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Understanding Disparities In Hypertension Treatment Cascade And Validating Blood Pressure Measurement Among Persons Living With Or At Risk For Hiv, Jessica Blair Jan 2024

Understanding Disparities In Hypertension Treatment Cascade And Validating Blood Pressure Measurement Among Persons Living With Or At Risk For Hiv, Jessica Blair

All ETDs from UAB

In the United States, 44% of adult women >18 years have hypertension. Although non-Hispanic Black adults were more likely to be aware of and treated for hypertension compared to non-Hispanic White adults, Black individuals had the highest prevalence of uncontrolled hypertension. Persons living with HIV have a higher prevalence of hypertension, which is a major modifiable risk factor for cardiovascular disease. Similar to the geographic distribution of hypertension in the US, people living in the South have higher incidence of both hypertension and HIV diagnoses compared to other US regions. Furthermore, accurate diagnosis of hypertension and initiation of treatment is …


Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter Jan 2024

Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter

All ETDs from UAB

Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …


A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen Jan 2024

A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen

All ETDs from UAB

Transgender individuals experience many challenges within the healthcare system including discrimination, socioeconomic struggles, financial strains, a lack of educated healthcare providers, and a health system framework that makes it even more challenging for them to receive their medical needs (Korpaisarn and Safer). One contributing factor to this lack of education is that on average medical schools in the United States only spend approximately five hours total on the health needs related to lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals (Miller et al.). Another contributing factor is the stigma around LGBTQ individuals within the medical community. The stigma is concerning …


Fentanyl Overdoses And Use Of Randox Multistat For Investigative Purposes, Clarissa Danielle Lawen Jan 2024

Fentanyl Overdoses And Use Of Randox Multistat For Investigative Purposes, Clarissa Danielle Lawen

All ETDs from UAB

The opioid epidemic started in the early 1990s with the rise of prescription overdoses. In more recent years, heroin and fentanyl use has rapidly increased. Fentanyl, specifically, is 50 to 100 times more potent than morphine. To keep up with the ever-evolving epidemic, the Randox MultiSTAT was validated for use in the medical examiner autopsy suite for the potential to aid medical examiners in triaging the need for a full autopsy versus an external examination with toxicology testing. The Randox MultiSTAT is a triage tool and investigatory screen designed to provide presumptive test results across multiple matrices. It can detect …


2023 In Review: Points Of Pride, Reporter Staff Dec 2023

2023 In Review: Points Of Pride, Reporter Staff

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No abstract provided.


Hla-Dqb1*06 And Select Neighboring Hla Variants Predict Chlamydia Reinfection Risk, Kanupriya Gupta, Howard W. Wiener, Hemant K. Tiwari, William M. Geisler Oct 2023

Hla-Dqb1*06 And Select Neighboring Hla Variants Predict Chlamydia Reinfection Risk, Kanupriya Gupta, Howard W. Wiener, Hemant K. Tiwari, William M. Geisler

APC Fund

Associations of HLA class II alleles with genital chlamydial infection outcomes have been reported, especially HLA DQB1*06. However, the potential role of DQB1*06 in influencing reinfection risk has still not been established. The purpose of this study was to determine whether the association of DQB1*06 with chlamydia reinfection was impacted by any other nearby HLA class II variants that were also associated with reinfection. We used next-generation sequencing to map HLA class II variants spanning the HLA-DQ and -DR loci. DQB1*06 as well as DQB1*04 were confirmed as significant predictors of chlamydia reinfection, when controlling for age and percent African …


Antiviral Treatment Of Maternal And Congenital Cytomegalovirus (Cmv) Infections, Swetha Pinninti, Suresh Boppana Oct 2023

Antiviral Treatment Of Maternal And Congenital Cytomegalovirus (Cmv) Infections, Swetha Pinninti, Suresh Boppana

APC Fund

Human Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection. While a majority of HCMV infections in children and adults are asymptomatic, HCMV is well known to cause severe infections in the immunocompromised individual and maternal infections with variable long-term sequelae after maternal–fetal transmission with primary or nonprimary infections. HCMV seroprevalence and cCMV incidence vary by geographic area and demographic characteristics like race and socioeconomic status. While cCMV birth prevalence ranges from 0.2% to 6% in different parts of the world, it is influenced by regional HCMV seroprevalence …


Get Your Flu Shot In October, Early November To Stay Flu-Free This Season, Staff Oct 2023

Get Your Flu Shot In October, Early November To Stay Flu-Free This Season, Staff

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No abstract provided.


October 17, 2023 Ereporter, University Of Alabama At Birmingham Oct 2023

October 17, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Pspa-Mediated Aggregation Protects Streptococcus Pneumoniae Against Desiccation On Fomites, Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela Sep 2023

Pspa-Mediated Aggregation Protects Streptococcus Pneumoniae Against Desiccation On Fomites, Jessica R. Lane, Muralidhar Tata, Rahena Yasmin, Hansol Im, David E. Briles, Carlos J. Orihuela

APC Fund

Streptococcus pneumoniae (Spn) resides in the nasopharynx where it can disseminate to cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA), which promotes survival by blocking the antimicrobial peptide lactoferricin. PspA has also been shown to mediate attachment to dying epithelial cells in the lower airway due to its binding of cell surface-bound mammalian (m)GAPDH. Importantly, the role of PspA during colonization is not well understood. Wildtype Spn was present in nasal lavage elutes collected from asymptomatically colonized mice at levels ∼10-fold higher that its isogenic PspA-deficient mutant (ΔpspA). Wildtype Spn also …


A Fate Determination Fork-In-The-Road For Germinal Center Tfh And T Memory Cells, Jeff Hansen Aug 2023

A Fate Determination Fork-In-The-Road For Germinal Center Tfh And T Memory Cells, Jeff Hansen

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No abstract provided.


August 9, 2023 Greenmail, University Of Alabama At Birmingham Aug 2023

August 9, 2023 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.


August 4, 2023 Ereporter, University Of Alabama At Birmingham Aug 2023

August 4, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Three Uab Faculty Members Elected To The Association Of American Physicians, Staff May 2023

Three Uab Faculty Members Elected To The Association Of American Physicians, Staff

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No abstract provided.


Saag Announced As Keynote Speaker For The Spring 2023 Uab Office Of Service Learning And Undergraduate Research Expo, Micah Hardge Apr 2023

Saag Announced As Keynote Speaker For The Spring 2023 Uab Office Of Service Learning And Undergraduate Research Expo, Micah Hardge

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No abstract provided.


Norovirus: The Unwanted Guest That Brings Misery, Adam Pope Feb 2023

Norovirus: The Unwanted Guest That Brings Misery, Adam Pope

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No abstract provided.


January 4, 2023 Greenmail, University Of Alabama At Birmingham Jan 2023

January 4, 2023 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.


Hiv And Addiction Services For People Who Inject Drugs: Healthcare Provider Perceptions On Integrated Care In The U.S. South, Davis Bradford, Mariel Parman, Sara Levy, Wesli H. Turner, Li Li, Leah Leisch, Ellen Eaton, Kaylee B. Crockett Jan 2023

Hiv And Addiction Services For People Who Inject Drugs: Healthcare Provider Perceptions On Integrated Care In The U.S. South, Davis Bradford, Mariel Parman, Sara Levy, Wesli H. Turner, Li Li, Leah Leisch, Ellen Eaton, Kaylee B. Crockett

APC Fund

This qualitative study evaluates physician training and experience with treatment and prevention services for people who inject drugs (PWID) including medications for opioid use disorder (MOUD) and HIV pre-exposure prophylaxis (PrEP). The Behavioral Model of Healthcare Utilization for Vulnerable Populations was applied as a framework for data analysis and interpretation. Two focus groups were conducted, one with early career physicians (n = 6) and one with mid- to late career physicians (n = 3). Focus group transcripts were coded and analyzed using thematic analysis to identify factors affecting implementation of treatment and prevention services for PWID. Respondents identified that increasing …


Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin Jan 2023

Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin

All ETDs from UAB

Polyphosphate (polyP) is an ancient, conserved, inorganic biomolecule. Biological systems have adapted many functions for this high-energy molecule, ranging from immune regulation in mammals to gene regulation in prokaryotes. Of particular interest is its use in bacterial stress responses. Bacteria use polyP to resist hazardous environmental elements like toxic molecules or nutrient starvation. In many bacterial species, polyP is synthesized by polyphosphate kinases (PPKs). PPK – discovered in Escherica coli (E. coli) – hydrolyzes adenosine-5’-triphosphate (ATP) to synthesize polyP. Species that use PPK develop multiple pathogenic defects when PPK activity is impaired, including, among others, antibiotic susceptibility. There is no …


Factors Influencing Physical Activity Among Us Adults With Chronic Health Conditions: Mediation And Moderation Analysis, Sami M. Alqahtani Jan 2023

Factors Influencing Physical Activity Among Us Adults With Chronic Health Conditions: Mediation And Moderation Analysis, Sami M. Alqahtani

All ETDs from UAB

The prevalence of chronic health conditions (CHCs) is rising across all age groups, genders, and racial/ethnic groupings, making them the main cause of death globally. The majority of CHCs deaths occur in middle-to-low-income countries, although they are also a significant health issue in developed countries. A higher risk of developing CHCs is linked to physical inactivity. Global societies are experiencing increased prevalence of CHCs, which are directly assoicated with rising healthcare costs, workforce attendance, productivity challenges, and academic success. However, increased exercise and physical activity (PA) are linked to lower odds of developing CHCs. In fact, regular PA can help …


Mystique Cutaneous Cryptococcosis, Peshitha Nimmagadda, Dhivya Velu, Samir Allos Jan 2023

Mystique Cutaneous Cryptococcosis, Peshitha Nimmagadda, Dhivya Velu, Samir Allos

UAB Huntsville Research Day - All Presentations

2023 clinical vignette poster


Synthesis, Characterization, And Evaluation Of A Bionanomatrix And Antibiotic-Releasing Liposomes On Osseointegration, Vascularization, Inflammation, And Antibacterial Efficacy, Benjamin Kade Estep Jan 2023

Synthesis, Characterization, And Evaluation Of A Bionanomatrix And Antibiotic-Releasing Liposomes On Osseointegration, Vascularization, Inflammation, And Antibacterial Efficacy, Benjamin Kade Estep

All ETDs from UAB

Percutaneous osseointegrated prostheses (POP) implants combat the multitude of issues and limitations of contemporary prosthetic sockets/limbs, including range of motion, comfort/fit, irritation, gait, and osseoproprioception. However, POP implants lack long-term clinical success; specifically, several risks exist at the bone-implant interface, including superficial/deep infections, inflammation, poor vascularization, and inadequate osseointegration, resulting in implant loosening over time and ultimately removal of the implant. The goal of this thesis is to evaluate a multifunctional, nitric oxide-releasing bionanomatrix incorporated with antibiotic-releasing liposomes on osseointegration, inflammation, vascularization/angiogenesis, and bacterial infection. We successfully synthesized the bionanomatrix, and the antibiotic-releasing liposomes readily encapsulated the antibiotics. The antibiotic-releasing …


Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler Jan 2023

Examining The Impact Of The Covid-19 Pandemic And Subsequent Vaccine Availability On Children’S Social Play Opportunities With A Focus On The Autism Community, Jenni Koehler

All ETDs from UAB

Play, especially social play, is crucial to child development and impacts their cognitive, socioemotional, and motor growth. Children with an autism spectrum disorder (ASD) have social and motor impairments that act as barriers to their access to these critical social play opportunities. Those who are able to overcome these barriers through therapy have been shown to have better physical and mental outcomes. Unfortunately, the COVID-19 pandemic restricted social play opportunities for all children and disproportionately impacted children with ASD, further widening developmental gaps between them and their non-autistic peers. The development of the COVID-19 vaccine and its availability to children …


Resilience And Vulnerability: The Impact Of Deprivation, Social Capital, And Distance Sensitivity On Mental Health In Covid-19 Vaccine Seekers, Cesar Ivan Landeros Jan 2023

Resilience And Vulnerability: The Impact Of Deprivation, Social Capital, And Distance Sensitivity On Mental Health In Covid-19 Vaccine Seekers, Cesar Ivan Landeros

All ETDs from UAB

The COVID-19 pandemic has inflicted profound challenges upon California, exacerbating disparities in care, access, and health outcomes within vulnerable and deprived communities. Especially, this crisis has led to a surge in mental health issues, with anxiety and depression emerging as predominant psychopathologies, and the rates of anxiety and depression are alarmingly high in disadvantaged communities. In California, the strikingly high prevalence of these symptoms at 31.7%, compared to the national average of 32.3%, sounds a critical alarm. Despite empirical investigations into anxiety and depression rates across a range of demographic groups worldwide—such as survivors, healthcare professionals, children, adolescents, and adults—the …


Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow Jan 2023

Characterizing The Role Of Mapk Phosphatases In Age-Dependent Macrophage Dysfucntion And Increased Suceptiblity To Pneumonia In A Tnf-Dependent Manner, Katherine Lauren Kruckow

All ETDs from UAB

Lower respiratory infections are the primary cause of infectious death among the elderly. One reason for this is ‘inflamm-aging,’ a chronic low-grade inflammatory state that develops with advanced age. Pertinently, our group has shown increases in TNF levels to be responsible for age-dependent macrophage dysfunction (ADMD) and, in turn, enhanced susceptibility to Streptococcus pneumoniae, the leading cause of community-acquired pneumonia. The underlying molecular mechanisms responsible, however, remain unclear. Following adoptive transfer of alveolar macrophages (AM) from aged (18+ months) or young (3-6 month) mice into young mice, followed by infection with S. pneumoniae, we found that aged AM were sufficient …


Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao Jan 2023

Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao

All ETDs from UAB

The HIV care continuum is a public health model that outlines the steps or stages people with HIV go through from diagnosis to achieving and maintaining viral suppression. Retention in care, a key component of the HIV care continuum, is critical in achieving good health outcomes for people with HIV (PWH) and preventing HIV transmission. Consistent HIV care is essential for the health of PWH as a part of retention in care. De-spite no standard measure for retention in care to PWH, the missed (no-show) vis-its/appointments is one of the most commonly used methods for evaluating retention in HIV care. …


Understanding Attitudes, Subjective Norms, And Intent Of Covid-19 Vaccine Hesitancy And Refusal Among African Americans In The United States Using The Theory Of Reasoned Action, Deandrea Lashay Martinez Jan 2023

Understanding Attitudes, Subjective Norms, And Intent Of Covid-19 Vaccine Hesitancy And Refusal Among African Americans In The United States Using The Theory Of Reasoned Action, Deandrea Lashay Martinez

All ETDs from UAB

COVID-19 vaccine hesitancy and vaccine refusal contributed to many African Americans not receiving the COVID-19 vaccine. The reasons for vaccine hesitancy and vaccine refusal were unclear by sociodemographic factors (income, gender, education, and age) among African Americans. This research explored attitudes, subjective norms, and intent of COVID-19 vaccine hesitancy and vaccine refusal among African Americans in the United States using the Theory of Reasoned Action. The two research questions were (1) Among African Americans, do age, income, gender, and education factors remain stable across three study cohorts in differentiating subjects who are COVID-19 vaccine hesitant versus refusal from 2020–2022? (2) …


Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones Jan 2023

Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones

All ETDs from UAB

Kidney disease is the tenth-leading cause of death in the United States (US). There are significant racial disparities within kidney disease: African Americans (AAs) have the highest rates of CKD and carry a four-fold higher risk of developing end-stage renal disease (ESRD). They are also less likely to undergo kidney transplants, and among those who do, are more likely to experience graft rejection. Additionally, until 2021, kidney function equations were shown to underestimate the severity of kidney disease in AA due to the use of race coefficients. Among all populations, genetic and epigenetic factors contribute to kidney disease. However, AAs …


Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun Jan 2023

Aging With Hiv And Comorbid Chronic Obstructive Pulmonary Disease, Jun Yeong Byun

All ETDs from UAB

Older adults with human immunodeficiency virus (HIV) experience a high prevalence of chronic obstructive pulmonary disease (COPD). Considering having either HIV or COPD is related to worse health outcomes in older adults, aging with both HIV and COPD may synergistically and negatively affect the health outcomes of older people with HIV (PWH) and comorbid COPD. The purpose of this dissertation was to explore the aging of PWH with COPD. This purpose was accomplished through three articles: 1) an adaptation of a gerontological model investigating what is known about the aging of PWH and people with COPD and extrapolating that to …


The Effect Of Weather Events On Dengue Fever In Brazil 2014-2022, Maryclare Gabel Jan 2023

The Effect Of Weather Events On Dengue Fever In Brazil 2014-2022, Maryclare Gabel

All ETDs from UAB

Dengue fever is a mosquito-borne infectious disease that is spread through the bite of an infected Aedes aegypti or Aedes albopictus mosquito. Half the world's population lives in a dengue fever risk zone. There are an estimated 100 million symptomatic dengue fever cases each year, with 40,000 deaths reported. Brazil reports the highest annual dengue fever cases in Latin America. In 2022, Brazil recorded 2.36 million dengue fever cases, the highest number of cases ever recorded in the country. We designed a retrospective ecological study to evaluate the temporal trends and the association between weather events and dengue fever incidence …