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Macrophage Ipla2ss-Derived Lipid Signaling Contributes To Type 1 Diabetes Development, Abdulaziz Saad Almutairi Jan 2023

Macrophage Ipla2ss-Derived Lipid Signaling Contributes To Type 1 Diabetes Development, Abdulaziz Saad Almutairi

All ETDs from UAB

Type 1 Diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-secreting pancreatic β-cells that leads to hyperglycemia; however, the mechanism of β-cells destruction remains elusive. Ca2+-independent phospholipase A2β (iPLA2β), which hydrolyzes membrane phospholipids at the sn-2 position and releases bioactive lipids, modulates polarization of macrophages (M ). Data from our lab suggests that selective iPLA2β-derived lipid signals (iDLs) (i.e., PGs, HETEs, DHETs, LTB4) produced by M from spontaneous-T1D prone nonobese diabetic mice (NOD) are high during the pre-diabetic phase. However, the impact of macrophage-derived iDLs in T1D remains unclear. Therefore, we generated a NOD mouse model with …

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Factors Impacting Serious Illness Care In Alabama: An Assessment Of The Current State Of Hospital Palliative Care, Amy M. Beasley Jan 2023

Factors Impacting Serious Illness Care In Alabama: An Assessment Of The Current State Of Hospital Palliative Care, Amy M. Beasley

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BACKGROUND: Palliative care (PC) use has been shown to offer many benefits to patients and families. Hospital PC has expanded in the United States, though growth has been limited within hospital types and geographic locations. According to the Center to Advance Palliative Care (CAPC), Alabama was rated a “D,” indicating that significant improvements in PC are needed. The purpose of this study was to develop a thorough description of access to palliative care in Alabama hospitals. METHODS: A mixed methods multiple case study was employed with quantitative data embedded into a qualitative case study approach. Four hospitals were selected based …

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Streptococcus Mutans Biofilm Inhibiting Small Molecules With Anticariogenic Activity, Parmanand Ahirwar Jan 2023

Streptococcus Mutans Biofilm Inhibiting Small Molecules With Anticariogenic Activity, Parmanand Ahirwar

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Dental caries, a highly prevalent disease, is characterized by the erosion of the tooth surface. This disease is caused by the oral bacteria living in complex communities called biofilms. Streptococcus mutans, among the various pathogenic bacterial species inhabiting the oral cavity, is considered to be the major etiological agent for dental caries. This bacterium forms robust biofilms capable of producing significant amounts of acid, leading to the demineralization of hydroxyapatite in the tooth enamel and subsequent erosion over time. Biofilm penetration into the dentin and pulp causes severe pain, while the entry of the bacteria into the bloodstream can result …

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Epigenetic Aberrations In Systemic Sclerosis And Systemic Lupus Erythematosus, Peter C. Allen Jan 2023

Epigenetic Aberrations In Systemic Sclerosis And Systemic Lupus Erythematosus, Peter C. Allen

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Autoimmune diseases are a classification of more than eighty diseases where the immune system recognizes a self-antigen and mistakenly attacks the body’s own tissue, inducing inflammation a nd p otentially l eading t o d amage. Autoimmune diseases disproportionately affect women and develop at any age depending on the disease. The prevalence of some autoimmune diseases is increased in minority populations. Despite this, research into higher-risk populations is lacking. This highlights the need to contribute research into understanding autoimmune disease pathogenesis in diverse studies to understand why disease is more severe in these populations. We analyzed transcriptomes and methylomes of …

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Acute Placental Inflammation And Growth Outcomes In Preterm Infants, Emily Gunawan Jan 2023

Acute Placental Inflammation And Growth Outcomes In Preterm Infants, Emily Gunawan

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Background. Acute placental inflammation (API) has been associated with various adverse outcomes in preterm infants. However, little is known about how API affects their body composition and growth outcomes. This study aims to examine the association between API and growth outcomes in preterm infants. Methods. We conducted a retrospective cohort study of mother-infant dyads born < 326/7 weeks of gestation with fat mass (FM) accretion measured using air displacement plethysmography at term-equivalent age. API severity including maternal inflammatory response (MIR) and fetal inflammatory response (FIR) was staged according to criteria by Society for Pediatric Pathology based on placental pathology reports. We examined the differences in characteristics of mother-infant dyads by API severity using ANOVA or the Kruskall-Wallis test. The association between API severity and growth outcomes was analyzed using linear regression models and adjusted for statistically significant confounders. Mediation analyses were used to study the direct and indirect association of API and growth outcomes via gestational age. Results. Among 375 mother-infant dyads analyzed, 104 (28%) dyads had MIR. FIR was found in 82% of dyads with MIR. Adjusted models indicated that API severity progression was positively associated with FM accretion. Gestational age partially (49%) iv mediated the association between API severity and FM z score (indirect effect: b=0.12, 95% CI: 0.05-0.19; direct effect: b=0.12, 95% CI: 0.01-0.25). Conclusions. API severity is associated with growth outcomes and helps to accurately predict body composition in preterm infants.

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Unveiling The Commuting Experience Of An Urban University Community, Jannatul Adan Joarder Jan 2023

Unveiling The Commuting Experience Of An Urban University Community, Jannatul Adan Joarder

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Conducting a comprehensive commuter survey is a prevalent task that can help to guide traffic operations, planning, designing, and infrastructure development decision. It is one of the best approaches to comprehending commuters’ attitudes and preferences and the present commuting practices. The commuting behavior of the commuters at and around a university campus varies from that of residential or commercial areas as the university often serves a diverse community of transportation users such as students, faculty, and staff who serve the university or receive services from the university in a variety of ways. The University of Alabama at Birmingham (UAB) is …

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Failure Modes Of Different Zirconia Crown Heights And Materials On Titanium Base Abutments, Aikaterini Anastasaki Jan 2023

Failure Modes Of Different Zirconia Crown Heights And Materials On Titanium Base Abutments, Aikaterini Anastasaki

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Statement of the Problem: The existing scientific literature lacks comprehensive information regarding the influence of zirconia crown height on debonding and fracture occurrences between zirconia crowns and titanium base abutments. Additionally, there is a lack of comparative studies evaluating different zirconia materials as restorative options for screw-retained restorations. Purpose: The purpose of this study was to assess the failure modes of the zirconia crown/titanium implant abutment complex by investigating the impact of increasing zirconia crown heights and different zirconia materials. Materials and Methods: The experimental design encompassed six groups, each consisting of 10 specimens. Group 1 included 10 non-anatomical crowns …

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Role Of Dpy30 In The Epigenetic Regulation Of Odontoblast Differentiation In Vitro, Namrata Landge Rana Jan 2023

Role Of Dpy30 In The Epigenetic Regulation Of Odontoblast Differentiation In Vitro, Namrata Landge Rana

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Purpose: Dentin is produced from odontoblasts, derived from human Dental Pulp Cells (hDPCs), which are essential for dentin formation, remodeling, and mineral hemostasis. Epigenetic mechanisms are believed to be involved in odontoblast differentiation and function, and H3K4 methylation is associated with gene activation which is fundamental to histone-based epigenetics. The SET1/MLL complexes are mammals' major histone H3K4 methylation enzymes. DPY30 is a core subunit of SET1/MII complexes, mammalian's major histone H3K4 methyltransferases. It plays an important role in regulating fundamental processes including the determination of cell lineage, growth, and differentiation. Thus, histone-based epigenetic mechanisms are involved in odontoblast differentiation and …

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Molecular Determinants Of Retroviral Gag Targeting To The Plasma Membrane For Assembly, Dominik Herrmann Jan 2023

Molecular Determinants Of Retroviral Gag Targeting To The Plasma Membrane For Assembly, Dominik Herrmann

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Human T-cell leukemia virus 1 (HTLV-1) was the first oncogenic human retrovirus to be discovered. Several serious diseases have been linked to HTLV-1 infection, such as Adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Between 10-20 million people are infected with HTLV-1 making it a major cause of morbidity and mortality worldwide. A comprehensive understanding of the factors that govern retroviral replication precludes the development of efficient antiretroviral therapies (ARTs). In the example of HIV-1, atomic level structural data was paramount to developing and improving upon many of the ARTs used today, underscoring the need for structure …

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Early Life Stress And Endothelin Receptor Type A: Separate Roles In Mediating Colitis, Rachel Q. Muir Jan 2023

Early Life Stress And Endothelin Receptor Type A: Separate Roles In Mediating Colitis, Rachel Q. Muir

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Inflammatory bowel disease (IBD) results from the interplay of genetic susceptibility, environmental influences, the microbiota, and aberrant immune responses. Despite the fact that over 200 genetic susceptibility loci have been identified, the genetic contribution to disease onset is believed to be less than 50%. Environmental factors have arisen as key drivers of disease. Early life stress (ELS) is an understudied environmental trigger linked to IBD susceptibility. Utilizing 2 separate models of ELS, we show that ELS results in diminished colonic corticosterone and prolonged intestinal inflammation upon colitogenic insult. ELS-exposed animals consistently demonstrated high levels of colonic Tnf, concurrently with decreased …

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Parental Psychological Distress And Perception Of Children's Externalizing Behaviors: Potential Role Of Parental Resources, Abigail Jeanette Anderson Jan 2023

Parental Psychological Distress And Perception Of Children's Externalizing Behaviors: Potential Role Of Parental Resources, Abigail Jeanette Anderson

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The relations between parental psychological distress and parental resources in the perception and emergence of early childhood externalizing behaviors were investigated in a longitudinal study with a cross-lagged design. Both mothers and fathers participated in a longitudinal study, which began prenatally when parents were in the third trimester of pregnancy, with follow-up assessments when children were 6 months, 18 months, and 4 years of age. Parents reported on their own psychological distress, coping self-efficacy, and social support satisfaction during all four time points, and reported on their child’s externalizing behaviors during the latter two timepoints. Results suggest that mothers’ psychological …

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Improved Myocardial Infarct Repair Via Cardiac Tissue Engineering And Modified Rna, Lu Wang Jan 2023

Improved Myocardial Infarct Repair Via Cardiac Tissue Engineering And Modified Rna, Lu Wang

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Cardiovascular diseases remain the leading cause of death in the United States and the world. Myocardial infarction (MI) happens when there is an occlusion in the blood vessel. Cardiomyocytes (CM) die quickly after MI and are replaced by a fibrotic scar. Since adult mammalian cardiomyocytes have a limited capacity to regenerate, the damages induced by MI usually deteriorate into more severe symptoms such as heart failure. In order to achieve regeneration of the cardiomyocytes, numerous therapies have been proposed, including cellular therapy and CM cell cycle re-entry. During this dissertation study, we focused on improving myocardial infarct repair via cardiac …

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Sex-Stratified Genetic Analysis Of Gout And Comorbidities, Nicholas Andrew Sumpter Jan 2023

Sex-Stratified Genetic Analysis Of Gout And Comorbidities, Nicholas Andrew Sumpter

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Gout is a common inflammatory arthritis that is increasing in prevalence globally. It has clear sex differences, being more common among men, though comorbidities appear to be more common among women. It also varies in prevalence between populations, driven by a combination of genetic and socioeconomic factors. Genetic studies have identified gout-associated genetic variants, several of which are shared between different populations. Here, I combined gout-associated genetic variants into a gout polygenic risk score. This score was then used to elucidate the genetic underpinning of gout severity and presence of comorbidities, comparing its effects in different sexes and populations. I …

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Aberrant Signal Transduction Of Neuronal Injury: Trauma And Toxicology, Alan Umfress Jan 2023

Aberrant Signal Transduction Of Neuronal Injury: Trauma And Toxicology, Alan Umfress

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Neurological injuries occur in epidemic proportions worldwide. Neuronal injuries are events resulting in damage to the central nervous system (CNS) that impair neurological function. Subsequent impairments in neuronal function can be rapid, existing immediately after injury, or progressive and chronic impairments that persist for the lifetime of the survivor. CNS injury constitutes a broad class of environmental and pathophysiological insults ranging from blunt-force trauma to the brain or spinal cord, to acute ischemic and hemorrhagic strokes, and insults resultant from neurotoxic agents. While divergent in initial cause, many of these insults share underlying pathophysiological outcomes including excitotoxic cell signaling, neuroinflammation, …

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Mechanisms Of Simulated-Spinal Manipulative Therapy In Animal Models Of Low Back Pain, Carla Rigo Lima Jan 2023

Mechanisms Of Simulated-Spinal Manipulative Therapy In Animal Models Of Low Back Pain, Carla Rigo Lima

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Low back pain (LBP), a condition characterized by pain experienced between the 12th rib margin and gluteal folds, is a prevalent health problem that affects an ever-increasing population worldwide. First-line treatment for LBP often involves non-pharmacological approaches, including spinal manipulative therapy (SMT), which has demonstrated mild-to-moderate clinical efficacy. However, despite its therapeutic benefits, the physiological mechanisms underlying the analgesic effects of SMT in LBP are still not well understood. Recent evidence suggests that sensitization of peripheral and central nervous system structures contribute to the progression and maintenance of LBP with inflammatory cytokines, reactive glial cells, and/or aberrant muscle spindle activity …

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Enhancing Plant Functional Annotation By Integrating Graph Convolutional Networks And Natural Language Processing, Nilesh Kumar Jan 2023

Enhancing Plant Functional Annotation By Integrating Graph Convolutional Networks And Natural Language Processing, Nilesh Kumar

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Studying plant gene function is essential for understanding the underlying mechanisms that govern plant growth, development, and environmental adaptation. This knowledge can improve crop yields and food security by developing plants resistant to diseases, pests, and environmental stress. Moreover, understanding plant gene function can also aid in environmental conservation efforts by providing insight into the mechanisms that plants use to adapt to changing environments and can help preserve endan-gered plant species. For several reasons, studying gene function in plants can be more challenging than in animals. Plant genomes are larger and more complex than animal genomes, making it harder to …

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The Urban Pedagogue To Principal Pipeline: Elementary School Teacher Leaders' Perceptions Of Mentorship And Its Impact On Their School Leadership Preparation, Erica Jewel Littleton Jan 2023

The Urban Pedagogue To Principal Pipeline: Elementary School Teacher Leaders' Perceptions Of Mentorship And Its Impact On Their School Leadership Preparation, Erica Jewel Littleton

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Schools are complex and dynamic systems that require innovative leaders who are willing to invest in classroom teachers by giving them opportunities to lead beyond the four walls of the classroom. Because principals play an integral role in the academic achievement of students in their schools, it is incumbent upon principals to invest in teacher leaders to support students’ unique and multifaceted needs. The knowledge teachers gain because of leadership experiences often strengthens their professional dispositions and expands their interest in other critical roles in the system such as becoming an instructional coach, interventionist, principal, or curriculum specialist. A systematic …

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Understanding Patient Factors Influencing Outpatient Follow-Up Among Adult Survivors Of Acute Kidney Injury: A Mixed Methods Study, Ciara Mitchell Jan 2023

Understanding Patient Factors Influencing Outpatient Follow-Up Among Adult Survivors Of Acute Kidney Injury: A Mixed Methods Study, Ciara Mitchell

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Background: Acute kidney injury (AKI) is a growing health concern that is related to both short and long-term health consequences. AKI disproportionately impacts hospitalized patients who often experience competing health conditions that overrides knowledge and awareness concerning AKI diagnosis. Therefore, attending AKI follow-up care after hospital discharge may help increase knowledge and awareness as well as mitigate some of the poor health outcomes associated with AKI. However, AKI follow-up is low among this vulnerable population. Methods: To address this problem, a mixed-methods study was conducted to examine various patient factors influencing AKI follow-up and to explore the illness beliefs of …

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Comparing Three Resilience Frameworks Across Outcomes For Children Who Have Experienced Multiple Adverse Childhood Experiences, Kevin Keane Jan 2023

Comparing Three Resilience Frameworks Across Outcomes For Children Who Have Experienced Multiple Adverse Childhood Experiences, Kevin Keane

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Adverse childhood experiences (ACEs) have a well-established relationship with poorer mental health, health, and school-related outcomes among children. ACEs researchers have identified potential resilience frameworks like the National Scientific Council on the Developing Child (NSCDC), Health Outcomes from Positive Experiences (HOPE), and cumulative positive childhood experiences (PCEs) frameworks that identify protective factors to mitigate ACEs. However, each framework has a limited evidence base with no known studies comparing their effectiveness. The purpose of this dissertation was to compare the relationship between these three resilience frameworks and childhood outcomes in three domains (mental health, weight status, and school-related outcomes) among children …

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Strategies For Her2 Targeted Pet Imaging, Maxwell Adams Ducharme Jan 2023

Strategies For Her2 Targeted Pet Imaging, Maxwell Adams Ducharme

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Breast cancer is one of the most common and deadly cancers diagnosed in women each year. The HER2-positive subtype of breast cancer is associated with poor prognosis and lower progression-free survival. Early identification of HER2 expression is extremely important for the effective treatment of the disease. Current methods to diagnose HER2-positive breast cancer involve invasive biopsies to semi-quantitatively determine the amount of HER2 expression. However, many lesions are often unavailable for biopsy due to their location and there may be variable HER2 expression between the primary tumor and metastasis. Positron emission tomography (PET) can give a full-body, non-invasive evaluation of …

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Investigating Regulatory Mechanisms Of Transcription By Rna Polymerase I, Abigail Kate Huffines Jan 2023

Investigating Regulatory Mechanisms Of Transcription By Rna Polymerase I, Abigail Kate Huffines

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There are at least three eukaryotic RNA polymerases (Pols), Pols I, II, and III. These Pols are essential for transcription, where RNA is synthesized from various DNA templates. While transcription has been well-studied for decades, there are still many questions that remain unanswered about how this process is regulated for each of the three Pols. Transcription is highly regulated and complex, therefore, many different mechanisms exist to tightly control it in the cell. Some of these mechanisms include regulation by transcription factors and co-transcriptional RNA processing. While these regulatory mechanisms are of great interest, they have not yet been fully …

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Biochemical Characterization Of Rna Polymerases I, Ii, And Iii And Its Therapeutic Implications, Ruth Qian Jacobs Jan 2023

Biochemical Characterization Of Rna Polymerases I, Ii, And Iii And Its Therapeutic Implications, Ruth Qian Jacobs

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In contrast to Bacteria and Archaea that express a single DNA-dependent RNA polymerase (RNAP), eukaryotes express at least three structurally distinct, nuclear, DNA-dependent RNA polymerases (Pols I, II, and III) that are responsible for synthesizing all the genome-encoded RNA required by the cell. Despite the discovery of the Pols over 50 years ago, there remains a knowledge gap concerning their enzymatic properties. Over the course of evolution, we know that Pols I, II, and III have diverged in structure and function. They share a 10-subunit core and are each responsible for transcribing unique genetic loci. What remains to be understood …

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Molecular Phenotyping Of Serum Iga1 0-Glycoforms In The Context Of Iga Nephropthy, Ellenore P. Craine Jan 2023

Molecular Phenotyping Of Serum Iga1 0-Glycoforms In The Context Of Iga Nephropthy, Ellenore P. Craine

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IgA nephropathy (IgAN) is an autoimmune disease that is the most common form of glomerulonephritis in the world, and results in end-stage renal disease in 40% of patients. In IgAN, human immunoglobulin A1 (IgA1) has reduced levels of galactose (Gal) in the IgA1 O-glycosylated hinge region (HR) known as Gal deficient IgA1 (Gd-IgA1). These Gd-IgA1 glycoforms, which are elevated in circulation of IgAN patients, are recognized by Gd-IgA1-specific IgG autoantibodies, resulting in the formation of pathogenic immune complexes (CICs). Some of these CICs accumulate in the mesangium of glomeruli and induce kidney injury. Although the link between these deposits and …

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Neural-Glial-Vascular Interactions In Human Outer Retina, Deepayan Kar Jan 2023

Neural-Glial-Vascular Interactions In Human Outer Retina, Deepayan Kar

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The outer retinal metabolic ecosystem is a complex interplay among photoreceptors, RPE and blood supply from the retinal and choroidal microcirculation. Breakdown of any component of this ecosystem has detrimental effects and can lead to cellular dysfunction. For example, in age-related macular degeneration a major cause of vision loss in older adults, breakdown of this metabolic unit has severe structural and functional implications. Thus, every feature and component of this ecosystem seems to be optimized to protect non-replicating, terminally differentiated cells from being damaged. Remarkably, much of the cellular and subcellular organization of this system is available for observation in …

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In The Shadows, But Not Left Behind: Female Sex Workers' Acceptance Of Social Media For Hiv Prevention In Northwest And Southwest Provinces, Cameroon, Hassanatu Blake Jan 2023

In The Shadows, But Not Left Behind: Female Sex Workers' Acceptance Of Social Media For Hiv Prevention In Northwest And Southwest Provinces, Cameroon, Hassanatu Blake

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The purpose of this dissertation was to evaluate the acceptance of social media in HIV prevention education for female sex workers in Cameroon. The objectives included: (1) provide a review of literature on the use of social media in HIV prevention education among Female Sex workers (FSWs); (2) determine the acceptance of Secret Facebook Group (SFG) for HIV prevention education among FSW in Cameroon; and (3) explain the acceptance of SFG in HIV prevention education and social media platform alternatives to SFG in Cameroon. Utilizing a sequential explanatory mixed methods design, three methods were employed for this dissertation and guided …

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Neutrophil Heterogeneity And Alternative Granulopoiesis In Chronic Inflammatory Conditions, Ashley N. Connelly Jan 2023

Neutrophil Heterogeneity And Alternative Granulopoiesis In Chronic Inflammatory Conditions, Ashley N. Connelly

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Neutrophils, the most abundant type of circulating leukocyte, represent a heterogeneous population with distinct roles in immune regulation and disease pathogenesis. A major obstacle to our understanding of neutrophil biology is that neutrophils are readily activated during preparation. The lack of standardized methodology for neutrophil characterization makes the comparison of results across studies challenging. Here we provide a careful comparison of eight characterization methods and present a novel, optimized protocol for the characterization of whole blood neutrophils minimizing activationinduced phenotypic alterations during processing. Despite successful virological control, HIV-1-infected individuals maintain an increased risk of life-threatening comorbidities including liver, cardiovascular, and …

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Patterns Of Fatal Drug Overdose_ A Multi-City Investigation Of Geospatial Correlates, Keith R. Chichester Jan 2023

Patterns Of Fatal Drug Overdose_ A Multi-City Investigation Of Geospatial Correlates, Keith R. Chichester

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Fatal drug overdoses are now the leading cause of accidental death in the U.S., responsible for over 107,600 deaths in 2021. Since 2000 the rate of overdose fatalities has increased over 140%. This epidemic has been particularly impactful in rural areas as from 2006-2016, the rural overdose death rate surpassed those in urban areas. Geospatial analytics provide an effective strategy for identifying profiles and patterns in the spatial distribution of overdose locations as well as geographic and demographic variables that associate with overdose occurrences. Furthermore, predictive risk modeling platforms allow for the identification of anticipated overdose hotspots across a geography …

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Contributions Of Off-Season Training And Food Security Status On Body Composition And Performance In Collegiate Football Players, Kathryn Lee Stowers Jan 2023

Contributions Of Off-Season Training And Food Security Status On Body Composition And Performance In Collegiate Football Players, Kathryn Lee Stowers

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Body composition measurements are collected periodically in the collegiate athletic setting to evaluate health and predict athletic performance of individual athletes. However, the effects of remote training and food insecurity on body composition have yet to be fully investigated in this population. The purpose of this research was to evaluate the influence of remote training and food security status on body composition and performance changes during off-season training. Aims 1 and 2 focus specifically on how factors affect body composition changes in collegiate football players during off-season training. Data were collected from routine body composition testing and food security screening …

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Induction Of Antibiotic Activity Against Methicillin-Resistant Staphylococcus Aureus In Small Molecules Through Zinc Activation, Rachel Michaela Andrews Jan 2023

Induction Of Antibiotic Activity Against Methicillin-Resistant Staphylococcus Aureus In Small Molecules Through Zinc Activation, Rachel Michaela Andrews

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Methicillin-resistant Staphylococcus aureus (MRSA) is a serious human pathogen with a staggering potential for multi-drug resistance. Because of this, the Centers for Disease Control and Prevention and the World Health Organization monitor the spread of MRSA and encourage antibiotic development efforts targeting this pathogen. Despite this, few antibiotics have been developed and brought to market in recent decades. To continue treating infections caused by this organism, we must identify novel antibiotic molecules with different mechanisms of action from known antibiotics. Bacterial copper-dependent inhibitors (CDIs), molecules that become antibacterial in the presence of copper (Cu), have been studied as a novel …

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Eating Disorder Symptoms In Transgender Adults: The Impact Of Gender Dysphoria And Minority Stress On Eating Disorder Symptomatology, Elliott Botelho Jan 2023

Eating Disorder Symptoms In Transgender Adults: The Impact Of Gender Dysphoria And Minority Stress On Eating Disorder Symptomatology, Elliott Botelho

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Background: Transgender individuals experience more mental health challenges than their cisgender counterparts, and a growing area of research suggests that transgender in-dividuals are at increased risk of eating disorder symptoms. The Gender Minority Stress and Resilience model may help explain this health disparity in eating disorder symptoms. The model theorizes that this disproportionate mental health burden, such as eating disor-der symptoms, may arise from the stresses of belonging to a minoritized group. Another factor that may account for eating disorder disparities is gender dysphoria, a distressing and clinically significant state many transgender individuals experience when their physi-cal appearance is incongruent …

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