Digital Commons Network^™

Development Of Polyvinyl Alcohol Nanofiber Scaffolds Loaded With Flaxseed Extract For Bone Regeneration: Phytochemicals, Cell Proliferation, Adhesion, And Osteogenic Gene Expression, Ahmed G. Abdelaziz, Hassan Nageh, Mohga S. Abdalla, Sara M. Abdo, Asmaa A. Amer, Samah A. Loutfy, Nasra F. Abdel Fattah, Ali Alsalme, David Cornu, Mikhael Bechelany, Ahmed Barhoum

Research Outputs: 2025-Present

Introduction: Bone tissue engineering seeks innovative materials that support cell growth and regeneration. Electrospun nanofibers, with their high surface area and tunable properties, serve as promising scaffolds. This study explores the incorporation of flaxseed extract, rich in polyphenolic compounds, into polyvinyl alcohol (PVA) nanofibers to improve their application in bone tissue engineering. Methods: High-performance liquid chromatography (HPLC) identified ten key compounds in flaxseed extract, including polyphenolic acids and flavonoids. PVA nanofibers were fabricated with 30 wt.% flaxseed extract (P70/E30) via electrospinning. We optimized characteristics like diameter, hydrophilicity, swelling behavior, and hydrolytic degradation. MG-63 osteoblast cultures were used to assess scaffold …

Antimutagenic And Anticoagulant Therapeutic Effects Of Ag/Ag2O Nanoparticles From Olea Europaea Leaf Extract: Mitigating Metribuzin-Induced Hepato-And Nephrotoxicity, Manel Azzi, Ibtissam Laib, Abderrhmane Bouafia, Ifriqya Medila, Ali Tliba, Salah Eddine Laouini, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Ahmed Barhoum

Research Outputs: 2025-Present

Background: Silver nanoparticles (Ag/Ag₂O NPs) have garnered attention for their potent antioxidant, antimicrobial, and anti-inflammatory properties, showing promise for therapeutic applications, particularly in mitigating chemical-induced toxicity. Objective: This study aimed to synthesize Ag/Ag₂O NPs using Olea europaea (olive) leaf extract as a green, eco-friendly reducing agent and evaluate their protective effects against metribuzin-induced toxicity in Wistar rats, focusing on oxidative stress, hematological parameters, and lipid profiles, with specific dose optimization. Methodology: Ag/Ag₂O NPs were synthesized using Olea europaea leaf extract, and their properties were confirmed via XRD, FTIR, SEM, EDS, and UV-visible spectroscopy. Wistar rats exposed to metribuzin (110 mg/kg/day) …

A Roadmap For Improving Data Quality Through Standards For Collaborative Intelligence In Human-Robot Applications, Shakra Mehak, Inês F. Ramos, Keerthi Sagar, Aswin Ramasubramanian, John D. Kelleher, Michael Guilfoyle, Gabriele Gianini, Ernesto Damiani, Maria Chiara Leva

Research Outputs: 2025-Present

Collaborative intelligence (CI) involves human-machine interactions and is deemed safety-critical because their reliable interactions are crucial in preventing severe injuries and environmental damage. As these applications become increasingly data-driven, the reliability of CI applications depends on the quality of data, shaping the system’s ability to interpret and respond in diverse and often unpredictable environments. In this regard, it is important to adhere to data quality standards and guidelines, thus facilitating the advancement of these collaborative systems in industry. This study presents the challenges of data quality in CI applications within industrial environments, with two use cases that focus on the …

Competency-Based Training Within The Prison System: Enhancing The Likelihood Of Entrepreneurial Activity Upon Release, Martina Brophy, Ana Pérez-Luño, Thomas M. Cooney

Articles

Recidivism rates across the world remain high, and one of the key reasons for this situation is that people leaving the prison system have great difficulty in securing employment. Addressing this issue must be explored from a broad perspective, but one potential career option that is under-explored is self-employment, with few entrepreneurship programmes available within prison systems. This study explores a competency-based approach to training, examining the knowledge, skills, and behaviours needed to enhance the prospects of persons with lived experience of prison becoming entrepreneurs. Using thematic analysis on ten in-depth interviews, this article identifies three categories of competency (generic,specific, …

Building Services Engineering January/February 2024

Building Services Engineering

No abstract provided.

Novel Analog Holographic Wavefront Sensors In A Photopolymer Medium, Emma Branigan

Doctoral

Wavefront sensing is a vital technology that allows for recovery of information and image resolution, from otherwise corrupted signals. Combined with computational systems, wavefront sensors (WFS) enable rapid, accurate measurement of optical distortions, or aberrations. The analog holographic wavefront sensor (AHWFS) is a recent advancement that measures wavefront aberration modes using intensity ratios at paired diffraction spots. The modal AHWFS is an elegant solution to wavefront sensing that is low-cost, highly photon efficient, high speed, and insensitive to scintillation effects.

This work presents the first fabrication of an AHWFS in a self-developing acrylamide-based photopolymer for measuring defocus and spherical aberration. …

Ict-Enabled Change In Healthcare Organisations: Examining Implementation Practice Of Healthcare Documentation Projects, Selma Judia Furtado

Doctoral

No abstract provided.

Quality Reborn, Anders Vinther

Level 3

It is time for Quality leaders to not only fulfill the traditional role of ensuring cGMP compliance within the company but also take the Quality profession to the level of business leadership like Deming did in Japan after World War II. FDA has recently stated that they have low confidence in quality management maturity of the pharmaceutical industry.

For quality leaders to also become good business leaders we must educate them in ways that are different from what we currently do. The education should be in the 6 areas

• Visibly Demonstrating Responsibility of Quality
• Risk-Informed Decision Making and Communication
• Engaging …

Achieving Warranted Acceptance Of Biotechnologies, Emily Grayek, Baruch Fischhoff

Level 3

The U.S. has faced long-standing shortages of generic drugs, causing negative health effects and spikes in drug costs. To address these shortages, investments in critical technologies and policies to support their adoption will be needed. The success of these technologies and policies depends on public acceptance. We studied public acceptance using the mental model approach, which identifies gaps in understanding that can be addressed with communications. We began with semi-structured interviews with experts in pharmaceutical manufacturing. Based on these interviews, we developed and conducted surveys of the general public, physicians, and pharmacists. Similar strategies could be applied to improve communications …

Exploring The Role Of Knowledge In The Pharma Workplace Of The Future: An Interactive Workshop Exploring Culture, Km And Opex, Stephanie Friedrichsen, Nuala Calnan (Editor), Martin J. Lipa

Level 3

This article presents a summary of an interactive workshop facilitated by Nuala Calnan and Stephanie Friedrichsen during the conference: ‘ICH Q9(R1): The Next Frontier’ held in Technological University Dublin, Ireland, on 1 June 2023. The summary was prepared by the workshop facilitators in conjunction with Martin Lipa who was a participant at the workshop. The article is written to give a high-level overview of the discussions which took place during the workshop and is not intended to be a complete representation of all the activities, insights and findings.

Speaker Bios

Level 3

No abstract provided.

Regulators Are Exploring With Industry How To Strengthen Quality Risk Management Practices, With Revision Of Ich Q9 A Key Focal Point, ( Ipq )

Level 3

No abstract provided.

Smart Missions That Enable Innovation In High-Risk Environments., Ed Hoffman

Level 3

This article is a lightly edited version of Ed Hoffman’s talk on to the 01-June-2023 seminar hosted by the PRST entitled ICH Q9(R1): The Next Frontier – An audience with international thought leaders exploring how the effective use of knowledge can enhance QRM outcomes to benefit the patient. Ed’s remarks are focused on the future of work, and the needs for relationships, storytelling, and understanding the mission to get the best out of our collective intelligence and navigate the future of work.

Morning Panel Discussion, Alice Redmond, Aidan Harrington

Level 3

No abstract provided.

Introducing Research Collaboration And Gmp Human Resource Development At Three Universities With Gmp Laboratories In Japan, Shingou Sakurai, Osamu Hiruta, Ryoko Naruse

Level 3

This paper summarises initiatives presented on June 1^st 2023 at a seminar during a visit to Technological University Dublin. The authors travelled from 3 universities in Japan to share some of the collaborative research, education and training initiatives developed by them,

In their presentation the authors gave an overview of the current situation of Knowledge Management and Quality Culture in Japan, highlighting some recent issues and challenges, and presented some initiatives under development to specifically address these challenges.

Industry/Regulator Dialogue On Knowledge Management Is Intensifying In Wake Of Ich’S Q12 Initiative, ( Ipq )

Level 3

No abstract provided.

School Of Culinary Arts & Food Technology Newsletter - Winter Edition 2023, James Murphy

Other resources

The School of Culinary Arts and Food Technology, TU Dublin, Winter Newsletter captured the many events, sustainability, research, awards, significant contributions and special civic and community activities plus our school's committments to TU Dublin's SDGs which the students and staff members of the school across our (3) three campuses have successfully completed up to the Winter period of 2023. The successful completion of these activities would not be possible without the active and on-going support of the 'INSPIRED' friends of Culinary Arts (school supporters) and our school's industry association supporters.

Beauty Is In The Eye Of The Beholder: Reframing The Possible Employment Outcomes Of Leaving Certificate Applied (Lca) Students From Disadvantaged Communities, Vicki O'Reilly

Journal of Franco-Irish Studies

Researching disadvantage can potentially make a difference to the lives of those who are involved. Can we research disadvantage without adding to an already negative narrative or appearing to be condescending? Application of Active Research as a methodology can bring an inclusive and participatory approach to studying disadvantage. Comprehension of the impact of theories such as social reproduction and possible selves, their interaction and how one could be used to counteract the other, will allow an opportunity for conversation around positive solutions. Through understanding the language used to describe disadvantage we can bring an openness to challenge how we look …

Dealing With The Trauma Of Undiagnosed Dyslexia, Aisling Dolan

Journal of Franco-Irish Studies

The theme of my Master’s by research is an investigation into the condition and effects of dyslexia on one’s personality, academic experience and professional growth. I wish to examine and acknowledge the effects dyslexia has on an individual’s ability to learn and grow in a “typical” twenty-first-century society. I intend also to highlight the emotional impact this disability can have on a person’s sense of self and how they develop through childhood. I hope to demonstrate the link dyslexia has in fostering a visual form of thinking and expression. I also hope to evaluate how one’s dyslexia reveals itself in …

A Note From The Editors, Elaine Mahon

Journal of Franco-Irish Studies

No abstract provided.

Information Management Plan – Appointing Party, Robert Moore

Tools

Information Management Plan – Appointing Party is a support in a spreadsheet format that contains a number of client templates that ISO 19650 recommend the Employer/Client/Sanctioning authority should consider when appointing a delivery team to a delivery project for an Asset.

Build Digital has created Industry templates to allow organisations work in accordance with ISO 19650. These templates start to address the information requirements in the ISO 19650 series of standards. The templates are also in accordance with CEN-TR17654-2021” Guideline for the implementation of Exchange Information Requirements (EIR)and BIM Execution Plans (BEP) on European level based on EN ISO 19650-1 …

Project Information Standard – File Naming, Robert Moore

Tools

Project Information Standard – File Naming is a support in a spreadsheet format that contains a number of templates that give guidance on file naming in accordance with the Irish National Annexe to ISO 19650-2.

Build Digital has created Industry templates to allow organisations work in accordance with ISO 19650. These templates start to address the information requirements in the ISO 19650 series of standards. The templates are also in accordance with CEN-TR17654-2021” Guideline for the implementation of Exchange Information Requirements (EIR)and BIM Execution Plans (BEP) on European level based on EN ISO 19650-1 and -2”. Aspects of the Templates …

Energy Efficiency And Fault Tolerance In Open Ran And Future Internet, Saish Urumkar, Byrav Ramamurthy, Sachin Sharma

Conference papers

Open Radio Access Networks (Open RAN) repre- sent a promising technological advancement within the realm of the future internet. Research efforts are currently directed towards enhancing energy efficiency and fault tolerance, which are critical aspects for both Open RAN and the future internet landscape. In the context of energy saving in Open RAN, there exists a spectrum of methods for achieving energy efficiency. These methods include the toggling of on/off states for different hardware resources such as base station units, distributed units, and radio units. Conversely, for enhancing fault tolerance in Open RAN, Software-Defined Networking (SDN) and OpenFlow based techniques …

Information Management Plan - Organisational, Robert Moore

Tools

Information Management Plan – Organisational, is a support in a spreadsheet format that contains a number of client templates that ISO 19650 recommend the Employer/Client/Sanctioning authority should consider before starting a delivery project for an Asset.

Build Digital has created Industry templates to allow organisations work in accordance with ISO 19650. These templates start to address the information requirements in the ISO 19650 series of standards. The templates are also in accordance with CEN-TR17654-2021” Guideline for the implementation of Exchange Information Requirements (EIR)and BIM Execution Plans (BEP) on European level based on EN ISO 19650-1 and -2”. Aspects of the …

An Investigation Into Dietary Fibre Intake, Bowel Function And Mood Among A Sample Of Irish Adults, Sophie Mulligan, Ellen Lynch, Suzanne Doyle

SURE Journal: Science Undergraduate Research Experience Journal

Background

Previous studies have examined the relationship between dietary fibre intake and mood and bowel function separately, however, no cross-sectional study has yet explored the relationship between all three variables. This study examines the association between dietary fibre intake, bowel function and mood in a cohort of Irish adults at a university campus.

Methods

A cross-sectional study was conducted. An online questionnaire was distributed to staff and students of TU Dublin through email and publicised using posters. Three validated surveys were used in the design of the questionnaire, to assess dietary fibre intake, mood and bowel function. All staff and …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …

Improving Energy Efficiency In Open Ran Through Dynamic Cpu Scheduling, Saish Urumkar, Byrav Ramamurthy, Sachin Sharma

Conference papers

Open RAN is a promising cellular technology that is currently undergoing extensive research for future wireless radio access networks. Achieving optimal energy efficiency in Open RAN poses a significant challenge. This paper introduces a CPU scheduling algorithm that specifically targets this chal- lenge by optimizing energy consumption at the base station while maintaining optimal performance levels. With the goal of minimizing energy consumption, the proposed algorithm dynamically adjusts the CPU core states, seamlessly switching between active and sleep modes based on the load conditions. To evaluate the algorithm’s effectiveness in terms of energy saving and performance, experimental testing is conducted …

Advances In Diagnostic Tools And Therapeutic Approaches For Gliomas: A Comprehensive Review, Gayathree Thenuwara Nanolab Research Centre, James Curtin, Furong Tian Nanolab Research Centre

Articles

Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as …

Development Of An Optical Test Bed For The Fabrication And Characterisation Of An Analog Holographic Wavefront Sensor, Emma Branigan, Andreas Zepp, Suzanne Martin, Matthew Sheehan, Szymon Gladysz, Kevin Murphy

Conference Papers

A new holographic recording setup has been developed for the fabrication of single- and multi-mode photopolymer-based analog holographic wavefront sensors. A second setup has been built and used to characterise the sensor at several wavelengths.

The Need For Energy Storage On Renewable Energy Generator Outputs To Lessen The Geeth Effect, I.E. Short-Term Variations Mainly Associated With Wind Turbine Active Power Output, Tony Kealy

Articles

Many studies investigating the short-term variations associated with the power output from wind turbine generators utilise simulated or modelled data in the analysis. This current study uses short-term empirical data downloaded directly from operational wind turbines via electrical power quality meters. The empirical data shows that the short-term variations (one-second or sub-one-second timeframe) occur continuously over most of the power output range. A novel name is proposed, the Geeth Effect, for this variability phenomenon. The Geeth Effect is measured using the coefficient of variation mathematical expression and is likely contributing to (i) lower-than-expected financial and environmental benefits associated with …