Digital Commons Network^™

Magnetic Resonance Imaging In Pediatric Pulmonary Hypertension, Ayhan Pektas, Rana Olgunturk, Ayhan Cevik, Semiha Terlemez, Emre Kacar, Yusuf Ali Oner

The Texas Heart Institute Journal

The present study aims to determine the efficacy and reliability of cardiovascular magnetic resonance imaging in establishing the diagnosis and prognosis of pulmonary hypertension in children.

This is a retrospective comparison of 25 children with pulmonary hypertension and a control group comprising 19 healthy children. The diagnosis of pulmonary hypertension was made when the mean pulmonary artery pressure was ≥25 mmHg by catheter angiography.

The children with pulmonary hypertension had significantly lower body mass indices than did the healthy children (P=0.048). In addition, the children with pulmonary hypertension had significantly larger main pulmonary artery diameters and ascending aortic diameters (both …

Is Autologous Or Heterologous Pericardium Better For Valvuloplasty? A Comparative Study Of Calcification Propensity, Arthur W Bracey

The Texas Heart Institute Journal

No abstract provided.

Parent Perceptions Of Patient Safety Culture In The Neonatal Intensive Care Unit, Madelene J. Ottosen

Dissertations and Theses (Open Access)

Background: Understanding and promoting a positive culture of patient safety within neonatal intensive care units (NICU) has been to shown to decrease threats to patient safety. Parents are an integral part of the NICU culture, yet little is known about how they perceive patient safety and what role they would find meaningful and appropriate for engaging in safety promotion activities in the NICU. Therefore the purpose of this study was to determine how neonatal parents conceptualize patient safety and their role within the Neonatal Intensive Care Unit (NICU).

Methods: Using an ethnographic qualitative approach, semi-structured interviews and field observations of …

Induction Of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma, Christa A. Manton

Dissertations and Theses (Open Access)

New therapeutic options are needed for glioblastoma, a deadly disease with a median survival of only 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer proteasome inhibitors such as marizomib (MRZ) have unique inhibitory and death inducing properties that have not been well examined in GBM. Additionally, targeting other components of the ubiquitin-proteasome system is possible, but has not been explored in GBM. Questions also still remain about the ability of BTZ and MRZ to be delivered to brain tumors …

Obstetrician And Gynecologist Utilization Of The Nipt Expanded Testing Option, Sarah Mayes Ba

Dissertations and Theses (Open Access)

Noninvasive prenatal testing (NIPT) enables the detection of common fetal aneuploidies such as trisomy 21, trisomy 18, trisomy 13, and sex chromosome abnormalities via analysis of cell-free fetal DNA circulating in maternal serum. Although the accuracy of NIPT for fetal aneuploidy is expected to be higher than that of currently available alternative maternal serum screening options, the implications of results are not straight forward. In October 2013, the option to screen for additional trisomies and select microdeletion syndromes, such as 22q11.2 deletion syndrome and 5 p- syndrome, became clinically available. Due to this rapidly evolving prenatal screening technology, clinicians must …

Oxidative Protein Folding Pathways In Gram-Positive Actinobacteria, Melissa E. Robinson

Dissertations and Theses (Open Access)

Disulfide bonds are important for the stability of many secreted proteins. These covalent linkages, which result from the oxidation of neighboring cysteine (Cys) residues, are often rate-limiting steps for protein folding and maturation. Disulfide bond formation is restricted to extracellular oxidizing compartments like the eukaryotic endoplasmic reticulum and Gram-negative bacterial periplasm. Protein oxidation has been well-studied in these organisms, but largely ignored in Gram-positive bacteria. Due to the absence of an outer membrane, these organisms are thought to lack compartments in which to catalyze oxidative protein folding.

This thesis reveals that Gram-positive Actinobacteria use disulfide bond formation to help fold …

Targeted Inhibition Of Pi3k, Mtor, And Igf1r For The Treatment Of Undifferentiated Pleomorphic Sarcoma, Caitlin Denise May

Dissertations and Theses (Open Access)

Undifferentiated pleomorphic sarcoma (UPS) is an aggressive mesenchymal malignancy largely devoid of indicators for its originating tissue. Surgery remains the standard of care, as radiation therapy and systemic chemotherapy have limited efficacy in UPS patients with localized and metastatic disease, respectively. Therefore, it is imperative to identify and evaluate novel therapeutic targets in UPS in order to provide more efficacious treatment options for patients. Previous studies have revealed that members of the phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling pathway can be used to predict patient outcome in cohorts containing patients with various subtypes of soft tissue sarcoma. Furthermore, we have …

Spiritual Exploration In The Prenatal Genetic Counseling Session, Katelynn G. Sagaser

Dissertations and Theses (Open Access)

Religion and spirituality are important components of many individuals’ lives, and spiritual needs may present among persons receiving medical care. Spirituality has been demonstrated to be significant in the coping of women experiencing pregnancy complications (Breen et al. 2006; Price et al. 2007). To characterize the manner in which prenatal genetic counselors might address spiritual issues with their patients, we surveyed 283 patients receiving prenatal genetic counseling using the Brief RCope and a series of questions that examined interest in spiritual exploration. Counselors were concurrently surveyed to identify the spiritual language used within the session and the counselor’s perceived importance …

Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort And Circulating Dna Methylation In Bladder Cancer, Lixia Han

Dissertations and Theses (Open Access)

I. SOCIAL-DEMOGRAPHICS, HEALTH BEHAVIORS, AND TELOMERE LENGTH IN MEXICAN AMERICANS: A COHORT STUDY

Recent studies using a prospective cohort design have suggested that telomere length in peripheral blood leukocytes is not only a potential indicator of cellular aging that has been linked to stressful life experience and health behaviors, but also a prognostic marker for major chronic diseases; however, such study has never been done among adult Mexican Americans. In this current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight …

The Effect Of Room Environment On Patient Experience In A Prenatal Genetic Counseling Session, Elizabeth C. Baack

Dissertations and Theses (Open Access)

An important facet of aesthetic design, a topic of increasing interest in healthcare, is the concept of using positive distractions to promote wellness (Ulrich, 1991). To date, this concept has largely been explored in long-term, in-patient care settings and findings suggest these positive distractions decrease patient anxiety. This study sought to understand the effects of a supportive healthcare design characterized by positive distractions on patients receiving short term, out-patient care, specifically prenatal genetic counseling. Participants were patients at a Houston high-risk pregnancy clinic randomly assigned to one of two room environments: an experimental room which incorporated positive distractions, …

Using A Clinic-Based Screening Tool For Primary Care Providers To Identify Commercially Sexually Exploited Children, Kimberly S. G. Chang, Kevin Lee, Terrence Park, Elizabeth Sy, Thu Quach

Journal of Applied Research on Children: Informing Policy for Children at Risk

Introduction: Commercial Sexual Exploitation of Children (CSEC), which encompasses acts of domestic minor sex trafficking, is a hidden problem in the U.S. that affects an estimated 300,000 children. Significant health impacts to victims include violence, substance abuse, mental illness, sexually transmitted diseases, and unintended pregnancy. However, due to the covert nature of sexual exploitation, the lack of understanding among service providers and law enforcement, and complex psychological factors experienced by victims, identifying CSEC is a tremendous challenge. Primary care providers can play a critical role in identifying CSEC victims within clinical settings to help address this silent epidemic.

Objective: The …

Letting Kids Be Kids: Employing A Developmental Model In The Study Of Domestic Minor Sex Trafficking, Hadar S. Schwartz

Journal of Applied Research on Children: Informing Policy for Children at Risk

As American society has become increasingly aware of the plight of sex trafficked American children, attention has shifted from delinquency to victimhood (Mitchell, Finkelhor, & Wolak, 2010) with a corresponding awareness of the trauma that victims endure. This reconceptualization is incomplete without a larger understanding of the developmental vulnerabilities that leave children uniquely susceptible to recruitment and exploitation. Since the average age of entry into the commercial sex trade within the United States is 12-14 (Estes & Weiner, 2001), an exploration of the particular vulnerabilities of young teenagers--separation from parents; the process of identity formation; yearning for love and attention; …

Transcatheter Aortic Valve Implantation Despite Challenging Vascular Access, Angelo Nascimbene, Federico Azpurua, James J Livesay, R David Fish, Zvonimir Krajcer

The Texas Heart Institute Journal

We describe transcatheter aortic valve implantation in a patient who had severe peripheral artery disease. The patient's vascular condition required additional preliminary peripheral intervention to enable adequate vascular access.

A 78-year-old man with severe aortic stenosis, substantial comorbidities, and severe heart failure symptoms was referred for aortic valve replacement. The patient's 20-mm aortic annulus necessitated the use of a 23-mm Edwards Sapien valve inserted through a 22F sheath, which itself needed a vessel diameter of at least 7 mm for percutaneous delivery. The left common femoral artery was selected for valve delivery. The left iliac artery and infrarenal aorta underwent …

Regression Of Left Ventricular Mass After Implantation Of The Sutureless 3f Enable Aortic Bioprosthesis, Giovanni Concistrè, Antonio Miceli, Federica Marchi, Francesca Chiaramonti, Mattia Glauber, Marco Solinas

The Texas Heart Institute Journal

Left ventricular hypertrophy in aortic stenosis is considered a compensatory response for the maintenance of systolic function but a risk factor for cardiac morbidity and death. We investigated the degree of left ventricular mass regression after implantation of the sutureless Medtronic 3f Enable® Aortic Bioprosthesis.

We studied 19 patients who, from May 2010 through July 2011, underwent isolated aortic valve replacement with the 3f Enable bioprosthetic valve, with clinical and echocardiographic follow-up at 6 months. The mean age was 77.1 ± 5.1 years (range, 68–86 yr); 14 patients were women (73.7%); and the mean logistic EuroSCORE was 15.4% ± 11.8%. …

When The Chief Complaint Tells It All, Herbert L Fred

The Texas Heart Institute Journal

No abstract provided.

Pathways Involved In Interleukin-1Β-Mediated Murine Cardiomyocyte Apoptosis, Yi Shen, Jie Qin, Peili Bu

The Texas Heart Institute Journal

Accumulating evidence suggests that interleukin-1 (IL-1) signaling plays an essential role in the pathogenesis of heart failure by inducing cardiomyocyte apoptosis, but the mechanisms of this process are poorly defined. We further explored these molecular pathways.

We isolated cardiomyocytes from neonatal mice and then cultured and stimulated them with murine IL-1β in vitro. Cell apoptotic ratios were measured by means of flow cytometry. Expression of effector molecules was analyzed by means of enzyme-linked immunosorbent assay, Western blotting, and real-time quantitative polymerase chain reaction. The results showed that IL-1β induced murine cardiomyocyte apoptosis through a release of cytochrome c into cytoplasm …

Prenatal Diagnosis Of Left Pulmonary Artery-To-Pulmonary Vein Fistula And Its Successful Surgical Repair In A Neonate, Oleksii Ostras, Andrii Kurkevych, Lyubomyr Bohuta, Tetyana Yalynska, Tammo Raad, Mark Lewin, Illya Yemets

The Texas Heart Institute Journal

Pulmonary arteriovenous fistula is a rare disease. To the best of our knowledge, prenatal diagnosis of a fistula between the left pulmonary artery and the left pulmonary vein has not been described in the medical literature. We report a case of the prenatal diagnosis of a left pulmonary artery-to-pulmonary vein fistula, followed by successful neonatal surgical repair.

Prevalence Of Learned Grapheme-Color Pairings In A Large Online Sample Of Synesthetes, Nathan Withhoft, Jonathan Winawer, David M. Eagleman

Faculty, Staff and Students Publications

In this paper we estimate the minimum prevalence of grapheme-color synesthetes with letter-color matches learned from an external stimulus, by analyzing a large sample of English-speaking grapheme-color synesthetes. We find that at least 6% (400/6588 participants) of the total sample learned many of their matches from a widely available colored letter toy. Among those born in the decade after the toy began to be manufactured, the proportion of synesthetes with learned letter-color pairings approaches 15% for some 5-year periods. Among those born 5 years or more before it was manufactured, none have colors learned from the toy. Analysis of the …

Ms171: Interview With Robin Britt, Robin Britt Edd, Rn, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Robin Britt, EDD, RN of Texas Woman's University College of Nursing. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Elizabeth Travis, Elizabeth Travis Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Elizabeth Travis, PhD of MD Anderson Cancer Center. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Asha Kapadia, Asha Kapadia Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Asha Kapadia, PhD of University of Texas School of Public Health. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Janet Butel, Janet Butel Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An Oral history interview with Janet Butel, PhD of Baylor College of Medicine. See more at Texas Medical Center-Women's History Project and its finding aid.

More Than A Drop In The Bucket: The Social And Economic Costs Of Dropouts And Grade Retentions Associated With Exclusionary Discipline, Miner P. Marchbanks Iii, Jamilia J. Blake, Danielle Smith, Allison L. Seibert, Dottie Carmichael, Eric A. Booth, Tony Fabelo

Journal of Applied Research on Children: Informing Policy for Children at Risk

Each year many students are subject to exclusionary discipline, in fact, 60% of students in Texas are disciplined at-least once between grades 7 through 12. The purpose of this study is to examine the impact of school discipline contact on students’ risk for grade retention and school dropout using a statewide sample of nearly one million 7th grade students tracked through their 12th grade year. Results indicate that school discipline relates to a 24% increase in high school dropout. These additional dropouts are associated with an economic effect of between $750 million and $1.35 billion per year.

Results also indicate …

Avoid Simple Solutions And Quick Fixes: Lessons Learned From A Comprehensive Districtwide Approach To Improving Student Behavior And School Safety, David Osher, Jeffrey Poirier, Roger Jarjoura, Russell Brown, Kimberly Kendziora

Journal of Applied Research on Children: Informing Policy for Children at Risk

We examine the effects of the Cleveland Metropolitan School District’s (CMSD) districtwide efforts to improve school safety, order, and conditions for learning. These approaches include implementing (1) a social and emotional learning program for elementary students (PATHS); (2) a planning model for students exhibiting academic or nonacademic needs (student support teams); and (3) a learner-centered approach to discipline (planning centers). We found that improved conditions for learning as well as student support interventions can foster safer, more productive schools. Suspension and expulsion rates decreased, but racial/ethnic disparities remained. Implementation quality also mediated outcomes. Transforming conditions contributing to exclusionary discipline often …

Disturbing Inequities: Exploring The Relationship Between Racial Disparities In Special Education Identification And Discipline, Daniel Losen, Cheri Hodson, Jongyeon Ee, Tia Martinez

Journal of Applied Research on Children: Informing Policy for Children at Risk

This study used negative binomial regression to investigate whether exposure to novice teachers and risk for identification for special education predicted suspension rates. Data from the 2009-2010 Civil Rights Data Collection (CRDC) was used. The sample was comprised of 72,168 schools from nearly 7,000 school districts from nearly every state. Identification as having emotional disturbance and specific learning disabilities were found to predict an increase in suspension rates for some subgroups across some school levels. Conversely, identification as being autistic was found to predict a decrease in suspension rates for some subgroups across some school levels. Policy implications are discussed.

Sent Home And Put Off-Track: The Antecedents, Disproportionalities, And Consequences Of Being Suspended In The Ninth Grade, Robert Balfanz, Vaughan Byrnes, Joanna Fox

Journal of Applied Research on Children: Informing Policy for Children at Risk

This study is based upon a longitudinal analysis of data for a cohort of 181,897 Florida state students who were first time 9^th graders in the 2000-01 school year and follows them trough to high school and post-secondary outcomes. Analysis of 9^th grade suspension data finds that black students, students who are economically disadvantaged, and special education students are three demographics subgroups that are disproportionately suspended, both in the frequency of suspensions and the duration in number of school days lost. While poverty and ethnicity are themselves highly correlated, poverty alone does not explain the disproportionate suspension rates …

Eliminating The Racial Disparity In Classroom Exclusionary Discipline, Anne Gregory, Joseph P. Allen, Amori Yee Mikami, Christopher A. Hafen, Robert Pianta

Journal of Applied Research on Children: Informing Policy for Children at Risk

Advocates call for schools with high suspension rates to receive technical assistance in adopting “proven-effective” systematic supports. Such supports include teacher professional development. This call is justified given evidence that good teaching matters. But what types of professional development should be funded? Increasingly, research points to the promise of programs that are sustained, rigorous, and focused on teachers’ interactions with students. The current study tests whether a professional development program with these three characteristics helped change teachers’ use of exclusionary discipline practices—especially with their African American students. Exclusionary discipline is when a classroom teacher sends a student to the administrators’ …

Misbehavior, Suspensions, And Security Measures In High School: Racial/Ethnic And Gender Differences, Jeremy D. Finn, Timothy J. Servoss

Journal of Applied Research on Children: Informing Policy for Children at Risk

This study used merged data from three national surveys to address questions about security measures in American high schools, suspension rates, and student misbehavior. First, the study identified the characteristics of schools that implemented the most extreme security measures and those with the highest levels of discipline. Second, the study used data on individual students to examine misbehavior and race and gender disparities in suspensions not attributable to misbehavior. The main findings were: (1) In-school suspensions serve a ‘gateway’ function with regard to out-of-school suspensions. They may provide a time and place to address behavior problems before they escalate or …

Dads On The Dotted Line: A Look At The In-Hospital Paternity Establishment Process, Cynthia Osborne, Daniel Dillon

Journal of Applied Research on Children: Informing Policy for Children at Risk

In the U.S., two out of five children are born to unmarried parents. These children do not have a legal father until paternity is established, a process completed by most families in the hospital at the time of the birth. Over the last 30 years, the percentage of unmarried parents voluntarily establishing paternity in the hospital has climbed considerably, driven in large part by a series of policy changes aimed at easing and incentivizing the process. Despite the apparent success of these policies, few have examined the mechanics of the paternity establishment process itself to understand whether it is functioning …

Unintended Consequences: Reverberations Of Special Immigrant Juvenile Status, Lauren Heidbrink

Journal of Applied Research on Children: Informing Policy for Children at Risk

This paper details the socio-legal factors that shape the relationship between the child, the family, and the state, and the ways unaccompanied migrant children’s lives have come to be defined and contested. The legal identity of migrant children is socially situated within a history that intertwines social movements of helping professionals, legal jurisdictions characterized by increasingly intolerant approaches to juveniles, and shifts in the treatment of unauthorized migrant youth under immigration law over time. In a globalized world, this triangular relationship between children, families, and the state becomes increasingly complex and dynamic. Social policies and legal norms often lag far …