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Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke Jan 2007

Insulin Dynamics In African Americans And European Americans: Mechanistic Aspects, And Association With Inflammation, Radhika P. Phadke

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Identification and characterization of ethnic differences in insulin dynamics, insulin sensitivity (SI), and inflammation may shed light on the greater risk for type 2 diabetes in African Americans (AA), relative to European Americans (EA). Ideally, such studies should take into account the potential confounding roles of adiposity, fat distribution, genetic background, and socioeconomic status (SES). The objectives of this study were, 1) to evaluate ethnic differences in insulin dynamics in AA and EA children and adults using robust measures of insulin secretion and clearance; 2) to identify the contributions of genetic admixture and SES to insulin dynamics; 3) to examine …

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Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps Jan 2007

Genetic And Epigenetic Modulation Of Telomerase Activity In Development And Disease, Sharla Marion Ostein Phipps

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The end replication problem of linear chromosomes leads to the erosion of telomeric DNA with each cell division. A mechanism to counteract telomeric attrition involves the activity of the specialized ribonucleoprotein telomerase. Expression of the catalytic subunit of telomerase, hTERT, is tightly regulated and this regulation is achieved through both genetic and epigenetic mechanisms. Activators such as c- MYC and SP1 and repressors such as MAD1, Menin, and p53 mediate hTERT transcription. Epigenetic control mediated by DNA methylation and histone modifications such as methylation and acetylation can reversibly and potently regulate telomerase activity. Not only is there synergism between the …

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Enterprise Configuration Management In A Service-Oriented Architecture Environment Delivering It Services, Robert E. Raygan Jan 2007

Enterprise Configuration Management In A Service-Oriented Architecture Environment Delivering It Services, Robert E. Raygan

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Information Technology (IT) is a collaboration environment for business and engineering. The past decade has seen a reduction in business understanding of engineering principles because of the lack of trained engineers working in IT, while businesses have become increasingly dependent upon new and complex technologies. These new technologies, often still evolving, are system-of-systems environments and present significant challenges to early implementers. Service-Oriented Architecture (SOA) is one such system-of-systems that pushes the discipline of Software Configuration Management (SCM) beyond traditionally defined bounds. Evolving standards associated with SOA and the nature of SOA contribute to these challenges of governance and management: loose …

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Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan Jan 2007

Trafficking Of Hantaviral Nucleocapsid Proteins, Harish N. Ramanathan

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Hantaviruses are enveloped, negative-sense RNA viruses belonging to genus Hantavirus, within the family Bunyaviridae. Hantaviruses include many serious human pathogens and are classified as Old and New World based on the geographic distribution of rodent reservoirs and their ability to in induce distinct illnesses in humans. Currently there are no reservoirs known for hantaviruses other than the rodents. Human transmission of hantaviruses occurs via inhalation of aerosolized rodent excreta leading to hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Hantavirus genome consists of small (S), medium (M) and large (L) segments that encode nucleocapsid (N) protein, two …

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The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read Jan 2007

The Role Of Complement In Experimental Autoimmune Uveitis, Russell W. Read

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The complement system has been increasingly implicated in the pathophysiology of autoimmune disease. Complement expression in the normal human eye had not been previously completely defined. We performed immunohistochemical studies for membrane complement proteins in normal human retina to provide a baseline for future studies. We found expression of the anaphylatoxin receptors, CD55, and CD59 in the inner retina and CD46 in a polarized fashion on the retinal pigment epithelium. Previous studies in uveitis have shown activated fragments of complement in human eyes with uveitis and animal models have shown an effect on disease by complement depletion with cobra venom …

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Development And Initial Validation Of A Self-Efficacy Scale For Use With Registered Dietitians Working With Overweight Youth, Christopher M. Reinold Jan 2007

Development And Initial Validation Of A Self-Efficacy Scale For Use With Registered Dietitians Working With Overweight Youth, Christopher M. Reinold

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This study developed and validated the Youth-Directed Obesity Counseling Self-efficacy (Y-DOCS) Scale to evaluate the self-efficacy of registered dietitians (RDs) working with childhood overweight. The specific purpose of this study was to create an evaluation instrument that can measure the effectiveness of continuing education (CE) that provides behavioral counseling training. Two research questions guided this investigation into measuring the self-efficacy of RD’s: (a) Is the Y-DOCS scale for dietitians a reliable instrument for assessing self-efficacy among dietitians who receive training? (b) Is the Y-DOCS scale for dietitians a valid instrument for assessing self-efficacy among dietitians who receive training? The population …

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Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves Jan 2007

Pathogenesis And Therapeutic Potential Of Plasmacytoid Dendritic Cells In Siv/Shiv-Infected Macaques, R Keith Reeves

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Plasmacytoid dendritic cells (pDCs) are among the first responders during acute viral infections and are the primary producers of IFN-α, a cytokine known to inhibit viral replication and to activate natural killer (NK) cells. In HIV patients pDCs are decreased in number, are dysfunctional, and can harbor HIV-1 proviruses. However, since the time of transmission is usually unknown, pDC-virus interactions immediately after exposure to HIV remain unclear. Using the SIV/SHIV-macaque model, we showed that an acute and sustained loss of blood pDCs occurred during SIVmac239 infections, and when compared to those from naïve controls, pDCs were also significantly reduced in …

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In Vivo Imaging Studies In Animal Models Of Myocardial Infarction With And Without Cell Injections, Balazs Ruzsics Jan 2007

In Vivo Imaging Studies In Animal Models Of Myocardial Infarction With And Without Cell Injections, Balazs Ruzsics

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After prolonged myocardial ischemia, myocardial infarction occurs. Several tissue changes are associated with myocardial infarction and iron labeled cell injections. In the present thesis our major aim was to develop methods to monitor these tissue changes with MRI and MDCT. In the first chapter we used transendocardial injection to deliver iron labeled allogen skeletal myoblasts one week after myocardial infarction. Our goal was to identify the cells and/or injection sites in the myocardium. We used our new Tissue Characterization Mapping method to delineate tissue edema and hemorrhage in the myocardium. The T2 weighted signal intensity enhancement, T2w SIE region was …

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Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders Jan 2007

Factors Influencing The Adoption Of Administrative Innovations, Tom J. Sanders

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The purpose of this dissertation was to investigate the influence of selected environmental and organizational factors on the adoption of administrative innovations in order to better understand strategic adaptation by organizations. General systems theory, various organizational theories, strategic adaptation and management theories, and adoption and diffusion of innovation literature were used to develop a theoretical framework to address four primary and sixteen secondary hypotheses. The administrative innovation used for this study was the magnet hospital concept for enhancing attraction and retention of registered nurses in order to address a persistent workforce shortage in U.S. hospitals. Secondary data related to U.S. …

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Caste As A Determinant Of Utilization Of Maternal And Neonatal Healthcare Services In Maitha, Uttar Pradesh, India, Ekta Saroha Jan 2007

Caste As A Determinant Of Utilization Of Maternal And Neonatal Healthcare Services In Maitha, Uttar Pradesh, India, Ekta Saroha

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Caste among Hindus in India is a non-modifiable socio-demographic characteristic, often the basis of segregation and discrimination. Despite the provision of subsidized maternal and child healthcare services, utilization in rural Uttar Pradesh (UP), India is poor. Studies showed that upper caste (UC) women were more likely to utilize healthcare services than the lower caste (LC) women but this association is inadequately researched. We explored whether caste was a determinant of utilization of maternal healthcare (MH) and neonatal healthcare (NH) services among rural Hindu women and neonates in Maitha, UP, India. Data from the ‘Morbidity and Performance Assessment’ study for 482 …

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A Grounded Theory Study: Hispanic Adolescents' Experience Of Being Overweight, Wilma Powell Stuart Jan 2007

A Grounded Theory Study: Hispanic Adolescents' Experience Of Being Overweight, Wilma Powell Stuart

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The number of overweight adolescents worldwide has continued to increase over the past several decades. Intervention studies for weight management with overweight adolescents are challenged by high rates of attrition and have failed to achieve sustained outcomes. Hispanic adolescents have a higher risk of being overweight than their African American and White peers do. However, Hispanic overweight adolescents have been poorly represented in intervention studies with overweight adolescents. The factors that influence the Hispanic overweight adolescents’ perceptions of weight and weight loss management are not known. This qualitative study used ground theory methodology to identify the factors that influence perceptions …

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The Characterization Of The Subcellular Localization Of Bile Acid Coa: N-Acyltransferase, Nathan Allen Styles Jan 2007

The Characterization Of The Subcellular Localization Of Bile Acid Coa: N-Acyltransferase, Nathan Allen Styles

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The liver plays a central role in metabolism. It controls protein metabolism through deamination and transamination of amino acids, removal of ammonia through urea synthesis, synthesis of non-essential amino acids and synthesis of the majority of plasma proteins such as albumin. The liver regulates blood glucose levels through glyconeogenesis and glyconeolysis of glycogen, as well as gluconeogenesis from amino acids. It regulates fat metabolism through oxidation of triglycerides and fatty acids, as well as synthesis of cholesterol, lipoproteins, and phospholipids. Furthermore, the liver is the only site of formation of bile acids and their conjugates, physiologically important compounds that solubilize …

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Bacillus Anthracis Spore-Host Interactions, Melissa K. Swiecki Jan 2007

Bacillus Anthracis Spore-Host Interactions, Melissa K. Swiecki

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The use of Bacillus anthracis as a bioweapon depends on the dispersal of its spores into the environment, entrance into the body, spore uptake by human host cells, germination of the spores in the host and the pathological consequences of the virulence factors produced by the vegetative cells. Prior to 2001, very little was known about the mechanisms of spore entry into the host, including targeting cell types at airway, digestive and skin surfaces, potential spore receptors on these cells and spore encounters with cellular and humoral elements of the innate and adaptive immune systems. To this end, we have …

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Relaxation Rate-Based Magnetic Resonance Imaging Quantification Of Myocardial Infarction, Pal Suranyi Jan 2007

Relaxation Rate-Based Magnetic Resonance Imaging Quantification Of Myocardial Infarction, Pal Suranyi

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Ischemic heart disease is the leading cause of mortality in western societies. Treatment needs to be tailored for each individual, which requires accurate assessment of the underlying pathology. Magnetic Resonance Imaging (MRI) is a relatively young modality in the field of cardiovascular imaging, and boasts with the lack of harmful radiation, excellent soft tissue contrast, and high spatial-temporal resolution. The very foundation of the concept of MRI was the finding that pathology causes changes in the relaxation rates of tissues. Measurement of relaxation rates is more time consuming than generating simple signal intensity images weighted by the longitudinal or transverse …

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A Study Of Perceived Stress, Anxiety, Somatic Symptoms, And Spirituality In Practitioners Of The Martial Art Aikido, Howell E. Tapley Jan 2007

A Study Of Perceived Stress, Anxiety, Somatic Symptoms, And Spirituality In Practitioners Of The Martial Art Aikido, Howell E. Tapley

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The purpose of this study was to examine relationships between physical, mental and spiritual health. An additional purpose was to determine if the practice of aikido was associated with measurable levels of somatic symptoms, perceived stress, anxiety and spirituality. Measurement instruments included Cohen’s 10-item Perceived Stress Scale (PSS), Spielberger’s 20-item Trait Anxiety Inventory (TAI), the Patient Health Questionnaire-15 (PHQ-15), and the 16-item Daily Spiritual Experiences Scale (DSES). A cross-sectional research design was utilized in this study to test the following hypotheses: 1) After controlling for demographic variables, daily spiritual experience will explain variability in perceived stress, anxiety and somatic symptoms, …

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Genetic And Epigenetic Regulation Of Dihydropyrimidinase And Beta-Ureidopropionase In Individuals With Altered Uracil Catabolism And Normal Dihydro Pyrimidine Dehydrogenase Enzyme Activity, Holly Reed Thomas Jan 2007

Genetic And Epigenetic Regulation Of Dihydropyrimidinase And Beta-Ureidopropionase In Individuals With Altered Uracil Catabolism And Normal Dihydro Pyrimidine Dehydrogenase Enzyme Activity, Holly Reed Thomas

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There remain a number of patients presenting with 5-fluorouracil (5-FU) toxicity despite normal dihydropyrimidine dehydrogenase (DPD) enzyme activity, suggesting possible deficiencies in the two enzymes downstream of DPD in the uracil catabolic pathway: dihydropyrimidinase (DHP), encoded by the DPYS gene, or β-ureidopropionase (BUP-1), encoded by the UPB1 gene. Unlike DPD, which is expressed in peripheral blood mononuclear cells (PBMCs), DHP and BUP-1 enzyme activity is detected in only the liver and kidney, thus requiring an invasive biopsy for determination of activity. This dissertation, therefore, focuses on the role of the genetic and epigenetic regulation of DPYS and UPB1. The genetic …

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Influence Of A Sacs Review Of One Previously Unaccredited, Urban Middle School: A Qualitative And Quantitative Analysis, Carole Elaine Braden Tull Jan 2007

Influence Of A Sacs Review Of One Previously Unaccredited, Urban Middle School: A Qualitative And Quantitative Analysis, Carole Elaine Braden Tull

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The need for data-driven education and proof of accountability has become apparent since the reform movement in American education that began with A Nation at Risk (National Commission on Excellence in Education, 1983). Accreditation identifies schools as quality institutions, yet little K-12 research is available pertaining to the Southern Association of Colleges and Schools (SACS). In this longitudinal study, quantitative and qualitative methods were used to explore the impact of an initial SACS review on an urban, Title I middle school. The target school gained full SACS membership in May 2004. For the next three years the researcher gathered Stanford …

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Perceived Stress, Pain Coping Strategies, Pain Interference, And Social Support: Mediators And M Oderators Of Depression In A Spinal Cord Injury Sample With Chronic Pain, Michael W. Wilson Jan 2007

Perceived Stress, Pain Coping Strategies, Pain Interference, And Social Support: Mediators And M Oderators Of Depression In A Spinal Cord Injury Sample With Chronic Pain, Michael W. Wilson

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Chronic pain and depression are frequently co-reported secondary complications following spinal cord injury (SCI) that impact multiple psychosocial domains. This study investigated the contribution of pain intensity, perceived stress, pain coping strategies, pain interference, and social support in depression and sought to identify mediator and moderator effects in the pain-depression relationship among persons with chronic SCI pain. Perceived stress, pain coping strategies, and pain interference were proposed as likely mediators of pain intensity and depression. Different types of social support were proposed as likely moderators of pain intensity and depression. The SCI sample consisted of 60 people with chronic pain …

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Effects Of Optical Blur On Visual Performance And Comfort Of Computer Users, Ferial M. Zeried Jan 2007

Effects Of Optical Blur On Visual Performance And Comfort Of Computer Users, Ferial M. Zeried

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Background. The study examined the effects of optical blur on the visual performance and comfort of computer workers. Since most workers have significant degrees of optical blur, the study may elucidate improved methodology for workplace comfort and function. Methods. Since young and old workers experience blur from different sources, the study incorporated two different designs. The study examined the correction of optical blur using a randomized, double-blind, placebo-controlled, crossover design. The primary outcomes of the study were visual comfort and productivity. In study one, subjects were required to be 19-35 yrs of age, have at least 0.50D uncorrected refractive error …

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The Relationship Of Risk For Unintentional Injury And Externalizing Behavior In Childhood., Elizabeth B. Bowling Jan 2007

The Relationship Of Risk For Unintentional Injury And Externalizing Behavior In Childhood., Elizabeth B. Bowling

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No abstract provided.

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An Evaluation Of Neighborhood Context And Health Lifestyles: Implications For Obesity Outcomes Among Children, Akilah Dulin Jan 2007

An Evaluation Of Neighborhood Context And Health Lifestyles: Implications For Obesity Outcomes Among Children, Akilah Dulin

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No abstract provided.

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Cost-Effectiveness Of A Multi-Stage School-Based Asthma Case Detection Program In An Urban School System, Joe K. Gerald Jan 2007

Cost-Effectiveness Of A Multi-Stage School-Based Asthma Case Detection Program In An Urban School System, Joe K. Gerald

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No abstract provided.

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Does Speed Of Processing Training Impact Driving Mobility In Older Adults?, Lesley Anne Ross Jan 2007

Does Speed Of Processing Training Impact Driving Mobility In Older Adults?, Lesley Anne Ross

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No abstract provided.

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Acute Effects Of Ambient Ozone On Daily Hospital Admissions And Daily Mortality For Respiratory And Cardiovascular Diseases Among Residents Of Bangkok, Thailand, Kannika Ruangdej Jan 2007

Acute Effects Of Ambient Ozone On Daily Hospital Admissions And Daily Mortality For Respiratory And Cardiovascular Diseases Among Residents Of Bangkok, Thailand, Kannika Ruangdej

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No abstract provided.

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Prepubertal Bisphenol A Exposure In The Rat Mammary Gland: Mechanism Of Action For Carcinogenesis, Nandini Raghuraman Jan 2007

Prepubertal Bisphenol A Exposure In The Rat Mammary Gland: Mechanism Of Action For Carcinogenesis, Nandini Raghuraman

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No abstract provided.

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Maternal Characteristics Associated With Language Outcomes Of Children Born At Less Than 32 Weeks Gestational Age, Richard V. Rector Jan 2007

Maternal Characteristics Associated With Language Outcomes Of Children Born At Less Than 32 Weeks Gestational Age, Richard V. Rector

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No abstract provided.

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Factors Affecting The Quality Of Rehabilitation Care For Inpatients With Spinal Cord Injury, Haiyan Qu Jan 2007

Factors Affecting The Quality Of Rehabilitation Care For Inpatients With Spinal Cord Injury, Haiyan Qu

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No abstract provided.

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Dysregulated Enac And Nhe Function In Cilium-Deficient Renal Collecting Duct Cell Monolayers, A Model Of Polycystic Kidney Disease, Dragos S. Olteanu Jan 2007

Dysregulated Enac And Nhe Function In Cilium-Deficient Renal Collecting Duct Cell Monolayers, A Model Of Polycystic Kidney Disease, Dragos S. Olteanu

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No abstract provided.

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Aging Differences In Mechanisms Of Human Skeletal Muscle Hypertrophy, David J. Kosek Jan 2007

Aging Differences In Mechanisms Of Human Skeletal Muscle Hypertrophy, David J. Kosek

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No abstract provided.

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Sunscreen Fluorescence In Skin, Skin Cells, And Dielectric Nanospheres: A New Method To Evaluate Sunscreen In A Novel Model System For Skin, Rajagopal Krishnan Jan 2007

Sunscreen Fluorescence In Skin, Skin Cells, And Dielectric Nanospheres: A New Method To Evaluate Sunscreen In A Novel Model System For Skin, Rajagopal Krishnan

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No abstract provided.

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