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September 12, 2025 Ereporter, University Of Alabama At Birmingham Sep 2025

September 12, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

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Financial Outcomes In Value-Based Care: A Comparative Claims-Based Study Of Medicare Advantage Patients In Investor-Backed Primary Care Practices Pre/Post Investment, Aaron Mark Bujnowski Sep 2025

Financial Outcomes In Value-Based Care: A Comparative Claims-Based Study Of Medicare Advantage Patients In Investor-Backed Primary Care Practices Pre/Post Investment, Aaron Mark Bujnowski

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Medicare Advantage (MA) plans are value-based care (VBC) models aimed at improving cost and quality through prevention to counter the traditional fee-for-service (FFS) Medicare care model, which disincentivizes preventive care and risks misuse and overutilization. Some primary care practices purporting VBC capabilities have attracted private capital investors, yet whether external investment improves cost outcomes has not yet been definitively established. This dissertation examines whether investor-backed primary care organizations participating in MA demonstrate statistically significant reductions in per-patient, per-year claims costs after investment for seven ambulatory care–sensitive conditions. The study applies two-way fixed-effects regression models to a sample of 98,014 patient-year …

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Structural Analysis Of Pseudomonas Phage Dev Virion-Associated Rna Polymerase (Gp71), James Scherer Sep 2025

Structural Analysis Of Pseudomonas Phage Dev Virion-Associated Rna Polymerase (Gp71), James Scherer

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DEV is a Pseudomonas aeruginosa bacteriophage part of a newly reclassified genus called Schitoviridae. This group of bacteriophages is also referred to as “N4-like” phages, after the prototypical Escherichia coli phage N4, originally isolated from sewage water in 19661. N4, and other phages in the group, contain a large, virion-associated RNA polymerase (vRNAP). This vRNAP is vital to the proliferation of the phage, as it performs the transcription of the early gene products and potentially acts as a motor that helps eject the viral genome into the host bacteria. In DEV, the vRNAP is also known as gene product 71 …

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The Hepatic Glucagon Receptor As A Novel Regulator Of Lifespan, Alexander Tate Lasher Sep 2025

The Hepatic Glucagon Receptor As A Novel Regulator Of Lifespan, Alexander Tate Lasher

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In developed nations the average lifespan has nearly doubled over the last 200 years, and the proportion of humans living into old age is ever increasing. While this is certainly a testament to the effectiveness of modern medicine and infrastructure, it presents a unique challenge to public health. Gains to health have not necessarily kept pace with the gains in lifespan, and the expanding aged population positions age-associated diseases to reach unprecedented prevalence. In light of this challenge, a mechanistic understanding of the aging process is necessary to identify factors that control longevity and to ultimately develop strategies for healthy …

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Fqhc Turnaround Success – Does Leadership Matter?, Luis Orlando Amaro Sep 2025

Fqhc Turnaround Success – Does Leadership Matter?, Luis Orlando Amaro

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Background: Federally Qualified Health Centers (FQHCs) are essential providers of primary care in underserved communities but face growing risks of financial instability. Leader transitions, particularly at the executive level, may influence an organization's ability to recover from fiscal distress. This study examined whether executive succession—and the type of succession (internal vs. external)—was associated with financial turnaround among distressed FQHCs. Methods: Financial distress was assessed using the Modified Altman Z-Score, a validated indicator of fiscal health in nonprofit organizations. A longitudinal, quantitative design was used to analyze 850 FQHCs across the United States over a six-year period (2017–2022). Financial performance was …

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The Resilience In Black Families Scale: A Validation Study, Destiny Kelly Sep 2025

The Resilience In Black Families Scale: A Validation Study, Destiny Kelly

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The Resilience in Black Families Scale (RBFS) was developed to be a culturally relevant measure designed to assess the family resilience processes utilized within Black families. The purpose of this study was to validate the RBFS, which consists of a three-factor structure modeled after Walsh’s family resilience framework and is further enhanced with culturally relevant protective factors. Using a sample of 200 participants, confirmatory factor analysis (CFA) was conducted to test the theoretical hierarchical factor structure of the Resilience in Black Families model, consisting of 13 first order factors (making meaning of adversity, positive outlook, religiosity and spirituality, ethnic-racial socialization, …

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Interactions Between Staphylococcus Aureus And Corynebacterium Species In The Context Of Chronic Rhinosinusitis, Joshua Tucker Huffines Sep 2025

Interactions Between Staphylococcus Aureus And Corynebacterium Species In The Context Of Chronic Rhinosinusitis, Joshua Tucker Huffines

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Chronic rhinosinusitis (CRS) is a complex inflammatory disease affecting the upper respiratory tract (URT) for a large portion of the populace, leading to significant economic burdens. Staphylococcus aureus is considered as a significant contributor to CRS inflammation through the production of toxins regulated through quorum sensing (QS). Microbiome studies have characterized the microbial communities present in the healthy URT and in CRS. These studies show that the genus Corynebacterium is associated with the healthy URT, decreased in CRS, and has a negative correlation with S. aureus regardless of health status. A few studies have partially characterized a mechanism to explain …

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Leveraging Computational Modelling/Simulation, Machine Learning, And Additive Manufacturing For Customized Design Of Periodontal And Bone Tissue Scaffolds, Rakesh Pemmada Sep 2025

Leveraging Computational Modelling/Simulation, Machine Learning, And Additive Manufacturing For Customized Design Of Periodontal And Bone Tissue Scaffolds, Rakesh Pemmada

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The current dissertation presents an overarching pipeline for the development and production of custom-made scaffolds for periodontal tissue regeneration using finite element analysis (FEA), machine learning (ML), and additive manufacturing (AM).CAD anatomically realistic scaffolds were generated from CT-based maxilla and mandible models. The FEA simulation results under masticatory (100 N), parafunctional (500–550 N), and traumatic (800–850 N) loads showed region-specific distribution of stresses and strains, which guided structural reinforcement strategies. Over 1000 3D-printed PCL scaffolds were printed using various pore diameters (200–300 µm) and filament diameters. Five ML models were constructed for predicting print quality based on process factors. Classification …

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Mechanism Of Targeted Cancer Therapeutics-Induced Cardiotoxicity, Angelica Toro-Cora Sep 2025

Mechanism Of Targeted Cancer Therapeutics-Induced Cardiotoxicity, Angelica Toro-Cora

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Targeted cancer therapies are known to cause cardiovascular (CV) complications in human patients. Agents such as osimertinib, a tyrosine kinase inhibitor (TKI), as well as immune checkpoint inhibitors (ICIs) have been demonstrated to induce severe cardiotoxicities, including heart failure and myocarditis. Nevertheless, the mechanisms of TKIs and ICIs-induced cardiotoxicity remain poorly understood. Herein, we developed the first in vivo preclinical model of osimertinib-induced cardiotoxicity using a transverse aortic constriction (TAC) mouse model. Osimertinib-treated mice displayed severe cardiac dysfunction, elevated markers of heart failure and fibrosis, and failed to undergo compensatory hypertrophic remodeling, resulting in cardiomyocyte death. Mechanistically, we identified suppression …

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Breath Acetone As A Biomarker For Concussion, Allyn Abadie Sep 2025

Breath Acetone As A Biomarker For Concussion, Allyn Abadie

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Concussions represent a critical public health concern, affecting millions annually yet remain challenging to diagnose and manage. Concussions involve a range of often invisible signs and symptoms. Traditional assessments rely heavily on subjective symptom reporting, with limited objective data which may complicate return-to-play decisions. Objective physiological biomarkers are needed to complement traditional methods, detect subtle disruptions, and improve decision-making. Following concussion, the brain undergoes a neurometabolic cascade involving disrupted glucose utilization, ionic imbalances, neurotransmitter release, and reduced cerebral blood flow. This cascade creates a metabolic crisis, potentially shifting energy metabolism toward alternative substrates such as ketones. Breath acetone, a measurable …

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The Role Of Histone Deacetylase Complexes In Cardiomyocyes And Heart Diseases, Meimei Wang Sep 2025

The Role Of Histone Deacetylase Complexes In Cardiomyocyes And Heart Diseases, Meimei Wang

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Histone deacetylase complexes play pivotal roles in cardiac biology, however their specific functions in cell fate transitions and adult heart maintenance re-main unclear. We identified the role of HDAC complex in vitro during direct cardiac repro-gramming and in vivo through specific cardiomyocyte deletion of ELMSAN1, a core component of the MiDAC complex. We perform direct cardiac reprogram-ming using a polycistronic construct (hMGT133) expressing MEF2C, GATA4, TBX5, and miR-133. MEF2C expression peaked early, while cardiac markers such as cardiac troponin and α-actinin emerged by Day 9. HDAC1 levels and global histone acetylation (H3K9ac, H3K14ac, H3K27ac) declined over time. An RNAi screen …

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Exploring The Influence Of Leadership On The Organizational Performance Of Federally Qualified Health Centers In The United States Through The Lens Of The Upper Echelons Theory, Devdutt Shriram Upadhye Sep 2025

Exploring The Influence Of Leadership On The Organizational Performance Of Federally Qualified Health Centers In The United States Through The Lens Of The Upper Echelons Theory, Devdutt Shriram Upadhye

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This study examines the influence that leaders have on the performance of Federally Qualified Health Centers (FQHCs) in the US. The framework through which the study examines this relationship is the Upper Echelons Theory (UET), which posits that managers and leaders take actions that shape the organization they lead, and these actions are based on a confluence of experiential and characteristic factors. The current study focuses on a leader’s influence through three proxies, viz. educational background, role tenure, and sex, on the organizational performance of FQHCs. Performance is captured using both financial and quality metrics. Data for the study was …

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Immune And Endothelial Cell Mechanisms Of Cardiovascular And Kidney Disease Risk In Obesity, Claudia Edell Sep 2025

Immune And Endothelial Cell Mechanisms Of Cardiovascular And Kidney Disease Risk In Obesity, Claudia Edell

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Obesity is a major risk factor for cardiovascular and chronic kidney disease. Both inflammation and endothelial dysfunction are hallmark signs of adverse health outcomes in obesity. Previous data from our lab has shown that a 2-week time restricted feeding (TRF) intervention reduces kidney CD3+ (T) cells and fibrosis and improves endothelial function in a mouse model of diet induced obesity (DIO). There is little known about kidney damage and T cells in obesity. We hypothesized that TRF reduces kidney damage in obese mice through mitigating T cell inflammation. We use a 20-week DIO model, with 18 weeks of ad libitum …

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Effects Of Probiotic Lactobacilli On Streptococcus Mutans: Implications For Early Childhood Caries, Walaa Al-Turki Sep 2025

Effects Of Probiotic Lactobacilli On Streptococcus Mutans: Implications For Early Childhood Caries, Walaa Al-Turki

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Effects of Probiotic Lactobacilli on Streptococcus mutans: Implications for Early Childhood Caries WALAA MOHIEDEN AL TURKI DENTISTRY ABSTRACT Purpose: Probiotic Lactobacillus species have been shown to have beneficial effects against early childhood caries (ECC) by inhibiting the growth of cariogenic bacteria. However, the acidogenicity of Lactobacillus spp. could have potential carcinogenic effect. The objective of this study was to investigate the effects of probiotic lactobacilli and cariogenic lactobacilli on the growth, biofilm formation, and acid production of Streptococcus mutans (S. mutans). Methods: Growth competition between probiotic L. rhamnosus GG (L-GG) or caries-associated L. rhamnosus M72-26 (L-M72) and S. mutans UA159 …

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A Noncanonical Role Of T Follicular Helper Cells In Promoting Peripheral Tolerance By Supporting T Regulatory Cells, Shivangi Dave Sep 2025

A Noncanonical Role Of T Follicular Helper Cells In Promoting Peripheral Tolerance By Supporting T Regulatory Cells, Shivangi Dave

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T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that sup-port germinal center (GC) B cells and promote antibody (Ab)-mediated immunity. There is growing recognition of the heterogeneity and functional diversity of Tfh cells, supported by accumulating evidence that highlights their context-specific roles across a range of disease settings. While their contribution to B cell responses is well-established, our data demonstrate that Tfh cells have a broader and more dynamic function. In this study, we uncover a novel function of Tfh cells in maintaining immune homeostasis by supporting T regulatory cell (Treg) responses under normal physiological …

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Bayesian Survival Analysis For High-Dimensional Compositional Data, Zhenying Ding Sep 2025

Bayesian Survival Analysis For High-Dimensional Compositional Data, Zhenying Ding

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Survival analysis integrating microbiome and clinical data offers powerful insights into human health. The microbiome influences immunity, inflammation, and cancer outcomes. Combining microbial profiles with clinical factors like tumor stage, treatment, and demographics enhances understanding of how host-microbe interactions affect survival. To analyze these complex datasets, advanced statistical methods, including Bayesian models, penalized Cox proportional hazards models, and machine learning techniques are employed. These approaches can uncover novel biomarkers and therapeutic targets, leading to personalized treatment strategies that optimize patient survival. However, challenges arise due to the compositionality, high-dimensionality, and phylogenetic relation between taxa in microbiome data. In this dissertation, …

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The Role Of The Glycerol Metabolism Regulator Glpr On Pseudomonas Aeruginosa’S Physiology, Nicholas Jordan Evans Sep 2025

The Role Of The Glycerol Metabolism Regulator Glpr On Pseudomonas Aeruginosa’S Physiology, Nicholas Jordan Evans

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Chronic infections with Pseudomonas aeruginosa are a leading cause of morbidity and mortality in people with cystic fibrosis. P. aeruginosa persists in the CF lung through adaptations, including altering the expression of metabolic genes to acquire nutrients that are abundant in the CF airway. Glycerol in the airway is imported and metabolized by proteins encoded in the glp regulon, which is regulated in part by GlpR. The loss of GlpR was previously shown to increase biofilm development in a P. aeruginosa CF isolate compared to a wound isolate. In the first half of this work, we investigated the influence that …

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A Short Trip: A Mixed Methods Investigation Of The Perceived Effects Of Vaporized Dmt Vs Vaporized 5-Meo-Dmt, Cynthia Estrella Ortiz Sep 2025

A Short Trip: A Mixed Methods Investigation Of The Perceived Effects Of Vaporized Dmt Vs Vaporized 5-Meo-Dmt, Cynthia Estrella Ortiz

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The rise in psychedelic use has been accompanied by increased interest in alternative routes of administration, including vaporization. However, little is known about the characteristics and outcomes associated with vaporized forms of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). This mixed-methods study examined the subjective experiences and mental health correlates of individuals who reported using vaporized DMT, vaporized 5-MeO-DMT, or psilocybin mushrooms in the past six months. A total of 209 adults completed an online survey assessing demographic variables, substance use, and psychological functioning, including measures of global health (PROMIS), subjective happiness, magical ideation, spiritual connection, psychosis-like experiences (CAPE-42), and hypomanic symptoms. …

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Investigating The Role Of Fibroblast Growth Factor Signaling In The Cystic Fibrosis Airways, Meghan June Hirsch Sep 2025

Investigating The Role Of Fibroblast Growth Factor Signaling In The Cystic Fibrosis Airways, Meghan June Hirsch

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Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene which results in complications in organs such as the lung, pancreas, liver, and intestines. In the lung, defective CFTR results in thick, sticky mucus that causes susceptibility to colonization of opportunistic pathogens such as Pseudomonas aeruginosa (PA), progressive lung damage, and ultimately a decrease in life expectancy in affected individuals depending on severity of disease. Additionally, one of the characteristics of this disease, with and without PA infection, is chronic inflammation. Chronic inflammation has also been associated with accelerated aging …

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Compartmentalized Antigen Presentation By Intestinal Epithelial Cells Directs Cd4 T Cell Fate, Christopher Garrett Wilson Sep 2025

Compartmentalized Antigen Presentation By Intestinal Epithelial Cells Directs Cd4 T Cell Fate, Christopher Garrett Wilson

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The intestinal epithelium maintains a complex relationship with both commensal microbiota and enteric pathogens while orchestrating local immune responses. Although intestinal epithelial cells (IECs) can express MHC class II molecules during inflammation, their functional contribution to pathogen-specific adaptive immunity and immunological memory remains poorly defined. This dissertation investigates the hypothesis that IECs actively shape CD4+ T cell responses through antigen presentation, using Citrobacter rodentium infection as a physiologically relevant model of human attaching and effacing bacterial pathogens. The C. rodentium model offers unique advantages for dissecting epithelial-immune interactions: it naturally infects mice through oral inoculation, exhibits precise anatomical tropism for …

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Access To Care, Structural Barriers, And Recovery Identity In Mental Health And Substance Use Disorder Treatment, Yahya Alnashri Sep 2025

Access To Care, Structural Barriers, And Recovery Identity In Mental Health And Substance Use Disorder Treatment, Yahya Alnashri

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Substance use disorders (SUDs) remain one of the most pressing public health and economic challenges in the United States, with growing recognition that recovery is a multidimensional process shaped by clinical, social, and structural factors. This dissertation explores recovery at the levels of health policy, population, and experiential levels to assess gaps in access to recovery support services, identify patterns and predictors of recovery identity, and highlight the lived experiences of individuals with opioid use disorder. First, we evaluated whether state Medicaid expansion under the ACA (2010–2019) was associated with changes in the availability of consumer-run peer support services in …

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Pao Induces Er Stress In Endothelial Cells Leading To Barrier Function Dysfunction And Inhibition Of Brd4 Prevents Lewisite-Induced Peribronchial Fibrosis, Huaxiu Zeng Sep 2025

Pao Induces Er Stress In Endothelial Cells Leading To Barrier Function Dysfunction And Inhibition Of Brd4 Prevents Lewisite-Induced Peribronchial Fibrosis, Huaxiu Zeng

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Arsenicals are members of one of the most important global environmental vesicants and are a persistent bio accumulative carcinogen. One of the vesicants and chemical warfare agents is lewisite, which causes lung injury with pulmonary edema, hemorrhage, and respiratory failure. A single cutaneous exposure to lewisite in mice induces systemic lung injury through arsenical-mediated mechanisms. Some subjects develop Bronchiolitis Obliterans Syndrome (BOS) where there is evidence of airway dysfunction and pathologic narrowing of the airways with extracellular protein deposition and fibroblast invasion. In vitro for human lung endothelial cells, Phenyl arsine Oxide (PAO) exposure, as surrogate of lewisite, leads to …

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Proteasome Augmentation Is Protective Against Alzheimer’S Disease And Agerelated Cognitive Decline, Kanisa Davidson Sep 2025

Proteasome Augmentation Is Protective Against Alzheimer’S Disease And Agerelated Cognitive Decline, Kanisa Davidson

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Proteostasis is essential for the degradation of oxidized, misfolded proteins and proper function of neuronal plasticity. Proteasome inhibition has been shown to exacerbate cognitive and behavioral deficits in aging and Alzheimer’s Disease (AD) models. Proteasomal activity is decreased across human and animal models of AD. We hypothesize that aging and AD markers, β-amyloid and/or hyperphosphorylated tau, impair proteasome function, thereby preventing the proteasome’s capacity to degrade critical synaptic proteins essential for memory formation. We investigated the role of pharmacological and genetic augmentation on proteasomal function, to rescue aging and AD-like cognitive deficits in cell culture, Drosophila, and mice. We demonstrate …

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Promoting Mental Health And Social-Emotional Development In Underserved Families, Brianna Paquette Sep 2025

Promoting Mental Health And Social-Emotional Development In Underserved Families, Brianna Paquette

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The overarching goal of this dissertation was to investigate interventions that aimed to support mental health and child development in underserved families. Individuals from low-income households often experience mental health difficulties, such as higher rates of caregiver depression. Additionally, children from disadvantaged backgrounds are more likely to face difficulties with social and emotional development. This dissertation is comprised of three papers exploring interventions to facilitate child development and well-being in low-income families. The first paper is a systematic review and meta-analysis on home visiting interventions aimed at supporting the social-emotional development of children from birth to five years of age. …

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Identifying Functional Regional Changes In Patients With Parkinson’S Disease And Freezing Of Gait, Taylor Robin Davis Sep 2025

Identifying Functional Regional Changes In Patients With Parkinson’S Disease And Freezing Of Gait, Taylor Robin Davis

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Freezing of gait (FOG) affects anywhere from 20-80% of those with Parkinson’s Disease (PD) with the prevalence increasing with disease severity and length. This detrimental symptom is unpredictable and poorly characterized, which adds to the negative experience of FOG as it is difficult to treat. Using resting-state fMRI (rs-fMRI), we set out to determine the functional changes in those with PD-FOG and map onto regions of the brain where signal power, measured using fractional amplitude of low-frequency fluctuations (fALFF), synchronicity, as measured by regional homogeneity (ReHo), and strength and direction of intra-network connections as measured by static effective connectivity, are …

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Understanding Visual Memory Encoding And The Effects Of Endurance Exercise In Healthy Adults And People With Temporal Lobe Epilepsy, Brandon Steve Mitchell Sep 2025

Understanding Visual Memory Encoding And The Effects Of Endurance Exercise In Healthy Adults And People With Temporal Lobe Epilepsy, Brandon Steve Mitchell

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The visual memory encoding (VME) of indoor and outdoor scenes is a complex cognitive process that primarily utilizes the bilateral hippocampi and medial temporal lobe (MTL) structures along the parahippocampal gyrus. Alpha and theta frequency band oscillations are important in the processing of visual information and memory formation, respectively. We completed hree studies investigating the cognitive process of VME in healthy adults and people with temporal lobe epilepsy (pwTLE). The first study was cross-sectional and utilized a functional magnetic resonance imaging (fMRI)-constrained magnetoencephalography (MEG) analysis in healthy adults to explore VME. The fMRI results were used as spatial priors to …

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Measuring Emotional Well-Being Across Neurodevelopmental Disorders, Alecia Mercier Sep 2025

Measuring Emotional Well-Being Across Neurodevelopmental Disorders, Alecia Mercier

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Emotional well-being has emerged as a crucial determinant of both physical and mental health, with implications for public health initiatives aimed at improving quality of life and reducing mortality. However, a clear and consistent understanding of emotional well-being, its components, and optimal measurement strategies remains lacking, especially for individuals with neurodevelopmental disorders. This dissertation investigated how emotional well-being is conceptualized and measured in individuals with neurodevelopmental disorders. Paper one was a scoping review that identified 20 emotional well-being measures developed or adapted for individuals with intellectual and developmental disabilities. Findings demonstrated that many existing measures do not include emotional well-being …

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Bayesian Mediation Analyses For Zero-Inflated Data, Jinhong Cui Sep 2025

Bayesian Mediation Analyses For Zero-Inflated Data, Jinhong Cui

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Mediation analysis is a fundamental tool in causal inference, enabling researchers to disentangle the pathways through which an exposure affects an outcome via intermediate variables (mediators). It has been widely applied in social sciences, psychology, and healthcare-related studies. Traditionally, mediation analysis has been conducted within the linear structural equation modeling (LSEM) framework. However, recent advances have shifted attention toward the counterfactual framework due to its flexibility in defining causal effects and its capacity to accommodate non-linear relationships, parametric and non-parametric models. Building on this foundation, methodological developments in mediation analysis have expanded to address more complex data structures, such as …

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Differential Susceptibility: How Parenting Behaviors Predict Adolescent Antisocial Behavior In The Context Of Candidate Plasticity Genes, Amanda Moore Sep 2025

Differential Susceptibility: How Parenting Behaviors Predict Adolescent Antisocial Behavior In The Context Of Candidate Plasticity Genes, Amanda Moore

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Adolescent antisocial behavior (ASB) has been consistently linked to parenting behaviors, yet individual variability in response to parenting remains poorly understood. Grounded in the differential susceptibility theory, this study examined how candidate plasticity genes interact with poor parenting to predict ASB in adolescents. A sample of 272 youth from the Birmingham Youth Violence Study provided genetic data and participated in two waves of behavioral and parenting assessments. Parenting behaviors were measured using a composite index of harsh, inconsistent, and low-nurturance parenting. ASB was assessed through self- and parent-reported measures of delinquency, aggression, and conduct problems. The study tested whether individual …

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Psychedelics And Psychosis: An Interdisciplinary Re-Examination, Haley Maria Dourron Sep 2025

Psychedelics And Psychosis: An Interdisciplinary Re-Examination, Haley Maria Dourron

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Psychedelics have long been described as potential drug models of psychosis. There is also concern that psychedelics might worsen psychotic symptoms in individuals with a history of psychotic disorders. This dissertation examines the overlap between psychedelic-induced states and non-affective psychotic disorders (NAPD) from both subjective and neurological perspectives, as well as the perceived impact of psychedelic use in people with a history of NAPD. Nineteen people with a history of NAPD who had used psychedelics were interviewed about their experiences. Participants generally described psychedelic and psychotic experiences as distinct, though both affected similar experiential domains, such as sensory alterations. Altered …

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