartum Women Living With Hiv, Kevin Owuor

All ETDs from UAB

The joint United Nations Programme on HIV/AIDS (UNAIDS) has set targets to end the HIV epidemic by improving HIV diagnosis, treatment, and viral suppression to reduce new infections and improve health outcomes for people living with HIV (PLHIV), including pregnant and postpartum women living with HIV (PPWH). After diagnosis, linking PPWH to antiretroviral (ART) treatment is critical to suppress the virus and prevent mother-to-child transmission (MTCT) of HIV. Continuous engagement in care is essential for achieving and maintaining virologic suppression in the peripartum and postpartum period for PPWH, both for their own health and the health of their family. Disengagement …

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Precision Imaging For Head And Neck Tumors, Logan Daniel Stone Jan 2025

Precision Imaging For Head And Neck Tumors, Logan Daniel Stone

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Antibody-based imaging modalities have become more common in the field of imaging oncology as more biomarkers are identified for certain cancers. Epidermal growth factor receptor (EGFR) is overexpressed in several cancer types including head and neck squamous cell carcinoma (HNSCC) and ameloblastoma (AB). The over- expression in these cancers has been targeted with antibodies such as Panitumumab and Cetuximab for imaging modalities. These antibodies can be conjugated with IRDye800 molecules for intraoperative fluorescence imaging or radiolabel for pre-operative positron emission tomography/ computed tomography (PET/CT) imaging. These agents could provide surgeons with additional exams to identify carcinoma in scenarios where only …

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"It Says Mommy’S Coffee!": Environmental Print As A Tool To Support Young Children’S Emergent Literacy And Family Engagement In Early Care And Education, Melissa Dawn Sudduth Jan 2025

"It Says Mommy’S Coffee!": Environmental Print As A Tool To Support Young Children’S Emergent Literacy And Family Engagement In Early Care And Education, Melissa Dawn Sudduth

All ETDs from UAB

This study addressed topics related to family engagement in early childhood education, emergent literacy skills, and the use of environmental print (EP) to support young children’s emergent literacy. The children of interest in this study were young children between the ages of birth and 5-years enrolled in licensed, private early care and education (ECE) centers in Alabama. The researcher employed an explanatory sequential mixed methods design using a quantitative survey and qualitative interviews to address the following mixed methods questions: How do families of young children perceive family engagement?, Which emergent literacy skills do families of young children value and …

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Child Risk For Obesity And Physical Activity, Bethany Moore Oct 2024

Child Risk For Obesity And Physical Activity, Bethany Moore

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Childhood obesity is a significant health problem in the United States with consequences presenting themselves in the short- and long-term. Physical activity is a modifiable factor associated with adiposity and can at least partially attenuate the consequences of childhood obesity. There are many factors which influence children’s participation in regular physical activity, some of which are also associated with pediatric obesity. The overarching purpose of this research is to investigate potential influences on the association of obesity and physical activity among typically developing children. Aim 1 used a secondary analysis of n=163 children to explore independent and interactive effects of …

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October 25, 2024 Ereporter, University Of Alabama At Birmingham Oct 2024

October 25, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

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Examining Daily-Self Weighing As A Stand-Alone Intervention For Obesity Management, Ashley Parish Sep 2024

Examining Daily-Self Weighing As A Stand-Alone Intervention For Obesity Management, Ashley Parish

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Obesity is an epidemic that has substantial implications for both individuals with the disease as well as the healthcare system in the United States. Individuals with obesity are at increased risk for developing associated co-morbid conditions such as cardiovascular disease, type 2 diabetes, and some forms of cancer, which can affect quality of life and lead to mortality. There are many health behavior interventions which target weight loss, maintenance of weight loss, or weight gain prevention in those with obesity; however, interventions have unique barriers that can vary based on personal, environmental, and social factors. Primary care (PC) settings, which …

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Carpool, Alina Stefanescu Sep 2024

Carpool, Alina Stefanescu

PoemMemoirStory (literary magazine)

pp. 107-113

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Temp, Callie Mauldin Sep 2024

Temp, Callie Mauldin

PoemMemoirStory (literary magazine)

pp. 124-132

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Investigating The Role Of The Static And Hyperviscous Mucus Defect On The Development Of Bacterial Infection In The Cystic Fibrosis Rat, Mikayla Murphree-Terry Sep 2024

Investigating The Role Of The Static And Hyperviscous Mucus Defect On The Development Of Bacterial Infection In The Cystic Fibrosis Rat, Mikayla Murphree-Terry

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INVESTIGATING THE ROLE OF THE STATIC AND HYPERVISCOUS MUCUS DEFECT ON THE DEVELOPMENT OF BACTERIAL INFECTION IN THE CYSTIC FIBROSIS RAT MIKAYLA MURPHREE-TERRY GRADUATE BIOMEDICAL SCIENCES - MICROBIOLOGY ABSTRACT Cystic fibrosis (CF) is a genetic disease caused by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in dysfunctional CFTR. In the lungs, CFTR dysfunction results in dehydrated mucus that is adherent to epithelia. In the gut, thick mucus can mix with feces to form an obstruction, known as distal intestinal obstruction syndrome (DIOS). Additionally, CF mucus has a higher percentage of solids. The main solid component of …

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Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon Sep 2024

Effects Of Probiotic Lactobacilli On Candida Albicans: Implications For Early Childhood Caries, Leena Unnikrishnan Menon

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Purpose: Probiotic Lactobacillus species are shown to have beneficial effects against early childhood caries (ECC). On the other hand, the wide use of probiotic Lactobacillus spp. in dairy foods is believed to underline the global increase in ECC prevalence. Candida albicans has been frequently detected in children with ECC and has shown cariogenic potential in animal models of dental caries. The objective of this study was to determine the interactions between lactobacilli and C. albicans in growth competition, biofilm formation and acid production. Methods: Growth competition between C. albicans SC5314 and probiotic L. rhamnosus GG or caries-associated L. rhamnosus M72-26 …

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Phylogenetic Diversity Of Flagellin Differentiates Commensal Gut Bacteria That Induce Distinct Intestinal Epithelial Cell Responses, Melissa Simone Jennings Sep 2024

Phylogenetic Diversity Of Flagellin Differentiates Commensal Gut Bacteria That Induce Distinct Intestinal Epithelial Cell Responses, Melissa Simone Jennings

All ETDs from UAB

Flagellins belonging to bacteria from the Lachnospiraceae family are immunodom-inant antigens in inflammatory bowel disease. Flagellin, the basic unit of flagella utilized by bacteria for motility, is recognized by the host via toll-like receptor 5 (TLR5). Due to the diversity of flagellated bacteria, we investigated if this diversity results in distinct interac-tions between the bacteria and the host. Phylogenetic analysis on over 200 flagellin se-quences, primarily from Lachnospiraceae bacteria, revealed two divergent clusters we refer to as Group 1 (G1) and Group 2 (G2). In gnotobiotic mice colonized with G1 or G2 bacte-ria, both groups induce colonic interleukin 10 (IL-10)-producing …

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Cross-Sectional Retrospective Study To Determine The Prevalence Of Periodontal Bone Loss As A Function Of Age In The Predoctoral Clinic Patient Population, Lincoln Nguyen Sep 2024

Cross-Sectional Retrospective Study To Determine The Prevalence Of Periodontal Bone Loss As A Function Of Age In The Predoctoral Clinic Patient Population, Lincoln Nguyen

All ETDs from UAB

Age has a significant effect on the body’s ability fight off disease, recover, and maintain collagen structures, and it has been observed that older adults have a higher prevalence of periodontal diseases. Studies have shown that age is a risk factor for alveolar bone loss. However, there is a lack of research done looking at if this is a linear progression or if there is a specific age that susceptibility increases. The aim of this study is to investigate (1) changes in radiographic bone loss in varying age groups in the University of Alabama patient population and (2) to evaluate …

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O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips Sep 2024

O-Glcnacylation And Modulation Of Gabaergic Transmission, Shekinah Phillips

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Changes in the strength of GABAergic transmission is heavily influenced by posttranslational modifications and allosteric modulators like benzodiazepines and neurosteroids. O-GlcNAcylation (O-GlcNAc) is a post-translational modification that is tightly regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which add or remove the O-GlcNAc moiety of β–N-acetylglucosamine to serine and threonine residues on proteins, respectively. Published reports from our lab have demonstrated that an acute increase in O-GlcNAcylation induces a long-term depression (LTD) of evoked GABAAR mediated IPSCs (eIPSCs) and reduces the amplitude and frequency of spontaneous IPSC (sIPSC) in hippocampal principal cells, however the mechanism in which this occurs is …

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The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Responses When Controlling For Medication In Individuals With Type 2 Diabetes, Andrew Tyler Sep 2024

The Effects Of Acute Beetroot Juice Intake On Glycemic And Blood Pressure Responses When Controlling For Medication In Individuals With Type 2 Diabetes, Andrew Tyler

All ETDs from UAB

The prevalence of cardiometabolic diseases has continued to rise within the United. Physical activity and poor dietary choices are two factors that are known to contribute to the rise in cardiometabolic diseases. Thus, it is critical to identify strategies that may mitigate the negative impact from these behaviors. Several recent studies have shown that consumption of dietary inorganic nitrate (diNO3) may improve vascular health and glucose regulation in animal models and some human studies. However, the improvements in glucose regulation have yet to be corroborated in humans with type 2 diabetes (T2D). Thus, the purpose of this study was to …

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Sleep And Stigma: Novel Factors In The Relationship Between Weight Status And Cognitive Function?, Lindsay M. Stager Sep 2024

Sleep And Stigma: Novel Factors In The Relationship Between Weight Status And Cognitive Function?, Lindsay M. Stager

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U.S. obesity rates are rising. Impaired cognitive function (CF) negatively correlates with obesity and may impact food consumption. However, the mechanisms of action demand assessment. This study aimed to identify adiposity-based differences in adolescent CF and food consumption and determine the roles of sleep and stigma within these relationships. Adolescents completed questionnaires including the Behavior Rating Inventory of Executive Function and Brief Version of the Stigmatizing Situations Inventory assessing weight stigma. Actigraphy and food diaries assessed typical sleep duration and food consumption. Participants then completed two sleep conditions in a randomized order: adequate (AS; >8 hours asleep) and restricted (RS; <5 hours asleep) sleep. Each condition was preceded by a 2-night washout period (9 hours in bed per night) and followed by a morning lab visit involving a cognitive battery and self-serve breakfast. Adolescents with healthy weight (HW) demonstrated greater performance-based episodic memory compared to adolescents with overweight/obesity (OWOB), but self-reported poorer inhibition, self-monitoring, and planning/organizing. Findings were similar in models using total body fat percent (TBF%) as a predictor, and stigma did not mediate these relationships. Adiposity did not relate to typical self-reported food consumption. RS predicted poorer performance-based global cognition, fluid cognition, and cognitive flexibility for adolescents with OWOB and improved cognitive flexibility among adolescents with HW. Adolescents with OWOB also had poorer attention compared to adolescents with HW following RS, while there were no group differences following AS. Findings were similar in models using TBF% as a predictor. However, adolescents with TBF% elevated above 42, also had poorer processing speed following RS, and the relationship between sleep and attention did not vary based on TBF%. RS also predicted decreased consumption of total calories, calories from processed foods, and fat for both BMI groups. This study increases understanding of the relationships among weight, CF, and food consumption, and the roles of sleep and stigma within these relationships. Adolescents with OWOB were more vulnerable to the negative cognitive effects of RS and RS predicted decreased consumption of calories and fat. Promotion of improved sleep hygiene and duration may be critical for the cognitive health of adolescents with OWOB.

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Testicular Phenotypes Of Rdhe Dko Mice, Aja Slay Sep 2024

Testicular Phenotypes Of Rdhe Dko Mice, Aja Slay

All ETDs from UAB

The bioactive form of vitamin A, all-trans-retinoic acid (RA), plays a critical role in cell differentiation, metabolism, and cellular proliferation by regulating gene transcription. RA signaling is critical during embryogenesis to ensure proper development and during adulthood for tissue maintenance. Disruption of the RA signaling pathway induced by vitamin A deficiency and genetic defects in vitamin A metabolizing enzymes results in embryonic malformations. Previous studies implicate the short-chain dehydrogenase/reductase (SDR) family members as important in RA synthesis. Among the SDR family are retinol dehydrogenase epidermal 2 (RDHE2) and RDHE2-similar (RDHE2S)- collectively RDHE. To gain insight into how RDHE influences the …

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The Association Of Environment And Organizational Factors And Community Collaboration To Address ‘Social Determinants Of Health', Ishwari Venkataraman Sep 2024

The Association Of Environment And Organizational Factors And Community Collaboration To Address ‘Social Determinants Of Health', Ishwari Venkataraman

All ETDs from UAB

Upstream social and non-medical factors, known as social determinants of health (SDOH), significantly impact an individual and community’s health status. (SDOH includes housing, food, utility, transportation, education, and employment). It is not a hospital’s core competency to address SDOH. The preferred way to address SDOH and achieve health equity in a community is through a multi-sector collaborative effort. This study aimed to explore the association between a hospital’s environmental and organizational factors and the reported levels of collaboration with its community partners in addressing SDOH. The conceptual framework used in this study included the Interorganizational Collaboration Theory (IOC) and Contingency …

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The Effect Of Lower Limb Neuromuscular Electrical Stimulation On The Muscle And Metabolic Health After Acute Spinal Cord Injury, Amal Alharbi Sep 2024

The Effect Of Lower Limb Neuromuscular Electrical Stimulation On The Muscle And Metabolic Health After Acute Spinal Cord Injury, Amal Alharbi

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Spinal cord injury (SCI) is a devastating event with long-term consequences for individuals and their families. It causes immediate disruption to neuronal pathways, leading to paralysis and loss of muscle function below the injury level. A few weeks after the injury, there is a rapid decline in contractile activity, muscle mass, and cross-sectional area. This leads to muscle fiber degeneration and a shift towards a higher proportion of fast glycolytic fibers, which are more prone to fatigue and less efficient in energy utilization. Severe muscle atrophy in SCI is closely linked to metabolic dysfunction, affecting overall health and rehabilitation recovery. …

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Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob Sep 2024

Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob

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With combination antiretroviral therapy (cART), the population of older people living with HIV (PLWH) is growing. There is a need to better understand everyday functioning, including instrumental activities of daily living (IADLs), to improve real-world outcomes for this clinical population. This dissertation attempts to (1) characterize factors related to self-report and performance of IADLs in PLWH, (2) examine correlates of self-awareness for functional abilities, and (3) apply a theoretical model to examine complex relationships between factors that impact self-awareness for functional abilities. Participants in these retrospective analyses included 260 PLWH who completed a comprehensive neurobehavioral evaluation including neuropsychological tests, measures …

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Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith Sep 2024

Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith

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The overarching goal of the three-paper dissertation is to address the gaps in the literature on the clinical care burden of preventable spina bifida on the global neurosurgical community and the need for a universal food vehicle for fortification with folic acid as a novel prevention strategy. It is known that sufficient intake of folic acid is imperative to prevent neural tube defects (spina bifida) in the developing fetus in the first month post-conception. It is also known that fortifying staple foods is the most cost-saving and effective prevention method. However, very few countries have mandatory fortification policies. Therefore, the …

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The Effects Of The Home Food Environment On Habits Towards Foods, Demetria R. Pizano Sep 2024

The Effects Of The Home Food Environment On Habits Towards Foods, Demetria R. Pizano

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Habits are the learned and reinforced behavioral patterns that predict an individual's tendencies to engage in an action in their environment (Gardner, de Bruijn & Lally, 2011). Behaviors consistently triggered by an environmental context, such as a home, allow the formation of habitual responses towards health practices such as food consumption (van't Riet et al., 2011). The home food environment (HFE), the availability and access to healthy foods, influences an individual's food selection and consumption behaviors that ultimately shape their eating habits (Nilsen, Roback, Brostrom, & Ellstrom, 2012). Similarly, an individual's executive function (EF), which represents their cognitive ability to …

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Understanding Engagement With A Web-Based Diet And Exercise Program For Older Cancer Survivors, Aurora Tafili Sep 2024

Understanding Engagement With A Web-Based Diet And Exercise Program For Older Cancer Survivors, Aurora Tafili

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The purpose of this dissertation is to develop an understanding of engagement with a web-based diet and exercise program. The three objectives of this dissertation include: (1) determining what theoretical underpinnings technology-based health behavior change interventions are utilizing and applying; (2) developing an understanding of older cancer survivors’ process of engagement with a web-based diet and exercise intervention through the utilization of a mixed methods grounded theory approach; and (3) identify what evidence-based strategies to promote engagement can be devised and dissemination based on process of engagement identified. Three methodologies were utilized to conduct this dissertation: (1) a systematic review …

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The Relationship Between Socioeconomic Status And Polygenic Risk Scores On Body Mass Index Among Non-Hispanic White Americans, Tomiwa Joshua Ayetigbo Sep 2024

The Relationship Between Socioeconomic Status And Polygenic Risk Scores On Body Mass Index Among Non-Hispanic White Americans, Tomiwa Joshua Ayetigbo

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The prevalence of obesity in the United States remains high, especially among individuals of low socioeconomic status (SES). Studies examining the joint influence of genetics and social factors, such as early life SES and education, in association with obesity remain underreported. These social factors might be related to a heightened risk of obesity. Genetic factors may further exacerbate the high-weight predisposition of those at risk. Genetic and social factors may act together to shape individuals’ weight. Therefore, this research ex-amined (a) whether the association between polygenic risk for BMI (PGS-BMI) and Body Mass Index (BMI) is independently modified by early …

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Investigating Theoretical Constructs Of Social Cognitive Theory As Working Mechanisms Of Web-Based Diet And Physical Activity Interventions Among Cancer Survivors, Harleen Kaur Sep 2024

Investigating Theoretical Constructs Of Social Cognitive Theory As Working Mechanisms Of Web-Based Diet And Physical Activity Interventions Among Cancer Survivors, Harleen Kaur

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Cancer survivors are a high-risk population with poor lifestyle behaviors and a higher prevalence of obesity, necessitating effective lifestyle interventions to promote weight management, consumption of a healthy diet, and increased physical activity. Recently, lifestyle interventions have evolved to web-based platforms that are easily accessible. However, there is a need to understand how web-based lifestyle interventions work, and who they work best for to maximize impact. Thus, the objective of this dissertation was to evaluate social cognitive theory (SCT) mechanisms (i.e., self-efficacy, social support, and perceived barriers) through which two web-based lifestyle interventions, DUET and AMPLIFY, mediate changes in diet, …

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Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen Sep 2024

Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen

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Aspergillus fumigatus (Af) is one of the most common molds in the airways of people with Cystic Fibrosis (pwCF). The infection of Af is often preceded by Pseudomonas aeruginosa (PsA) infection and its correlated treatment. PsA is considered a highly prevalent bacteria in the CF lung. PwCF suffers from complex and sophisticated coinfections within the airway that negatively impact the health outcomes of patients. Despite this, why fungal and bacterial coinfection occurs in pwCF is still being determined. However, abnormal mucus production and its characteristics are suspected of creating an environment that promotes Af germination and disease progression. This study …

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