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Investigation On The Epigenetic Mechanisms Modified By Dietary Phytochemicals In Inhibiting Mammary Cancer, Mohammad Mijanur Rahman Sep 2024

Investigation On The Epigenetic Mechanisms Modified By Dietary Phytochemicals In Inhibiting Mammary Cancer, Mohammad Mijanur Rahman

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Breast cancer (BC) is global burden for the health of women. It is the most commonly diagnosed cancer in women and the second leading cause of cancer mortality among women in the United States. One in every eight women in the USA has a chance of developing invasive BC in her lifetime. The limitations of the available therapeutics for BC treatment have brought the dietary prevention of BC to the attention of the scientific community as a safe, natural, and easy to implement therapeutic strategy. In this regard, our laboratory with many other laboratories have demonstrated the anti-BC effect of …

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Use Of Molecular Dynamics Simulations To Characterize Structural Interactions Of Protein And Drug In Antiviral Drug Discovery, Caitlin Joan Smith Sep 2024

Use Of Molecular Dynamics Simulations To Characterize Structural Interactions Of Protein And Drug In Antiviral Drug Discovery, Caitlin Joan Smith

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Since 2019, the novel coronavirus SARS-CoV-2 the etiological cause of the COVID-19 pandemic has led researchers and physicians to look for effective antiviral treatments as interventions in mitigating COVID-19 disease. The severity of the disease and the limitations of current treatments have led to antiviral drug research beyond currently approved antiviral drugs. Many antivirals exist and are currently approved by the Food and Drug Administration (FDA) for other viral illnesses, yet currently only remdesivir and nirmatrelvir/ritonivir are approved for COVID-19 (October 2020, May 2023, respectively), while molnupiravir is still under emergency FDA use authorization [1, 2, 3]. Here, we have …

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Promoting Endogenous Cardiomyocyte Proliferation In Large Mammal Hearts Via Cell Transfer Therapy Or Apical Resection: Understanding The Underlying Mechanism, Yuhua Wei Sep 2024

Promoting Endogenous Cardiomyocyte Proliferation In Large Mammal Hearts Via Cell Transfer Therapy Or Apical Resection: Understanding The Underlying Mechanism, Yuhua Wei

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Cardiovascular diseases are the leading causes of global death. Due to the limit regenerative capacities of adult mammalian cardiomyocytes (CMs), myocardium is repaired with non-contractile fibrotic scar after a myocardial infarction (MI). Various strategies, including apical resection (AR) and cardiac cell therapy, are being explored to promote heart regeneration after MI. This dissertation research aimed to identify proliferating pig CM population after AR and understand the underlying mechanism of human induced pluripotent stem cells (hiPSCs) derived CMs (hiPSC-CMs) implantation for regenerating the pig hearts after MI. Our previous study showed that AR prolonged the heart regeneration window to postnatal day-28 …

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The Association Of Environment And Organizational Factors And Community Collaboration To Address ‘Social Determinants Of Health', Ishwari Venkataraman Sep 2024

The Association Of Environment And Organizational Factors And Community Collaboration To Address ‘Social Determinants Of Health', Ishwari Venkataraman

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Upstream social and non-medical factors, known as social determinants of health (SDOH), significantly impact an individual and community’s health status. (SDOH includes housing, food, utility, transportation, education, and employment). It is not a hospital’s core competency to address SDOH. The preferred way to address SDOH and achieve health equity in a community is through a multi-sector collaborative effort. This study aimed to explore the association between a hospital’s environmental and organizational factors and the reported levels of collaboration with its community partners in addressing SDOH. The conceptual framework used in this study included the Interorganizational Collaboration Theory (IOC) and Contingency …

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The Impact Of Substrate Stiffness On Glycocalyx Expression In Cultured Endothelial Cells, Frances Green Sep 2024

The Impact Of Substrate Stiffness On Glycocalyx Expression In Cultured Endothelial Cells, Frances Green

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Cardiovascular diseases associated with aging pose a significant public health challenge, with vascular stiffening playing a central role in disease progression. This research explores the complex relationship between vascular stiffening and endothelial cell (EC) dysfunction, focusing specifically on the endothelial glycocalyx (eGCX), a critical protective layer of proteins and glycans that covers endothelial cells (ECs). Our approach involves culturing lung microvascular ECs on various ratios of polydimethylsiloxane (PDMS) substrates to simulate vascular stiffening conditions. The results of our study demonstrate an inverse correlation between substrate stiffness and eGCX expression, with softer substrates promoting eGCX integrity. Future research directions will incorporate …

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The Effect Of Lower Limb Neuromuscular Electrical Stimulation On The Muscle And Metabolic Health After Acute Spinal Cord Injury, Amal Alharbi Sep 2024

The Effect Of Lower Limb Neuromuscular Electrical Stimulation On The Muscle And Metabolic Health After Acute Spinal Cord Injury, Amal Alharbi

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Spinal cord injury (SCI) is a devastating event with long-term consequences for individuals and their families. It causes immediate disruption to neuronal pathways, leading to paralysis and loss of muscle function below the injury level. A few weeks after the injury, there is a rapid decline in contractile activity, muscle mass, and cross-sectional area. This leads to muscle fiber degeneration and a shift towards a higher proportion of fast glycolytic fibers, which are more prone to fatigue and less efficient in energy utilization. Severe muscle atrophy in SCI is closely linked to metabolic dysfunction, affecting overall health and rehabilitation recovery. …

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Hydrogen Peroxide Regulates Protein N-Glycosylation, Alexandria Hernandez-Nichols Sep 2024

Hydrogen Peroxide Regulates Protein N-Glycosylation, Alexandria Hernandez-Nichols

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N-glycosylation is a co- and post-translational modification wherein a variety of sugars are added to proteins in a linear pathway progressing from high mannose (HM) to hybrid, to complex type N-glycans. This modification is important to the understanding of protein maturation, stability, and function. Studies have shown that changes in cell N-glycomes, in particular, the HM N-glycan category, could be hallmarks of various pathologies. The biosynthetic pathway for N-glycosylation is well studied and the key enzymes involved in the progression of HM to hybrid N-glycans are the a-mannosidases. Little is understood about the regulation of this highly complex post-translational modification …

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Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob Sep 2024

Everyday Functioning In Middle Aged And Older Adults With Hiv: Factors That Influence Everyday Functioning And Awareness Of Functioning, Alexandra Elaine Jacob

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With combination antiretroviral therapy (cART), the population of older people living with HIV (PLWH) is growing. There is a need to better understand everyday functioning, including instrumental activities of daily living (IADLs), to improve real-world outcomes for this clinical population. This dissertation attempts to (1) characterize factors related to self-report and performance of IADLs in PLWH, (2) examine correlates of self-awareness for functional abilities, and (3) apply a theoretical model to examine complex relationships between factors that impact self-awareness for functional abilities. Participants in these retrospective analyses included 260 PLWH who completed a comprehensive neurobehavioral evaluation including neuropsychological tests, measures …

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The Association Between Social Connectedness And Opioid Reuse Among Vulnerable Groups Receiving Medication For Opioid Use Disorder, Jolanda Lynn Hudson Sep 2024

The Association Between Social Connectedness And Opioid Reuse Among Vulnerable Groups Receiving Medication For Opioid Use Disorder, Jolanda Lynn Hudson

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THE ASSOCIATION BETWEEN SOCIAL CONNECTEDNESS AND OPIOID REUSE AMONG VULNERABLE GROUPS RECEIVING MEDICATION FOR OPIOID USE DISORDER JOLANDA L. HUDSON PUBLIC HEALTH ABSTRACT Introduction: Opioid Use Disorder (OUD) is a serious illness that continues to persist despite the many efforts of researchers, physicians, government agencies, state, and local programs, to eliminate the mortality rate associated with this disease. Although manageable, OUD is still taking the lives of citizens due to illegal opioid misuse. Understanding the dynamics of the disease and the contributing factors in various populations may inform researchers in successful intervention outcomes. Methods: A retrospective secondary data analysis utilizing …

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Changes In Drug And Alcohol Behaviors Before And After An Educational Intervention Among At-Risk Adults And Youth, Isabel Cuellar Acker Sep 2024

Changes In Drug And Alcohol Behaviors Before And After An Educational Intervention Among At-Risk Adults And Youth, Isabel Cuellar Acker

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Introduction: Substance abuse is defined as the excessive use of a drug in a way that is detrimental to oneself, society, or both. Gender is important to examine because it is becoming more common for females to develop substance use disorders and for their substance use to be more severe. This study will address the role of an education-based intervention on substance abuse in an area that is at the intersection of rural and urban geography with a unique pool of participants. Methods: This is a longitudinal cohort study that has a pre-post intervention design. A linear model was used …

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Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith Sep 2024

Prevention Of Spina Bifida Through Fortification Of Iodized Salt With Folic Acid, Anastasia Arynchyna Smith

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The overarching goal of the three-paper dissertation is to address the gaps in the literature on the clinical care burden of preventable spina bifida on the global neurosurgical community and the need for a universal food vehicle for fortification with folic acid as a novel prevention strategy. It is known that sufficient intake of folic acid is imperative to prevent neural tube defects (spina bifida) in the developing fetus in the first month post-conception. It is also known that fortifying staple foods is the most cost-saving and effective prevention method. However, very few countries have mandatory fortification policies. Therefore, the …

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Combination Of 64/67cu Theranostics And Immunotherapy Targeting Fibroblast Activation Protein In Triple Negative Breast Cancer, Fnu Sharmila Sridhar Sep 2024

Combination Of 64/67cu Theranostics And Immunotherapy Targeting Fibroblast Activation Protein In Triple Negative Breast Cancer, Fnu Sharmila Sridhar

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Triple negative breast cancer (TNBC) makes up 10-20% of breast cancer cases. Even with advancements in science, TNBC is treatment resistant due to the lack of any type of hormonal receptors on the cell surface making it difficult for targeted hormonal therapy. New research avenues have led to studies of the Tumor-microenvironment (TME) in detail. TME is a complex network of stromal cells, extracellular matrix (ECM) and cancer associated fibroblasts (CAFs) with pro-tumorigenic properties and plays a major role in tumor growth. Fibroblast activation protein (FAP) is a marker of CAF and promotes ECM remodeling through several pathways and has …

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Health Seeking Behaviors Of Pregnant And Post-Partum Women Living With Hiv In A Rural Region Of Kenya - A Mixed Method Study, Sandra Korkor Chrapah Sep 2024

Health Seeking Behaviors Of Pregnant And Post-Partum Women Living With Hiv In A Rural Region Of Kenya - A Mixed Method Study, Sandra Korkor Chrapah

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Maternal and Child Health (MCH) services, including antenatal care (ANC), postnatal care (PNC), and HIV services are crucial in preventing adverse pregnancy outcomes for pregnant/postpartum women and their infants. However, the utilization of these services remains low for pregnant/postpartum women living in Africa. The recent COVID-19 pandemic with the associated low utilization of MCH services poses a threat to the improvements made over the years. This dissertation proposal aimed to examine the relationship between HIV status and health service utilization (HSU) and outcomes for pregnant/postpartum women living in a rural region in Kenya. I adopted a convergent parallel mixed methods …

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It's A Man's World: The Association Between Safe Sex Practices, Relationship Power, & Resilience Among African American Emerging Adults Between 18-24 In The Deep South, Jessica Morgan Sep 2024

It's A Man's World: The Association Between Safe Sex Practices, Relationship Power, & Resilience Among African American Emerging Adults Between 18-24 In The Deep South, Jessica Morgan

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The purpose of this dissertation was to examine the impact that power imbalance has on safe sex practices among African American emerging adults. The objectives included: provide a thorough review of preexisting literature that explores the impact of power imbalance on safe sex practices among African American women; understand the impact that power imbalance has on safe sex practices among African American emerging adults comparing data from men and women; and understand if resilience is associated with power imbalance among African American emerging adult women in the United States. Utilizing a retrospective, cross-sectional, quantitative study design, three methods were used …

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Biologic Evaluation Of 64cu & 67cu As Potential Theranostic Agents For Cancer Radiotherapy, Lakshmi Madhusoodanan Sep 2024

Biologic Evaluation Of 64cu & 67cu As Potential Theranostic Agents For Cancer Radiotherapy, Lakshmi Madhusoodanan

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Immunotherapy has become a mainstay in the treatment of several types of cancer, with the potential to induce durable remission, albeit in a limited percentage of patients. More recently, radiopharmaceuticals have gained recognition in cancer treatment due to their ability to localize within cancer cells and deliver radiation, reducing adverse effects precisely. Cancer radiotherapy has the potential to synergize with immunotherapy due to its induction of immunogenic cell death (ICD), which results in distinct cellular injuries such as the formation of single-strand breaks (SSBs) and double-stranded breaks (DSBs), disruption of mitochondrial integrity, and the excessive generation of reactive oxygen species …

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Adolescents' Life Stressors And Mental Health Trajectories In Young Adulthood: Findings From The Nlsy97 Cohort, Monir Hossain Sep 2024

Adolescents' Life Stressors And Mental Health Trajectories In Young Adulthood: Findings From The Nlsy97 Cohort, Monir Hossain

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Prior research demonstrates that early life adversity lowers mental health in young adulthood; however, there has been less attention to adversity occurring in adolescence and how this affects mental health over time. Further, little research has considered how the type of adversity (here called Adolescent Life Stressors (ALSs)) may affect mental health over time differently. The life course perspective directs attention to how adversity in adolescence and the type of ALS experienced may be especially consequential to the extent that it disrupts normative adult role attainment—education, employment, marriage, and parenthood—in the transition to adulthood. To address these gaps, I use …

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Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia Sep 2024

Determination Of Readthrough Susceptibility Among Different Schwann Cell Lines Carrying Nonsense Mutations, Trushali Vansadia

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Neurofibromatosis Type 1 (NF1) is a genetic disorder that affects the nervous system through the formation of tumors or neurofibromas. Encoded by the NF1 gene, neurofibromin functions as a tumor suppressor by converting active GTP-Ras to inactive GDP-Ras. 20% of NF1 patients carry a genomic nonsense mutation, which generates a premature termination codon (PTC) in the NF1 mRNA, leading to the formation of a truncated neurofibromin protein. Termination at PTCs can be suppressed by the incorporation of an amino acid at the site of the PTC, also known as readthrough. Readthrough results in continued translation elongation downstream of the PTC …

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Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith Sep 2024

Disruption Of Cochlear Development By Murine Cytomegalovirus Infection And Therapeutic Approaches That Prevent Hearing Loss, Matthew Smith

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Human cytomegalovirus (HCMV) is a ubiquitous virus, infecting greater than 50% of most populations worldwide. Although rarely causing symptomatic infection in immunocompetent individuals, HCMV can cause life-threatening and severe end-organ disease in immunocompromised hosts including the developing fetus. HCMV can cross the placenta and is the most common viral infection of the developing fetus. Most newborn infants with congenital HCMV infection (cCMV) exhibit no clinical evidence of infection; however, up to 15% will develop long term neurodevelopmental sequelae including sensorineural hearing loss (SNHL). No prophylactic vaccines or effective antiviral treatments exist for cCMV infection, which may in part be secondary …

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The Effects Of The Home Food Environment On Habits Towards Foods, Demetria R. Pizano Sep 2024

The Effects Of The Home Food Environment On Habits Towards Foods, Demetria R. Pizano

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Habits are the learned and reinforced behavioral patterns that predict an individual's tendencies to engage in an action in their environment (Gardner, de Bruijn & Lally, 2011). Behaviors consistently triggered by an environmental context, such as a home, allow the formation of habitual responses towards health practices such as food consumption (van't Riet et al., 2011). The home food environment (HFE), the availability and access to healthy foods, influences an individual's food selection and consumption behaviors that ultimately shape their eating habits (Nilsen, Roback, Brostrom, & Ellstrom, 2012). Similarly, an individual's executive function (EF), which represents their cognitive ability to …

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Barriers And Facilitators To Mental Health Care Among Suicide Attempt Survivors, Mercedes Tarasovich Sep 2024

Barriers And Facilitators To Mental Health Care Among Suicide Attempt Survivors, Mercedes Tarasovich

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This mixed methods study examined factors associated with met and unmet mental health care needs among suicide attempt survivors in the U.S. Quantitative survey data from 74 participants was analyzed using fuzzy set Qualitative Comparative Analysis (fsQCA) to determine configurations of conditions associated with met and unmet needs. Qualitative data from the surveys and 21 in-depth interviews were analyzed thematically. Key integrated findings show social and economic factors act in combination to affect outcomes of met and unmet mental health care needs, including the gray areas of “needs partially met.” Configurations of conditions which included lack of perceived suicide stigma, …

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Understanding Engagement With A Web-Based Diet And Exercise Program For Older Cancer Survivors, Aurora Tafili Sep 2024

Understanding Engagement With A Web-Based Diet And Exercise Program For Older Cancer Survivors, Aurora Tafili

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The purpose of this dissertation is to develop an understanding of engagement with a web-based diet and exercise program. The three objectives of this dissertation include: (1) determining what theoretical underpinnings technology-based health behavior change interventions are utilizing and applying; (2) developing an understanding of older cancer survivors’ process of engagement with a web-based diet and exercise intervention through the utilization of a mixed methods grounded theory approach; and (3) identify what evidence-based strategies to promote engagement can be devised and dissemination based on process of engagement identified. Three methodologies were utilized to conduct this dissertation: (1) a systematic review …

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The Relationship Between Socioeconomic Status And Polygenic Risk Scores On Body Mass Index Among Non-Hispanic White Americans, Tomiwa Joshua Ayetigbo Sep 2024

The Relationship Between Socioeconomic Status And Polygenic Risk Scores On Body Mass Index Among Non-Hispanic White Americans, Tomiwa Joshua Ayetigbo

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The prevalence of obesity in the United States remains high, especially among individuals of low socioeconomic status (SES). Studies examining the joint influence of genetics and social factors, such as early life SES and education, in association with obesity remain underreported. These social factors might be related to a heightened risk of obesity. Genetic factors may further exacerbate the high-weight predisposition of those at risk. Genetic and social factors may act together to shape individuals’ weight. Therefore, this research ex-amined (a) whether the association between polygenic risk for BMI (PGS-BMI) and Body Mass Index (BMI) is independently modified by early …

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Radiotherapy Dose Calculation Algorithm Sensitivity To High-Density Artifacts, Kylie Blue Sep 2024

Radiotherapy Dose Calculation Algorithm Sensitivity To High-Density Artifacts, Kylie Blue

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Radiotherapy planning can be adversely affected by inaccurate dose calculations due to the presence of high-density objects. High-density objects, such as surgical clips, produce artifacts in CT images which can result in errors in dose calculation. Manual correction of voxels containing incorrect information is recommended to prevent calculation errors, but this process can be cumbersome and sometimes results in planners compromising with crude corrections to save time. In this study we aim to determine the significance of small high-density objects and the artifacts they cause in radiotherapy treatment plans. To evaluate the impact of density overrides on calculations, a phantom …

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A Five-Year Review Of State Dental Board Disciplinary Actions, Phorum Desai Sep 2024

A Five-Year Review Of State Dental Board Disciplinary Actions, Phorum Desai

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Introduction: Ethical violations not only tarnish the reputation of dental professionals but also compromise the trust patients place in the dental field. A review of documented legal violations provides valuable insights into the common ethical transgressions and potential deficiencies in dental ethics education. This study aims to identify common violations reported by state dental boards and trends of violations over five years. Material and Methods: After a broad preliminary search, nine state dental boards with fully accessible records from January 2017 to December 2021 were selected for a thorough review: California, Iowa, Kentucky, Maine, Minnesota, Nebraska, New Jersey, South Dakota, …

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The Association Between Environmental Factors And Substance Use Outcomes Among A Vulnerable Veteran Population, Leah Nixon Bryan Sep 2024

The Association Between Environmental Factors And Substance Use Outcomes Among A Vulnerable Veteran Population, Leah Nixon Bryan

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Background. Illicit substance use among veterans is a complex and multifaceted issue. As individuals who have served in the armed forces return to civilian life, they may face a range of challenges, including mental health issues, physical injuries, and difficulties readjusting to societal norms. Unfortunately, for some veterans, these challenges can contribute to the allure of illicit substances as a coping mechanism. The intersection of the unique stressors associated with military service creates a population with an increased vulnerability to select health and psychosocial issues and susceptible to substance misuse (Tsai & Rosenheck, 2015). In addition to military experiences, environmental …

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Investigating Theoretical Constructs Of Social Cognitive Theory As Working Mechanisms Of Web-Based Diet And Physical Activity Interventions Among Cancer Survivors, Harleen Kaur Sep 2024

Investigating Theoretical Constructs Of Social Cognitive Theory As Working Mechanisms Of Web-Based Diet And Physical Activity Interventions Among Cancer Survivors, Harleen Kaur

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Cancer survivors are a high-risk population with poor lifestyle behaviors and a higher prevalence of obesity, necessitating effective lifestyle interventions to promote weight management, consumption of a healthy diet, and increased physical activity. Recently, lifestyle interventions have evolved to web-based platforms that are easily accessible. However, there is a need to understand how web-based lifestyle interventions work, and who they work best for to maximize impact. Thus, the objective of this dissertation was to evaluate social cognitive theory (SCT) mechanisms (i.e., self-efficacy, social support, and perceived barriers) through which two web-based lifestyle interventions, DUET and AMPLIFY, mediate changes in diet, …

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The Relationship Of Sleep Disturbance And Disease-Related Factors On Neural And Neurocognitive Function In Youth Living With Sickle Cell Disease, Tiffany Devaughn Tucker Sep 2024

The Relationship Of Sleep Disturbance And Disease-Related Factors On Neural And Neurocognitive Function In Youth Living With Sickle Cell Disease, Tiffany Devaughn Tucker

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Youth living with sickle cell disease (SCD) often face neurocognitive challenges, regardless of accompanying neurological issues. SCD involves red blood cell deformation, leading to complications including chronic anemia, vaso-occlusion, and acute crises such as pain and overt stroke. While screening and intervention advancements have improved survival, enhancing functional capacity and quality of life (QoL) remains a targeted area of intervention. Disease-related factors, sleep disturbances, and social determinants significantly impact neurocognitive health in youth living with SCD. Deficits across all cognitive domains, including attention, working memory, and executive function (EF), are common, affecting academic achievement and QoL. Brain-related issues, such as …

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Mapping Work Histories And Measuring Work Quality: Differences By Race, Gender, And Motherhood, Clifford James Ross Sep 2024

Mapping Work Histories And Measuring Work Quality: Differences By Race, Gender, And Motherhood, Clifford James Ross

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It is well-established that work has a strong association with health and that work is also a key driver of health inequality. However, there is little research that incorporates multiple components of work into one cohesive measure and examines how work patterns unfold over the life course. By incorporating three theoretical frameworks (1) The Sociology of Work and Health, (2) The Life Course, and (3) The Stress Process, and using over 40 years of employment data (collected from 1979-2018) from the National Longitudinal Survey of Youth 1979 (N=3,302), I introduce a comprehensive work measure called “Work Quality”. Then, using work …

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Impact Of Alpha-Synuclein Aggregates On Synaptic Structure In The Amygdala, Nolwazi Zakithi Gcwensa Sep 2024

Impact Of Alpha-Synuclein Aggregates On Synaptic Structure In The Amygdala, Nolwazi Zakithi Gcwensa

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Parkinson’s disease is the most common motor neurodegenerative and is characterized by intracellular inclusions of misfolded protein α-synuclein termed Lewy Pathology. At least 80% of PD sufferers also experience non-motor symptoms along with, and sometimes preceding, the motor symptoms. Symptoms such as apathy, hallucinations, anxiety and depression could be caused by α-synuclein inclusions causing dysfunction in the amygdala. Lewy pathology in the amygdala of PD patients is robust and has also been observed in a number of other diseases like Dementia with Lewy Bodies and Alzheimer's disease. In our lab, we have shown that using preformed fibrils to induce α-synuclein …

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Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen Sep 2024

Pseudomonas Aeruginosa And Tobramycin Effects On Aspergillus Fumigatus Infection In Cystic Fibrosis Airway, Tuan Anh Nguyen

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Aspergillus fumigatus (Af) is one of the most common molds in the airways of people with Cystic Fibrosis (pwCF). The infection of Af is often preceded by Pseudomonas aeruginosa (PsA) infection and its correlated treatment. PsA is considered a highly prevalent bacteria in the CF lung. PwCF suffers from complex and sophisticated coinfections within the airway that negatively impact the health outcomes of patients. Despite this, why fungal and bacterial coinfection occurs in pwCF is still being determined. However, abnormal mucus production and its characteristics are suspected of creating an environment that promotes Af germination and disease progression. This study …

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