Digital Commons Network^™

Genetically Controlled Variation Of “Acid” Beta-Galactosidase Detected In Rattus Norvegicus By Isoelectric Focusing, T C Douglas, K A Kimmel, P E Dawson

Faculty, Staff and Student Publications

Two genetically variant forms of rat "acid" beta-galactosidase were found to differ in isoelectric point and pH dependence, but not in thermostability or sensitivity to inhibition by p-mercuribenzoate (PMB). The results of two backcrosses and an intercross indicated that the isoelectric focusing phenotypes are controlled by two codominant alleles at a single autosomal locus, for which we propose the name Glb-1. No significant linkage between Glb-1 and albino (LG I), brown (LG II), or hooded (LG VI) was observed. Strain-specific differences in total levels of kidney beta-galactosidase were detected, but it is not yet known whether the variation is controlled …

Polymorphisms, Linkage And Mapping Of Four Enzyme Loci In The Fish Genus Xiphophorus (Poeciliidae), D C Morizot, M J Siciliano

Faculty, Staff and Student Publications

Electrophoretic variants at four additional enzyme loci--two esterases (Est-2, Est-3), retinal lactate dehydrogenase (LDH-1) and mannose phosphate isomerase (MPI)--among three species and four subspecies of fish of the genus Xiphophorus were observed. Electrophoretic patterns in F1 hybrid heterozygotes confirmed the monomeric structures of MPI and the esterase and the tetrametric structure of LDH in these fishes. Variant alleles of all four loci displayed normal Mendelian segregation in backcross and F2 hybrids. Recombination data from backcross hybrids mapped with Haldane's mapping function indicate the four loci to be linked as Est-2--0.43--Est3--0.26--LDH-1--0.19--MPI. Significant interference was detected and apparently concentrated in the Est-3 …

In Vitro Incorporation Of Molybdate Into Demolybdoproteins In Escherichia Coli, Randolph H. Scott, George T. Sperl, John A. Demoss

Faculty, Staff and Student Publications

When Escherichia coli was grown in the presence of tungstate, inactive forms of two molybdoenzymes, nitrate reductase and formate dehydrogenase, accumulated and were converted to their active forms upon incubation of cell suspensions with molybdate and chloramphenicol. The conversion to the active enzymes did not occur in cell extracts. When incubated with [(99)Mo]molybdate and chloramphenicol, the tungstate-grown cells incorporated (99)Mo into protein components which were released from membranes by procedures used to release nitrate reductase and formate dehydrogenase and which migrated with these activities on polyacrylamide gels. Although neither activity was formed during incubation of the crude extract with molybdate, …

Three Linked Enzyme Loci In Fishes: Implications In The Evolution Of Vertebrate Chromosomes, D C Morizot, D A Wright, M J Siciliano

Faculty, Staff and Student Publications

A three-point linkage group comprised of loci coding for adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PDH), and 6-phospho-gluconate dehydrogenase (6PGD) is described in fish of the genus Xiphophorus (Poeciliidae). The alleles at loci in this group were shown to assort independently from the alleles at three other loci--isocitrate dehydrogenase 1 and 2, and glyceraldehyde-3-phosphate dehydrogenase 1. Alleles at the latter three loci also assort independently from each other. Data were obtained by observing the segregation of electrophoretically variant alleles in reciprocal backcross hybrids derived from crosses between either X. helleri guentheri or X. h. strigatus and X. maculatus. The linkage component …

Atomic Models For The Polypeptide Backbones Of Myohemerythrin And Hemerythrin, W A Hendrickson, K B Ward

Faculty, Staff and Students Publications

Background: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly after its identification in December 2019 to cause a global pandemic. The respiratory tract is the primary site of infection, and there is a large range in the severity of respiratory illnesses caused by the virus. Defining molecular and cellular factors for protection from severe disease and death has been a goal to better understand and to predict and mitigate the effects of SARS-CoV-2 and future coronaviruses.

Objective: Despite well-known susceptibilities to respiratory viral infections, respiratory allergy and allergic asthma have not been identified as risk factors …

Ic084: Interview With Randolph Lee Clark, Md Transcript, Randolph Lee Clark (1906-1994)

Texas Medical Center Video and Audiovisual Recordings: 1973-1991

Transcript of "Interview with Randolph Lee Clark, MD 1973-11-30". This typed transcript is housed on box 1 of the collection and has been scanned to facilitate access. See more at Interview with Randolph Lee Clark, MD and its finding aid.

Texas Medical Center --- Its Origins, Houston Chamber Of Commerce

Texas Medical History E-Books

This document details the people and institutions who were instrumental in the establishment and development of the Texas Medical Center (TMC). Biographical information about the founders, role the M. D. Anderson Foundation, and opening of the main institutions in the early 1950s is detailed. A copy of a speech given in 1958 by W. B. Bates, one of the trustees of the M. D. Anderson Foundation, on the history and development of the TMC is significant because he was one of the founders of the TMC.

This document was commissioned by the Houston Chamber of Commerce in 1971 as the …

The Parenchymal Cells Of The Rat Pineal Gland, E Tapp, M Blumfield

Faculty, Staff and Students Publications

Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare hematologic disorder with improved survival due to advancements in treatment. However, long-term cardiovascular morbidity and mortality remain significant. Established cardiovascular risk calculators, such as the 2008 Framingham Heart Study (FHS) global cardiovascular disease (CVD) and the American College of Cardiology/American Heart Association (ACC/AHA) atherosclerotic CVD (ASCVD) risk estimators, may not adequately account for the elevated and unique cardiovascular risks in iTTP survivors.

Objectives: To evaluate the discrimination and calibration of the ACC/AHA ASCVD and FHS global CVD models in predicting major adverse cardiovascular events (MACEs) among iTTP survivors.

Methods: This retrospective …

Annual Report 1960, Houston Academy Of Medicine-Texas Medical Center Library

Annual Reports: 1943 - Present

The file contains the annual report for the library from 1960.

Medicine Man In Texas, George Plunkett Red

Texas Medical History E-Books

The author George (Georgia?) Plunkett Red was the wife of Samuel Clark Red (1861-1940). Dr. Red was the son of Texas pioneer physician Dr. George Clark Red. Dr. Samuel Clark Red was “the county physician of Harris County, one of the organizers of the Harris County Medical Society, a fellow of the American College of Surgeons, and president of the Texas Medical Association.”

Not much is known about the author, but given her husband’s position and family history, it can be surmised that she was interested in history and had access to some of the children of other pioneer medical …

Three Years In A Mad-House: The Story Of My Life At The Asylum, My Escape, And The Strange Adventures Which Followed, E. B. Fleming, Augustin Fleming

Texas Medical History E-Books

No abstract provided.

Rb 002 Guide To Herman Detering Book Collection On Psychiatry And Photography, Detering Family

Rare Books Finding Aids

The Herman Detering History of Photography and Psychiatry collection contains 324 books.. This collection was also processed as a manuscript collection so that the materials in the collections could be discoverable. This collection explores the relationship and history of photography and psychiatry, especially 19th century photography and the “insane.” The primary focus of the collection is the treatment and study of people suffering from various forms of mental illness. See more at RB 002.

Rb 005 Guide To Mcgovern Collection On The History Of Medicine, John P. Mcgovern (1921-2007)

Rare Books Finding Aids

The McGovern Collection contains over 5,500 titles focused on the development of the medical specialties in the late nineteenth century and early twentieth. There are significant sections on pediatrics, allergy and cardiology. The collection emphasis has been American Imprints and English language materials. There are a small number of titles in French or German from the eighteenth century. See more at RB 005.

Rb 001 Guide To Burbank-Fraser Collection On Arthritis, Rheumatism And Gout, John P. Mcgovern Historical Collections & Research Center

Rare Books Finding Aids

The Burbank/Fraser Collection contains over 3,600 volumes, including books, pamphlets, bound reprints, and translations. With publications ranging from a sixteenth century manuscript to the modern works of John Talbott and Charles Short, this collection documents the changing regimens for rheumatic diseases and the foundations of the modern specialty of rheumatology. With publications from over 20 countries, the collection offers innumerable opportunities for research on the history of the rheumatic diseases and the cross-cultural transference of medical information. The collection equals 337.4 linear with titles that date from 15th Century to the early 20th Century. See more at RB 001.

Parents' Interests And Abilities As Sources Of Young Children's Everyday Learning Opportunities, Carl J. J. Dunst 4320065

Journal of Family Strengths

Findings from a national survey of parents’ strengths (personal interests and individual abilities) and how interests and abilities were used as sources of young children’s everyday learning opportunities are reported. The participants were 368 parents of young children birth to 6 years of age residing in 49 of the 50 United States. Participants were asked to indicate if any of 70 everyday activities were personal interests or individual abilities, if their youngest children were routinely involved in the activities, and if involved, if their children learned new behavior or skills. Data analysis was guided by a transactional, participation-based paradigm where …