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Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al.

Faculty, Staff and Students Publications

BACKGROUND: Gestational diabetes mellitus (GDM) is one of most common complications of pregnancy, with incidence rates varying by maternal age, race/ethnicity, obesity, parity, and family history. Given its increasing prevalence in recent decades, covariant environmental and sociodemographic factors may be additional determinants of GDM occurrence. OBJECTIVE: We hypothesized that environmental risk factors, in particular measures of the food environment, may be a diabetes contributor. We employed geospatial modeling in a populous US county to characterize the association of the relative availability of fast food restaurants and supermarkets to GDM. STUDY DESIGN: Utilizing a perinatal database with >4900 encoded antenatal and …

Sugar In School Breakfasts: A School District's Perspective, Jennifer G. Lengyel Ms, Rdn, Ld, Nan Cramer Rdn, Ld, Amanda Oceguera Ms, Rdn, Ld, Lana Pigao Ma, Houston Independent School District, Nutrition Services Department

Journal of Applied Research on Children: Informing Policy for Children at Risk

A recent series of emails and phone calls from parents concerned about the sugar content of Houston Independent School District’s school breakfasts revealed that a new issue had risen to the surface. This prompted us to look closely at the sugar content of our breakfast items. School districts participating in the National School Breakfast Program follow a strict set of nutritional regulations set forth by the USDA under the Healthy Hunger Free Kids Act (HHFKA) of 2010 in response to the childhood obesity epidemic. HHFKA made significant changes to the breakfast meal pattern, but did not set standards for the …

A Cross-Sectional Exploration Of Food Security, Depression, And Chaos In Low-Income Households With Children, Courtney A. Pinard, Eric E. Calloway, Hollyanne E. Fricke, Amy L. Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Depression has been linked to food security, particularly among low-income mothers. However, less is known about the relationship between CHAOS (Confusion, Hubbub, and Order Scale), a measure of family functioning such as timeliness and order, and varying levels food security. The purpose of this paper was to evaluate the relationship between depression, CHAOS, and sociodemographics on the level of food insecurity in a cross-sectional sample of low-income households with children, ages 0-18 years.

Participants were recruited from low-income communities in a medium sized Midwestern city in the United States. Eligible participants were ≥19 years of age, a parent or primary …

Monthly Snap Benefit Duration And Its Association With Food Security, Hunger-Coping, And Physiological Hunger Symptoms Among Low-Income Families, Eric E. Calloway, Hollyanne E. Fricke, Courtney A. Pinard, Teresa M. Smith, Amy L. Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose

The purpose of this study was to examine relationships between monthly Supplemental Nutrition Assistance Program (SNAP) benefit duration (i.e., the number of weeks each month a participants’ SNAP benefits provide food), and five primary outcome variables: food security, three hunger-coping behavior scales (rationing food supplies, financial strategies, making trade-offs), and physiological hunger symptoms, among a sample of families with children 0-18 years currently receiving SNAP benefits.

Methods

Baseline survey data were collected as part of a community-based intervention to alleviate child hunger. Participants included in the analytic sample were current SNAP recipients, parents (or caregivers), and 19 years of …

Food Matters: Food Insecurity Among Pregnant Adolescents And Infant Birth Outcomes, Stephanie A. Grilo, Valerie A. Earnshaw, Jessica B. Lewis, Emily C. Stasko, Urania Magriples, Jonathan Tobin, Jeannette R. Ickovics

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objectives: The objectives of this study are to: (1) document prevalence of food insecurity among pregnant adolescents; (2) determine if food insecurity is associated with adverse birth outcomes (i.e., lower birth weight, earlier gestational age) among their newborns; and (3) examine whether depressive symptoms, anxiety, nutrition and/or weight gain mediate these associations.

Methods: Pregnant adolescents (14-21 years old; N-881) in prenatal care at community hospitals and health centers in New York City completed a health and psychosocial survey during second and third trimesters of pregnancy. Birth weight and gestational age were recorded from medical records.

Results: Over one-half of the …

Trends In Household And Child Food Insecurity Among Families With Young Children From 2007 To 2013, Allison R. Bovell, Stephanie Ettinger De Cuba, Patrick H. Casey, Sharon Coleman, John T. Cook, Diana Cutts, Timothy C. Heeren, Alan Meyers, Megan Sandel, Maureen M. Black Ph.D,, Mariana Chilton, Deborah A. Frank

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: 2007-2013 spanned an economic downturn with rising food costs. While Supplemental Nutrition Assistance Program (SNAP) benefits increased during those years by 13.6% from the 2009 American Recovery Reinvestment Act (ARRA), the impact of these competing conditions on household food insecurity (HFI, household food insecure but child food secure) and child food insecurity (CFI, household and child food insecure) in households with infants and toddlers has not been investigated.

Objective: To describe HFI and CFI in households participating in SNAP vs. households likely eligible but not participating (No SNAP).

Design: Repeat cross-sectional

Participants/Setting: 19,999 caregivers of childrenChildren’s HealthWatch survey in …

Community Food Security Strategies: An Exploratory Study Of Their Potential For Food Insecure Households With Children, Michelle L. Kaiser, Kareem Usher, Colleen Spees

Journal of Applied Research on Children: Informing Policy for Children at Risk

This research sought to explore nutrition and related health issues of 151 households with children who participated in a survey addressing food access, food security, nutrition, health, food provisioning strategies, and barriers to optimal food consumption. This study explored the potential use of community food security strategies as a tool to address public health concerns through increasing fruit and vegetable intake by improving access to affordable healthy foods. Poor diet, stress, and food insecurity impacts adults and children in terms of cognitive development, mental health, and risk for costly chronic diseases. This research contextualized consumer responses within a contemporary policy …

Multidisciplinary Approaches To Address Food Insecurity And Nutrition Among Youth And Their Families, Shreela V. Sharma, Daphne C. Hernandez, Deanna M. Hoelscher, Amy L. Yaroch

Journal of Applied Research on Children: Informing Policy for Children at Risk

Our aim in publishing this issue of JARC on nutrition and food insecurity is to understand the factors associated with nutrition and food insecurity in the U.S. and around the world; to elucidate the potential consequences of food insecurity on physical and mental health; and to raise awareness and identify solutions to address this complex issue. We also aim to encourage collaboration across disciplines in order to frame initiatives that reduce these threats to child health, well-being and success.

A Rare Family: Exploring Genetic Literacy In An Online Support Group, Heather H. Goltz, Sandra Acosta

Journal of Family Strengths

Healthy People 2020 and the Institute of Medicine (IOM) define health literacy as the “degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.” Essential components of health literacy include oral and print literacy, numeracy, and cultural and conceptual knowledge; the latter is influenced by sociodemographic factors and cultural understandings and approaches to concepts such as healthcare. Genetic literacy, a form of health literacy, may be defined as the knowledge, skills and attitudes necessary to individual understanding of genetic information, and genetic-based health, behavior, technology …

Literacy: Varied, Dynamic, And Multidimensional, Stephen B. Kucer Dr.

Journal of Family Strengths

This article examines the complex nature of literacy through a variety of lenses. The linguistic lens focuses on literacy as a language and multimodal process. The cognitive reveals the mental processes and strategies readers and writers employ to construct meanings through the linguistic and multimodal dimension. Not just a linguistic and cognitive process, the sociocultural lens examines literacy use within social and cultural contexts. Finally, the developmental lens explores the very active nature of literacy learners and their mediators.

Literacy: A Multidimensional And Ever-Present Entity, Amelia Hewitt, Kim Pinkerton

Journal of Family Strengths

Special Issue Editors Amelia Hewitt and Kim Pinkerton introduce the special edition of Journal of Family Strengths, outlining key points of multidimensional literacy and the significance of literacy in our families and communities.

Literacy: A Continuously Evolving Concept, Angelo P. Giardino, Robert D. Sanborn, Elvon Christopher Lloyd, William V. Flores

Journal of Family Strengths

Angelo P. Giardino, Robert Sanborn, William V. Flores and E. Christopher Lloyd discuss the latest issue of the Journal of Family Strengths.

More Than A Zip Code: Addressing Home Factors Influencing Kindergarten Readiness Levels, Julie Baker Finck Ph. D., Allison Shea

Journal of Family Strengths

Families and primary caregivers play an important role in developing essential emergent literacy skills of children from birth so that they are ready for kindergarten and have a strong foundation for future academic success. This article explores factors that influence the emergent literacy development process and offers strategies to boost school readiness levels and literacy rates among children.

"What Is Essential Is Invisible To The Eye": Culturally Responsive Teaching As A Key To Unlocking Children's Multiple Literacies, Shanna Peeples

Journal of Family Strengths

Refugee students, language learners, and students in poverty are often viewed through a deficit model of everything they do not have in the way of school preparedness. However, many of them are survivors who possess courage and resilience. They also possess exceptional visual literacy developed through experiences with video and other images. Leveraging their visual literacy builds a bridge to help them understand text, which in turn helps them understand how literature reflects all of our experiences. Increased textual literacy helps students engage with vexing human questions. These questions form an inquiry base from which students can approach writing as …

Promoting Health Literacy For People With Disabilities And Clinicians Through A Teamwork Model, David W. Hollar Jr., Jennifer Rowland

Journal of Family Strengths

Current health literacy programs for people with disabilities lack clear operational definitions, rely on inconsistent health literacy statistics, and tend to follow a medical model approach that often fallaciously assumes people with disabilities have limited health knowledge. The central issue in addressing and improving health literacy among people with disabilities is to focus on clear and effective health communication among health care team members, including people with disabilities, which can ultimately improve this population’s health outcomes. Our proposed teamwork model builds upon the World Health Organization’s International Classification of Functioning, Disability and Health (ICF) biopsychosocial model, decision-making theory, and health …

Big Read: Collaborations Between A University And A Community, Chris Birchak, Keri Bell, Rachel Dickson, Vida Robertson, Leigh Van Horn

Journal of Family Strengths

University and community partners write about their collaborations around the reading of Ernest Gaines’ A Lesson Before Dying. When an urban university received a National Endowment of the Arts Big Read Grant, they immediately began making connections to existing key initiatives within the university and in the surrounding community. As the partners collaborated within and among the university and community programs and events created for the Big Read they made multiple discoveries regarding the importance of planning together, analyzing the intended audience for each program and event, including multiple ways to access the text, and considering the ways that readers …

Process Mining Of Medication Revisions In Electronic Health Records, Deevakar Rogith

Dissertations and Theses (Open Access)

Objective: The objective of this work is to develop process mining techniques for analysing Electronic Health Record (EHR) events in order to uncover factors contributing to the event, and understanding deviations in the process. We have outlined a method for combining data mining with expert review to model the EHR process and develop automated algorithms that can be used to detect potential deviations for a defined process.

Introduction: To analyse EHR events meaningfully, process mining can be applied to distil structured process description from a set of real executions. Process mining can be applied for 1) Discovery, 2) Conformance, and …

Community-Based Participatory Research To Improve Early Detection And Treatment Of Hypertension In A Suburban Community In Thailand, Chuncharaporn Sinsiri

Dissertations and Theses (Open Access)

Communities have a significant role in working with health personnel to detect new and previously diagnosed cases of high blood pressure during community BP screening programs. In Thailand there are many people with elevated BP who do not access care. The purpose of this Community-Based Participatory Research (CBPR) was to build a community partnership following the CBPR approach to develop a health program to improve early detection and treatment of hypertension. Three specific aims were: Aim 1. Using CBPR principles, describe the process of building a community partnership to develop a community health program to improve early detection and treatment …

Trim28 Interacts With Ezh2 To Regulate Its Activity, Jing Li, Jing Li

Dissertations and Theses (Open Access)

In this dissertation, I discovered that TRIM28 interacts with EZH2 and regulates its activity in breast cancer cells. EZH2, the major H3K27 tri-methyltransferase, is over expressed in multiple subtypes of breast cancer; however, whether EZH2 plays an active role in breast cancer progression or treatment resistance is unknown. Here, we determined EZH2-interacting proteins in MCF7 cells by immunoprecipitation/mass spectrometry and detected TRIM28 with a high confidence score. TRIM28 is a transcription co-regulator with an N-terminal tri-partite RING finger, B-boxes and a coiled-coil domain (RBCC) and a C-terminal PHD/Bromo domain. Domain mapping revealed that the RBCC domain of TRIM28 interacts with …

Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy, Paloma Del C. Monroig

Dissertations and Theses (Open Access)

The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule inhibitors represent an attractive approach to pursue this. However, the absence of molecular structures for most of the miRNAs makes it very difficult to predict which inhibitors can bind to them. Herein we designed a strategy to screen for small molecules by assesing whether they could directly bind/ interact with miR-10b/miR-21. As part of our …

Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity, Stephanie M. Dorta-Estremera Ph.D.

Dissertations and Theses (Open Access)

Humoral autoimmunity is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral autoimmunity as a result of pDC activation have not been characterized. Moreover, the B cell subset(s) responsible for the generation of autoantibodies remains to be clearly identified.

The immunization of DNA-containing amyloids into non-autoimmune mice triggers the activation of pDCs and induction …

Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age, Michelle L. Bolner

Dissertations and Theses (Open Access)

The thymus maintains T cell receptor (TCR) repertoire diversity through perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found that early thymus involution precipitates the age-associated shift favoring memory T cell dominancy in young control mice. Furthermore, we have shown that age-related thymus involution is prevented in mice expressing a keratin 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the …

Investigation Of Quatitative Image Features From Pretreatment Ct And Fdg-Pet Scans In Stage Iii Nsclc Patients Undergoing Defintive Radiation Therapy, David Fried

Dissertations and Theses (Open Access)

The purpose of this work was to determine if quantitative image features (QIFs) extracted from computed tomography (CT) and flourodeoxyglucose (FDG) positron emission tomography (PET) could provide prognostic information to improve outcome models. Our goal for this work was to determine if it may one day be feasible to incorporate QIFs into personalized cancer care. QIFs were used to quantitatively characterize patient disease as seen on imaging. A leave-one-out cross-validation procedure was used to assess the prognostic ability of QIFs extracted from CT and PET in addition to conventional prognostic factors (CPFs). QIFs were found to improve model fit for …

Identifying Protein Kinase Tbk1 As A Novel Inhibitor Of Intestinal Tumorigenesis, Amber L. Mathews

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third most common cancer diagnosed in women and men， causing almost 600,000 annual deaths worldwide. There is a clear need to understand how CRC forms and progresses in order to improve the strategies of CRC prevention and therapy. A major factor that drives the development of CRC is genetic mutations that lead to activation of oncogenes and inactivation of tumor suppressor genes in intestinal epithelial cells (IECs). In addition, the initiation and progression of CRC involve environmental and immunological factors. In particular, chronic inflammatory conditions are known as an important risk factor for CRC. Intestinal …

The Role Of Dna Methylation And Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis, Jason Williams

Dissertations and Theses (Open Access)

Atherosclerosis is a chronic arterial disease which impacts systemically the function of organs and tissues by causing inflammation and disruption of blood supply. During atherogenesis, lipid deposits, inflammation, and cells accumulate within the walls of arteries, ultimately leading to a buildup of fatty plaques and occlusion of the arterial lumen. In a multifactorial disease like atherosclerosis there are complex interplays between environmental, genetic and epigenetic risk factors. The epigenetics of atherosclerosis involving DNA methylation has been progressing from single gene to genome wide analyses. Although these epistudies have provided evidence that DNA methylation exists within certain genes during atherogenesis, the …

Prediction Of Laser Ablation In Brain: Sensitivity, Calibration, And Validation, Samuel J. Fahrenholtz

Dissertations and Theses (Open Access)

The surgical planning of MR-guided laser induced thermal therapy (MRgLITT) stands to benefit from predictive computational modeling. The dearth of physical model parameter data leads to modeling uncertainty. This work implements a well-accepted framework with three key steps for model-building: model-parameter sensitivity analysis, model calibration, and model validation.

The sensitivity study is via generalized polynomial chaos (gPC) paired with a transient finite element (FEM) model. Uniform probability distribution functions (PDFs) capture the plausible range of values suggested by the literature for five model parameters. The five PDFs are input separately into the FEM model to gain a probabilistic sensitivity response …

Characterization Of Erbb4 Expression In Osteosarcoma, Nupur Lala

Dissertations and Theses (Open Access)

ERBB4 (Her-4) is a member of the ERBB family of Class I receptor tyrosine kinases. ERBB4 is unique within the ERBB family for alternate splicing in its juxtamembrane and cytoplasmic regions, which produces four juxtamembrane isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane isoforms, Jm-a and Jm-d, can undergo proteolytic cleavage and produce an 80-kDa cytoplasmic fragment referred to as “p80,” which has been demonstrated to enhance cellular survival and malignant behavior in many solid tumors [44]. ERBB4 was almost exclusively 80 kDa in size and localized to the nucleus in primary tumors and metastases in studies characterizing ERBB4 expression …

Regulation Of The Oxidative Stress Response By Arid1a, Suet Yan Kwan

Dissertations and Theses (Open Access)

SWI/SNF is mutated in about 20% of all human cancers; in particular ARID1A is the most frequently mutated SWI/SNF subunit. ARID1A is a tumor suppressor gene, inactivating mutations in ARID1A are most frequently found in ovarian and endometrial cancers, specifically uterine corpus endometrioid carcinomas (UCEC), ovarian clear cell carcinomas (OCCC) and ovarian endometrioid carcinomas (OEC). The functional roles of ARID1A are not completely understood and there are limited therapeutic strategies that specifically target ARID1A-mutant cancers. Given that ARID1A expression is lost in cancer, ARID1A mutations cannot be targeted directly and novel therapeutic strategies are required to target ARID1A-mutant …

In Vivo Functional Significance Of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome, Maitri Y. Shah

Dissertations and Theses (Open Access)

Long non-coding RNAs form the largest part of the mammalian non-coding transcriptome and control gene expression at various levels including chromatin modification, transcriptional and post-transcriptional processing. Although the underlying molecular mechanisms are not yet entirely understood, lncRNAs are implicated in initiation and progression of several cancers. CCAT2 is a lncRNA that spans the highly conserved 8q24 region associated with increased risk for various cancers. CCAT2 has been shown to play an important role in inducing chromosomal instability and supporting cell proliferation and cell cycle arrest. However, a causal role of CCAT2 in initiation of tumorigenesis and the importance of G/T …

Role Of Stat3 In Human Nk Cell Functions, Prasad V. Phatarpekar

Dissertations and Theses (Open Access)

Natural Killer (NK) cells are cytotoxic lymphocytes, which play a critical role in the immune response against malignant cells and microbial infections. NK cells are equipped with activating receptors, which upon detecting ligands expressed on stressed cells induce cytolytic activity of NK cells. Stimulation of NK cell proliferation and priming of NK cytolytic capability are accomplished by cytokines, which mediate their signals mainly through JAK-STAT signaling pathway. Previously, we found that K562 cells genetically modified to express membrane bound IL-21 (mbIL-21), which predominantly activates STAT3, induce robust expansion and activation of human NK cells. Further investigations revealed role of STAT3 …