Digital Commons Network^™

Ns5-Targeting Nucleoside Analogs Inhibit Dengue Virus And Other Flaviviruses, Priyanka Bhakt, Swechha Pokharel, Yue Li, Tamanna Srivastava, Jesse Miller, Mark Dittmar, Yongqing Zhu, David Nguyen, Zachary Walter, Kasirajan Ayyanathan, Matthew Tudor, Chenguang Yu, Arnab Chatterjee, Holly Ramage, David Schultz, Sara Cherry

Department of Microbiology and Immunology Faculty Papers

Dengue virus (DENV) is a mosquito-transmitted flavivirus that circulates globally as four distinct serotypes and poses a substantial threat to public health. There are an estimated ~96 million symptomatic infections yearly, including severe cases of dengue fever, underscoring the urgency of identifying effective therapeutics targeting all four serotypes. Nucleoside analogs, which mimic endogenous nucleosides to inhibit viral RNA replication, offer a promising strategy for broad-spectrum antiviral development. Here, we conducted a high-throughput screen of 1,101 nucleoside analogs against DENV serotype 2 (DENV2) in a panel of human cell models, including human epithelial cells, hepatocytes, and fibroblasts. Candidates that were active …

Evaluating The American Society Of Hematology Quality Measure On Timeliness Of Analgesics For Sickle Cell Disease Pain Crisis, Ibrahim Gwarzo, Harish Chandra Dega, Paula Tanabe, Robin Miller, David C. Brousseau

Department of Medicine Faculty Papers

The American Society of Hematology (ASH) proposed the median time to first emergency department (ED) administration of pain medication for patients with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE) as a site-level quality measure. Generalizable studies assessing current guideline adherence recommending pain medications within 60 minutes are lacking. We leveraged multisite electronic health record data from Epic's Cosmos research platform to analyze ED encounters for SCD VOE from 1 January 2019 to 31 December 2024, with administration of at least 1 pain medication. We calculated the quality measure (median time to first pain medication) and ranked sites based on …

Molecular Profiling And Tumor Biomarker Analysis Of Gog281/Logs: A Positive Late-Phase Trial Of Trametinib For Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma, Robert L. Hollis, Austin Miller, Heather A. Lankes, Kwong-Kwok Wong, William Rodgers, David Millan, Karen Carty, Robert L. Coleman, Kathleen N. Moore, Angeles Alvarez Secord, David M. O'Malley, John K. Chan, Andrea R. Hagemann, Stephanie Gaillard, Saketh R. Guntupalli, Mitchell I. Edelson, Peter G. Rose, Oliver Dorigo, Susana Banerjee, Ailith Ewing, Michael Churchman, Anil K. Sood, C. Simon Herrington, Charlie Gourley, David M. Gershenson

Abington Jefferson Health Papers

PURPOSE: Low-grade serous ovarian carcinoma (LGSOC) is a distinct form of ovarian cancer characterized by younger patient age and relative chemoresistance. The GOG281/LOGS trial (NCT02101788) investigated the efficacy of the MEK inhibitor trametinib compared with physician's choice standard-of-care (SOC) in patients with LGSOC with persistent/recurrent disease. The study demonstrated significantly improved progression-free survival (PFS) in the trametinib-treated arm.

EXPERIMENTAL DESIGN: Two hundred and sixty patients with recurrent/persistent LGSOC were enrolled and randomly assigned in GOG281. We performed molecular analysis of 170 patients with available tumor specimens, comprising whole-exome sequencing and phospho-ERK (pERK) IHC, to identify biomarkers of clinical benefit from …

S6k1 Modulates Stat3 Activation To Promote Resistance To Radiotherapy In Lung Cancer, Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Radiotherapy is a mainstay in the management of locally advanced lung cancer; however, intrinsic and acquired radioresistance contribute to poor prognosis. S6K1, a serine/threonine kinase, regulates cell growth, protein synthesis, and survival, and is increased in tumors, which is linked to enhanced survival under therapeutic stress, including radiation. The mechanisms, however, are not fully understood. This study investigates the role of S6K1 in lung cancer radioresistance and the mechanisms involved. Intrinsic radioresistance in lung cancer cells was associated with increased S6K1 activation. Pharmacologic inhibition or genetic deletion of S6K1 enhanced radiosensitivity both in vitro and in vivo, highlighting the therapeutic …

Metastatic Castrate-Resistant Prostate Cancer To The Penis Resulting In Malignant Priapism And Urethral Obstruction, Courtney Stewart, Joon Yau Leong, William Kevin Kelly, Mihir Shah

Department of Urology Faculty Papers

A 76-year-old male with metastatic castrate-resistant prostate cancer was found to have metastatic disease to the urethra and penis on PSMA PET scan. This resulted in constant pain due to obstruction of blood flow through the corpora cavernosum resulting in priapism and urethral obstruction. The patient underwent a radical penectomy, partial urethrectomy and perineal urethrostomy creation. Final pathology confirmed metastatic prostatic adenocarcinoma. Although rare, prostate cancer can metastasize to the corpora spongiosum or cavernosa. Treatment options are limited, and surgical excision with urinary diversion is likely to provide the most durable outcomes for one's quality of life.

Metformin Exposure After Glioblastoma Diagnosis And Mortality: A Large Population-Based Study, Vittorio Maio, Roshani Shah, Manisha Lin, Patrick J. Moeller, Iyad Alnahhas, Richard Hass, Wenyin Shi, Scott W Keith

College of Population Health Faculty Papers

BACKGROUND: Glioblastoma (GBM) is an aggressive primary brain malignancy with limited therapeutic options and poor survival outcomes. Recent real-world studies and early-phase clinical trials evaluating metformin have yielded mixed findings. This study assessed the association between post-diagnosis metformin exposure and all-cause mortality in a large population-based cohort of older adults with GBM.

METHODS: A retrospective cohort study was conducted utilizing the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Adults aged ≥66 years diagnosed with GBM between 2007 and 2018 were included, excluding those with other malignancies or diagnoses made by autopsy or death certificate. Metformin exposure was modeled as …

Relationship Between Navigation Success, Diagnostic Accuracy, And Ventilation Strategy: Retrospective Chart Review Of 224 Consecutive Navigational Bronchoscopic Procedures Performed Under General Anesthesia, Basavana Goudra, Prarthna Chandar, Divakara Gouda, Harrison Yang, Ganan Muhunthan, Suvan Sundaresh, Michael Stuart Green

Department of Medicine Faculty Papers

Background: Navigational bronchoscopy (NB) enables precise sampling of peripheral and central pulmonary nodules using shape-sensing or electromagnetic guidance. A major challenge is anesthesia-induced atelectasis, which alters lung anatomy, reduces registration accuracy, and is known to lower diagnostic accuracy. To counteract this, ventilatory protocols such as the Ventilatory Strategy to Prevent Atelectasis (VESPA) and the Lung Navigation Ventilation Protocol (LNVP) have been recommended. Their adoption and clinical impact, however, remain uncertain. Methods: We conducted a retrospective review of 224 consecutive NB procedures performed under general anesthesia at a single academic medical center (January 2020–August 2024). Demographic, anesthetic, and ventilatory data were …

Feasibility And Form Factor Validation Of Reflective Shoulder-Mounted Pulse Oximeter In Patients With Suspected Sleep Apnea, Katie N. Kanter, Aaron Wang, David Gordon, Adina Singer, Jacob S. Brenner, Indira Gurubhagavatula, Anush Lingamoorthy, Olumuyiwa Oni, Cameron M. Baston

SKMC Student Presentations and Publications

The shoulder may be an effective central site for continuous oxygen saturation (SpO2) monitoring but studies of shoulder-mounted pulse oximetry technology are limited. We hypothesized that an alternative location would be similar in function and user acceptance to a standard FDA-cleared finger-based pulse oximeter. We conducted a quantitative and descriptive pilot study of two prototype biosensor designs in patients with clinical suspicion of hypoxic episodes at an outpatient sleep center. Participants wore two prototype biosensors-the primary a shoulder-mounted adhesive and the secondary a combination ring-bracelet-in addition to a control FDA-approved finger-based pulse oximeter. We assessed the comfort of the devices …

Evaluating Website Resources Shared Online Amongst Women With Intimate Partner Violence Experiences: Analysis Of An Online Health Community, Vivian Hui, Lidan Tian, Malavika Eby, Bohan Zhang, Rose E. Constantino

SKMC Student Presentations and Publications

INTRODUCTION: Intimate partner violence (IPV) affects around one in four women globally, posing substantial health risks. IPV survivors often consult online health communities for anonymous assistance rather than formal services. Though online health community members frequently share websites to answer questions, no studies have investigated the characteristics and relevance of websites shared in IPV online health communities. This study aims to identify the categories of websites shared in IPV online health communities and evaluate associations between post characteristics and website relevance to survivors' help-seeking needs.

METHODS: Data were extracted from posts and comments on the r/domesticviolence, a subreddit (topic-specific community) …

Evolving Strategies In Prostate Cancer: Emerging Approaches And Unmet Needs From The Bridging The Gaps In Prostate Cancer Expert Panel, Rana Mckay, Benjamin Maughan, Alicia Morgans, Neal Shore, Evan Yu, Ravi Madan, Jacob Berchuck, Bradley Carthon, Steven Finkelstein, Leonard Gomella, Michael Gorin, Andrew Hahn, Stacy Loeb, Vivek Narayan, Daniel Petrylak, Charles Ryan, Karine Tawagi, Phuoc Tran, Tanya Dorff

Department of Urology Faculty Papers

BACKGROUND: The expansion of treatment options for prostate cancer (PC) has improved disease-specific and overall survival outcomes but has also raised questions about the optimal level of treatment needed for patients based on their individual prognosis and accounting for potential toxicity, incorporating quality of life considerations.

METHODS: A panel of experts met to discuss current controversies in the care of patients with PC across the disease continuum. Multidisciplinary experts review advances and persistent uncertainties in biomarker-guided assessment, imaging, and systemic therapy for prostate cancer. The discussion outlines priority gaps in evidence that must be addressed to optimize individualized patient care. …

P-15 Peptide Enhanced Bone Graft In Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study Demonstrating Improved Composite Clinical Success, James Harrop, John E. O'Toole, Michael P. Steinmetz, Rick C. Sasso, Christopher D. Chaput, K. Brandon Strenge, Greg Maislin, Jeffrey P. Mullin, Thomas B. Freeman, Anthony Guanciale, Howard Lantner, Michael E. Janssen, David G. Schwartz, John M. Small, Wellington K. Hsu, Paul M. Arnold

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Prospective, multicenter, single-blind, randomized, controlled pivotal study.

OBJECTIVE: To evaluate whether P-15L (PearlMatrix P-15 Peptide Enhanced Bone Graft) is noninferior in effectiveness to local autograft when applied in single-level instrumented transforaminal lumbar interbody fusion (TLIF).

SUMMARY OF BACKGROUND DATA: P-15L, an FDA-designated Breakthrough Drug-Device, is a composite drug-device combination bone graft containing P-15, a 15-amino acid polypeptide, which enhances cell binding, proliferation, and differentiation, resulting in bone formation.

MATERIALS AND METHODS: Skeletally mature patients, aged 22 to 80 years, with degenerative disc disease (DDD) were randomized 1:1 to P-15L (investigational) or to the local autograft (control) during single-level …

Safety Of Carotid Endarterectomy In The Elderly And Octogenarian Population: A Nationwide Study Including 80,000 Patients, Victor Gabriel El-Hajj, Joanna Roy, Basel Musmar, Wi Jin Kim, Michael Rizzuto, Nathaniel Ellens, Rabab Alshahrani, Victor Staartjes, Adrian Elmi-Terander, Ramachandra Tummala, Stavropoula Tjoumakaris, Michael Gooch, Robert Rosenwasswer, Ziad Khabbaz, Pascal Jabbour

Department of Neurosurgery Faculty Papers

INTRODUCTION: Carotid endarterectomy (CEA) is an established procedure for stroke prevention in patients with carotid artery stenosis. While CEA is considered safe in younger patients, perioperative risks in octogenarians remain debated, with current guidelines classifying the procedure as "high-risk" in this patient population. This study aimed to evaluate short-term outcomes of CEA across age groups and to assess whether comorbidity burden better predicts outcomes than chronological age.

METHODS: The ACS-NSQIP database (2013-2020), was used to identify patients eligible for inclusion. The cohort was stratified based on age <  60, 60-80, and > 80 years. Propensity score matching and multivariable logistic regression were used to compare …

Generative Artificial Intelligence: Clinical Perceptions And Use In Physical Therapy Practice, Robert Dekerlegand, Malachy Clancy, Alison Bell, Erin Pletcher, Travis Pollen

Department of Physical Therapy Posters

Background and Purpose

• Generative artificial intelligence (GenAI) is an innovative technology that is reshaping healthcare with potentials ranging from improved efficiency to advancing personalized medicine.¹
• Ensuring the appropriate use of GenAI in teaching and learning has expanded in academia to also ensure graduates can competently use and partner with this technology in their fields.^2-4
• GenAI needs to be both accepted and adopted for these initiatives to translate into professional practice.
• Use of GenAI in physical therapy (PT) is being explored5,6and though therapists appear to understand aspects of this technology, current perceptions and actual use of GenAI in practice …

Reliability Of Existing Measures And Classification Systems For Trochlear Dysplasia, Sean R. Waldron, Nihar S. Shah, Matthew W. Veerkamp, Brendan A. Williams, John A. Schlechter, Lauren H. Redler, Matthew D. Ellington, Shital N. Parikh

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Patellofemoral instability (PFI) is common in adolescent patients and can lead to a reduction in quality of life and function, as well as long-term arthritis. Treatment of PFI involves assessing and, at times, surgically correcting underlying anatomic abnormalities. Trochlear dysplasia is the most common anatomic risk factor present in PFI.

PURPOSE: To determine the interrater reliability of existing measures and classification systems for the assessment of trochlear dysplasia.

STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3.

METHODS: As part of the PRISM (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) patellar instability Research Interest Group (RIG) project, a …

Primary Membranoproliferative Glomerulonephritis: Natural History, Pathogenesis, And Treatment, Edward J. Filippone, John L. Farber

Division of Nephrology Faculty Papers

Primary membranoproliferative glomerulonephritis (MPGN) is an ultrarare disease characterized by immunofluorescence microscopy as either immune-complex mediated (IC-MPGN) or C3 glomerulopathy (C3), the latter subdivided by electron microscopy to C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both IC-MPGN and C3G typically have obvious C3 staining differentiating them from other causes of MPGN histology. Secondary causes must be excluded, including infections, autoimmune disease, and neoplasia. Clinical presentations are variable, including urinary sediment abnormalities, nephrotic syndrome, or a rapidly progressive course. The prognosis is unfavorable with about 50% reaching kidney failure by 10 years. Recurrence following transplantation is frequent, and allograft survival …

Green Vessel Signal On Multicolor Imaging As An Early Sign Of Ischemic Vasculitis In Irvan Syndrome: A Case Report, Daniel M. Markowitz, Jirat Nimworaphan, Carl Regillo, James P. Dunn, Robert C. Sergott

Wills Eye Hospital Papers

PURPOSE: Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is typically diagnosed after characteristic intravenous fluorescein angiography (IVFA) findings develop. This case demonstrates that identifying a green intravascular and perivascular signal on multicolor fundus imaging may be a potential noninvasive imaging sign for ischemic retinal vasculitis in IRVAN.

OBSERVATIONS: A 55-year-old female presented with bilateral optic disc edema and subtle peripapillary retinal vascular changes. Multicolor imaging showed a distinct green intravascular and perivascular signal before undergoing IVFA evaluation. Subsequent IVFA ultimately showed peripheral capillary nonperfusion, microaneurysms, and leakage consistent with IRVAN.

CONCLUSIONS AND IMPORTANCE: This case demonstrates the potential utility …

Designing A Wellness Initiative Residents Actually Use: Data From Four Years Of Opt-Out Check-Ins, Meghan O’Meara, Phd, Lpc, Alexandra Hughes, Lcsw, Shawn Blue, Psyd, Emily Lisco, Md

Department of Psychiatry and Human Behavior Posters

Background

• Resident well-being remains a critical concern in GME, with increasing rates of burnout, mental health challenges, and persistent barriers to accessing care.^2,4
• Burnout among residents is linked to higher rates of medical errors and lower patient satisfaction.^4,5
• ACGME emphasizes the importance of fostering a culture of wellness including the opportunity for residents to attend healthcare appointments during working hours; however, programs often struggle to translate these goals into sustainable, practical interventions.¹
• Opt-out programs have been used to target residents and medical students to increase help-seeking and provide access to mental health care with limited barriers.
• Stigma, …

The Impact Of Neighborhood Socioeconomic Factors And Insurance Status On Outcomes Following Reduction Mammoplasty, Shin Heng Teresa Chan, Kelsey Van Housen, Emily Isch, Judith Monzy, Julianne Bartz, Matthew Jenkins, David Kim, Andrew Newman, Heather Mcmahon

Phase 1

Introduction: The impact of and neighborhood socioeconomic factors on surgical outcomes in reduction mammoplasty remains unclear. This study evaluated the effect of area deprivation index (ADI) and insurance status on postoperative outcomes following reduction mammoplasty.

Methods: A retrospective review of reduction mammoplasty cases was conducted at a single institution over a 7-year period. Patients ≥18 years old who underwent reduction mammoplasty for benign macromastia were included. Zip-code linked ADI, insurance type, and postoperative complication rate were assessed.

Results: In total, 594 patients were analyzed. Mean age was 36.2 ± 13.1 years, mean body mass index (BMI) was 32.6 ± 5.2 …

Maternal Perceptions Of Group Well Child Care For Mothers With Opioid Use Disorder, Regan King, Taylor Carrubba, Erica Sood, Meghan Gannon, Vanessa Short, Neera Goyal

Phase 1

Introduction/Purpose: Routine well child care (WCC) is critical for monitoring growth, development, and family wellbeing. Children born to mothers with opioid use disorder are less likely to receive adequate WCC, contributing to preventable health disparities. A Philadelphia-based substance use treatment program provides comprehensive care for pregnant and parenting individuals with substance use disorders, including an on-site pilot group- based WCC model designed to enhance access to and quality of WCC.

Methods: As part of a larger cluster-randomized controlled trial comparing traditional WCC with the group WCC model, qualitative interviews were conducted with ten mothers who completed three or more group …

The Relationship Between Disease-Modifying Therapy And Quality Of Life For People Living With Sickle Cell Disease, Lana King, Sophie Lanzkron

Phase 1

Introduction/Purpose: Despite the availability of disease-modifying therapies (DMT), adults with sickle cell disease (SCD) experience a multitude of adverse health effects that impact quality of life (QOL), with pain being the most common complication. There are few studies that objectively assess the relationship between DMT use and QOL in adults. This study aims to understand whether the currently used tools are sensitive to the use of DMT.

Methods: Data included 141 adult patients from three institutions in a national sickle cell disease registry (GRNDaD). A validated questionnaire, specific for patients with SCD (ASCQ-Me), was used to assess QOL in 5 …

A Retrospective Analysis On Oxygen Therapy And Adverse Outcomes, Matthew Marhefka, Brian Schonewald,, Ross Summer

Phase 1

Introduction/Purpose: Oxygen therapy is widely utilized for cases of hypoxemia. However, limited data evaluate the adverse effects of oxygen therapy in large cohorts. We hypothesize oxygen therapy correlates to an increased rate of trips, falls, and fractures, potentially due to limited mobility and the oxygen tubing posing a hazard.

Methods: TriNetX, a deidentified electronic health record database, was utilized to create two cohorts. Both cohorts consisted of patients with a COPD diagnosis, validated with PFTs. One group had the criterion of “dependence on supplemental oxygen,” while the other group had it excluded. In order to have more balanced cohorts, both …

Identification Of Socioeconomic And Demographic Predictors Of Somatic Genomic Testing Rates In Prostate Cancer, Erin Welch, Kevin K. Zarrabi, Khaldoun Hamade, Christopher Mcnair

Phase 1

Introduction/Purpose: Somatic genomic testing in metastatic prostate cancer (mPC) identifies genomic variants which provide clinical insight into the disease biology. Somatic testing results determine eligibility for standard of care targeted therapies and clinical trial eligibility. While national guidelines recommend testing for all mPC patients, patients with adverse social determinants of health (SDOH), racial minority groups and patients with low socioeconomic status (SES) have historically undergone lower rates of testing compared to national standards. This study aims to identify barriers to testing in mPC patients in the Jefferson system and ultimately understand the factors that influence testing rates.

Methods: Epic’s clinical …

Reproducibility Of Spatially-Defined Structural Cluster Analysis Using Automated Superpixel Metrics On Swept-Source Optical Coherence Tomography, Sahil Shah, Fabio Lavinsky, Bo Young Kim, Darron King, Ronald Zambrano, Fernanda Mari Fujihara, Dilru Amarasekera, Lauren E. Hock, Ping Huang, Natasha Kolomeyer, Reza Razeghinejad, Jonathan Myers, Gadi Wollstein, Joel Schuman

Phase 1

INTRODUCTION: Optical Coherence Tomography (OCT) is essential to detect and monitor structural damage in glaucoma. However, current practices focus on global and sectoral values, not localized changes. The study explores a novel approach using spatially determined superpixel clusters from swept- source OCT (SS-OCT) to assess localized changes in both healthy and glaucomatous eyes. We hypothesize that this method will provide reproducible results comparable with standard OCT parameters.

METHODS: Healthy and glaucoma subjects with ≥ 2 qualified same-visit optic nerve head (ONH) and macular Triton SS-OCT scans were included. Automated segmentation generated superpixel thickness values from 3D disc and macula arrays. …

Effects Of A Student-Delivered Glycemic Load Education Program (Jeffgl) On Depression, Emily La, Cindy Cheng

Phase 1

Introduction/Purpose: Previous studies have demonstrated that diabetes is linked to mental health disorders, including depression. In our student-delivered education program, Jefferson Glycemic Load (JeffGL), we aim to investigate the effects of glycemic load patient education on depression in diabetic and prediabetic patients. We hypothesize that participants will demonstrate reduced depression scores compared to baseline, measured using the Patient Health Questionnaire-9 (PHQ-9), after participation in JeffGL.

Methods: Over four weeks with long-term follow up, thirty overweight or obese patients with prediabetes or diabetes recruited from Jefferson’s Department of Family Medicine will participate in one-on-one and group Zoom sessions weekly concerning topics …

Evaluating The Residential Lead Remediation Program In The City Of Lancaster, Kaitlin Mcgowan, Divine Oludi, Harriet Okatch

Phase 1

Introduction: Residential lead remediation is an effective primary prevention approach for addressing lead exposure. Current guidelines require residents of a home get relocated during the remediation. Relocation is often for a period of ten days; however, no study has explored the effect of relocation on families. This study aims to understand the experiences of relocated families with a goal to develop a framework for relocation informed by the experiences of previously relocated families.

Methods. Ten semi-structured interviews were conducted with individuals from the city of Lancaster whose homes had been remediated during the last two years. Participants described their …

Resident Mental Health: Creating An Innovative, Sustainable, And Scalable Counseling Program, Emily Lisco, Md, Alexandra Hughes, Lcsw, Shawn Blue, Psyd Thomas Jefferson University, Meghan O’Meara, Phd, Lpc

Department of Psychiatry and Human Behavior Posters

Background

• The ACGME Common Program Requirements emphasize resident well-being and expect GME programs to support resident mental health.¹
• There are limited specific guidelines on how mental health support should be delivered, resulting in wide variability.^1,3
• Research on resident-specific mental health services is limited, making best practices difficult to define.
• Medical students typically receive care through student counseling centers; but this support ends after graduation.³
• Residents occupy a dual role as both hospital employees and learners, creating gaps in existing support models, as employee assistance programs are often underutilized by residents.
• Residents experience higher rates of burnout than …

Trauma-Informed Care In Graduate Nursing Education: A Scoping Review, Keziah Smallhouse, Stephen Didonato, Phd, Lpc

Phase 1

Introduction
Trauma-Informed Care (TIC) is a holistic, organizational framework that recognizes the widespread impact of trauma and emphasizes creating safe, supportive, and empowering environments. There is a lack of standardized and evidence-based approaches for delivering TIC education in graduate nursing programs. This project aims to examine current practices and enhance the delivery of TIC education for nursing students.

Methods
A scoping review was conducted to map the existing literature on trauma-informed nursing education in higher education settings. The review followed PRISMA-ScR guidelines, with study screening and management using Covidence. Eligible studies described higher education and included nursing students or faculty, …

Editorial: Unveiling The Next Generation Of Cancer Immunity & Immunotherapy, Mohanraj Sadasivam, Nethaji Muniraj, Chellappagounder Thangavel

Center for Translational Medicine Faculty Papers

[This corrects the article DOI: 10.3389/fimmu.2025.1769324.].

Age-Related Challenges Of Blood Pressure Management In Patients With Spinal Cord Injury, Brian Frost, Maclain Capron, Michael Stillman

Phase 1

Introduction/Purpose: Autonomic dysreflexia (AD), orthostatic hypotension (OH), and postprandial hypotension (PPH) are forms of dysautonomia that can affect people with spinal cord injury (SCI). Life expectancy for individuals with SCI has increased in recent decades, so it is critical to understand how triggers of these conditions change throughout the lifespan. This study will answer the question “What challenges do patients with SCI face regarding autonomic dysfunction as they age, and what are their perceptions of these challenges?”

Methods: This survey-based study aims to better understand dysautonomia in order to educate the medical community about specific challenges of growing older with …

The Impact Of Icare Home Tonometry On Glaucoma Management: A Retrospective Observational Study, Irene P. Kim, Natasha Nayak Kolomeyer, Jonathan Myers, Reza Razeghinejad

Phase 1

Introduction/Purpose: Home intraocular pressure (IOP) monitoring helps detect elevated IOPs that may be missed during routine office visits for glaucoma. This study examined whether home IOP tonometry provides additional information that changes glaucoma management.

Methods: This study included 82 eyes from 46 patients examined by the Wills Eye Glaucoma Service that had iCare HOME tonometry done between 2020 to 2023. Patient demographic data, prior surgical interventions and medications, and management changes following home tonometry were collected. iCare HOME tonometry data and the presence of IOP spikes were also recorded. Physician interpretations of optical coherence tomography imaging and visual field testing …