Impact Of Vitamin A And Carotenoids On The Risk Of Tuberculosis Progression, Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Alayne G Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Low and deficient levels of vitamin A are common in low- and middle-income countries where tuberculosis burden is high. We assessed the impact of baseline levels of vitamin A and carotenoids on tuberculosis disease risk.

METHODS: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary tuberculosis case patients in Lima, Peru. We defined case patients as human immunodeficiency virus (HIV)-negative HHCs with blood samples in whom tuberculosis disease developed ≥15 days after enrollment of the index patient. For each case patient, we randomly selected 4 controls from among contacts in whom tuberculosis …

Intersex And Families: Supporting Family Members With Intersex Variations, Tiffany Jones

Journal of Family Strengths

People with intersex variations have congenital atypical sex characteristics (chromosomal, hormonal, and/or anatomical) and receive protection against discrimination in only three countries globally; these include Australia, where the case study on which this chapter centers was based. This article considers the complex dynamics of family for people with intersex variations from their own perspective, filling a significant gap in the existing literature on family strengths studies of intersex issues. It draws on data from an Australian survey of 272 people with intersex variations and specifically considers in detail for the first time questions on these participants’ family discussions of intersex …

Clinical And Therapeutic Significance Of Obesity In Melanoma, Jennifer L. Mcquade

Dissertations and Theses (Open Access)

While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, de novo and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to both targeted and immune therapy. The IGF-1/PI3K/AKT pathway has also been shown to play a key role in the pathogenesis of obesity in other malignancies. To date, the impact of energy balance on clinical outcomes and therapeutic response in MM has not been studied. I hypothesized that energy balance would impact the molecular biology, behavior, and drug sensitivity …

Gsk3b Regulates Epithelial-Mesenchymal Transition And Cancer Stem Cell Properties And Is A Novel Drug Target For Triple-Negative Breast Cancer, Geraldine Vidhya Raja

Dissertations and Theses (Open Access)

Abstract

GSK3β regulates Epithelial-Mesenchymal-Transition and Cancer Stem Cell properties and is a novel drug target for Triple-Negative Breast Cancer.

Geraldine Vidhya Raja, MS.

Advisory Professor: Sendurai Mani, Ph.D.

Triple-Negative breast cancers (TNBCs) are highly aggressive and lack the expression of Estrogen Receptor (ER), Progesterone Receptor (PR) as well as Human Epidermal Growth Factor Receptor (HER2). Consequently, patients diagnosed with TNBCs have poor overall- and disease-free survival rates compared to other subtypes of breast cancer due to lack of targeted therapies as well as de novo or acquired chemoresistance, disease recurrence, and lack of targeted therapy. Hence it is critical to …

Predictors Of Obesity In African American College Students, Christiana Chinenye Osuagwu

Journal of Family Strengths

Abstract

Introduction: Obesity is the second highest cause of death in the United States due to its numerous co-morbidities, and data reveal that African Americans are at greatest risk for this disease. The study explored the multiple factors that predict obesity in the African American college students.

Method: Using a hybrid of the PRECEDE-PROCEED and the vital renewal models, a mixed methods study design that included 142 male and female African American college students was conducted. A Likert-scaled survey for the quantitative phase and a focus group interview for the qualitative arm were utilized. Constructs of attitude, culture, environment, …

Addressing Nutritional Literacy In Preschool Learning Environments, Cynthia Warren

Journal of Family Strengths

INTRODUCTION: Obesity among preschool children is more common among lower-income families. Prevalence of type 2 diabetes in U.S. Mexican and African American populations has steadily increased and is associated with modifiable risk factors, such as poor dietary habits.

AIM: The purpose of this study was to conduct an assessment of the preschool Bienestar/NEEMA Health Program, focusing on: students’ knowledge increase, teacher input on the classroom materials used, parental feedback on take-home activities, and input on the program's food service training by the school district's nutrition coordinator.

SAMPLE: Curriculum was implemented and assessed in one Head Start school over …

Mathematical Modeling Reveals That G2/M Checkpoint Override, Hui Ju Hsieh

Dissertations and Theses (Open Access)

Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor cells, the signaling network has been rewired due to epigenetic and genetic alterations, which result in resistance to the cell cycle control, and thus resistance to chemotherapy or radiation therapy. Therefore, it is critical to identify molecules required for checkpoint recovery or adaptation after DNA damage.

To achieve this goal, we performed a multidisciplinary study combining reverse …

Statistical Methods For Assessing Structural Change In Human & Microbial Genomes, Xuan Zhu

Dissertations and Theses (Open Access)

Genetic sequencing has been recognized as an effective approach to accurately address biological problems, such as clinical detection of disease, mutation discovery, and targeting specific biomarkers associated with complex diseases. Compared with conventional Sanger sequencing, next-generation sequencing costs much less due to massively parallel high-throughput sequencing. However, due to large numbers of short read sequences, the accuracy of high-throughput sequencing data remains a challenge in that the data obtained from next-generation sequencing often has higher error rates, which may impact downstream genomic analysis. Even if the downstream genomic analysis performs well, the quality of the result will still be impacted …

Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors, Hui Ju Hsieh

Dissertations and Theses (Open Access)

Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor cells, the signaling network has been rewired due to epigenetic and genetic alterations, which result in resistance to the cell cycle control, and thus resistance to chemotherapy or radiation therapy. Therefore, it is critical to identify molecules required for checkpoint recovery or adaptation after DNA damage.

To achieve this goal, we performed a multidisciplinary study combining reverse …

Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors, Hui-Ju Hsieh

Dissertations and Theses (Open Access)

Cell cycle checkpoints determine whether cells meet requirements to progress through the next stage. In response to DNA damage, how cells activate checkpoints have been well studied, but little is known about checkpoint deactivation (recovery), which directly impacts on cell fate. In tumor cells, the signaling network has been rewired due to epigenetic and genetic alterations, which result in resistance to the cell cycle control, and thus resistance to chemotherapy or radiation therapy. Therefore, it is critical to identify molecules required for checkpoint recovery or adaptation after DNA damage.

To achieve this goal, we performed a multidisciplinary study combining reverse …

Supporting Parent Engagement In Linguistically Diverse Families To Promote Young Children’S Life Success, Sandra Barrueco, Sheila Smith, Samuel A. Stephens

Journal of Applied Research on Children: Informing Policy for Children at Risk

This paper examines research that can inform policies aimed at building the capacity of early care and education programs to promote parent engagement in linguistically diverse families. The key questions addressed include:1 )What factors affect linguistically diverse families’ access to early care and education programs?; 2)What do we know about linguistically diverse families and how parents in these families support their young children’s learning and development?; 3) What features of early care and education programs appear to contribute to high levels of parent engagement in linguistically diverse families?; and 4) What policies can help increase the capacity of early care …

Risk Factors For Poor Multidrug-Resistant Tuberculosis Treatment Outcomes In Kyiv Oblast, Ukraine, Omowunmi Aibana, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P Flanigan, Vasyl Petrenko, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Ukraine is among ten countries with the highest burden of multidrug- resistant TB (MDR-TB) worldwide. Treatment success rates for MDR-TB in Ukraine remain below global success rates as reported by the World Health Organization. Few studies have evaluated predictors of poor MDR-TB outcomes in Ukraine.

METHODS: We conducted a retrospective analysis of patients initiated on MDR-TB treatment in the Kyiv Oblast of Ukraine between January 01, 2012 and March 31st, 2015. We defined good treatment outcomes as cure or completion and categorized poor outcomes among those who died, failed treatment or defaulted. We used logistic regression analyses to identify …

Pre-K In Texas: A Critical Component For Academic Success, Robert Sanborn, Katie Mcconnell, Mandi Kimball, Andy Canales, Jesus Davila, Shay Everitt, Kellie O'Quinn, Claire Treacy, Carlos Villegas

Journal of Applied Research on Children: Informing Policy for Children at Risk

With funding from the Meadows Foundation and the Miles Foundation, researchers at CHILDREN AT RISK engaged in a study to examine how participation in Texas public PreKindergarten Pre-K1 is associated with performance on the 3rd Grade State of Texas Assessment of Academic Readiness (STAAR) Reading assessment.

CHILDREN AT RISK tracked approximately 47,000 students from the 2010-2011 school year to the 2014-2015 school year.2 These students began public Pre-K in 2010 and completed 3rd grade in 2015. The study focused on five major independent school districts (ISD) in Texas (Austin ISD, Dallas ISD, Fort Worth ISD, Houston ISD, and San Antonio …

Extending The Jamaican Early Childhood Development Intervention, Sally Grantham-Mcgregor, Joanne A. Smith

Journal of Applied Research on Children: Informing Policy for Children at Risk

We review the development of the Jamaican home visiting intervention for children under 4 years and its evidence base. The intervention has focused on supporting mothers to promote the development of their children through interacting in a responsive way, labelling the environment and activities. The curriculum is structured and cognitively orientated. It has been used in 13 studies in 4 countries, 7 in Jamaica, 6 in Bangladesh, one each in Colombia and Peru. In all studies some benefit to children’s cognitive and language development has been found. Different types of children from severely malnourished to children living in poverty have …

Behavioral Economics And Developmental Science: A New Framework To Support Early Childhood Interventions, Lisa Gennetian, Matthew Darling, J Lawrence Aber

Journal of Applied Research on Children: Informing Policy for Children at Risk

Public policies have actively responded to an emergent social and neuroscientific evidence base documenting the benefits of targeting services to children during the earliest period of their development. But problems of low utilization, inconsistent participation, and low retention continue to present themselves as challenges. Although most interventions recognize and address structural and psycho-social barriers to parent’s engagement, few take seriously the decision making roles of parents. Using insights from the behavioral sciences, we revisit assumptions about the presumed behavior of parents in a developmental context. We then describe ways in which this framework informs features of interventions that can be …

Integrating Behavioral Trigger Messages Into A Mhealth System Design For Chronic Disease Management, Scott Sittig

Dissertations and Theses (Open Access)

Recent changes in health information technology have dramatically altered the face, delivery, and management of healthcare particularly as it relates to mHealth. With increases in smart phone ownership, mHealth potentially has the ability to provide far-reaching transformation of chronic disease management particularly when aligned with behavioral change theories and persuasive technology. MHealth applications have an advantage over computers and various print communications as the consumer can engage with the application at any time and at any location. The Interactive Health Communication Application (IHCA) states that by combining support mechanisms such as behavior change theories into electronic devices as a method …

Patient Predictors Of Poor Drug Sensitive Tuberculosis Treatment Outcomes In Kyiv Oblast, Ukraine, Omowunmi Aibana, Andrej Slavuckij, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P Flanigan, Vasyl Petrenko, Megan B Murray

Faculty, Staff and Student Publications

Background: Ukraine has high rates of poor treatment outcomes among drug sensitive tuberculosis (DSTB) patients, while global treatment success rates for DSTB remain high.

We evaluated baseline patient factors as predictors of poor DSTB treatment outcomes.

Methods: We conducted a retrospective analysis of new drug sensitive pulmonary TB patients treated in Kyiv Oblast, Ukraine between November 2012 and October 2014. We defined good treatment outcomes as cure or completion and poor outcomes as death, default (lost to follow up) or treatment failure. We performed logistic regression analyses, using routine program data, to identify baseline patient factors associated with poor outcomes. …

Sustainability And Spread Of Community-Based Initiatives: A Case Study Of Community Cares, A Children’S Hospital’S 16 Year Effort To Serve Its Community, Robert F. Austin, Patricia Coleman, Stephanie Meads, Angelo P. Giardino

Journal of Family Strengths

The sustainability and spread of innovations is often elusive, presenting continuous challenges to clinicians and healthcare leaders. Somewhere between 33 - 70% of all innovations are reportedly not sustained, and even fewer are spread beyond the original team, or to other units within an organization. In plain language, sustainability is defined as locking in progress, while continually building upon that foundation, while spread is the exchange of knowledge and experience to others beyond the original implementing team. The literature supports the concept that sustainability is both multi-dimensional and multi-factorial and has several characteristics and pre-conditions. Tax-exempt, not-for-profit organizations in the …

Influence Of Maternal Breast Milk Ingestion On Acquisition Of The Intestinal Microbiome In Preterm Infants, Katherine E Gregory, Buck S Samuel, Pearl Houghteling, Guru Shan, Frederick M Ausubel, Ruslan I Sadreyev, W Allan Walker

Faculty, Staff and Students Publications

BACKGROUND: The initial acquisition and early development of the intestinal microbiome during infancy are important to human health across the lifespan. Mode of birth, antibiotic administration, environment of care, and nutrition have all been shown to play a role in the assembly of the intestinal microbiome during early life. For preterm infants, who are disproportionately at risk of inflammatory intestinal disease (i.e., necrotizing enterocolitis), a unique set of clinical factors influence the establishment of the microbiome. The purpose of this study was to establish the influence of nutritional exposures on the intestinal microbiome in a cohort of preterm infants early …

Head Start Since The War On Poverty: Taking On New Challenges To Address Persistent School Readiness Gaps, Pamela Joshi, Kimberly Geronimo, Dolores Acevedo-Garcia

Journal of Applied Research on Children: Informing Policy for Children at Risk

This article explores Head Start’s overall effectiveness in improving school readiness outcomes and its potential to reduce gaps in these outcomes in light of changing program goals, resource and funding capacity, and the demographic changes in the low-income child population it serves. Although not an explicit goal of the Head Start program, we assess whether and how the program can address reducing school readiness gaps between children of different racial and ethnic backgrounds and income groups. Because of changing policy priorities and targeting vulnerable groups of children with diverse needs, meeting Head Start goals within funding constraints can be challenging. …

50 Years After The War On Poverty: Successes Should Inspire The Next Bold Steps For Poor Children, Olivia Golden

Journal of Applied Research on Children: Informing Policy for Children at Risk

Safety net programs emerging from the War on Poverty and later antipoverty efforts such as Head Start, Medicaid, the Earned Income Tax Credit (EITC), and the Supplemental Nutrition Assistance Program (SNAP), among others have reduced poverty, and strengthened longer-term outcomes for poor children, leading to better health and greater economic success into adulthood. Unfortunately, despite the strong positive effect of these public programs, the poverty rate is still too high, particularly among America’s next generation of children and young adults. Struggling with economic insecurity is now a typical experience for America’s next generation, with the overwhelming majority of low-income households …

Trends In Child Poverty By Race/Ethnicity: New Evidence Using An Anchored Historical Supplemental Poverty Measure, Laura Nolan, Irwin Garfinkel, Neeraj Kaushal, Jaehyun Nam, Jane Waldfogel, Christopher Wimer

Journal of Applied Research on Children: Informing Policy for Children at Risk

Official poverty statistics have been criticized, however, for being based on an outdated measure of poverty (Blank, 2008; Citro and Michael, 1995). First put into use in the 1960s, the official poverty measure’s (OPM) concept of needs has been updated for inflation but still reflects the living standards, family budgets, and family structures of that time. Moreover, when tallying family resources, the OPM misses key government programs such as Food Stamps and tax credits that have expanded since the 1960s. For these reasons, the Census Bureau and the Bureau of Labor Statistics (BLS) implemented an improved “supplemental poverty measure” (SPM) …

50 Years After The War On Poverty, Thomas Mcinerny

Journal of Applied Research on Children: Informing Policy for Children at Risk

Guest editor Thomas McInerny introduces Volume 7, Issue 1: 50 Years After the War on Poverty: Historic Victories and New Challenges.

An Unconditional War On Poverty: Action And Reaction, Robert Sanborn, Christopher Greeley

Journal of Applied Research on Children: Informing Policy for Children at Risk

Christopher Greeley and Robert Sanborn's introduction to Volume 7, Issue 1: 50 Years After the War on Poverty: Historic Victories and New Challenges.

Investigation Of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers, Joshua S. Niedzielski

Dissertations and Theses (Open Access)

Radiation injury in the esophagus occurs with high frequency from the treatment of non-small cell lung cancer (NSCLC). Radiation esophagitis is an acute normal tissue toxicity that negatively affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical quantification of this toxicity is typically achieved by utilizing physician grading scales, assigning complication severity on an ordinal scale of symptom presentation and/or physician chosen interventions. These criteria are subjective in nature, both from the physician assigning the grade and the patient reporting the symptom. Furthermore, radiation therapy planning guidelines for the esophagus are derived from toxicity prediction models utilizing …

Brown Beauty: Body Image, Latinas, And The Media, D. Milton Stokes, Christopher F. Clemens, Diana I. Rios

Journal of Family Strengths

This paper examines the understudied Latina population and the effects of media on their body image. To date, research has ignored this population or aggregated all Latin-American sub-cultures into one general category, missing the nuances of each culture. A review of current literature utilizing cultivation theory and social comparison theory is offered. Important findings suggest that social support and ethnic identity may offer a buffering effect between media exposure and body dissatisfaction, but more research needs to clarify this process. The effects of media and the internalization of the ‘thin ideal’ become stronger the longer Latina women live in the …

Repetitive, Pre-Anesthetic Fasting And Malnutrition In A Pediatric Oncology Population Undergoing Radiation Therapy, Laura P. Santibáñez

Dissertations and Theses (Open Access)

Background: Pediatric oncology patients often experience nutritional status changes, particularly malnutrition, which may adversely affect their outcomes. Although the consequences of malnutrition are elucidated, its causes remain unclear. A possible cause of malnutrition in pediatric oncology patients is repetitive, pre-anesthetic fasting prior to non-invasive procedures and treatments, such as anesthesia-assisted radiation therapy (AART). This exploratory study investigated the association between repetitive, pre-anesthetic fasting and non-fasting days and malnutrition in pediatric oncology patients receiving AART.

Procedure: A retrospective cohort of 138 pediatric oncology patients (£ 10 years of age) who received any type of radiation therapy (RT) with or without anesthesia …

Periodontitis In Chronic Heart Failure, Hanna Fröhlich, Kristina Herrmann, Jennifer Franke, Alamara Karimi, Tobias Täger, Rita Cebola, Hugo A Katus, Christian Zugck, Lutz Frankenstein

The Texas Heart Institute Journal

Periodontal disease has been associated with an increased risk of cardiovascular events. The purpose of our study was to investigate whether a correlation between periodontitis and chronic heart failure exists, as well as the nature of the underlying cause.

We enrolled 71 patients (mean age, 54 ± 13 yr; 56 men) who had stable chronic heart failure; all underwent complete cardiologic and dental evaluations. The periodontal screening index was used to quantify the degree of periodontal disease. We compared the findings to those in the general population with use of data from the 4th German Dental Health Survey.

Gingivitis, moderate …

In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis, Frank J. Lowery Iii

Dissertations and Theses (Open Access)

Brain metastasis, which frequently arises from breast cancer, lung cancer, melanoma, and colorectal cancer, remains a severely unmet medical need and its incidence continues to rise while treatment options remain palliative. To better understand the biology underlying its aggressive, incurable nature, I performed an unbiased in vivo kinome screen to identify potential driver kinases of experimental brain metastasis in a nude xenograft model using the human breast cancer cell line MDA-MB-231. Several of the kinase pools led to decreased brain metastasis-specific survival in nude mice, shortening survival time by up to 50% relative to controls. Targeted next-generation sequencing (NGS) was …

Nutrition And Food Insecurity, Christopher Greeley, Robert D. Sanborn

Journal of Applied Research on Children: Informing Policy for Children at Risk

Christopher Greeley and Robert Sanborn's introduction to Volume 6, Issue 2: Nutrition and Food Insecurity.