Digital Commons Network^™

Aura Vena, Bassem Fayek, Isaac Kravatz, Robert Pugliese, Pharmd

Phase 1

Introduction: Peripheral intravenous (IV) access remains a common problem faced across healthcare, leading to significant healthcare losses in terms of working hours, resources, as well as patient pain and discomfort. At Thomas Jefferson University Hospital’s (TJUH) infusion center, many healthcare workers utilize hot towels and disposable heat packs to warm patients’ arms if IV access is difficult- a wasteful solution that provides limited heating.

Methods: Nurses at TJUH’s infusion center were interviewed to define the problem and identify optimal product requirements for healthcare workers. In conjunction with market research, a heat-warming sleeve is designed and created. The design of the …

Mapping The Pathology Competencies For Medical Education (Pcme) To The Sidney Kimmel Medical College’S Jeffmd Gi Curriculum, Emma Sanders, Alexander Macnow, Md, Mhpe

Phase 1

Introduction/Purpose: Sidney Kimmel Medical College’s competency-based curriculum, JeffMD, is structured around SMART objectives. However, evaluation of the alignment of these objectives against the PCME, a collection of graduation competencies published by the Association for Academic Pathology, has not yet been performed. This study investigated how comprehensively the GI/Liver block of the JeffMD curriculum addresses the corresponding PCME learning objectives, thereby piloting a pathology curriculum map and allowing evaluation of this curriculum.

Methods: In this study, a curriculum map was created of all learning events covered within the JeffMD GI/Liver block. Each learning event was cross-matched with competencies within the gastrointestinal …

Patient Perceptions Of Medicare Annual Wellness Visits: Findings From A Pilot Survey, Payton Mccready, Amy Cunningham, Susan Parks

Phase 1

Purpose

Medicare Annual Wellness Visits (AWVs) were introduced in 2011 to promote preventive care among Medicare beneficiaries, yet patient satisfaction remains understudied. Participating in the  Age-Friendly Health Systems Initiative, Jefferson Health’s Center for Healthy Aging (CHA) is redesigning its AWVs to align with Age-Friendly principles. This study aimed to obtain baseline data on Medicare patients’ familiarity, experience, and satisfaction with AWVs in a geriatrics practice before implementing the redesigned model.

Methods

This cross-sectional survey was conducted in July 2025 at Jefferson Health’s CHA, a geriatrics practice serving about 2,000 Medicare patients. Eligible participants were Medicare-enrolled CHA patients. An eight-item survey …

Interviewing Rural Primary Care Physicians To Inform Learning Objectives For A Rural Health Curriculum, Luke May, Caleb Gayman, Robert J. Motley, Md, Mhcds

Phase 1

Introduction/Purpose: Pennsylvania has a large rural population with too few physicians to meet medical needs. The Physician Shortage Area Program (PSAP) at SKMC works to address the shortage of primary care physicians in rural Pennsylvania. To adequately prepare future rural physicians, this project sought to obtain input from practicing PSAP graduates to inform learning objectives for a future curriculum intervention for preclinical PSAP students.

Methods: The target learner population is preclinical PSAP students at SKMC. A codebook was generated based on SKMC Graduation Competencies. Semi-structured interviews with PSAP graduates were conducted via video call, focused on those graduates practicing primary …

Understanding The Benefits Of Sustainable Ir Fellowship To A Large Public Hospital In Kenya, Abigael Gebremariam, Kevin Anton

Phase 1

In 2021, Kenya had 10 interventional radiologists for a population of about 54 million. RAD-AID, a non-profit organization improving global radiology, partnered with the University of Nairobi and Kenyatta National Hospital to establish the first IR fellowship program in Kenya in 2021. Through the program, the number of practicing IRs in Kenya has nearly doubled; however, their practice is limited by capital and supply resources. This study will demonstrate the benefit of the program to the hospital system and the patient population in Kenya.

The project employed a retrospective and comparative analysis of IR services at a large public hospital …

The Effect Of Prior Work And Educational Experience On Medical School Small Group Case-Based Learning, Alexandra Kelleher, Alisa Losasso, Md

Phase 1

Purpose

Medical students have varied academic and professional backgrounds, many taking gap years in healthcare or research before matriculation. Prior studies suggest these experiences may reduce burnout, enhance patient skills, and improve teamwork capabilities, but their impact on early case-based learning (CBL) performance and perceived comfort level is unclear. This study explores how prior healthcare and research experience influence perceived preparedness and participation for first-year medical students in CBL at SKMC.

Methods

This mixed-methods study was conducted among 66 rising second-year JeffMD students. Participants completed an online 15-item survey assessing undergraduate background and self-reported confidence in CBL. Ten students were …

Interviewing Rural Primary Care Physicians To Inform Learning Objectives For A Rural Health Curriculum, Caleb Gayman, Luke May, Robert J. Motley, Md, Mhcds

Phase 1

Introduction/Purpose: There is a significant shortage of physicians in rural Pennsylvania. Programs like the Physician Shortage Area Program (PSAP) at SKMC aim to address this gap by providing support and guidance for medical students who grew up in rural areas and hope to return to practice in a rural area. This project focuses on identifying rural health topics and modes of delivery recommended by practicing primary care physicians to inform new learning objectives (LOs) for a future curriculum intervention for first and second-year medical students.

Methods: SKMC PSAP graduates practicing in rural areas were interviewed using semi-structured interviews that included …

Artificial Intelligence In Case-Based Learning: A Survey Of Student Current Practices In Small Group Self-Directed Learning Pedagogy, Clarice Pamplona, Joshua Kim

Phase 1

Introduction: Although Artificial Intelligence (AI) is expected to become an essential clinical tool, its incorporation into the undergraduate medical curricula is disproportionately lacking. Notably, limited research remains on medical student use and perspective on AI, specifically within small-group learning settings. This study explores AI use and perspectives among medical students within Case-Based Learning (CBL) groups at Sidney Kimmel Medical College (SKMC) with the aim to establish a formal AI curriculum.

Methods: The population studied includes the Class of 2028 at SKMC. An anonymous Qualtrics survey was distributed within the class Group Me between April and May 2025, exploring student demographics, …

Identification Of Gene Signatures Of Metabolic Dysfunction-Associated Steatotic Liver Disease In Patients With Pancreatic Ductal Adenocarcinoma Via Whole Transcriptome Sequencing, Chaitanya Karimanasseri Bse, Pongsakorn Choochuen Md, Phd, Yotsawat Pomyen Phd, Hien Dang Phd

Phase 1

Introduction
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality worldwide. While the only curative treatment for PDAC is surgical excision of the tumor, often surgery is ineffective due to early metastasis to other organs. A better understanding of PDAC’s risk factors would contribute to earlier PDAC diagnoses and thus more effective surgical resections before metastasis occurs.

One pathology related to PDAC is metabolic dysfunction-associated steatotic liver disease (MASLD), a metabolic disease leading to triglyceride accumulation in the liver. MASLD is known to cause worse PDAC outcomes versus non-MASLD PDAC. Further elucidating the mechanism through which MASLD increases …

The Impact Of Neighborhood Socioeconomic Factors And Insurance Status On Outcomes Following Reduction Mammoplasty, Shin Heng Teresa Chan, Kelsey Van Housen, Emily Isch, Judith Monzy, Julianne Bartz, Matthew Jenkins, David Kim, Andrew Newman, Heather Mcmahon

Phase 1

Introduction: The impact of and neighborhood socioeconomic factors on surgical outcomes in reduction mammoplasty remains unclear. This study evaluated the effect of area deprivation index (ADI) and insurance status on postoperative outcomes following reduction mammoplasty.

Methods: A retrospective review of reduction mammoplasty cases was conducted at a single institution over a 7-year period. Patients ≥18 years old who underwent reduction mammoplasty for benign macromastia were included. Zip-code linked ADI, insurance type, and postoperative complication rate were assessed.

Results: In total, 594 patients were analyzed. Mean age was 36.2 ± 13.1 years, mean body mass index (BMI) was 32.6 ± 5.2 …

Evaluation Of Clinical Outcomes Following Conventional And Hypofractionated Radiotherapy In Who Grade I Meningiomas: A Single Institution Retrospective Cohort Analysis, Toren Ikea-Mario, Wenyin Shi

Phase 1

Background: Meningiomas are the most common primary intracranial tumors. WHO Grade I meningiomas are considered benign and demonstrate high radiosensitivity, with excellent outcomes following conventionally fractionated radiotherapy (CFRT) or hypofractionated stereotactic radiotherapy (hSRT). Despite widespread clinical adoption of both approaches, direct comparative data assessing local control (LC) remain limited. This study aims to evaluate the relative efficacy of CFRT and hSRT to better inform optimal regimen selection for patients with Grade I meningioma.

Methods: We conducted a retrospective review of patients with Grade I meningiomas treated with RT at Thomas Jefferson University Hospital. Eligible patients received CFRT (2015 - 2025) …

Temporal Trends In Orthopaedic Residency Applicant Publications, Joseph Kelly, Jarod Olson, Jonathan Dalton, William A. Green, Mitchell K. Ng, Adam Fano, Robert J. Oris, Joydeep Baidya, Rachel Huang, Chloe Herczeg, Keyur Patel, Griffin White, Nikhil Sai, Alan S. Hilibrand, Alex R. Vaccaro, Christopher K. Kepler, Gregory D. Schroeder

Phase 1

Introduction/Purpose: Orthopaedic surgery is among the most competitive residency specialties, and applicants have historically relied on USMLE Step 1 scores as a metric of ability for applications. However, as Step 1 has transitioned to pass/fail in 2022, there has been a shift in emphasis toward other metrics such as research productivity. The purpose of this project is to evaluate the research trends among orthopaedic residency applicants over time with the hypothesis that post-pass/fail Step 1 applications would demonstrate higher research output at the time of application.

Methods: Residents from the top 30 orthopaedic residencies (PGY-5=211, PGY-3=211, PGY-1=213) were included. PubMed …

Maternal Perceptions Of Group Well Child Care For Mothers With Opioid Use Disorder, Regan King, Taylor Carrubba, Erica Sood, Meghan Gannon, Vanessa Short, Neera Goyal

Phase 1

Introduction/Purpose: Routine well child care (WCC) is critical for monitoring growth, development, and family wellbeing. Children born to mothers with opioid use disorder are less likely to receive adequate WCC, contributing to preventable health disparities. A Philadelphia-based substance use treatment program provides comprehensive care for pregnant and parenting individuals with substance use disorders, including an on-site pilot group- based WCC model designed to enhance access to and quality of WCC.

Methods: As part of a larger cluster-randomized controlled trial comparing traditional WCC with the group WCC model, qualitative interviews were conducted with ten mothers who completed three or more group …

Effects Of A Student-Delivered Glycemic Load Education Program (Jeffgl) On Depression, Emily La, Cindy Cheng

Phase 1

Introduction/Purpose: Previous studies have demonstrated that diabetes is linked to mental health disorders, including depression. In our student-delivered education program, Jefferson Glycemic Load (JeffGL), we aim to investigate the effects of glycemic load patient education on depression in diabetic and prediabetic patients. We hypothesize that participants will demonstrate reduced depression scores compared to baseline, measured using the Patient Health Questionnaire-9 (PHQ-9), after participation in JeffGL.

Methods: Over four weeks with long-term follow up, thirty overweight or obese patients with prediabetes or diabetes recruited from Jefferson’s Department of Family Medicine will participate in one-on-one and group Zoom sessions weekly concerning topics …

Analysis Of Predictive Variables For Atrial Fibrillation Detection In Patients With Cryptogenic Stroke, Paranshu Shah, Cindy Fang, Avinash Saraiya, Behzad Pavri

Phase 1

Introduction: Underlying atrial fibrillation (AF) is commonly screened for in patients with stroke of unknown cause, cryptogenic stroke (CS), using implantable loop recorders (ILRs). However, the risk factors correlated with AF detection after CS are poorly identified. Thus our goals were to elucidate which characteristics correlate with AF detection in patients with CS and to investigate if there is an age below which ILR implantation is clinically irrelevant.

Methods: We conducted a retrospective cohort study on patients with CS who underwent ILR implantation at TJUH from 4/2019-4/2021 (n=282). Exclusion criteria were < 6 months of follow-up data, ILR placement >1 year after CS, or pre-existing AF (n=64). Demographics …

Impact Of Solid Organ Transplant History On Outcomes In Head And Neck Microvascular Reconstruction, Domenica Voli, Sarah R. Harrington, Daniel Uralov, Janvi J. Shukla, Hani Samarah, Marina Aweeda, Krishna Koka, Shaunak Ganju, Kelly Bridgham, Eric V. Mastrolonardo, Arielle G. Thal, Richard A. Goldman, Adam J. Luginbuhl, Larissa Sweeny, Mark K. Wax, Joseph M. Curry

Phase 1

Introduction/Purpose: Free tissue transfer (FTT) is a commonly used technique in head and neck reconstructions. Many factors influence FTT success, including immunosuppression. Patients with solid organ transplants represent a unique population, as the lifelong immunosuppression predisposes them to head and neck cancers and poor wound healing. This study assesses postoperative outcomes and long-term survival in patients with head and neck cancer requiring FTT with a history of solid organ transplant (SOT), compared to matched non-transplant controls.

Methods: Patients with head and neck cancer who underwent FTT were identified in multi-institutional databases and the national TriNetX database. Patients with a history …

Identification Of Socioeconomic And Demographic Predictors Of Somatic Genomic Testing Rates In Prostate Cancer, Erin Welch, Kevin K. Zarrabi, Khaldoun Hamade, Christopher Mcnair

Phase 1

Introduction/Purpose: Somatic genomic testing in metastatic prostate cancer (mPC) identifies genomic variants which provide clinical insight into the disease biology. Somatic testing results determine eligibility for standard of care targeted therapies and clinical trial eligibility. While national guidelines recommend testing for all mPC patients, patients with adverse social determinants of health (SDOH), racial minority groups and patients with low socioeconomic status (SES) have historically undergone lower rates of testing compared to national standards. This study aims to identify barriers to testing in mPC patients in the Jefferson system and ultimately understand the factors that influence testing rates.

Methods: Epic’s clinical …

Progression Of Optic Nerve Head And Macular Parameters From Optical Coherence Tomography In Glaucomatous Eyes With Concomitant Epiretinal Membrane, Alisha Desai, Fabio Lavinsky, Joel S. Schuman

Phase 1

Introduction/Purpose: Epiretinal membrane (ERM) can distort macular and peripapillary architecture, altering optical coherence tomography (OCT)–derived measurements and potentially obscuring glaucomatous progression. The present study aimed to determine whether glaucoma-related structural progression can still be detected over time in primary open-angle glaucoma (POAG) eyes with concomitant ERM by evaluating longitudinal changes in optic nerve head (ONH) and macular parameters. Understanding these changes may reduce the risk of delayed diagnosis and irreversible vision loss.

Methods: This retrospective longitudinal study included adults (>18 years) with POAG and ERM from two tertiary care centers. Eyes with at least three visits were included, while …

Effect Of Adherent Cpap Use On Dyslipidemia, Evelyn Miller, Cindy Cheng, Md, Phd

Phase 1

Introduction/Purpose: Obstructive sleep apnea (OSA) is characterized by upper airway closure during sleep, resulting in surges of sympathetic activity, elevated blood pressure and arterial oxygen desaturation. Over time, this can lead to systemic hypertension, congestive cardiac failure, and acute coronary syndrome. The current gold standard treatment is CPAP (continuous positive pressure airway),  which reduces blood pressure and heart rate while improving oxygen saturation. However, the effect of CPAP treatment on dyslipidemia is less understood.  Accordingly, this study aims to determine the effect of adherent CPAP use on dyslipidemia in our sleep medicine practice in Philadelphia.

Methods: The retrospective …

Anterior Cervical Discectomy And Fusion Leads To Greater Functional And Physical Improvement Compared To Posterior Cervical Decompression And Fusion In Patients With Preoperative Myelomalacia, Nicholas M. Wang, Yulia Lee, Mitchell Ng, Robert J. Oris, Chloe Herczeg, William A. Green, Joshua Mathew, Yasmine K. Eichbaum, Gregorio Baek, Morgan Hitchner, Jonathan Dalton, Alan S. Hilibrand, Christopher Kepler, Gregory D. Schroeder, Alex R. Vaccaro

Phase 1

Introduction/Purpose: Myelomalacia can signal advanced cervical myelopathy. Postoperative function and pain following surgery for cervical myelopathy may impact patient satisfaction. However, patient-reported outcome measures (PROMs) for patients with preoperative myelomalacia who undergo anterior cervical discectomy and fusion (ACDF) or posterior cervical decompression and fusion (PCDF) has not been explored. This study compares PROMs between ACDF and PCDF for patients with preoperative myelomalacia.

Methods: A 2010 to 2023 single institution retrospective cohort study was conducted on adults with preoperative myelomalacia who underwent ACDF or PCDF not for tumor/trauma/infection. Demographics, preoperative diagnosis, surgical attributes, and manual motor testing was obtained. Strength of …

Simulated Or Traditional Clinical Learning Environments: Comparison Survey To Assess Learner Preparation, Audrey Zapletal, Ms, Otd, Otr/L, Cla, Chse, Joanne Baird, Phd, Otr/L, Chse, Faota, Jean Prast, Otd, Otrl, Chse, Tracy Van Oss, Dhsc, Otr/L, Chse, Faota, Maureen Hoppe, Edd, Ma, Otr/L Chse, Ketki Raina, Phd, Otr/L, Faota

Department of Occupational Therapy Posters and Presentations

Background

• Occupational therapy is a cornerstone rehabilitation profession that provides client-centered care for individuals experiencing a loss of independence at any age. 
• Over 90% of occupational therapy educational programs use simulation.⁶
• Research suggests that simulation can be used to prepare occupational therapy students for their full-time clinical placements.^1,5
• However, little is known about occupational therapy students' perceptions of the effectiveness of simulations compared to introductory clinical fieldwork experiences to enhance specific clinical skills.

Ai Scribe Use In Residency Training: A Call For Specialty Society Guidance In Graduate Medical Education, Julia A. Giordano, Elizabeth Jones

Department of Dermatology and Cutaneous Biology Faculty Papers

Artificial intelligence (AI) is increasingly used for documentation purposes in clinical practice, yet guidance for resident use is limited. Given the substantial documentation burden on medical trainees, AI-powered scribing tools may offer benefits, but their integration into residency training raises educational, supervisory, and patient safety considerations. This study aimed to assess the availability of resident-specific guidance on AI scribe use from major medical and specialty organizations and to summarize current evidence on AI scribes in residency. We reviewed five major medical and specialty society websites (AAD, AMA, ACGME, AAMC, ABMS) via website searches and direct emails and conducted a PubMed …

Hydroxypropyl Methylcellulose As A Mucoadhesive Polymer In Ethanol-Free Buprenorphine Gel For Neonatal Sublingual Delivery, Sanskruti Dave, Viren Soni, Samarth A. Shah, Walter K. Kraft, Gagan Kaushal

College of Pharmacy Faculty Papers

Buprenorphine (BUP) is widely used in the treatment of neonatal opioid withdrawal syndrome (NOWS). However, the most compounded formulation contains 30% ethanol, despite regulatory and clinical concerns regarding ethanol exposure in pediatric patients. Thus, this research aimed to develop an ethanol-free sublingual (SL) gel formulation of BUP that would be safe, stable, and suitable for NOWS. Multiple polymers were screened as gelling agents, with hydroxypropyl methylcellulose (HPMC) emerging as the ideal base polymer for the formulation due to its optimal pH, rheological characteristics, and stability. The formulated gels were stored at room temperature and refrigerated conditions for 30 days and …

Itbs Stimulation Of The Bilateral Ifg/Ipl Alters The Oscillatory Pattern In Asd, Mitra Assadi, Reza Koiler, Ryan Ally, Richard Fischer, Rod C. Scott

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impairments in social communication, reciprocity, and adaptive behavior. Converging neurobiological evidence suggests that these clinical features arise from aberrant connectivity and dysregulated neuronal oscillations across distributed brain networks. In particular, dysfunction within the mirror neuron regions, concentrated in the inferior frontal gyrus (IFG) and inferior parietal lobule (IPL), has been implicated in deficits of imitation, empathy, and social cognition in ASD. Non-invasive neuromodulation using repetitive transcranial magnetic stimulation (rTMS) has shown modest behavioral benefits in ASD. However, most studies apply the conventional protocols targeting the dorsolateral prefrontal cortex. The …

Dupilumab Beyond The Airway: Decreased Morbidity In A Real-World Analysis, Emma J. Anisman, Spencer Short, Emma Tam, Benjamin F. Bitner, Abdulghafoor Alani, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Elina Toskala, Gurston G. Nyquist

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Background: Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real-world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and sleep apnea in dupilumab-treated CRSwNP and/or asthma patients compared to those not taking dupilumab, and to other biologics.

Methods: This retrospective cohort study used TriNetX, a de-identified database containing over 100 million patient records. Demographics and adverse effects associated with immunotherapy use were collected.

Results: We identified 21,249 dupilumab-treated CRSwNP and/or asthma patients. After …

Shoulder Strength And Total Arc Range Of Motion: Associations With Upper-Extremity Joint Kinetics And Ball Velocity In Adolescent Baseball Pitchers, Tomohiro Ide, Stephen J. Thomas, Takato Ogasawara, Adam B. Rosen, Brian A. Knarr, Kazuma Akehi, Samuel J. Wilkins

Department of Exercise Science Faculty Papers

BACKGROUND: Adolescent baseball pitchers are vulnerable to upper-extremity injuries because of the repetitive, high-stress nature of throwing movements. While shoulder strength and range of motion (ROM) are commonly measured, they are often interpreted in isolation during injury prevention assessments.

PURPOSE: To determine the relationship between clinical measures (shoulder ROM and strength) and throwing arm joint kinetics in adolescent baseball pitchers.

STUDY DESIGN: Descriptive laboratory study.

METHODS: This study was conducted in a laboratory setting. A total of 43 adolescent baseball pitchers (age, 15-18 years) were recruited through convenience sampling. Participants underwent clinical assessments of shoulder ROM and isokinetic concentric strength …

Human Papillomavirus Vaccine Perceptions Among Noncollege Young Adults And Tiktok Influencers: Qualitative Study, Amelia Burke-Garcia, Dasha Afanaseva, Erin Cutroneo, Kayla Madden, Angela Sustaita-Ruiz, Estefany Rivera Sanchez, Amy Leader

Department of Medical Oncology Faculty Papers

BACKGROUND: Human papillomavirus (HPV) vaccination is a proven and effective tool for preventing several types of cancers, yet vaccination rates among young adults remain suboptimal, particularly among those not enrolled in 4-year colleges. This population can be more difficult to reach due to fewer established institutional touchpoints, limited engagement with campus-based health services, and greater variability in access to preventive care. At the same time, social media has become a dominant source of information for young adults, with TikTok (ByteDance) emerging as one of the most widely used platforms. Approximately 41% of TikTok's users are between the ages of 16 …

Identifying Barriers And Facilitators To Audit & Feedback In General Practice In Italy: A Qualitative Study, Anna Acampora, Andriy Melnyk, Emanuele La Gatta, Angelo Nardi, Laura Angelici, Rosemary Frasso, Nera Agabiti

College of Population Health Faculty Papers

BACKGROUND: Audit & Feedback (A&F) interventions are recognized as effective strategies for enhancing healthcare quality, yet they remain relatively underutilized in Italian primary care settings. Recent literature highlights the importance of examining the factors influencing the implementation of these interventions across diverse clinical and organizational settings. Thus, this study aimed to identify such factors by exploring the experiences of professionals involved in an A&F intervention tailored for General Practitioners (GPs) treating chronic illnesses.

METHODS: Using qualitative research methods, this study organized focus groups (FGs) separately for each professional role involved in A&F: GPs, GPs acting as internal group coordinators, Public …

Translating Social Accountability Values Into Practice: Doctors’ Experiences From Problem- Based Learning Medical Curriculum In The United Arab Emirates, Nihar Ranjan Dash, Ahmed Alrazzak Hasswan, Mayar Abbas Ahmed Essam Samaha, Kamel A. Samara, Mohamed Hassan Taha

Abington Jefferson Health Papers

Purpose: Medical schools play a crucial role in preparing future doctors to address the health needs of patients and their communities. Graduates are expected to provide socially accountable care by upholding values such as relevance, equity, quality, and cost- effectiveness. This study explores how these values are understood and applied by medical graduates trained in problem-based learning (PBL) curricula. Methods: A cross-sectional online survey was conducted among University of Sharjah medical graduates to assess their exposure to and practice of social accountability values. Results: Of the 689 graduates invited, 503 (73%) responded, including 329 (65%) women. Most respondents, 375 (75%), …

Mutations Altering The Dna Binding Domains Of The Human Rad52 Protein Exert Distinct Effects On Homologous Recombination Repair In Saccharomyces Cerevisiae, Glenn M. Manthey, Elise W. Wolf, Jason Xu, M. Cristina Negritto, Renee A. Bouley, Ruben C. Petreaca, Adam M. Bailis

College of Health Professions Faculty Papers

RAD52 is a conserved member of the homologous recombination repair (HRR) apparatus from yeast to humans. Mutating conserved amino acids in the internal and external DNA binding domains of the human RAD52 protein (HsRAD52) has discrete effects in vitro. Previous studies have shown that HsRAD52 supports multiple mechanisms of HRR in budding yeast, suggesting the utility of this model system for exploring the correspondence between losses of HsRAD52 function in vitro and their impact in vivo. We report that disrupting the internal and external DNA binding domains of HsRAD52 produced distinct effects on the repair of genomic DNA double-strand breaks …