Digital Commons Network^™

Is Whole-Exome Sequencing An Ethically Disruptive Technology? Perspectives Of Pediatric Oncologists And Parents Of Pediatric Patients With Solid Tumors, Laurence B Mccullough, Melody J Slashinski, Amy L Mcguire, Richard L Street, Christine M Eng, Richard A Gibbs, D William Parsons, Sharon E Plon

Faculty, Staff and Students Publications

BACKGROUND: It has been anticipated that physician and parents will be ill prepared or unprepared for the clinical introduction of genome sequencing, making it ethically disruptive.

PROCEDURE: As a part of the Baylor Advancing Sequencing in Childhood Cancer Care study, we conducted semistructured interviews with 16 pediatric oncologists and 40 parents of pediatric patients with cancer prior to the return of sequencing results. We elicited expectations and attitudes concerning the impact of sequencing on clinical decision making, clinical utility, and treatment expectations from both groups. Using accepted methods of qualitative research to analyze interview transcripts, we completed a thematic analysis …

Nutrition And Food Insecurity, Christopher Greeley, Robert D. Sanborn

Journal of Applied Research on Children: Informing Policy for Children at Risk

Christopher Greeley and Robert Sanborn's introduction to Volume 6, Issue 2: Nutrition and Food Insecurity.

Binomial Regression With A Misclassified Covariate And Outcome, Sheng Luo, Wenyaw Chan, Michelle A Detry, Paul J Massman, R S. Doody

Faculty, Staff and Students Publications

Misclassification occurring in either outcome variables or categorical covariates or both is a common issue in medical science. It leads to biased results and distorted disease-exposure relationships. Moreover, it is often of clinical interest to obtain the estimates of sensitivity and specificity of some diagnostic methods even when neither gold standard nor prior knowledge about the parameters exists. We present a novel Bayesian approach in binomial regression when both the outcome variable and one binary covariate are subject to misclassification. Extensive simulation results under various scenarios and a real clinical example are given to illustrate the proposed approach. This approach …

Early Rescue Of Interneuron Disease Trajectory In Developmental Epilepsies, Ms Siehr, Jl Noebels

Faculty, Staff and Students Publications

The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several …

Efficacy Of Psychosocial Interventions In Inducing And Maintaining Alcohol Abstinence In Patients With Chronic Liver Disease: A Systematic Review, A Khan, A Tansel, Dl White, Wt Kayani, Wt Bano, J Lindsay, Hb El-Serag, F Kanwal

Faculty, Staff and Students Publications

BACKGROUND & AIMS: We conducted a systematic review of efficacy of psychosocial interventions in inducing or maintaining alcohol abstinence in patients with chronic liver disease (CLD) and alcohol use disorder (AUD). METHODS: We performed structured keyword searches in PubMed, PsychINFO, and MEDLINE for original research articles that were published from January 1983 through November 2014 that evaluated the use of psychosocial interventions to induce or maintain alcohol abstinence in patients with CLD and AUD. RESULTS: We identified 13 eligible studies that comprised 1945 patients; 5 were randomized controlled trials (RCTs). Delivered therapies included motivational enhancement therapy, cognitive behavioral therapy (CBT), …

Eosinophilic Esophagitis In Children And Its Relationship With Parental Allergies: Texas Children's Hospital Experience, G Hiremath, D Byramji, A Pacheco, G Constantine, C Davis, R Shulman, A Olive

Faculty, Staff and Students Publications

BACKGROUND: Eosinophilic esophagitis (EoE) is an allergen-mediated, clinicopathological condition affecting all ages. The characteristics of children with EoE in the southwestern USA have not been fully described. Furthermore, very little is known about the relationship between parental allergies and risk of EoE in their offspring in this patient population. AIMS: To characterize children with EoE and to examine the relationship between prevalence of parental allergies and occurrence of EoE in their offspring at a single referral pediatric center in the southwestern USA. METHODS: Demographic and clinical information of 126 children (=18 years of age) with EoE was abstracted in a …

Endosteal Biologic Augmentation For Surgical Fixation Of Displaced Femoral Neck Fractures, Lionel E Lazaro, Jacqueline F Birnbaum, Nadja A Farshad-Amacker, David L Helfet, Hollis G Potter, Dean G Lorich

Faculty, Staff and Student Publications

OBJECTIVES: To report outcomes of a cohort with displaced femoral neck fractures (FNFs) treated with a length/angle-stable construct augmented with an endosteal fibular allograft serving as a biologic dowel.

DESIGN: Prospective.

SETTING: Level I Trauma Center.

PATIENTS: The study group consists of 27 patients with isolated FNF surgically treated by a single surgeon.

INTERVENTION: Open reduction of the femoral neck, fixed with a length- and angle-stable construct of 2 fully threaded cannulated screws augmented with an endosteal fibular allograft serving as a biologic dowel.

MAIN OUTCOME MEASUREMENTS: Clinical and radiographic outcomes of the fixation construct and the viability of both …

Benefits Of A Snacking Intervention As Part Of A School-Based Obesity Intervention For Mexican American Children, Jennette P. Moreno, Afshan Mohammed, Carolyn E. Moore, Craig Johnston

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objective: To examine the impact of adherence to a healthy snacking component of a 6 month school-based intervention program for overweight and obese children.

Design: Randomized controlled intervention trial

Methods: Mexican American children who were ≥ 85^th percentile for body mass index (BMI) were recruited between 2005-2012 from three Houston schools. Children participated in a 12-week instructor led intensive intervention program that included nutrition education, physical activity, and a snacking component which consisted of a daily choice of peanuts and/or peanut butter snacks. Children (12±0.6 years) (n= 257) were divided into either low or high snacking adherence groups based …

Household Food Insecurity Status And Hispanic Immigrant Children’S Body Mass Index And Adiposity, Daphne C. Hernandez, Layton Reesor, Yanely Alonso, Sally G. Eagleton, Sheryl O. Hughes

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objectives: Despite the high prevalence rates of food insecurity and obesity among children of Hispanic immigrants, there has been a dearth of research on the direct relationship between food insecurity and obesity among this population. Further, prior research examining the association between food insecurity and body composition among children of Hispanic immigrants have not considered adiposity, specifically percent body fat (%BF) and waist circumference (WC), as outcome measurements. The following study contributes to the literature by examining the association between food insecurity and two adiposity measurements, %BF and WC, along with body mass index (BMI) among a sample of young …

Food Security, Hunger-Coping, And Hunger-Symptoms, And Their Relationship With Daily Fruit And Vegetable Intake Frequency In A Low-Income Sample, Hollyanne E. Fricke, Eric E. Calloway, Teresa M. Smith, Courtney A. Pinard, Amy Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose To examine daily fruit and vegetable (FV) intake frequency by household food security status (high food security, marginal food security, low food security, and very low food security), and scores on three hunger-coping behavior scales (i.e., “rationing food supplies”, “financial strategies”, and “trade-off strategies”), and one physiological hunger symptoms scale among a very low-income population in the Midwestern United States.

Methods Adult participants (aged 19 and older and caregivers to at least one child aged 0-18) were recruited from public libraries, food pantries, and other community locations to participate in a cross-sectional self-administered survey (n = 306). The primary …

Food Insecurity And Cardiovascular Risk Factors In U.S. Adolescents, Elisabeth L P Sattler, Vibha Bhargava

Journal of Applied Research on Children: Informing Policy for Children at Risk

Introduction: Disparities in cardiovascular diseases are one of today’s most important public health challenges. Pathological processes related to modifiable cardiovascular risk factors have shown to begin in childhood and disparities in these risk factors have been reported in adolescence. Food insecurity is significantly associated with cardiovascular risk factors in adults; however, little is known about cardiovascular risk in food insecure adolescents.

Objective: The objective of this study was to examine the relationship between food insecurity and cardiovascular risk factors in U.S. adolescents aged 12-17 years.

Methods: Using cross-sectional data on 1,853 adolescents aged 12-17 years from the National Health and …

The Impact Of The California Drought On Food Security Among Rural Families Of Mexican Origin, Lizette Rodriguez, Marcel Horowitz, Dorina Espinoza, Alberto Aguilera, Adela De La Torre, Lucia L. Kaiser

Journal of Applied Research on Children: Informing Policy for Children at Risk

Introduction:

The year 2015 marks the fourth year of a drought in California. With no signs of the drought improving, communities in California are left to prioritize their water usage. In the Central Valley, the limited water supply has forced farmers to prioritize on acreage and planting, decisions that trickle down and may impact farmworker families.

Objective:

The purpose of this study was to explore the impact of a drought in California on family decision-making and coping strategies in the context of broader community changes affecting rural families of Mexican-origin.

Methods:

This study recruited participants from the Niños Sanos, …

The Influence Of “Westernization” On Nutrition And Physical Activity Behaviors Of Adolescents In New Delhi, India: Are We Exporting An Epidemic Of Obesity?, Melissa Harrell, Emily Ussery, Blanche Greene-Cramer, Nalini Ranjit, Shreela V. Sharma, Monika Arora

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose. To examine the relationships between “westernization” and nutrition and physical activity behaviors among older adolescents in Delhi, India. These relations have not been explored, despite increasingly strong and pervasive socio-cultural influences from the West.

Methods. Students (n=1818) in 8^th and 10^th grades in 4 Private (higher SES) and 4 Government (lower SES) schools in Delhi, India participated in a cross-sectional study. Height and weight were measured to determine weight status. Information on “westernization” and nutrition, physical activity, sedentary, and dieting behaviors was collected in a survey. The measure of “westernization” assessed 4 domains of culture on a …

Associations Between Neighborhoods And Summer Meals Sites: Measuring Access To Federal Summer Meals Programs, Rachel L. Wilkerson, Durwesh Khalfe, Kathy Krey

Journal of Applied Research on Children: Informing Policy for Children at Risk

While the challenge of access to healthy food features prominently in the literature, access to federal nutrition programs, specifically USDA’s Summer Meals Program, is relatively undocumented. Participation in the program depends on a number of complex variables, including site availability, neighborhood dynamics, and community investment. The purpose of this study is to determine neighborhood indicators that correlate with the coverage and density of summer meals sites in Texas. Attributes of the community and the number of meal sites were collected at the census tract level, and paired t-tests revealed the statistical significance of differences between tracts with and without meal …

Understanding Eating Behaviors Of New Dehli's Youth, Melissa Harrell, Jose Medina, Blanche Greene-Cramer, Shreela V. Sharma, Monika Arora, Gaurang Nazar

Journal of Applied Research on Children: Informing Policy for Children at Risk

This qualitative study documents perceived benefits of and barriers to engaging in healthy eating behaviors among adolescents in New Delhi, India. Researchers explored factors that influenced the consumption of breakfast, fruits and vegetables, and soft drinks in this population and adolescents’ ideas about how to intervene to encourage or discourage, respectively, these behaviors. Students (n=151 6^th and 8^th graders) from five private schools participated in focus group discussions. Findings showed that the majority of youth eat breakfast that may consist of traditional and Western choices. Despite sound knowledge of the benefits of fruits and vegetables consumption, adolescents do …

Ms225: 2016 Faculty Meeting Minutes, Thomas R. Cole

Thomas R. Cole, PhD Papers

Original Filename: Faculty Meeting Minutes 010616.docx. Format Details: fmt/412; Microsoft Word for Windows; 2007 onwards. See more at Thomas R. Cole, PhD Papers and its finding aid.

Caring Minds, University Of Texas Health Science Center At Houston School Of Nursing

Caring Minds

No abstract provided.

Cme/Cne Article: A Framework Of Care In Multiple Sclerosis, Part 1, Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones

Faculty, Staff and Student Publications

Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org.

TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS).

LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) …

Local Corticotropin Releasing Hormone (Crh) Signals To Its Receptor Crhr1 During Postnatal Development Of The Mouse Olfactory Bulb, Isabella Garcia, Paramjit K Bhullar, Burak Tepe, Joshua Ortiz-Guzman, Longwen Huang, Alexander M Herman, Lesley Chaboub, Benjamin Deneen, Nicholas J Justice, Benjamin R Arenkiel

Faculty, Staff and Students Publications

Neuropeptides play important physiological functions during distinct behaviors such as arousal, learning, memory, and reproduction. However, the role of local, extrahypothalamic neuropeptide signaling in shaping synapse formation and neuronal plasticity in the brain is not well understood. Here, we characterize the spatiotemporal expression profile of the neuropeptide corticotropin-releasing hormone (CRH) and its receptor CRHR1 in the mouse OB throughout development. We found that CRH-expressing interneurons are present in the external plexiform layer, that its cognate receptor is expressed by granule cells, and show that both CRH and CRHR1 expression enriches in the postnatal period when olfaction becomes important towards olfactory-related …

Nutritional Status And Tuberculosis Risk In Adult And Pediatric Household Contacts, Omowunmi Aibana, Xeno Acharya, Chuan-Chin Huang, Mercedes C Becerra, Jerome T Galea, Silvia S Chiang, Carmen Contreras, Roger Calderon, Rosa Yataco, Gustavo E Velásquez, Karen Tintaya, Judith Jimenez, Leonid Lecca, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; or whether nutritional status predicts this risk in children. We assessed the impact of body mass index on incident TB infection and disease among adults and children.

METHODS AND FINDINGS: We conducted a prospective cohort study among household contacts of pulmonary TB cases in Lima, Peru. We determined body mass index at baseline and followed participants for one year for TB infection and disease. We used …

Activation Of Signal Transduction Pathways During Hepatic Oncogenesis, W Chung, M Kim, S De La Monte, L Longato, R Carlson, B L. Slagle, X Dong, J R. Wands

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS: Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) was achieved and transgenic mice were followed from birth to age 21 months. Liver and tumor tissue were assessed for histologic changes as well as activation of signal transduction pathways by qRT-PCR and multiplex ELISA protein assays. RESULTS: Overexpression of HBx and IRS1 stimulates liver cell proliferation in the double transgenic mice. Only the male mice …

Effect Of Two-Year Caloric Restriction On Bone Metabolism And Bone Mineral Density In Non-Obese Younger Adults: A Randomized Clinical Trial, Dt Villareal, L Fontana, Sk Das, Et Al.

Faculty, Staff and Students Publications

Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on bone metabolism and bone mineral density (BMD) in healthy younger adults. Two-hundred eighteen non-obese (body mass index [BMI] 25.1?±?1.7?kg/m(2) ), younger (age 37.9?±?7.2 years) adults were randomly assigned to 25% CR (CR group, n?=?143) or ad libitum (AL group, n?=?75) for 2 years. Main outcomes were BMD and markers of bone turnover. Other outcomes included body composition, bone-active hormones, nutrient intake, and physical activity. Body weight (-7.5?±?0.4 versus …

Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al.

Faculty, Staff and Students Publications

BACKGROUND: Gestational diabetes mellitus (GDM) is one of most common complications of pregnancy, with incidence rates varying by maternal age, race/ethnicity, obesity, parity, and family history. Given its increasing prevalence in recent decades, covariant environmental and sociodemographic factors may be additional determinants of GDM occurrence. OBJECTIVE: We hypothesized that environmental risk factors, in particular measures of the food environment, may be a diabetes contributor. We employed geospatial modeling in a populous US county to characterize the association of the relative availability of fast food restaurants and supermarkets to GDM. STUDY DESIGN: Utilizing a perinatal database with >4900 encoded antenatal and …

Identification Of A Novel Gene On 10q221 Causing Autosomal Dominant Retinitis Pigmentosa (Adrp), Stephen P Daiger, Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Susan H Blanton, Dianna K Wheaton, Cheryl E Avery, Elizabeth D Cadena, Robert K Koenekoop, Robert S Fulton, Richard K Wilson, George M Weinstock, Richard A Lewis, David G Birch

Faculty, Staff and Students Publications

Whole-genome linkage mapping identified a region on chromosome 10q21.3-q22.1 with a maximum LOD score of 3.0 at 0 % recombination in a six-generation family with autosomal dominant retinitis pigmentosa (adRP). All known adRP genes and X-linked RP genes were excluded in the family by a combination of methods. Whole-exome next-generation sequencing revealed a missense mutation in hexokinase 1, HK1 c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members. One severely-affected male is homozygous for this region by linkage analysis and has two copies of the mutation. No other potential mutations were detected in the linkage region nor were …

Sugar In School Breakfasts: A School District's Perspective, Jennifer G. Lengyel Ms, Rdn, Ld, Nan Cramer Rdn, Ld, Amanda Oceguera Ms, Rdn, Ld, Lana Pigao Ma, Houston Independent School District, Nutrition Services Department

Journal of Applied Research on Children: Informing Policy for Children at Risk

A recent series of emails and phone calls from parents concerned about the sugar content of Houston Independent School District’s school breakfasts revealed that a new issue had risen to the surface. This prompted us to look closely at the sugar content of our breakfast items. School districts participating in the National School Breakfast Program follow a strict set of nutritional regulations set forth by the USDA under the Healthy Hunger Free Kids Act (HHFKA) of 2010 in response to the childhood obesity epidemic. HHFKA made significant changes to the breakfast meal pattern, but did not set standards for the …

A Cross-Sectional Exploration Of Food Security, Depression, And Chaos In Low-Income Households With Children, Courtney A. Pinard, Eric E. Calloway, Hollyanne E. Fricke, Amy L. Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Depression has been linked to food security, particularly among low-income mothers. However, less is known about the relationship between CHAOS (Confusion, Hubbub, and Order Scale), a measure of family functioning such as timeliness and order, and varying levels food security. The purpose of this paper was to evaluate the relationship between depression, CHAOS, and sociodemographics on the level of food insecurity in a cross-sectional sample of low-income households with children, ages 0-18 years.

Participants were recruited from low-income communities in a medium sized Midwestern city in the United States. Eligible participants were ≥19 years of age, a parent or primary …

Monthly Snap Benefit Duration And Its Association With Food Security, Hunger-Coping, And Physiological Hunger Symptoms Among Low-Income Families, Eric E. Calloway, Hollyanne E. Fricke, Courtney A. Pinard, Teresa M. Smith, Amy L. Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose

The purpose of this study was to examine relationships between monthly Supplemental Nutrition Assistance Program (SNAP) benefit duration (i.e., the number of weeks each month a participants’ SNAP benefits provide food), and five primary outcome variables: food security, three hunger-coping behavior scales (rationing food supplies, financial strategies, making trade-offs), and physiological hunger symptoms, among a sample of families with children 0-18 years currently receiving SNAP benefits.

Methods

Baseline survey data were collected as part of a community-based intervention to alleviate child hunger. Participants included in the analytic sample were current SNAP recipients, parents (or caregivers), and 19 years of …

Food Matters: Food Insecurity Among Pregnant Adolescents And Infant Birth Outcomes, Stephanie A. Grilo, Valerie A. Earnshaw, Jessica B. Lewis, Emily C. Stasko, Urania Magriples, Jonathan Tobin, Jeannette R. Ickovics

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objectives: The objectives of this study are to: (1) document prevalence of food insecurity among pregnant adolescents; (2) determine if food insecurity is associated with adverse birth outcomes (i.e., lower birth weight, earlier gestational age) among their newborns; and (3) examine whether depressive symptoms, anxiety, nutrition and/or weight gain mediate these associations.

Methods: Pregnant adolescents (14-21 years old; N-881) in prenatal care at community hospitals and health centers in New York City completed a health and psychosocial survey during second and third trimesters of pregnancy. Birth weight and gestational age were recorded from medical records.

Results: Over one-half of the …

Trends In Household And Child Food Insecurity Among Families With Young Children From 2007 To 2013, Allison R. Bovell, Stephanie Ettinger De Cuba, Patrick H. Casey, Sharon Coleman, John T. Cook, Diana Cutts, Timothy C. Heeren, Alan Meyers, Megan Sandel, Maureen M. Black Ph.D,, Mariana Chilton, Deborah A. Frank

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: 2007-2013 spanned an economic downturn with rising food costs. While Supplemental Nutrition Assistance Program (SNAP) benefits increased during those years by 13.6% from the 2009 American Recovery Reinvestment Act (ARRA), the impact of these competing conditions on household food insecurity (HFI, household food insecure but child food secure) and child food insecurity (CFI, household and child food insecure) in households with infants and toddlers has not been investigated.

Objective: To describe HFI and CFI in households participating in SNAP vs. households likely eligible but not participating (No SNAP).

Design: Repeat cross-sectional

Participants/Setting: 19,999 caregivers of childrenChildren’s HealthWatch survey in …

Community Food Security Strategies: An Exploratory Study Of Their Potential For Food Insecure Households With Children, Michelle L. Kaiser, Kareem Usher, Colleen Spees

Journal of Applied Research on Children: Informing Policy for Children at Risk

This research sought to explore nutrition and related health issues of 151 households with children who participated in a survey addressing food access, food security, nutrition, health, food provisioning strategies, and barriers to optimal food consumption. This study explored the potential use of community food security strategies as a tool to address public health concerns through increasing fruit and vegetable intake by improving access to affordable healthy foods. Poor diet, stress, and food insecurity impacts adults and children in terms of cognitive development, mental health, and risk for costly chronic diseases. This research contextualized consumer responses within a contemporary policy …