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Full-Text Articles in Entire DC Network
Turn On, Tune In, Drop Shame: Exploring The Unique Therapeutic Potential Of Psychedelics For Sexual And Gender Minority Populations, Nicholas Carlisle
Turn On, Tune In, Drop Shame: Exploring The Unique Therapeutic Potential Of Psychedelics For Sexual And Gender Minority Populations, Nicholas Carlisle
All ETDs from UAB
Sexual and gender minority (SGM) individuals face significant disparities in mental and physical health compared to their heterosexual and cisgender counterparts, due in part to chronic exposure to distal and proximal minority stressors. Shame – a self-focused characterized by a global sense of personal deficiency or unworthiness – has emerged as a key intrapersonal mechanism linking minority stressors to adverse health outcomes. This dissertation explores the role of shame in SGM health inequities and investigates the emerging potential of psychedelics to reduce shame and improve health and wellbeing in these populations. This three-paper dissertation begins with a scoping review (Paper …
Influenza A Virus Increases Susceptibility To Streptococcus Pneumoniae By Damaging The Airway Epithelium, Erin Yepsen Earnhardt
Influenza A Virus Increases Susceptibility To Streptococcus Pneumoniae By Damaging The Airway Epithelium, Erin Yepsen Earnhardt
All ETDs from UAB
Influenza A Virus (IAV) is commonly complicated by secondary bacterial infections with Streptococcus pneumoniae (Spn), leading to increased morbidity and mortality. Recent work from our lab demonstrates that an IAV-induced loss of cystic fibrosis transmembrane conductance regulator (CFTR) in the airway disrupts the rheostatic properties of the airway surface liquid (ASL). In cystic fibrosis, caused by mutations in the CFTR gene, there is an increase in the bacterial burden of the airway. However, the underlying mechanisms and damage caused by IAV-induced CFTR dysfunction in the airway remains unknown. Using a primary differentiated human bronchial airway epithelial cell culture (HBEC) system, …
Mcl1 And Hexokinase 2 Form A Glucose Metabolic Regulatory Axis, Robert Lee
Mcl1 And Hexokinase 2 Form A Glucose Metabolic Regulatory Axis, Robert Lee
All ETDs from UAB
Hexokinase 2 (HK2) initiates glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate providing the starting substrate for a vast array of metabolic pathways such as glycolysis, pentose phosphate pathway (PPP), amino acid biosynthesis and others. While HK2’s metabolic role in normal physiologic function (such as in cardiomyocytes) and cancers (through driving the Warburg Effect) are well established, there is emerging evidence that supports HK2 is also a critical mediator of protein-protein interactions that regulate cell survival. Through comprehensive review, we explore how HK2 contributes to cell survival through metabolic and protein scaffolding roles. We also investigate a novel …
Lineage-Associated Zinc Metalloprotease B And Its Impact On Cardiac Damage Elicited During Invasive Pneumococcal Disease, Jennifer Nichelle Luck
Lineage-Associated Zinc Metalloprotease B And Its Impact On Cardiac Damage Elicited During Invasive Pneumococcal Disease, Jennifer Nichelle Luck
All ETDs from UAB
During invasive disease, certain strains of Streptococcus pneumoniae (Spn) can invade the myocardium, damaging cardiomyocytes and predisposing patients to life-threatening cardiac complications. To identify genetic loci involved in pneumococcal cardio-virulence, we performed a bacterial genome-wide association study using 825 genomes corresponding to 17 distinct Spn lineages associated with varying rates of cardiac complications during hospitalization for pneumonia. This led to the identification of an allele of zmpB, the gene encoding Zinc metalloprotease B (ZmpB). Infection of mice with a ZmpB deficient mutant, i.e., TIGR4ΔzmpB, found that ZmpB was required to form foci of infection in the heart, i.e., cardiac microlesions. …
Virulence Factors And Their Binding Partners: A Biochemical Study, Morgan E. Blake
Virulence Factors And Their Binding Partners: A Biochemical Study, Morgan E. Blake
All ETDs from UAB
Virulence factors are an important mechanism by which viruses combat the host immune system, therefore a thorough understanding of the workings of these proteins will be of significant value in prevention of disease associated with viral infections. In this dissertation we investigate the main virulence factors of two viruses, the Influenza A Virus (IAV) and SARS-CoV-2, and their interactions with host proteins, providing critical information for structure-based drug design. In chapter one we studied the nonstructural protein 1 (NS1) of IAV and its interaction with the 30-kda subunit of the cleavage and polyadenylation specificity factor (CPSF30) to inhibit host cell …
Amygdala Npy+ Interneurons Are Activated By Aversive Stim-Uli, Patric Perez
Amygdala Npy+ Interneurons Are Activated By Aversive Stim-Uli, Patric Perez
All ETDs from UAB
Neuropeptide Y (NPY) serves as a critical endogenous anxiolytic and stress-buffering molecule, yet the temporal and spatial dynamics of NPY+ cells during fear learning re-main unknown. Temporal dynamics can be measured with in vivo calcium imaging tech-niques, which enable real-time monitoring of cell-type-specific neural activity in freely behaving animals. Snapshots of neuronal activation can be measured using c-Fos im-munohistochemistry, thereby providing excellent spatial resolution. Here, I employ cut-ting-edge approaches to characterize the temporal and spatial activation patterns of NPY+ cells in amygdala, a key fear-regulating brain region negatively impacted by aversive events. I first used in vivo fiber photometry, together …
Understanding Psychotic Disorders Using Normative Modeling-Derived Individual-Level Brain Structural Abnormalities, Natalie Remiszewski
Understanding Psychotic Disorders Using Normative Modeling-Derived Individual-Level Brain Structural Abnormalities, Natalie Remiszewski
All ETDs from UAB
Psychosis is an heterogenous condition that occurs in many psychiatric disorders. It has a variable symptom presentation and recent initiatives have suggested that investigating the underlying neurobiology of psychiatric disorders rather than their symptomatology would provide a more accurate picture for diagnosis, prognosis, and treatment. Grey matter has been implicated in the pathophysiology of psychosis and psychotic disorders, though significant natural variation due to age and sex have impeded the distinction of pathologically relevant grey matter abnormalities in psychosis. Additionally, case-control approaches to exploring grey matter abnormalities in psychotic disorders often obscure subtle variation in individuals. Here, we utilize a …
Standardizing Sea Urchin Husbandry: Tank Effects, Gamete Production, And Co-Culture, Raven Amber Edwards
Standardizing Sea Urchin Husbandry: Tank Effects, Gamete Production, And Co-Culture, Raven Amber Edwards
All ETDs from UAB
This dissertation seeks to further knowledge of sea urchin husbandry in three major areas that have so far not been investigated substantially: optimal conditions for housing sea urchins in a lab-based recirculating aquaculture systems (RAS), impacts of repetitive spawning regimens on reproductive output, and co-culture utilizing juvenile oysters. All studies utilize a commercial recirculating aquaculture system that is relatively novel for culturing sea urchins. The first chapter investigated the influence of housing conditions on sea urchin growth outcomes. Under the conditions of this study, the size of the tank showed limited influence on growth; however, stocking density was found to …
Structural And Functional Investigation Of The Influenza Nuclear Export Protein, Andrew James Staup
Structural And Functional Investigation Of The Influenza Nuclear Export Protein, Andrew James Staup
All ETDs from UAB
The influenza A nuclear export protein (NEP) is a multi-functional protein that mediates the export of progeny viral ribonucleoprotein (vRNP) complexes from the host nucleus, regulates the activity of the RNA-dependent RNA polymerase (RdRp), and is implicated in zoonosis. It is therefore critical to understand the mechanisms of NEP’s functions at the molecular level to inform its roles in the viral lifecycle and influenza zoonosis. In this dissertation, we report the structure of NEP in complex with the host nuclear export holo-complex as well as investigate the biophysical effects of the adaptive M16I mutation on NEP. We solved the cryo-electron …
Wellness Perspectives Of Early Career Teachers: An Exploratory Study Of School Culture And Environment, Amy Day Carr
Wellness Perspectives Of Early Career Teachers: An Exploratory Study Of School Culture And Environment, Amy Day Carr
All ETDs from UAB
Purpose: The purpose of this grounded theory dissertation was to explore Alabama early career teachers’ perceptions of personal wellness, the wellness culture and environment of their school system, and the impact of the culture on teacher wellness and job satisfaction. Early career teachers face unique challenges that contribute to high turnover rates, yet their wellness has not been systematically studied. This study sought to answer three primary research questions with sub-questions. Teachers were asked to describe their personal wellness, the wellness culture at their schools, and the effect of the wellness culture and environment of the school on teachers in …
Strength Of Self-Adhesive Resin Cements To Shortened Zirconia Crowns With And Without An Additional Coat Of Adhesive, Abraham John
Strength Of Self-Adhesive Resin Cements To Shortened Zirconia Crowns With And Without An Additional Coat Of Adhesive, Abraham John
All ETDs from UAB
Self-adhesive cements have gained popularity due to their ease of manipulation as they do not require a separate etch, primer, or bonding agent to bond to the tooth or crown surfaces. However, the use of an adhesive bonding agent with a self-adhesive resin cement has been claimed to improve its bond strength. The objective of this study is to compare the retention bond strength of 2 self-adhesive cements on to the tooth surface with and without the use of bonding agents with a known control. Materials and Methods: A total of 50 extracted non-carious second premolar teeth were collected. The …
Reducing The Risk Of Phishing Attacks Through Providing Consistent Training Via The Kaizen Education Platform, Dalton E. Pena
Reducing The Risk Of Phishing Attacks Through Providing Consistent Training Via The Kaizen Education Platform, Dalton E. Pena
All ETDs from UAB
Introduction: Many healthcare organizations have experienced cybersecurity related phishing email attacks, costing these organizations many thousands to many millions of dollars to release ransomed data to maintain patient care delivery and operations. Use of technology alone has proven to be insufficient, as most occurrences of data breaches are related to human behaviors. Background: Cybersecurity is a threat increasingly common to healthcare organizations, and it is gaining in both sophistication and complexity, aided by artificial intelligence. Healthcare organizations have adopted new technologies and increased the prevalence of cybersecurity training to develop a healthy cyber culture and construct a human firewall against …
Influence Of Transportation Access And Geographic Distance On Retention And Completion In Substance Use Treatment: A Retrospective Study Of In-Person And Telehealth Modalities, Yasemin Tanik Morgan
Influence Of Transportation Access And Geographic Distance On Retention And Completion In Substance Use Treatment: A Retrospective Study Of In-Person And Telehealth Modalities, Yasemin Tanik Morgan
All ETDs from UAB
Substance use disorder (SUD) remains a public health concern in the United States. Low-income and underserved populations continue to face barriers to accessing effective treatment. The rapid expansion of telehealth has been proposed as a solution to barriers such as geographic distance and transportation. However, it is unclear whether telehealth effectively addresses these barriers or how access-related factors influence treatment outcomes across care modalities. This retrospective cohort study, guided by the Social Determinants of Health (SDOH) framework, evaluated the impact of treatment modality, transportation access, and geographic distance on retention and completion in a publicly funded Intensive Outpatient Program (IOP) …
Murder On The Axonal Express: Synucleinopathy Disruption Of 14-3-3 Protein-Protein Interactions Impairs Axonal Trafficking, Frank Sanders Pair
Murder On The Axonal Express: Synucleinopathy Disruption Of 14-3-3 Protein-Protein Interactions Impairs Axonal Trafficking, Frank Sanders Pair
All ETDs from UAB
14-3-3s are a family of proteins highly expressed in the brain. These proteins exert their functions mainly through protein-protein interactions (PPIs) and have thousands of binding partners. 14-3-3s have been shown to be present in pro-teinaceous aggregates of alpha-synuclein (αsyn), a pathological hallmark of synucleinopathies. This includes such diseases as Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB). 14-3-3 proteins, particularly the 14-3-3θ isoform, have been shown to be protective in multiple synucleinopathy models. However, reduced soluble levels of 14-3-3s and increased phosphorylation of 14-3-3θ at S232 observed in synucleinopathies like DLB may impair their protec-tive ability, potentially due …
Attitudes Of Optometrists Towards Referring Patients For Nutrition And Lifestyle Changes To Treat Diabetic Retinopathy And Age-Related Macular Degeneration, Samantha Chapman
Attitudes Of Optometrists Towards Referring Patients For Nutrition And Lifestyle Changes To Treat Diabetic Retinopathy And Age-Related Macular Degeneration, Samantha Chapman
All ETDs from UAB
Some ocular diseases, including diabetic retinopathy and age-related macular degeneration, have direct links to systemic diseases or the condition of the body as a whole. Specific diet and lifestyle changes have been studied in relation to these two diseases and, while it is not within the scope of optometry to prescribe these changes for patients, an optometrist may refer to a variety of specialists so that patients can receive the most holistic care available. The primary goal of this study is to assess the attitudes of currently practicing United States optometrists towards referring to nutrition and lifestyle professionals and their …
September 10, 2025 Blazer Weekly, University Of Alabama At Birmingham
September 10, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
September 9, 2025 Ereporter, University Of Alabama At Birmingham
September 9, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
September 5, 2025 Ereporter, University Of Alabama At Birmingham
September 5, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Prosthetics In The Time Of Proust, Ashley S. Mcguire
Prosthetics In The Time Of Proust, Ashley S. Mcguire
Patent Coloring Books
Patent coloring book
August 27, 2025 Blazer Weekly, University Of Alabama At Birmingham
August 27, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
August 26, 2025 Ereporter, University Of Alabama At Birmingham
August 26, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 19, 2025 Ereporter, University Of Alabama At Birmingham
August 19, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 15, 2025 Ereporter, University Of Alabama At Birmingham
August 15, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 12, 2025 Ereporter, University Of Alabama At Birmingham
August 12, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 8, 2025 Ereporter, University Of Alabama At Birmingham
August 8, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 6, 2025 Blazer Weekly, University Of Alabama At Birmingham
August 6, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
Uab Libraries News, 08/09 2025, Uab Libraries
Uab Libraries News, 08/09 2025, Uab Libraries
UAB Libraries News
No abstract provided.
August 1, 2025 Ereporter, University Of Alabama At Birmingham
August 1, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
July 30, 2025 Blazer Weekly, University Of Alabama At Birmingham
July 30, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
July 29, 2025 Ereporter, University Of Alabama At Birmingham
July 29, 2025 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.