Digital Commons Network^™

Short-Wavelength Enrichment Of Polychromatic Light Enhances Human Melatonin Suppression Potency., George Brainard, John P. Hanifin, Benjamin Warfield, Marielle K. Stone, Mary E. James, Melissa Ayers, Alan Kubey, Brenda Byrne, Mark Rollag

Department of Neurology Faculty Papers

The basic goal of this research is to determine the best combination of light wavelengths for use as a lighting countermeasure for circadian and sleep disruption during space exploration, as well as for individuals living on Earth. Action spectra employing monochromatic light and selected monochromatic wavelength comparisons have shown that short-wavelength visible light in the blue-appearing portion of the spectrum is most potent for neuroendocrine, circadian, and neurobehavioral regulation. The studies presented here tested the hypothesis that broad spectrum, polychromatic fluorescent light enriched in the short-wavelength portion of the visible spectrum is more potent for pineal melatonin suppression in healthy …

The Significance Of Macrophage Polarization Subtypes For Animal Models Of Tissue Fibrosis And Human Fibrotic Diseases., Peter J. Wermuth, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecular pathways involved in their pathogenesis are complex and despite intensive investigations have not been fully elucidated. Whereas chronic inflammatory cell infiltration is universally present in fibrotic lesions, the central role of monocytes and macrophages as regulators of inflammation and fibrosis has only recently become apparent. However, the precise mechanisms involved in the contribution of monocytes/macrophages to the initiation, establishment, or progression of the fibrotic process remain largely unknown. Several monocyte and …

Measuring And Using Light In The Melanopsin Age., Robert J Lucas, Stuart N Peirson, David M Berson, Timothy M Brown, Howard M Cooper, Charles A Czeisler, Mariana G Figueiro, Paul D Gamlin, Steven W Lockley, John B O'Hagan, Luke L A Price, Ignacio Provencio, Debra J Skene, George C Brainard

Department of Neurology Faculty Papers

Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production, and application of light. A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, …

Theodor Billroth And His Musical Life., Patrick A. Hartendorp, B.S., Charles J. Yeo, Md, Pinckney J. Maxwell, Iv, Md

Department of Surgery Gibbon Society Historical Profiles

Although most widely recognized for the two types of gastric reconstructions that bear his name, Christian Albert Theodor Billroth was one of the most innovative surgeons of his time. His contributions included developing techniques for procedures on the larynx, breast, and esophagus. He pioneered sterility and antisepsis in operating rooms. He also improved surgical education by advocating for longer apprenticeships, which helped create a framework for today’s residency programs. However, what often goes unnoticed was Dr. Billroth’s love for music, a passion that fueled him throughout his life.

Sci-Tech Book News Reviews

Sci-Tech News

This section consists of 100 book reviews selected from Sci-Tech Book News, reprinted with the permission of Book News, Inc.

Clinical And Translational Implications Of The Caveolin Gene Family: Lessons From Mouse Models And Human Genetic Disorders., Isabelle Mercier, Jean-Francois Jasmin, Stephanos Pavlides, Carlo Minetti, Neal Flomenberg, Richard G Pestell, Philippe G Frank, Federica Sotgia, Michael P Lisanti

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement …

Chapter Vi, Pp. 106-118

The Jefferson Medical College of Philadelphia, Benefactors, alumni, hospital etc. Its founders, officers, instructors, 1826--1904 A HISTORY (Volume 1)

No abstract provided.

Chapter 7- Eminent Jefferson Professors, Pp. 231-386

Legend and Lore: Jefferson Medical College

No abstract provided.

Molecular Processes That Handle — And Mishandle — Dietary Lipids, Kevin Jon Williams

Department of Medicine Faculty Papers

Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation — but possible reversibility — in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.

Sensitivity Of The Human Circadian System To Short Wavelength (420 Nm) Light, George C. Brainard, David Silney, John P. Hanifin, Gena Glickman, Brenda Byrne, Jeffrey M. Greeson, Samar Jasser, Edward Gerner, Mark D. Rollag

Department of Neurology Faculty Papers

The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment, melanopsin. Nine action spectrum studies using rodents, monkeys, and human for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 nm to 484 nm, with some disagreement in short wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420 nm light for plasma melatonin suppression. Adult female (N=14) and male (N=12) subjects participated in two studies, each employing a …

Meeting Report: The Role Of Environmental Lighting And Circadian Disruption In Cancer And Other Diseases, Richard G. Stevens, David E. Blask, George C. Brainard, Johnni Hansen, Steven W. Lockley, Ignacio Provencio, Mark S. Rea, Leslie Reinlib

Department of Neurology Faculty Papers

Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect of light on circadian organization, including the production of several hormone rhythms. Changes in light-dark exposure (e.g., by nonday occupation or transmeridian travel) shift the timing of the circadian system such that internal rhythms can become desynchronized from both the external environment and internally with each other, impairing our ability to sleep and wake at the appropriate times and compromising physiologic and metabolic processes. Light can also have …

Jefferson Alumni Bulletin – Volume Xlvii, Number 2, March 1998

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 2, March 1998

Department Restructurings Respond to the Evolution in Scientific Disciplines, Page 4

The Rb2/p130 Gene and Endometrial Cancer, Page 7

Gene Therapy Trial for Glioblastoma, Page 8

Ovarian Cancer Vaccine is Promising in First Tests, Page 9

Transgenic Mouse for Study of Photoaging, Page 10

Uric Acid Reduces MS Symptoms in Mice, Page 11

Albert Einstein Healthcare Network Will Join Jefferson Health System by July, Page 12

Proposed Amendments to Alumni Association Bylaws, Page 14

Joseph Seltzer, ’71, the Next Alumni President, Page 15

Wallace Miller ’56 Receives RSNA Gold Medal, …

Jefferson Alumni Bulletin – Volume Xliii, Number 3, Fall 1994

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIII, Number 3, Fall 1994 Diary of an SCI, page 5 Colleagues honor Cotler with portrait, page 7 Neurosensory institute is established, department of neurosurgery expands, page 7 Teaching molecular medicine, preparing for practice in the 21st Century, page 8 On campus, page 11 Jefferson Research, page 12 Giving to Jefferson, page 14 Obituaries, page 16 Class notes, page 18

Jefferson Alumni Bulletin – Volume Xliii, Number 4, Summer 1994

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIII, Number 4, Summer 1994

The social transformation of practice, page 8

How medicine is taught differently now, page 8

The only constant is change, page 8

Medicine is being challenged and physicians must respond, page 8

Vascular Ectasias of the colon, page 9

Jefferson and AIDS care in Uganda, page 10

Laparoscopic cholecystectomy at Pennsylvania hospital, page 10

Nintendo comes to medicine: 3-D MRI of congenital heart disease, page 11

Imaging of psychiatric conditions, page 12

Effects of space flight on human physiology: A Jefferson Study, page 12

Aesthetic considerations after trauma, page 13 …

Part I: Jefferson Medical College 1835 To 1845 (Pages 27-54)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part I: Jefferson Medical College 1866 To 1876 (Pages 125-156)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Jefferson Alumni Bulletin – Volume Xxxviii, Number 3, Spring 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 3, Spring 1989

The Gibbon Scholars program, Page 2

The Jefferson scene, page 12

Class notes, Page 29

Part Ii: Basic Sciences --- Chapter 5: Department Of Physiology (Pages 158-181)

Thomas Jefferson University - tradition and heritage, edited by Frederick B. Wagner, Jr., MD, 1989

No abstract provided.

Part Iii: Clinical Departments And Divisions --- Chapter 12: Division Of Gastroenterology And Hepatology (Pages 327-337)

Thomas Jefferson University - tradition and heritage, edited by Frederick B. Wagner, Jr., MD, 1989

No abstract provided.

1979 Commencement For Jefferson Medical College, College Of Graduate Studies, And College Of Allied Health Sciences

Jefferson College of Biomedical Sciences Commencement

No abstract provided.

1979 Commencement For Jefferson Medical College, College Of Graduate Studies, And College Of Allied Health Sciences

Jefferson College of Health Professions and Jefferson College of Pharmacy

No abstract provided.

1979 Commencement For Jefferson Medical College, College Of Graduate Studies, And College Of Allied Health Sciences

Sidney Kimmel Medical College Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xx, Number 1 Fall 1970

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XX, Number 1 Fall 1970

Admissions at Jefferson, page 2

Physiology in evolution, page 9

Student government, page 16

Alumni achievement award, page 24

Profile, page 26

The Jefferson scene, page 28

Faculty notes, page 31

Class notes, page 33

Jefferson Alumni Bulletin – Volume Xiii, Number 2 May 1963

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XIII, Number 2 May 1963

Department of Physiology, Page 2

Promotions, new appointments and resignations, Page 21

Dr. Albrecht promoted to professor of preventive medicine, Page 21

Dr. Waelder joins Department of Psychiatry, Page 22

Third Jefferson postgraduate medical seminar, Page 23

Alumni placement bureau, Page 24

News of college departments, Page 25

33rd annual Black and Blue Ball, Page 30

Dr. Fry’s Annual Giving Fund report, Page 31

Class standings – 15th Alumni Giving Fund drive, Page 32

1963 graduate assembly day program, Page 34

Class reunion day and alumni day programs, Page 35 …

Jefferson Medical College Alumni Bulletin-Vol. 1 No. 6; May, 1926

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Table of Contents – Vol. 1 No. 6; May, 1926 William Potter Obituary, Page 1 A Sketch of the Life of William Potter, Page 2 The Annual Banquet, Page 3 The Penn Athletic Club, Page 4 The Jefferson Medical College Then and Now – A Retrospect, Page 5 Notes on Alumni Gatherings, Page 9 Faculty Resignations, Page 10 The Monthly Meeting of the Jefferson Hospital Staff, Page 11 100 Per Cent of the Class of 1926 Join the Alumni Association, Page 11 Portrait of William Harvey Presented to the Jefferson Medical College, Page 12 Jefferson Smokers in Connection with State …

1925 Clinic Yearbook

Sidney Kimmel Medical College Yearbooks

The Clinic is the yearbook of the Sidney Kimmel Medical College (formerly Jefferson Medical College) at Thomas Jefferson University.

Modern Surgery - Chapter 4. Repair, John Chalmers Da Costa

Modern Surgery, 4th edition, by John Chalmers Da Costa

No abstract provided.

Sixty-Second Annual Announcement Of The Jefferson Medical College Of Philadelphia: The Session Of 1886-87

Jefferson Medical College Catalogs

No abstract provided.

Sixty-First Annual Announcement Of The Jefferson Medical College Of Philadelphia: The Session Of 1885-86

Jefferson Medical College Catalogs

No abstract provided.

Fifty-Ninth Annual Announcement Of The Jefferson Medical College Of Philadelphia: The Session Of 1883-84

Jefferson Medical College Catalogs

No abstract provided.