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Articles 661 - 690 of 14418
Full-Text Articles in Entire DC Network
An Unusual Case Of Plasma Cell Leukemia Presenting As Pericardial Effusion, Ahmed Qaedi, Ethan Barnes, Ali Hachem, Farrah Ibrahim
An Unusual Case Of Plasma Cell Leukemia Presenting As Pericardial Effusion, Ahmed Qaedi, Ethan Barnes, Ali Hachem, Farrah Ibrahim
UAB Huntsville Research Day - All Presentations
No abstract provided.
A Rare Case Of Maternal Hypercalcemia Causing Fetal Hydrops, Hinal Rathi, Aditya Gowda, Vasudha Reddy
A Rare Case Of Maternal Hypercalcemia Causing Fetal Hydrops, Hinal Rathi, Aditya Gowda, Vasudha Reddy
UAB Huntsville Research Day - All Presentations
No abstract provided.
Cough, Shortness Of Breath, And Runny Nose Oh You Have Pneumonia But Do You Really?, Hinal Rathi, Aesha Patel, Ali Hassoun
Cough, Shortness Of Breath, And Runny Nose Oh You Have Pneumonia But Do You Really?, Hinal Rathi, Aesha Patel, Ali Hassoun
UAB Huntsville Research Day - All Presentations
No abstract provided.
A Not-So-Common Interaction Of A Common Medication: Metformin And It’S Rare Challenge, Hinal Rathi, Aesha Patel, Alina Sehar, John Fanning
A Not-So-Common Interaction Of A Common Medication: Metformin And It’S Rare Challenge, Hinal Rathi, Aesha Patel, Alina Sehar, John Fanning
UAB Huntsville Research Day - All Presentations
No abstract provided.
One Million Platelets With An Interesting Twist, Hinal Rathi, Alina Sehar, Parekha Yedla, Farrah Ibrahim
One Million Platelets With An Interesting Twist, Hinal Rathi, Alina Sehar, Parekha Yedla, Farrah Ibrahim
UAB Huntsville Research Day - All Presentations
No abstract provided.
A Case Of Type B Aortic Dissection Leading To Acute Renal Failure, Hinal Rathi, Daniel Neuberger, John Fanning
A Case Of Type B Aortic Dissection Leading To Acute Renal Failure, Hinal Rathi, Daniel Neuberger, John Fanning
UAB Huntsville Research Day - All Presentations
No abstract provided.
Elderly And Hematochezia: A Rare Diagnosis Of Gastric B Cell Lymphoma, Hinal Rathi, Gracy Meyer, Soumyadeep Bag, Dakota Turner, Nessy Abraham-Philip
Elderly And Hematochezia: A Rare Diagnosis Of Gastric B Cell Lymphoma, Hinal Rathi, Gracy Meyer, Soumyadeep Bag, Dakota Turner, Nessy Abraham-Philip
UAB Huntsville Research Day - All Presentations
No abstract provided.
Strep Strikes: A Case Of Group A Streptococcal Bacteremia And Second Trimester Pregnancy Loss, Jalen Spain, Racquel Mccrary, Miranda Worley, Rebecca Daugherty
Strep Strikes: A Case Of Group A Streptococcal Bacteremia And Second Trimester Pregnancy Loss, Jalen Spain, Racquel Mccrary, Miranda Worley, Rebecca Daugherty
UAB Huntsville Research Day - All Presentations
No abstract provided.
A New Hope For Depression: Nv-5138’S Game-Changing Potential, Mina Takahashi, Clinton Martin, Richard Shelton
A New Hope For Depression: Nv-5138’S Game-Changing Potential, Mina Takahashi, Clinton Martin, Richard Shelton
UAB Huntsville Research Day - All Presentations
No abstract provided.
Comparative Analysis Of Lewy Body Dementia And Other Dementia Types, Mina Takahashi, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
Comparative Analysis Of Lewy Body Dementia And Other Dementia Types, Mina Takahashi, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
UAB Huntsville Research Day - All Presentations
No abstract provided.
Exploring Alzheimer’S Disease: Advances In Understanding And Care, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
Exploring Alzheimer’S Disease: Advances In Understanding And Care, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
UAB Huntsville Research Day - All Presentations
No abstract provided.
Inside Pick’S Disease: A Case Of Frontotemporal Dementia, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
Inside Pick’S Disease: A Case Of Frontotemporal Dementia, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
UAB Huntsville Research Day - All Presentations
No abstract provided.
Vascular Dementia: Protect Your Blood Flow, Preserve Your Memory, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
Vascular Dementia: Protect Your Blood Flow, Preserve Your Memory, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin
UAB Huntsville Research Day - All Presentations
No abstract provided.
Family Narratives Of Immigration And Identity, Miranda Victoria Brunn
Family Narratives Of Immigration And Identity, Miranda Victoria Brunn
All ETDs from UAB
This study investigates themes and lessons present in diverse intergenerational family stories of immigration. Effects of participant perceptions of lesson valence on resilience and relational closeness were observed in an emerging adult sample (N = 42), using the lens of Communicated Narrative Sensemaking Theory (CNSM). Additionally, participant perception of lesson utility was observed in relation to emerging adults’ prior thought and intent to share their family stories. Lastly, with whom emerging adults share their family stories was considered. A mixed methods approach was employed, utilizing an online survey with scales and open-ended text boxes. Findings revealed thirty-three distinct themes and …
Rural Adolescent Girls' Experiences With Female Antiheroes: A Phenomenological Study Of Literature Discussions And Mentorship, Candice Kennedy Byers
Rural Adolescent Girls' Experiences With Female Antiheroes: A Phenomenological Study Of Literature Discussions And Mentorship, Candice Kennedy Byers
All ETDs from UAB
This phenomenological research study focused on the experiences of rural adolescent girls reading female led multicultural young adult literature with the guidance of a female mentor teacher. Using two multicultural young adult novels one with a strong female protagonist and one with a female antihero protagonist, this five-week study sought to explore the lived experiences of 14 adolescent girls in the rural Southeast. The theoretical frameworks of Radical Feminism (Lawford-Smith, 2022; hooks, 2015; Kreps 1972; Rhodes, 2005), Critical Race Theory (Crenshaw, 1988; Ladson-Billings. 2003; Delgado, 1989; Harris 1993), and Multicultural Young Adult Literature (Nieto, 2002; Fox & Short, 2003; Boyd …
Evaluation Of The Niosh Sound Level Meter App In Real Work Settings, Maxwell Scott Costlow
Evaluation Of The Niosh Sound Level Meter App In Real Work Settings, Maxwell Scott Costlow
All ETDs from UAB
With the significant presence of occupational noise exposure, the development of mobile sound measurement applications has been reported. These apps have the potential to help reduce purchasing costs of sampling equipment for small businesses. One of the most promising apps is the National Institute for Occupational Safety and Health (NIOSH) Sound Level Meter (SLM), but most studies on the accuracy of the app have been conducted in controlled labs. The purpose of this study was to examine the differences between the NIOSH SLM and type 2 noise measuring instruments in real work settings. Both short-term and long-term noise sampling was …
Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus
Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus
All ETDs from UAB
An understanding of nutrition can improve culture of sea urchins, whether as a research model or in the production of seafood products. Macronutrients, including dietary protein sources, can affect growth and reproductive profiles and alter resource allocation to somatic and gametic tissues. Although sea urchins in culture can be fed natural products, diet formulations using various ingredients can be developed to reliably produce desired outcomes. Single-cell protein sources represent a potential alternative to current industry standards of animal-derived protein sources such as fish and squid meal, which are becoming increasingly overfished and expensive. In the present study, we evaluated the …
Optimizing Recruitment Strategies, Outcome Measures, And Intervention In Clinical Research With Adults With Multiple Sclerosis: Insights From The Tele-Exercise And Multiple Sclerosis (Teams) Study, Tracy Flemming Tracy
Optimizing Recruitment Strategies, Outcome Measures, And Intervention In Clinical Research With Adults With Multiple Sclerosis: Insights From The Tele-Exercise And Multiple Sclerosis (Teams) Study, Tracy Flemming Tracy
All ETDs from UAB
Background: Recruiting people with multiple sclerosis (PwMS) into research can be a significant challenge. This is often due to limited awareness of the research objectives, lack of accessibility, and restrictive inclusion criteria. In addition to a general reluctance to participate, assessing multiple sclerosis (MS) and assigning appropriate interventions can be challenging due to the heterogeneity of symptoms. Identifying outcome measures that accurately reflect a participant’s perception and functional performance, while remaining sensitive to change across different levels of disability, poses a challenge. Methods: Data from the Tele-Exercise and Multiple Sclerosis (TEAMS) trial was analyzed to identify effective recruitment strategies (Study …
Effect Of Pre-Treatment Lab-Based Comorbidities On Treatment Related Outcomes Among Patients With Cancer, Jeffrey Alan Franks
Effect Of Pre-Treatment Lab-Based Comorbidities On Treatment Related Outcomes Among Patients With Cancer, Jeffrey Alan Franks
All ETDs from UAB
Cancer is one of the leading causes of mortality and morbidity in the United States. In addition to their cancer, nearly 50% of individuals have a comorbid condition. This adds complexity to the treatment of these patients as it may delay cancer diagnosis or treatment or prevent treatment all together. Lab-values are an important tool to measure comorbidities and end-organ damage as they are routinely captured as part of standard of care and the basis of clinician decision making. However, despite the widespread multimorbidity and how crucial they are to decision making, few studies assess the association of lab abnormalities …
Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet
Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet
All ETDs from UAB
Radioactive iodine (RAI) has been effective in the treatment of thyroid cancer, the most common endocrine neoplasia, since its introduction into clinical use over eighty years ago. However, not all patients benefit from RAI. Up to 20% of patients with well-differentiated thyroid cancer (WDTC) become radioactive iodine refractory (RAI-R). These RAI-R patients have 5-year survival rates of 50% and 10-year survival rates of 10%. In addition, more aggressive subtypes including oncocytic thyroid carcinoma (OC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC) are less responsive to RAI therapy. Despite accounting for less than 5% of annual thyroid cancer …
Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain
Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain
All ETDs from UAB
The adult mammalian heart lacks regenerative capacity to replenish cardiomyocytes (CMs) lost due to myocardial infarction (MI). Instead, the damaged heart undergoes extensive remodeling that significantly impairs normal cardiac function and may eventually lead to heart failure. Recent therapies that implant engineered tissues fabricated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have shown promising results with improved cardiac function and structural integration. However, the extent of electrophysiological coupling between engineered and host tissue remains unclear. This is a critical factor for functional integration of the implant as well as for arrhythmia risk arising from the implant. Our study aims …
Development Of A Resistive Force Paradigm For The Treatment Of Hemiparesis, Jonathan Daniel Hill
Development Of A Resistive Force Paradigm For The Treatment Of Hemiparesis, Jonathan Daniel Hill
All ETDs from UAB
Hemiparesis is weakening of one side of the body as a result of a stroke that contributes to a decrease in propelling forces (i.e. propulsion) while walking. Existing research to improve propulsion of individuals post-stroke has implemented single-belt and split-belt treadmills, various walking speeds, asynchronous belt speeds (on split-belt treadmills), and a variety of methods for inducing resistive force upon a paretic limb in an attempt to strengthen the paretic limb and improve overall gait symmetry. However, despite this concerted effort of clinicians and scientists, gait deficits remain. Novel methods are required to improve reduced propulsion of individuals post-stroke. Recently, …
The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh
The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh
All ETDs from UAB
Aquaporin-3 (AQP3) mediates basolateral water transport in the kidney collecting duct principal cells, contributing to vasopressin-mediated urine concentration. We previously identified a novel post-translational modification of AQP3, the acetylation of lysine 282 (K282), which we hypothesized as a positive regulator of AQP3 water permeability. First, we found that collecting duct K282 acetylated AQP3 increased upon water deprivation, suggesting an involvement in renal water balance. To decipher the functional role of this modification, we utilized AQP3 acetylation (K282Q or Q) and deacetylation (K282R or R) mimetic mutant mice models generated using CRISPR/Cas9 knock-in technology. Both male and female wild-type (WT) and …
The Impact Of Transportation Insecurity On No-Show Appointments And Acute Care Utilization In Pediatric Sickle Cell Patients, Seabrook Hannah Jeffcoat
The Impact Of Transportation Insecurity On No-Show Appointments And Acute Care Utilization In Pediatric Sickle Cell Patients, Seabrook Hannah Jeffcoat
All ETDs from UAB
Sickle cell disease (SCD) patients experience high levels of transportation insecurity. Missed or delayed medical care due to transportation barriers can result in worsened clinical outcomes and increased hospital admissions and emergency department (ED) visits. We hypothesized that the relationship between transportation insecurity and acute care utilization is partially mediated by no-show appointments. This retrospective cohort study included 101 SCD patients aged ≤ 21 treated through the Pediatric Sickle Cell Clinic at Children’s of Alabama (COA) hospital from 2023 to 2024 and completed a social determinants of health (SDoH) questionnaire. Negative binomial or Poisson regression was used to model ED …
Mechanoactivation Of Vegfr-2 Promotes Angiogenesis In The Tumor Microenvironment, Bronte Johnson
Mechanoactivation Of Vegfr-2 Promotes Angiogenesis In The Tumor Microenvironment, Bronte Johnson
All ETDs from UAB
Cancer progression relies on blood vessel growth; without vasculature, tumors would be limited to less than 200µm in diameter. With this reasoning, several cancer therapies have been developed that target the process of angiogenesis, or the growth of vessels off pre-existing vasculature. These treatments target the major promoters of angiogenesis, vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2); however, anti-angiogenic therapies are not effective by themselves. This is likely due to mechanoactivation of VEGFR-2 through physical alterations in the tumor microenvironment (TME). One prevalent mechanical change is increased strain on surrounding cells and matrix due to highly contractile …
In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi
In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi
All ETDs from UAB
After the Berlin Conference of 1884-1885, the Great Powers of Europe, including the newly-born German Empire, greatly expanded their influence and colonial possessions in Africa, with colonies in East Asia and the South Pacific quickly following suit. The German Empire, like its contemporaries, engaged with medicine as a necessary part of its colonial endeavors in order to keep both its native laborers and European settlers healthy. Using documents from the German Bundesarchiv (Federal Archive), including official reports made to the German Colonial Office and documenting of formally conducted expeditions, as well as the writings of colonial doctors, this research examines …
Investigating The Role Of Notch1 On Cell Viability In Pancreatic Neuroendocrine Tumor Cells In Hypoxia, Alexis Kennedy
Investigating The Role Of Notch1 On Cell Viability In Pancreatic Neuroendocrine Tumor Cells In Hypoxia, Alexis Kennedy
All ETDs from UAB
INVESTIGATING THE ROLE OF NOTCH1 ON CELL VIABILITY IN PANCREATIC NEUROENDOCRINE TUMOR CELLS IN HYPOXIA ALEXIS KENNEDY MULTIDISCIPLINARY BIOMEDICAL SCIENCE ABSTRACT Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms originating from neuroendocrine cells in the pancreas. Patients with advanced disease pose a complex challenge due to poor prognosis and limited treatment options. Notch signaling is a juxtracrine cell-cell communication mechanism whereby transmembrane Notch receptors (Notch 1-4) interact with neighboring cells through ligands binding, resulting in a cascade that regulates various developmental processes and cell fate decisions. Dysregulated Notch1 signaling is implicated in PNETs, affecting neuroendocrine tumor biology and potentially interacting with …
Evaluation Of In Vitro Cardiac Models For Characterizing The Role Of Autophagy In Streptococcus Pneumoniae Infection, Georgianna Khong
Evaluation Of In Vitro Cardiac Models For Characterizing The Role Of Autophagy In Streptococcus Pneumoniae Infection, Georgianna Khong
All ETDs from UAB
Streptococcus pneumoniae (Spn) is a gram-positive bacterium that causes community-acquired pneumonia, the most prevalent type of pneumonia and a predominant infectious disease. There is evidence linking Spn infection to cardiovascular damage through the ability of Spn to invade and replicate in the myocardium, inducing cardiomyocyte death and disrupting cardiac function. Spn infects cardiomyocytes intracellularly through clathrin-mediated endocytosis, with demonstrated evidence of inhibitory mechanisms including clathrin-mediated endocytosis inhibitors and antioxidants. As a result, autophagy is being investigated as a potential pathway for cardiomyocyte self-defense against Spn, as it may protect cardiomyocytes intracellularly. The primary objective of this study was to evaluate …
Optic Nerve Head Remodeling In Experimental High Myopia, Mahmoud Khalafallah
Optic Nerve Head Remodeling In Experimental High Myopia, Mahmoud Khalafallah
All ETDs from UAB
Myopia is a global health concern, with projected estimates that nearly half of the world's population will be myopic by 2050. While its refractive aspect can be corrected, the heightened susceptibility to sight-threatening comorbidities, particularly with high myopia, remains a challenge. Among these comorbidities, glaucoma is a major concern, with myopia recognized as an independent risk factor. However, the mechanistic link between myopia and glaucoma remains poorly understood. This dissertation investigates the multiscale remodeling changes in experimental high myopia and their potential implications for increased risk of glaucoma later in life. Using a multimodal approach, this dissertation investigates: (1) neural …
Endothelial Cell Cd36 In Alzheimer’S Disease And Breast Cancer Progression, Atul Kumar
Endothelial Cell Cd36 In Alzheimer’S Disease And Breast Cancer Progression, Atul Kumar
All ETDs from UAB
Vascular endothelial cells (ECs) are increasingly recognized as a distinct class of innate immune cells, with CD36, an innate immunity receptor, playing a pivotal role in regulating immune function and its regulation, angiogenesis, cancer progression, brain related disorder as well as the exchange of nutrients and waste. To investigate this further, we developed EC-specific CD36 knockout mice using the translating ribosome affinity purification (TRAP) technique. By isolating ribosome-bound mRNA directly from vascular endothelial cells in vivo in these knockout and control mice, we conducted deep RNA sequencing and transcriptional profiling. Our findings revealed that CD36 deficiency in brain endothelia led …