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University of Alabama at Birmingham

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Novel Mechanisms Mediating The Estradiol-Induced Increase In The Magnitude Of Long -Term Potentiation At Hippocampal Ca3 -Ca1 Synapses., Caroline C. Smith Jan 2006

Novel Mechanisms Mediating The Estradiol-Induced Increase In The Magnitude Of Long -Term Potentiation At Hippocampal Ca3 -Ca1 Synapses., Caroline C. Smith

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No abstract provided.


Examining Science Achievement Of African American Females In Suburban Middle Schools: A Mixed Methods Study., Kecia C. Topping Jan 2006

Examining Science Achievement Of African American Females In Suburban Middle Schools: A Mixed Methods Study., Kecia C. Topping

All ETDs from UAB

No abstract provided.


Inpatient Length Of Stay And Procedure Disparities In Acute Myocardial Infarction Treatment., Wensheng Fan Jan 2006

Inpatient Length Of Stay And Procedure Disparities In Acute Myocardial Infarction Treatment., Wensheng Fan

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No abstract provided.


Questionnaires Based On Social Cognitive Theory Constructs Do Not Predict Exercise Adherence In Older Adults After Discharge From Home Health Physical Therapy., Jason Hardage Jan 2006

Questionnaires Based On Social Cognitive Theory Constructs Do Not Predict Exercise Adherence In Older Adults After Discharge From Home Health Physical Therapy., Jason Hardage

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No abstract provided.


Mechanisms Of Effector Cd4+ T Cell Development And Trafficking., Paul R. Mangan Jan 2006

Mechanisms Of Effector Cd4+ T Cell Development And Trafficking., Paul R. Mangan

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No abstract provided.


Effects Of Breast Cancer Risk, Psychological Distress, And Dispositional Optimism On Immune Responses In Healthy Women., Na-Jin Park Jan 2006

Effects Of Breast Cancer Risk, Psychological Distress, And Dispositional Optimism On Immune Responses In Healthy Women., Na-Jin Park

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No abstract provided.


Verbal Learning And Mechanisms Of Adjustment To Disability During Inpatient Blind Rehabilitation., Margaret Mary Schmitt Jan 2006

Verbal Learning And Mechanisms Of Adjustment To Disability During Inpatient Blind Rehabilitation., Margaret Mary Schmitt

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No abstract provided.


Expression And Function Of Calcium -Activated Potassium Channels In Human Gliomas., Amy Katherine Weaver Jan 2006

Expression And Function Of Calcium -Activated Potassium Channels In Human Gliomas., Amy Katherine Weaver

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No abstract provided.


Relationship Of Parenting Stress And Social Support To Adolescent Maternal Parenting Behavior And Child Abuse Potential., Katrina K. Gilbert Jan 2006

Relationship Of Parenting Stress And Social Support To Adolescent Maternal Parenting Behavior And Child Abuse Potential., Katrina K. Gilbert

All ETDs from UAB

No abstract provided.


Fourth Graders' Reports Of Fruit And Vegetable Intake At School Lunch: Does Treatment Assignment Affect Accuracy?, Kathleen Fleege Harrington Jan 2006

Fourth Graders' Reports Of Fruit And Vegetable Intake At School Lunch: Does Treatment Assignment Affect Accuracy?, Kathleen Fleege Harrington

All ETDs from UAB

No abstract provided.


Antenatal Syphilis Management In Sub -Saharan Africa: Public Health Management Challenges And The Impact Of New Hiv Programs In Zambia., Dara G. Potter Jan 2006

Antenatal Syphilis Management In Sub -Saharan Africa: Public Health Management Challenges And The Impact Of New Hiv Programs In Zambia., Dara G. Potter

All ETDs from UAB

No abstract provided.


Medical Practice Variations Over Time In The United States., Charles Norman Saunders Jan 2006

Medical Practice Variations Over Time In The United States., Charles Norman Saunders

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No abstract provided.


Pediatric Iron Toxicity: The Impact Of Unit Dose Packaging., Ann P. Slattery Jan 2006

Pediatric Iron Toxicity: The Impact Of Unit Dose Packaging., Ann P. Slattery

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No abstract provided.


Multiple-Locus Variable-Number Tandem-Repeat Analysis (Mlva) For Clonal Characterization Of Methicillin Resistant Staphylococcus Aureus Strains, Matthew Box Jan 2006

Multiple-Locus Variable-Number Tandem-Repeat Analysis (Mlva) For Clonal Characterization Of Methicillin Resistant Staphylococcus Aureus Strains, Matthew Box

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Methicillin resistant Staphylococcus aureus (MRSA) strains have been observed to be associated with community based individuals (CA-MRSA) and hospitalized patients (HA-MRSA). The CA-MRSA and HA-MRSA are no longer distinguishable based on the location of patient when the isolate was first obtained from the patient. These strains are now observed both in the hospital and community settings. While the origin of the isolate does not appear to be critical, it is important to genetically define these isolates to assist in epidemiological investigations and evaluation of infection control measures effectiveness. The conventional method for analyzing this genetic information has been pulsed-field gel …


Micro-Computed Tomographic Analysis Of Bone Healing Subsequent To Graft Placement, Preeti M. Chopra Jan 2006

Micro-Computed Tomographic Analysis Of Bone Healing Subsequent To Graft Placement, Preeti M. Chopra

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A MicroCT analysis of bone healing subsequent to graft (tri calcium phosphate/TCP) placement in the maxillary sinus prior to dental endosteal implant placement was the objective of the current study. Ten trephined rod shaped human bone cores were obtained three months after the placement of particulate graft material and the samples were stored immediately in 10% neutral buffered formalin. Using a Microcomputed tomography, the samples were evaluated at resolutions of 6 and 20μm. The thresholds for bone and graft material were determined using visual image, intensity (grey level) and histogram analyses. The graft and bone threshold was 235 greylevel and …


Energy Audits Of State Buildings In Alabama, Harshad Prakash Shetye Jan 2006

Energy Audits Of State Buildings In Alabama, Harshad Prakash Shetye

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The purpose of this project was to perform preliminary energy audits at various state buildings in Alabama. Energy audits were conducted for a total of 18 buildings at the Department of Youth Services (Chalkville campus) and the Alabama State Capitol complex. Facility reports and summaries were prepared with the help of data obtained from building managers. Our research team identified areas in these facilties where energy conservation could be employed at no or low cost. The energy savings resulting from these audits were estimated based upon the guidelines presented in the Science Technology and Energy Division Guide for Calculating Program …


Underlying Purinergic Signaling Important For Monociliumdependent Signaling In Ductal Epithelia: Implications For Polycystic Kidney Disease, Michael Hovater Jan 2006

Underlying Purinergic Signaling Important For Monociliumdependent Signaling In Ductal Epithelia: Implications For Polycystic Kidney Disease, Michael Hovater

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This thesis concerns purinergic signaling in renal epithelial cells of normal and polycystic kidneys. The first section discusses first principles of “purinergic signaling” as they relate to the nephron and the urinary bladder. Remodeled and encapsulated cysts in autosomal dominant PKD (ADPKD) and remodeled “pseudocysts” in autosomal recessive polycystic kidney disease (ARPKD) of the renal collecting duct create an ideal microenvironment for purinergic signaling. Once “trapped” in these microenvironments in a “closed system,” purinergic signaling becomes chronic and plays a significant epigenetic and detrimental role in the progression of ADPKD in particular, once the remodeling of the renal tissue has …


Investigation Of Routing Protocols In A Sensor Network, Ramesh Praveenkumar Jan 2006

Investigation Of Routing Protocols In A Sensor Network, Ramesh Praveenkumar

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The objective of this thesis is to model the communication and computation resources of the sensor netork, develop a framework for lifetime estimation and performance evluation of the network, and explore routing schemes so as to extend the functional lifetime of both the individual nodes and the entire network. The sensor network is severly constrained by limited resources, so, energy efficiency is the most important factor in designing the network. Designing an efficient routing protocol in a sensor network is challenging due to various factors, such as limited resources, concentration of load to a limited portion of the network, and …


Multimodality Image Registration, Persis Prasai Jan 2006

Multimodality Image Registration, Persis Prasai

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Image registration has been a major area of research in the last few decades. It is a complex problem that involves handling large data sets. The relation between the real object and the image is very intricate and encompasses the object’s shape, surface properties, position, and illumination. In this thesis, a general solution to this problem was devised that can be applied to multimodality and within-modality image registration. The approach followed here is such that various factors such as illumination do not affect the algorithm. The algorithm considers the intensity of the images as raw data for the registration. The …


The Association Between 2002 Office Chlamydia Screening Rates, Physician Perception, And Physician Behavior, Blanche C. Collins Jan 2006

The Association Between 2002 Office Chlamydia Screening Rates, Physician Perception, And Physician Behavior, Blanche C. Collins

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Background: Chlamydia prevalence in reproductive-age females is 3-20%. This study aimed to determine if physicians’: • sexual activity prevalence perceptions • Chlamydia prevalence perceptions • Sexual history-taking were associated with mean office screening rates; and if physicians’ perceptions of: • sexual activity • Chlamydia were associated with sexual history-taking. Methods: A national MCO’s physicians participated and were asked about their perceptions of sexual activity and Chlamydia prevalence and their sexual history-taking. Data sources included mean office screening rates, online surveys, and AMA’s masterfile. Results: Only 15% of at-risk females were screened (n = 75). Physicians who estimated lower 18 year-old …


Modulation Of Cell Signaling By Tomoregulins In Embryogenesis And Cancer, Paul William Harms Jan 2006

Modulation Of Cell Signaling By Tomoregulins In Embryogenesis And Cancer, Paul William Harms

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Growth factor signals often regulate similar cellular processes both during embryogenesis and in adult homeostasis. Stringent control of these signals ensures proper embryonic development and correct cell physiology in mature individuals. Recently, a family of two members of Tomoregulin (or transmembrane protein with epidermal growth factor-like and two follistatin domains [TMEFF]) was found to interact with transforming growth factor-β (TGF-β) and ErbB signaling pathways, both of which are implicated in development and in cancer biology in the adult. The function as well as the mechanisms of TMEFFs in modulating these two signals has not been elucidated in detail. In this …


Lawrence County's Dropouts' Perceptions Of Why They Chose To Become Early Leavers., Jewell C. Satchel Jan 2006

Lawrence County's Dropouts' Perceptions Of Why They Chose To Become Early Leavers., Jewell C. Satchel

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No abstract provided.


The Effect Of Environmentally-Related Cardiovascular Disease Risk Factors On Mitochondrial Damage And Atherogenesis., Zhen Yang Jan 2006

The Effect Of Environmentally-Related Cardiovascular Disease Risk Factors On Mitochondrial Damage And Atherogenesis., Zhen Yang

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No abstract provided.


A Survey Assessment Of Veterinarians To Determine The Level Of Preparedness For An Infectious Disease Outbreak, Tamara Crutchley Bushell Jan 2006

A Survey Assessment Of Veterinarians To Determine The Level Of Preparedness For An Infectious Disease Outbreak, Tamara Crutchley Bushell

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Safeguarding animal health is of paramount importance to the US economy, public health and food safety. One of the most important causes of contamination in food products and of food-borne disease in humans is microorganisms that reside in the intestines of animals, such as Salmonella species and Escherichia coli O157:H7. A fundamental knowledge of the epidemiology of diseases, including an understanding of the agents and hosts, is a critical component of early (front-line) detection and prevention of contamination by microorganisms. Front-line detection is provided by animal handlers and personnel working with animals on a day-to-day basis, such as veterinarians. Currently …


Evalutation Of Sediment-Sensitive Biological Metrics As Bio-Monitoring Tools On Varied Spatial Scales, Janna Yvonne Smithey Owens Jan 2006

Evalutation Of Sediment-Sensitive Biological Metrics As Bio-Monitoring Tools On Varied Spatial Scales, Janna Yvonne Smithey Owens

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Sediment is one of the principal causes of water-quality impairment in surface waters of the United States. Although biological assessments are useful for characterizing the status of aquatic communities, reasons for impairment cannot be identified without quantifying associated variables physical variables that can be adequately related to bio-logical functions. Our objective was to explore potential relations between fish and ben-thic macroinvertebrate community structures and variables of sedimentation processes on a watershed and channel-reach scale. Biologic collections and habitat evaluations were conducted using the EPA’s Rapid Bioassessment Protocol over a period of three years (2000-2003) at sites in the upper Cahaba …


Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu Jan 2006

Increased Hexosamine Biosynthesis And Protein O-Glcnac Protect Isolated Rat Heart From Ischemia/Reperfusion Injury, Jia Liu

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Increased levels of protein-associated O-linked N-acetylglucosamine (O-GlcNAc) have been correlated with increased tolerance to stress. Therefore the goal of this study was to determine whether enhanced flux through the hexosamine biosynthesis pathway (HBP), which leads to elevated levels of O-GlcNAc, increased the tolerance of the heart to ischemia and reperfusion (I/R). Hearts from male rats were isolated and perfused with Krebs-Henseliet buffer containing 5mM glucose, and global, no-flow ischemia was induced for 20min followed by 60 min reperfusion. 20 min pre-treatment with 10 mM glucosamine, which enters the HBP directly, significantly improved functional recovery and decreased cardiac Troponin I release …


Congregation For Public Health Examines Community Engagement Knowledge Of Program Administrators And Community Health Advisors Using Social Capital And Community Capacity, Kimberly Mccall Jan 2006

Congregation For Public Health Examines Community Engagement Knowledge Of Program Administrators And Community Health Advisors Using Social Capital And Community Capacity, Kimberly Mccall

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This research study was designed to examine and compare how community engagement knowledge of Program Administrators and Community Health Advisors (CHAs) can be shaped and affected by social capital and community capacity. This was achieved by analyzing the Congregations for Public Health’s Search Your Heart Program. The analysis used a three one-way fixed-effects ANOVA model, one for each of the three research questions. Overall, the results showed that upon examination of each of the three relationship hypotheses there were no primary differences in average knowledge among the groups. The relationships were examined by characteristics such as project role, CHA training …


Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li Jan 2006

Regulation Of Ss-Catenin By Gli1 In Epithelial Transformation, Xingnan Li

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Gli family members-mediated continuous Hedgehog (Hh) pathway activity plays a role in the growth of a number of human cancers, including the common malignancy of skin, basal cell carcinoma (BCC), and other highly aggressive tumor types. However, the mechanism by which Gli proteins act to promote the outgrowth of cancer in response to stimulation of Hh signaling is poorly understood. Identified as zinc finger transcriptional factors, the Gli family of proteins has been shown to be involved in multiple cellular processes through activating its target genes. Therefore, to study the function of Gli target genes is important for our understanding …


Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu Jan 2006

Klf4 Regulates Notch1 Expression And Signaling During Epithelial Transformation, Zhaoli Liu

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Notch1 and KLF4 function in the specification of epithelial cell fates, and each can act as a context-dependent oncogene or tumor suppressor. We report that KLF4 directly regulates transcription of Notch1 and that cleavage of full-length Notch1 to the active intracellular form, N1IC, is necessary for transformation by KLF4. Paradoxically, KLF4 suppresses canonical Notch1-CSL signaling by up-regulating Hairless, an antagonist of this pathway. Dominant-negative inhibitors of the canonical Notch1 signaling pathway do not block transformation of epithelial cells by KLF4, while they greatly reduce the efficiency of transformation by N1IC. Thus, N1IC can transform cells by two distinct mechanisms: the …


Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash Jan 2006

Kiss1 Metastasis Suppressor Secretion Is Required For Metastasis Suppression, Kevin T. Nash

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Failure to reduce the number of cancer deaths over the last 50 years is due to the inability to selectively target metastatic disease. Recently, the KISS1 metastasis suppressor has emerged as a promising molecular agent for the management of metastatic disease. Although KISS1 has been implicated in the regulation of the metastatic phenotype in human cancers and in in vivo mouse models, little is known about its mechanism. Recent evidence suggests that KISS1 is a neuropeptide that is processed and secreted to interact with its cognate receptor GPR54 in the hypothalamus to trigger puberty and maintain the reproductive state. However, …