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Articles 2551 - 2580 of 14457
Full-Text Articles in Entire DC Network
Cell Type-Specific Diurnal Variation In Hippocampus Physiology, Lacy Kathryn Goode
Cell Type-Specific Diurnal Variation In Hippocampus Physiology, Lacy Kathryn Goode
All ETDs from UAB
Circadian rhythms are biological processes that cycle across 24 hours. Driven endogenously by widely expressed and highly conserved clock genes that compose the circadian molecular clock, circadian rhythms are exhibited in numerous facets of physiology across nearly every tissue throughout the body. Diurnal rhythms in cognition, long-term potentiation (LTP), and the expression of clock genes in hippocampus subfields support a role for circadian regulation of hippocampus physiology. However, little is known regarding the circadian molecular clock and diurnal rhythms in neurophysiology at the cellular level. Here, we characterized diurnal differences in spatial memory, LTP, excitability of and synaptic transmission onto …
The Use Of Vesgen For Analysis Of Retinal Vasculature In Pulmonary Arterial Hypertension, Mariana Desiree Dupont
The Use Of Vesgen For Analysis Of Retinal Vasculature In Pulmonary Arterial Hypertension, Mariana Desiree Dupont
All ETDs from UAB
Pulmonary artery hypertension is a chronic and progressive disease leading to right heart failure and, ultimately, death if untreated. The goal of the studies in this dissertation was to determine if fluorescein angiography (FA), and color fundus angiography (CF) imaging could be used to garner critical information about retinal changes in individuals with pulmonary artery hypertension (PAH). VESsel GENerational Analysis (VESGEN) is a noninvasive computer program that assigns branching generation to large and small vessels. VESGEN was utilized to investigate vascular alterations in FA, and CF imaging investigating disease progression in PAH. This dissertation demonstrated that PAH patients had aberrant …
Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight
Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight
All ETDs from UAB
Concerning trends for obesity, diabetes, heart attacks, and obesity-related cancers, or cardiometabolic disease (CMD), are developing within the emerging and young adult/adulthood (EYA) population. Evidence supports the concept that chronic stress leads to physiologic dysregulation, reduced mental health, chronic diseases, and reduced longevity; however, these are not inevitable outcomes, and resilience or vulnerability is determined by interacting environmental and biobehavioral factors. Although CMD manifests clinically in older adulthood, disease pathophysiology begins earlier, and thus, EYA is a critical time for observation and intervention. Growing evidence indicates inflammation is a major risk factor in CMD development and may be exacerbated by …
Predicting Change In Quality Of Life In Patients With Advanced Cancer And Family Caregivers Using Gps Data, Kyungmi Lee
Predicting Change In Quality Of Life In Patients With Advanced Cancer And Family Caregivers Using Gps Data, Kyungmi Lee
All ETDs from UAB
Patients with advanced cancer and their family caregivers often experience poor quality of life. Measuring patient and caregiver physical and mental quality of life is typically performed using participant reported outcome measures, especially validated questionnaires. However, this self-report approach has several limitations, including recall bias, respondent burden, and social desirability bias. One potential solution to these limitations may be to use passive data collected by personally owned smartphones (e.g., GPS data) to model and assess the quality of life in family caregivers and patients with advanced cancer. Yet, there is no evidence to date that passively collected smartphone data is …
Palliative Care Experiences And Educational Needs Of Healthcare Interprofessionals In Jamaica: A Mixed Methods Study, Rebecca L. Edwards
Palliative Care Experiences And Educational Needs Of Healthcare Interprofessionals In Jamaica: A Mixed Methods Study, Rebecca L. Edwards
All ETDs from UAB
Universal access to palliative care (PC) is a human right that much of the world has not accomplished and educating a PC workforce is critical to PC advancement. Higher PC disparities exist in low-and-middle income countries, such as Jamaica. The World Health Organization Public Health Model and the International PC Initiative’s PC roadmap emphasize the importance of PC education. The purpose of this mixed methods dissertation study was to investigate the PC experiences and educational needs of healthcare interprofessionals who provide care for patients with late-stage serious illnesses in Jamaica. Three specific aims incorporated quantitative investigation of physicians’, nurses’, and …
Intrinsically-Photosensitive Retinal Ganglion Cells And Their Functional Roles, Kevin Q. Chang
Intrinsically-Photosensitive Retinal Ganglion Cells And Their Functional Roles, Kevin Q. Chang
All ETDs from UAB
This project was conducted in Old World monkeys and focused on characterization of the intrinsically photosensitive retinal ganglion cells (ipRGCs) as they pertain to the pupillary light reflex, as well as on the neuroanatomical and electrophysiological characterization of the suprachiasmatic nucleus (SCN) of the hypothalamus as it pertains to circadian rhythms. A custom antibody was developed against the human melanopsin gene. We validated the antibody using western blot and immunohistochemistry. The functional role of ipRGCs in driving pupillary responses was investigated through immunotoxin-induced ablation in Rhesus macaques with the antibody conjugated to saporin. As hypothesized, the pupillary light reflex and …
Health Disparities In Cardiometabolic Risk Among African American And European American Adults, Catharine A. Couch
Health Disparities In Cardiometabolic Risk Among African American And European American Adults, Catharine A. Couch
All ETDs from UAB
African American (AA) individuals are disproportionately burdened by cardiometabolic disease, including type 2 diabetes (T2D) and cardiovascular disease (CVD), and associated risk factors. The objective of this dissertation research was to investigate pathophysiological and lifestyle contributors to racial disparities in cardiometabolic disease including beta-cell dysfunction, ectopic fat, the natriuretic peptide system, and diet. These first three risk factors, beta-cell dysfunction, ectopic fat, and the natriuretic peptide system, were explored in a cross-sectional study of young AA and European American (EA) adults. The fourth risk factor, diet, was explored in a large, national cohort of black and white adults. First, we …
Longitudinal Investigation Of Financial Capacity And Driving Performance In Mild Cognitive Impairment, Tyler P. Bull
Longitudinal Investigation Of Financial Capacity And Driving Performance In Mild Cognitive Impairment, Tyler P. Bull
All ETDs from UAB
Previous research has shown that Mild Cognitive Impairment (MCI) is an intermediary between normal aging and dementia that is associated with declines in financial capacity and driving performance, two important instrumental activities of daily living (IADLs). Both financial capacity and driving performance have been studied cross-sectionally within an MCI population, but there is limited information on the changes in performance over time. The present study utilized data from a recent longitudinal clinical trial of speed of processing training to further examine changes in driving performance and financial capacity over time. Participants included seventy-five older adults with MCI who completed an …
Il-22 Mediated Host Defense During Attaching-Effacing Pathogen Infection, Baiyi Cai
Il-22 Mediated Host Defense During Attaching-Effacing Pathogen Infection, Baiyi Cai
All ETDs from UAB
Intestinal infections are a cause of morbidity and mortality worldwide and remain a public threat. Interleukin (IL)-22 is central to host immune responses in the intestine during infection and inflammation. IL-22 can be produced by both innate and adaptive immune cells, yet their relative contributions to host protection remain unclear. Here we demonstrated the specific role and mechanism for IL-22 from innate and adaptive sources to protect the host. Using the Citrobacter rodentium (C.r) model, we found that IL-22 from innate cell, protect the host during early infection. IL-22 induces epithelial production of polymorphonuclear neutrophils (PMN) recruiting chemokine CXCL1, CXCL2 …
Self-Efficacy In Pulmonary Rehabilitation, Erica Anderson
Self-Efficacy In Pulmonary Rehabilitation, Erica Anderson
All ETDs from UAB
the fourth leading cause of death in the United States, Chronic Obstructive Pulmonary Disease (COPD) is a major contributor of morbidity and mortality. The disease is characterized by chronic irritation and inflammation of the airways. The most common symptoms include chronic cough and shortness-of-breath. Pulmonary rehabilitation is a comprehensive exercise and education program for people with lung disease. It is well-established as an intervention to improve symptoms and other qualityof- life outcomes in people with COPD. Self-efficacy is the belief in one’s own abilities. It is recognized by the American Thoracic Society and European Respiratory Society as an integral part …
Distinct Clinical Manifestations Associated With Autoantibodies And Cytokines In Systemic Lupus Erythematosus, Fatima K. Alduraibi
Distinct Clinical Manifestations Associated With Autoantibodies And Cytokines In Systemic Lupus Erythematosus, Fatima K. Alduraibi
All ETDs from UAB
Objective: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by production of autoantibodies (autoAbs) and cytokines. Moreover, lupus nephritis (LN) occurs in approximately 50% of SLE patients. AutoAb and cytokine levels produced by B and T cells are high in LN patients, although their relationship with histological patterns requires investigation. Methods: We analyzed the relationship between B cell cytokines and major T cell cyto-kines, including their association with autoAbs, and the clinical manifestations of SLE, especially LN. We also analyzed endogenous intracellular interferon beta (IFNβ) expression in the peripheral blood mononuclear cells and serum circulating nephritogenic autoAbs from …
Documenting Covid-19 At Uab: A Library’S Role In Preserving Accounts Of The Coronavirus Pandemic, Margaret Wood Balch, Anna Kaetz
Documenting Covid-19 At Uab: A Library’S Role In Preserving Accounts Of The Coronavirus Pandemic, Margaret Wood Balch, Anna Kaetz
Libraries Professional Work
In August of 2020, UAB Libraries of the University of Alabama at Birmingham (UAB) launched the Documenting COVID-19 at UAB project, seeking the stories of UAB students, faculty, staff, and health care workers navigating life during COVID-19 to preserve them in a born-digital collection. Since then, ninety-five items have been added to the collection, including photographs, video/audio productions, news items, and personal written accounts. This article discusses the planning and creation of the Documenting COVID-19 at UAB collection and highlights several submissions that provided uniquely insightful information about the pandemic. It also addresses how libraries play a key role in …
Dialing Through The Surges: Covid Contact-Tracers Face Burnout But Stay Motivated, Matt Windsor
Dialing Through The Surges: Covid Contact-Tracers Face Burnout But Stay Motivated, Matt Windsor
Browse All News
No abstract provided.
Turning New Year's Exercise Resolutions Into Realistic, Long-Term Habits, Alicia Rohan
Turning New Year's Exercise Resolutions Into Realistic, Long-Term Habits, Alicia Rohan
Browse All News
No abstract provided.
Robinson Appointed In Nih Advisory Committee For Research On Women's Health, Staff
Robinson Appointed In Nih Advisory Committee For Research On Women's Health, Staff
Browse All News
No abstract provided.
Setting Boundaries With Loved Ones: Why It Is Important And How To Do It, Alicia Rohan
Setting Boundaries With Loved Ones: Why It Is Important And How To Do It, Alicia Rohan
Browse All News
No abstract provided.
Uab Green Labs Programs Wins International Freezer Challenge, Staff
Uab Green Labs Programs Wins International Freezer Challenge, Staff
Browse All News
No abstract provided.
December 21, 2021 Ereporter, University Of Alabama At Birmingham
December 21, 2021 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Becoming Heersink Part 3: Our Future As Heersink, Mary Ashley Canevaro
Becoming Heersink Part 3: Our Future As Heersink, Mary Ashley Canevaro
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No abstract provided.
Orihuela Named Interim Chair For The Department Of Microbiology, Jessica Martindale
Orihuela Named Interim Chair For The Department Of Microbiology, Jessica Martindale
Browse All News
No abstract provided.
This Long-Running Study Proves That Nice People Finish First, Matt Windsor
This Long-Running Study Proves That Nice People Finish First, Matt Windsor
Browse All News
No abstract provided.
Program At Uab Helps Preserve Limbs In Patient With Diabetes, Staff
Program At Uab Helps Preserve Limbs In Patient With Diabetes, Staff
Browse All News
No abstract provided.
December 17, 2021 Ereporter, University Of Alabama At Birmingham
December 17, 2021 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Curriculum Changes Reflect Modern Medical Landscape, Uab Heersink School Of Medicine News
Curriculum Changes Reflect Modern Medical Landscape, Uab Heersink School Of Medicine News
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No abstract provided.
Pandemic Highlights Importance Of Uab/Ascension St. Vincent's Alliance, Uab Heersink School Of Medicine News
Pandemic Highlights Importance Of Uab/Ascension St. Vincent's Alliance, Uab Heersink School Of Medicine News
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No abstract provided.
Nurse Plays Pivotal Role In Combating Overdose Deaths Through New Naloxone Initiative, Adam Pope
Nurse Plays Pivotal Role In Combating Overdose Deaths Through New Naloxone Initiative, Adam Pope
Browse All News
No abstract provided.
Footprint For New Genomic Medicine Building Takes Shape, Uab Heersink School Of Medicine News
Footprint For New Genomic Medicine Building Takes Shape, Uab Heersink School Of Medicine News
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No abstract provided.
Planned Endowed Chair Gifts To Advance Alzheimer's And Als Programs, Uab Heersink School Of Medicine News
Planned Endowed Chair Gifts To Advance Alzheimer's And Als Programs, Uab Heersink School Of Medicine News
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No abstract provided.
Live Healthsmart Alabama And Bl Harbert Kick Off Revitalization Efforts In Bush Hills, Adam Pope
Live Healthsmart Alabama And Bl Harbert Kick Off Revitalization Efforts In Bush Hills, Adam Pope
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No abstract provided.
Art Imitating Life: How A Biology Student Uses Embroidery To Learn In Her Own Way, Haley Herfurth
Art Imitating Life: How A Biology Student Uses Embroidery To Learn In Her Own Way, Haley Herfurth
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No abstract provided.