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Maintaining Continuity In A Resident Run Clinic-Impact Of The 6+2 Scheduling., Odunayo Banjoko, Md, Doron Schneider, Md, Rachel Ramirez, Md

House Staff Quality Improvement and Patient Safety Conference (2016-2019)

Objective:

The aim of this study was to evaluate the continuity of care with regards to follow up with the same team (and optimally same resident) 1 year prior to implementing the 6+2 scheduling block and 1 year post schedule block change.

2017 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Jefferson College of Biomedical Sciences Commencement

Processional

• Trumpet Voluntary, JOHN STANLEY
• The Jefferson Processional, BURLE MARX
• Organist, THE REVEREND R. BRUCE TODD

Opening Proclamation

• RICHARD W. HEVNER, Chair, Board of Trustees, Thomas Jefferson University and Jefferson Health

Presentation of Colors

• U.S. Armed Forces Career Center, Philadelphia

The National Anthem

Convocation and Remarks

• STEPHEN K. KLASKO, MD, MBA President and CEO, Thomas Jefferson University and Jefferson Health

President's Award

• PRESIDENT KLASKO (HAROLD AND LYNNE HONICKMAN)

Conferring of Honorary Degrees

• PRESIDENT KLASKO (CAROLINE KIMMEL, Doctor of Science; SIDNEY KIMMEL, Doctor of Science; DONATO J . TRAMUTO, Doctor of Science)

Conferring of Degrees in Course (President Klasko)

Jefferson College …

2017 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Sidney Kimmel Medical College Commencements

Processional

• Trumpet Voluntary, JOHN STANLEY
• The Jefferson Processional, BURLE MARX
• Organist, THE REVEREND R. BRUCE TODD

Opening Proclamation

• RICHARD W. HEVNER, Chair, Board of Trustees, Thomas Jefferson University and Jefferson Health

Presentation of Colors

• U.S. Armed Forces Career Center, Philadelphia

The National Anthem

Convocation and Remarks

• STEPHEN K. KLASKO, MD, MBA President and CEO, Thomas Jefferson University and Jefferson Health

President's Award

• PRESIDENT KLASKO (HAROLD AND LYNNE HONICKMAN)

Conferring of Honorary Degrees

• PRESIDENT KLASKO (CAROLINE KIMMEL, Doctor of Science; SIDNEY KIMMEL, Doctor of Science; DONATO J . TRAMUTO, Doctor of Science)

Conferring of Degrees in Course (President Klasko)

Jefferson College …

2017 Commencement For Sidney Kimmel Medical College, Jefferson Graduate School Of Biomedical Sciences, And Jefferson School Of Population Health

Jefferson College of Population Health Commencement

Processional

• Trumpet Voluntary, JOHN STANLEY
• The Jefferson Processional, BURLE MARX
• Organist, THE REVEREND R. BRUCE TODD

Opening Proclamation

• RICHARD W. HEVNER, Chair, Board of Trustees, Thomas Jefferson University and Jefferson Health

Presentation of Colors

• U.S. Armed Forces Career Center, Philadelphia

The National Anthem

Convocation and Remarks

• STEPHEN K. KLASKO, MD, MBA President and CEO, Thomas Jefferson University and Jefferson Health

President's Award

• PRESIDENT KLASKO (HAROLD AND LYNNE HONICKMAN)

Conferring of Honorary Degrees

• PRESIDENT KLASKO (CAROLINE KIMMEL, Doctor of Science; SIDNEY KIMMEL, Doctor of Science; DONATO J . TRAMUTO, Doctor of Science)

Conferring of Degrees in Course (President Klasko)

Jefferson College …

2017 Commencement For Jefferson College Of Health Professions, Jefferson College Of Pharmacy, And Jefferson College Of Nursing

Jefferson College of Nursing Commencements

Jefferson College of Nursing

Monday, May 22, 2:30 p.m.

Processional

• Trumpet Voluntary, John Stanley
• The Jefferson Processional, Burle Marx
• The Reverend R. Bruce Todd, Organist

Opening Proclamation

• Richard W. Hevner, Chair, Board of Trustees Thomas Jefferson University and Jefferson Health

Presentation of Colors

U.S. Armed Forces Career Center, Philadelphia

The National Anthem

Convocation and Remarks

Stephen K. Klasko, MD, MBA, President and CEO Thomas Jefferson University and Jefferson Health

Mark L. Tykocinski, MD, Provost and Executive Vice President, Thomas Jefferson University Dean, Sidney Kimmel Medical College

Conferring of Honorary Degree

Eileen T. Breslin, PhD, RN, FAAN by President Klasko

Conferring …

2017 Commencement For Jefferson College Of Health Professions, Jefferson College Of Pharmacy, And Jefferson College Of Nursing

Jefferson College of Health Professions and Jefferson College of Pharmacy

Jefferson College of Health Professions and Jefferson College of Pharmacy Monday, May 22, 10:00 a.m.

Processional

• Trumpet Voluntary, John Stanley
• The Jefferson Processional, Burle Marx
• The Reverend R. Bruce Todd, Organist

Opening Proclamation

• Richard W. Hevner, Chair, Board of Trustees Thomas Jefferson University and Jefferson Health

Presentation of Colors

U.S. Armed Forces Career Center, Philadelphia

The National Anthem

Convocation and Remarks

Stephen K. Klasko, MD, MBA, President and CEO Thomas Jefferson University and Jefferson Health

Mark L. Tykocinski, MD, Provost and Executive Vice President, Thomas Jefferson University Dean, Sidney Kimmel Medical College

Conferring of Honorary Degree

Patrick T. Harker, PhD …

Research Proposal: Assessing The Effectiveness Of The "Business On Board" Program, Eugéne Louis De Klerk, Phd, Eileen Cunniffe, Joseph Sweeney, Edd, Larry M. Starr, Phd

School of Continuing and Professional Studies Student Papers

Board performance is widely recognized as a critical ingredient in a non-profit organization’s ability to achieve impact and to meet its mission and goals. The problem for many organizations, particularly those operating in the arts and culture environment, is that it can take new board members several months and often longer before they begin to function effectively in their governance role. To speed up the learning curve, BOB provides advance training to prepare new board members to hit the ground running so that they will be able to participate in their initial meetings with confidence. BOB also provides training for …

A Word From The Writing Center (May 2017), Jennifer Wilson, Ms, Els

A Word From the Writing Team (Newsletter)

This issue includes:

• Grammar writing tip on ZOMBIE nouns!
• Keep Reading with BrowZine

Fibulin-4 Is Essential For Maintaining Arterial Wall Integrity In Conduit But Not Muscular Arteries., Carmen M. Halabi, Thomas J. Broekelmann, Michelle Lin, Vivian S. Lee, Mon-Li Chu, Robert P. Mecham

Department of Dermatology and Cutaneous Biology Faculty Papers

Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial tortuosity, and aortic aneurysms. We sought to determine the consequences of a human disease-causing mutation in FBLN4 (E57K) on the cardiovascular system and vascular elastic fibers in a mouse model of ARCL1B. Fbln4^E57K/E57K mice were hypertensive and developed arterial elongation, tortuosity, and ascending aortic aneurysms. Smooth muscle cell organization within the arterial wall of large conducting vessels was abnormal, and elastic fibers were fragmented and had a moth-eaten appearance. …

Sigma1 Targeting To Suppress Aberrant Androgen Receptor Signaling In Prostate Cancer., Jeffrey D. Thomas, Charles G. Longen, Halley M. Oyer, Nan Chen, Christina M. Maher, Joseph M. Salvino, Blase Kania, Kelsey N. Anderson, William F. Ostrander, Karen E. Knudsen, Felix J. Kim

Department of Cancer Biology Faculty Papers

Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including resurgence of AR and AR splice variant (ARV) signaling. Emerging evidence suggests that Sigma1 (also known as sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein homeostasis. We reported previously that some Sigma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways. We hypothesized that these Sigma1-mediated responses could be exploited to suppress AR protein levels and activity. Here we demonstrate that …

Dysregulated Gpcr Signaling And Therapeutic Options In Uveal Melanoma., Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L. Benovic, Philip B. Wedegaertner, Andrew E. Aplin

Department of Biochemistry and Molecular Biology Faculty Papers

Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease. The liver is the predominant organ of metastasis. There is an important need to provide effective treatment options for advanced stage uveal melanoma. To provide the preclinical basis for new treatments, it is important to understand the molecular underpinnings of the disease. Recent genomic studies have shown that mutations within components of G protein-coupled receptor (GPCR) signaling are early events associated …

Strategic Plan For The Arlen Specter Center For Public Service, William Myles, Jim Plummer, Adena Johnston, Larry M. Starr, Phd

School of Continuing and Professional Studies Student Papers

The Arlen Specter Center for Public Service was established by Philadelphia University in 2010 to serve as a library for Senator Specter’s official papers. There was no formal plan for operations.

The Center needed a Strategic/Business Plan to provide a clearer focus and an articulation of the Center’s mission, vision, goals and objectives for the next five years, with recommended deliverables and structure.

Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction And Promotes Acute Lung Injury, Dilip Shah, Freddy Romero, Zhi Guo, Jianxin Sun, Jonathan C. Li, Caleb Kallen, Ulhas P. Naik, Ross Summer

Center for Translational Medicine Faculty Papers

Conclusion

• Lung endothelial dysfunction in DIO mice coincides with increased endoplasmic reticulum (ER) stress.
• Fatty acids in obese serum induce ER stress in the pulmonary endothelium leading to pulmonary endothelial cell dysfunction.
• Reducing protein load in the endoplasmic reticulum of pulmonary endothelial cells might protect against ARDS in obese individuals.

Not So Fast: Cultivating Mirs As Kinks In The Chain Of The Cell Cycle., Matthew J. Schiewer, Karen E. Knudsen

Department of Cancer Biology Faculty Papers

In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed "cell-cycle-targeting miRNAs," that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm.

Robert Reynolds Macintosh, M.D. (1897-1989): Forefather Of Anesthesiology, Advocate For Patient Safety., Haig Minassian, Scott W. Cowan, Charles J. Yeo

Department of Surgery Gibbon Society Historical Profiles

No abstract provided.

A Word From The Writing Center (April 2017), Jennifer Wilson, Ms, Els

A Word From the Writing Team (Newsletter)

This issue includes:

• Writing Tip: Punctuation
• Organizing your Research using a citation manager
• Writing Café hours

A Prospective Study Of Maternal, Fetal And Neonatal Outcomes In The Setting Of Cesarean Section In Low- And Middle-Income Countries., Margo S. Harrison, Omrana Pasha, Sarah Saleem, Sumera Ali, Elwyn Chomba, Waldemar A. Carlo, Ana L. Garces, Nancy F. Krebs, K. Michael Hambidge, Shivaprasad S. Goudar, Bhala Kodkany, Sangappa Dhaded, Richard J. Derman, Archana Patel, Patricia L. Hibberd, Fabian Esamai, Edward A. Liechty, Janet L. Moore, Dennis Wallace, Elizabeth M. Mcclure, Menachem Miodovnik, Marion Koso-Thomas, Jose Belizan, Antoinette K. Tshefu, Melissa Bauserman, Robert L. Goldenberg

Global Health Articles

INTRODUCTION: Cesarean section (CS) rates are increasing globally with an unclear effect on pregnancy outcomes. The study objective was to quantify maternal and perinatal morbidity and mortality associated with CS compared with vaginal delivery (VD) both within and across sites in low- and middle-income countries.

MATERIAL AND METHODS: A prospective population-based study including home and facility births in 337 153 women with a VD and 47 308 women with a CS from 2010 to 2015 was performed in Guatemala, India, Kenya, Pakistan, Zambia and Democratic Republic of Congo. Women were enrolled during pregnancy; delivery and 6-week follow-up data were collected. …

Clinician-Performed Bedside Ultrasound In Improving Diagnostic Accuracy In Patients Presenting To The Ed With Acute Dyspnea., Dimitrios Papanagnou, Michael Secko, John Gullett, Michael Stone, Shahriar Zehtabchi

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Diagnosing acute dyspnea is a critical action performed by emergency physicians (EP). It has been shown that ultrasound (US) can be incorporated into the work-up of the dyspneic patient; but there is little data demonstrating its effect on decision-making. We sought to examine the impact of a bedside, clinician-performed cardiopulmonary US protocol on the clinical impression of EPs evaluating dyspneic patients, and to measure the change in physician confidence with the leading diagnosis before and after US.

METHODS: We conducted a prospective observational study of EPs treating adult patients with undifferentiated dyspnea in an urban academic center, excluding those …

An Occupation-Based Learning Support Program For At-Risk Occupational Therapy Students, Arlene Lorch Otd, Otr/L, Ches

Department of Occupational Therapy Posters and Presentations

Objectives:

• Describe an occupation-based, learning support program offered to occupational therapy students struggling academically.

• Identify key learning issues identified by occupational therapy students and staff seeking academic support services.

• Develop an initial outline of steps to identify need and create an occupation-based, learning support program.

Functional Studies Of Ccaat/Enhancer Binding Protein Site Located Downstream Of The Transcriptional Start Site., Yujie Liu, Michael R. Nonnemacher, Aikaterini Alexaki, Vanessa Pirrone, Anupam Banerjee, Luna Li, Evelyn Kilareski, Brian Wigdahl

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Previous studies have identified a CCAAT/enhancer binding protein (C/EBP) site located downstream of the transcriptional start site (DS3). The role of the DS3 element with respect to HIV-1 transactivation by Tat and viral replication has not been characterized. We have demonstrated that DS3 was a functional C/EBPβ binding site and mutation of this site to the C/EBP knockout DS3-9C variant showed lower HIV-1 long terminal repeat (LTR) transactivation by C/EBPβ. However, it was able to exhibit similar or even higher transcription levels by Tat compared to the parental LTR. C/EBPβ and Tat together further enhanced the transcription level of the …

Advocacy Efforts In Trauma And Acute Care Surgery: Learning To Walk, Lewis J. Kaplan, Erik Barquist, Donald Jenkins, Orlando C. Kirton

Abington Jefferson Health Papers

No abstract provided.

Patient Perceptions Of Clinician's Empathy: Measurement And Psychometrics., Mohammadreza Hojat, Jennifer Desantis, Joseph S. Gonnella

Department of Psychiatry and Human Behavior Faculty Papers

The prominence of reciprocal understanding in patient–doctor empathic engagement implies that patient perception of clinician’s empathy has an important role in the assessment of the patient–clinician relationship. In response to a need for an assessment tool to measure patient’s views of clinician empathy, we developed a brief (5-item) instrument, the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE). This review article reports evidence in support of the validity and reliability of the JSPPPE.

Camp Signaling Enhances Hiv-1 Long Terminal Repeat (Ltr)-Directed Transcription And Viral Replication In Bone Marrow Progenitor Cells., Anupam Banerjee, Luna Li, Vanessa Pirrone, Fred C. Krebs, Brian Wigdahl, Michael R. Nonnemacher

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

CD34⁺ hematopoietic progenitor cells have been shown to be susceptible to HIV-1 infection, possibly due to a low-level expression of CXCR4, a coreceptor for HIV-1 entry. Given these observations, we have explored the impact of forskolin on cell surface expression of CXCR4 in a cell line model (TF-1). The elevation of intracellular cyclic adenosine monophosphate (cAMP) by forskolin through adenylyl cyclase (AC) resulted in transcriptional upregulation of CXCR4 with a concomitant increase in replication of the CXCR4-utilizing HIV-1 strain IIIB. Transient expression analyses also demonstrated an increase in CXCR4-, CCR5-, and CXCR4-/CCR5-utilizing HIV-1 (LAI, YU2, and 89.6, respectively) promoter …

Extensions Of D-Optimal Minimal Designs For Symmetric Mixture Models., Yanyan Li, Damaraju Raghavarao, Inna Chervoneva

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The purpose of mixture experiments is to explore the optimum blends of mixture components, which will provide desirable response characteristics in finished products. D-optimal minimal designs have been considered for a variety of mixture models, including Scheffé's linear, quadratic, and cubic models. Usually, these D-optimal designs are minimally supported since they have just as many design points as the number of parameters. Thus, they lack the degrees of freedom to perform the Lack of Fit tests. Also, the majority of the design points in D-optimal minimal designs are on the boundary: vertices, edges, or faces of the design simplex.

IN …

Co-Targeting Hgf/Cmet Signaling With Mek Inhibitors In Metastatic Uveal Melanoma., Hanyin Cheng, Vivian Chua, Connie Liao, Timothy J. Purwin, Mizue Terai, Ken Kageyama, Michael A. Davies, Takami Sato, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) inhibitors improve survival in V600 BRAF-mutated cutaneous melanoma patients but have limited efficacy in patients with uveal melanoma. Our previous work showed that hepatocyte growth factor (HGF) signaling elicits resistance to MEK inhibitors in metastatic uveal melanoma. In this study, we demonstrate that expression of two BH3-only family proteins, Bim-EL and Bmf, contributes to HGF-mediated resistance to MEK inhibitors. Targeting HGF/cMET signaling with LY2875358, a …

Surgical Site Infection And Transfusion Rates Are Higher In Underweight Total Knee Arthroplasty Patients., Jorge Manrique, Antonia F. Chen, Md, Mba, Miguel M. Gomez, Mitchell Maltenfort, Phd, William J. Hozack Md

Rothman Institute Papers

BACKGROUND: Underweight (UW) patients undergoing total hip arthroplasty have exhibited higher complication rates, including infection and transfusion. No study to our knowledge has evaluated UW total knee arthroplasty (TKA) patients. We, therefore, conducted a study to investigate if these patients are at increased risk for complications, including infection and transfusion.

METHODS: A case-control study was conducted using a prospectively collected institutional database. Twenty-seven TKA patients were identified as UW (body mass index [BMI] < 18.5 kg/m

RESULTS: The average BMI was 17.1 kg/m

CONCLUSIONS: Our study demonstrates that UW TKA patients have a higher likelihood of developing SSI and requiring blood transfusions. The …

A Word From The Writing Center (March 2017), Jennifer Wilson, Ms, Els

A Word From the Writing Team (Newsletter)

This issue includes:

• Learning Opportunity
• Books on writing
• Writing Cafe

Efficacy And Tolerability Of Adjunctive Brivaracetam In Patients With Prior Antiepileptic Drug Exposure: A Post-Hoc Study., Ali A. Asadi-Pooya, Michael R. Sperling, Steve Chung, Pavel Klein, Anyzeila Diaz, Sami Elmoufti, Jimmy Schiemann, John Whitesides

Department of Neurology Faculty Papers

Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle protein 2A, is a new antiepileptic drug (AED) for adjunctive treatment of focal (partial-onset) seizures in adults with epilepsy. This post-hoc analysis was conducted to explore the efficacy of adjunctive BRV in patients with prior levetiracetam (LEV) exposure and whether changes in efficacy were related to the similar mechanism of action of these two drugs. Data were pooled from three Phase III studies (NCT00490035; NCT00464269; NCT01261325) of adults with focal seizures taking 1-2 AEDs who received placebo or BRV 50-200mg/day without titration over a 12-week treatment period. Patients taking concomitant LEV …

Rehabilitation Therapy In Older Acute Heart Failure Patients (Rehab-Hf) Trial: Design And Rationale., Gordon R. Reeves, David J. Whellan, Pamela Duncan, Christopher M. O'Connor, Amy M. Pastva, Joel D. Eggebeen, Leigh Ann Hewston, Timothy M. Morgan, Shelby D. Reed, W. Jack Rejeski, Robert J. Mentz, Paul B. Rosenberg, Dalane W. Kitzman

Division of Cardiology Faculty Papers

BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. However, these are not addressed by current heart failure (HF) management strategies and there has been little study of exercise training in older, frail HF patients with recent ADHF.

HYPOTHESIS: Targeting physical frailty with a multi-domain structured physical rehabilitation intervention will improve physical function and reduce adverse outcomes among older patients experiencing a HF hospitalization.

STUDY DESIGN: REHAB-HF is a multi-center clinical trial in …

Influence Of Sex/Gender And Race On Responses To Raltegravir Combined With Tenofovir-Emtricitabine In Treatment-Naive Human Immunodeficiency Virus-1 Infected Patients: Pooled Analyses Of The Startmrk And Qdmrk Studies., Kathleen E. Squires, Linda-Gail Bekker, Christine Katlama, Yazdan Yazdanpanah, Yan Zhou, Anthony J Rodgers, Mark J Dinubile, Peter A Sklar, Randi Y Leavitt, Hedy Teppler

Department of Medicine Faculty Papers

BACKGROUND: Antiretroviral therapy in human immunodeficiency virus (HIV)-infected women and blacks merits particular scrutiny because these groups have been underrepresented in clinical trials.

METHODS: To document the effects of raltegravir across sex and racial lines, we conducted a pooled subgroup analysis of the efficacy and safety of raltegravir 400 mg BID plus tenofovir-emtricitabine by sex (women vs men) and self-identified race (black vs non-black) using phase 3 studies in treatment-naive patients.

RESULTS: Study participants included 42 black women, 102 non-black women, 48 black men, and 477 non-black men. Clade B infections were less common in women (43.8%) than men (84.6%) …