Digital Commons Network^™

Exploration Of The Activity, Delivery And Activation Of Androgen Receptor Potential Indane Scaffold Antagonists For Prostate Cancer Treatment, Shengxin Zhang, Gemma K Kinsella, Tao Zhang, James Curtin

Other resources

Androgen receptor (AR)-targeted therapy remains the gold standard strategy for the treatment of advanced prostate cancer. Several compounds of Indane derivatives have been reported to exhibit significant AR antagonist capabilities, starting at a concentration as low as 0.1 μM. However, an anti-prostate cancer lead molecule derived from Indane-related scaffold remains elusive. The project will investigate the interaction of novel bioactive indane scaffolds as androgen receptor antagonists through in silico and in vitro screening to complete the hit-to-lead, while also investigating potential drug delivery and drug activation/sensitisation mechanisms using a combination of colloid nanomaterial and cold atmospheric plasma to target AR-independent, …

Hidden Scientists/Hidden Creatives Exhibition 2024, Con Kennedy, Jesus Maria Frias, Steve Meaney, Claire Wynne, Niamh Ann Kelly

Research Outputs: 2025-Present

Hidden Scientists/Hidden Creatives is a poster exhibition about underrepresented women in STEM and Design.

As part of the Design and Career Management Module, second-year BA in Visual Communication Design students have crafted posters about women in STEM, drawing inspiration from influential female designers.

The exhibition was opened by Professor John Doran, Dean of the Faculty of Sciences and Health and acting President of TU Dublin and runs from 24 to 27 April 2024, East Quad Atrium, TU Dublin, City Campus, Grangegorman.

Arsenic Contamination Needs Serious Attention: An Opinion And Global Scenario, Abhijnan Bhat School Of Food Science And Environmental Health, Kamna Ravi Health, Engineering & Materials Sciences (Hems) Hub, Furong Tian Nanolab Research Centre, Baljit Singh Micra Biodiagnostics Technology Gateway

Articles

Arsenic (As) contamination is a serious global concern, polluting our natural resources, including water and soil, and posing a danger to the environment and public health. Arsenic is present in the groundwater of several countries and this contaminated water is used for irrigation, drinking, and food preparation, which poses the greatest threat to public health. Nearly 106 countries are affected by groundwater arsenic contamination and an estimated 230 million individuals worldwide are exposed to its adverse health effects, including increased cancer risks, associated cardiovascular disease and diabetes, skin lesions, neurological effects, kidney damage, and foetal or cognitive development-related complications. Arsenic …

Education And Training Networks, Ken Thomas, Robin Stubbs, Emily Shakespeare

Tools

Education And Training Networks Inventory is a review of relevant network in Ireland and the EU.

Processworkflows Cwmf To Iso 19650-2, Emma Hayes, Robert Moore

Tools

Process workflow that presents the Capital Works Management Framework (CWMF) according to ISO 19650-2, Government of Ireland.

doi:10.21427/nhzb-pp57

Existing Implementation Tool Inventory, Adhban Farea, Rahat Ullah, Joe Harrington, Ted Mckenna, Sean Carroll

Tools

No abstract provided.

Material Passports – Challenges, Opportunities, And Future Directions, Ioannis Markou, Derek Sinnott, Ken Thomas

Reports

The Built Environment is one of the main contributors to global resource consumption, waste generation and greenhouse gas (GHG) emissions, exacerbating environmental degradation and climate change (MacArthur Foundation, 2022). Circular Economy and sustainability concepts have emerged as promising strategies to address those challenges (EUR-Lex, 2015; European Commission, 2019). The Circular Economy aims to minimise waste and resource depletion, while sustainability emphasises on meeting the current and future needs of society with minimal environmental impact (Pomponi and Moncaster 2017a; Çetin et al. 2021; MacArthur Foundation 2022). The digital transition, facilitated by technological advancements, can accelerate the adoption of Circular Economy principles …

Digitalisation For A Circular Economy (Dice), Jimmy Fahy, Conan O'Ceallaigh

Reports

The construction industry is the world’s largest consumer of resources and is responsible for approximately 40% of global carbon emissions. In EU countries, building infrastructure plays a more significant role in energy consumption (40%) and energy-related Green House Gas (GHG) emissions (36%) (European Union, 2024) and for Ireland, the total GHG emissions of the built environment are estimated at 23 MtCO2eq/yr based on the 2018 level, which accounts for approximately 37% of national emissions, comprising 23% from building operations and 14% from embodied carbon (EC) emissions (O’Hegarty and Kinnane, 2022). These current emissions levels are stark given Ireland’s current commitment …

Employment Experience: Authentic Assessment Exemplar, Peter Monahan

Case studies: Assessment and Feedback

I supervise the Employment Experience Module with the semester 1 stage 2 Mechanical Engineering Ordinary Degree class. The Module MECH2039 is a voluntary module that if the students pass successfully, they receive an exemption from the module MECH2002 Professional Development in semester 2 stage 2. This module was initialized by a recommendation from Engineers Ireland to incorporate more employment related activities into the module. Also, it has noted through student attendance that a large part of the mechanical student cohort is engaged in part time employment, and it was agreed at departmental level that some academic benefit could be aligned …

Circular Economy Eu Networks Inventory, Mark Kelly, James O’Donnell, Derek Sinnott, Azedine Derardja, Sadaf Dalirazar, Ioannis Markou

Tools

Circular Economy EU Networks Inventory is a review of complementary EU research projects in the area of Circular Economy

Comparative Assessment Of Gold Nanoparticle-Antibody Conjugates With Two Differently Shaped Particles For Multimodal Colorimetric Lateral Flow Assay, Vinayak Sharma, Bilal Javed, Furong Tian

Articles

Novel detection strategies that exploit the unique properties of gold nanoparticles (AuNPs) hold great potential for the advancement of point-of-care (POC) diagnostics, such as lateral flow and dipstick immunoassay [1–3]. Owing to its biocompatibility and convenient surface modifications, gold nanoparticles with enhanced sensitivity reduce the sample-to-answer times to less than 5 min (Figure 1). Methods like covalent conjugation and electrostatic adsorption are explored for antibody immobilization to develop a gold nanoparticle-based biosensor for fast and sensitive localized surface plasmon resonance (LSPR) for both basic research and clinical diagnostics. The mounting of antibodies on the gold nanoparticle surface requires selective binding …

Using Chatgpt To Generate Gendered Language, Shweta Soundararajan, Manuela Nayantara Jeyaraj, Sarah Jane Delany

Conference papers

Gendered language is the use of words that denote an individual's gender. This can be explicit where the gender is evident in the actual word used, e.g. mother, she, man, but it can also be implicit where social roles or behaviours can signal an individual's gender - for example, expectations that women display communal traits (e.g., affectionate, caring, gentle) and men display agentic traits (e.g., assertive, competitive, decisive). The use of gendered language in NLP systems can perpetuate gender stereotypes and bias. This paper proposes an approach to generating gendered language datasets using ChatGPT which will provide data for data-driven …

Comparing Anova And Powershap Feature Selection Methods Via Shapley Additive Explanations Of Models Of Mental Workload Built With The Theta And Alpha Eeg Band Ratios, Bujar Raufi, Luca Longo

Articles

Background: Creating models to differentiate self-reported mental workload perceptions is challenging and requires machine learning to identify features from EEG signals. EEG band ratios quantify human activity, but limited research on mental workload assessment exists. This study evaluates the use of theta-to-alpha and alpha-to-theta EEG band ratio features to distinguish human self-reported perceptions of mental workload. Methods: In this study, EEG data from 48 participants were analyzed while engaged in resting and task-intensive activities. Multiple mental workload indices were developed using different EEG channel clusters and band ratios. ANOVA’s F-score and PowerSHAP were used to extract the statistical features. At …

Exploring The Design Of Low-End Technology To Increase Patient Connectivity To Electronic Health Records, Rens Kievit, Abdullahi Abubakar Kawu, Mirjam Van Reisen, Dympna O'Sullivan, Lucy Hederman

Conference papers

The tracking of the vitals of patients with long term health problems is essential for clinicians to determine proper care. Using Patient Generated Health Data (PGHD) communicated remotely allows patients to be monitored without requiring frequent hospital visits. Issues might arise when the communication of data digitally is difficult or impossible due to a lack of access to internet or a low level of digital literacy as is the case in many African countries. The VODAN-Africa project (van Reisen et al., 2021) started in 2020 and has greatly increased the capabilities of clinics in different countries in both Africa and …

Building Services Engineering March/April 2024

Building Services Engineering

No abstract provided.

Modelling Hoe Performance With An Extended Source; Experimental Investigation Using Misaligned Point Sources, Jorge Lasarte, Kevin Murphy, Izabela Naydenova, Maria Victoria Collados, Jesús Atencia, Suzanne Martin

Articles

Holographic optical elements (HOEs) have the potential to enable more compact, versatile, and lightweight optical designs, but many challenges remain. Volume HOEs have the advantage of high diffraction efficiency, but they present both chromatic selectivity and chromatic dispersion, which impact their use with wide spectrum light sources. Single-color light emitting diode (LED) sources have a narrow spectrum that reduces these issues and this makes them better suited for use with volume HOEs. However, the LED source size must be taken into consideration for compact volume HOE-LED systems. To investigate the design limits for compact HOE-LED systems, a theoretical and experimental …

Profess 12: Project Report 5: The Profess 12 Summer School - Evaluation, Una Beagon, Ruchita Jani, Janet Mckennedy, Brian Bowe, Margaret Morgan, Rosalind M Henry

Reports

This report outlines the evaluation of the summer school which was a key element of the PROFESS 12 project. The key steps involved in the 5-day summer school along with the method by which the feedback and the reflections of the participants of the summer school were collected is described here. Thereafter, the reflections received in the form of audio and text files are analysed and themes identified from the experience of the summer school participants are explained in detail.

The survey responses from the feedback on the summer school participation are also shown graphically. This analysis helped us identify …

Profess 12: Project Report 2: Priority Skills For Engineers On The Island Of Ireland: Key Stakeholder Perceptions, Rosalind M Henry, Margaret Morgan, Una Beagon, Ruchita Jani, Janet Mckennedy, Brian Bowe

Reports

Life on a shared island, in particular the island of Ireland (comprising Ireland and Northern Ireland), presents both challenges and opportunities, including for engineers tasked with addressing problems to help solve the SDGs that are indifferent to boundaries. Research demonstrates that (relative to current engineers) the engineer of the future will require a more diverse range of skills to navigate an increasingly complex work environment. Given this context, identification of relevant priority skills would therefore prove useful in focusing engineering educational initiatives.

Building on a European study (Beagon et al, 2022a) which identified at a European level the professional skills …

Ai And 6g Into The Metaverse: Fundamentals, Challenges And Future Research Trends, Muhammad Zawish, Fayaz Ali Dharejo, Sunder Ali Khowaja, Saleem Raza, Steven Davy, Kapal Dev, Paolo Bellavista

Articles

Since Facebook was renamed Meta, a lot of attention, debate, and exploration have intensified about what the Metaverse is, how it works, and the possible ways to exploit it. It is anticipated that Metaverse will be a continuum of rapidly emerging technologies, usecases, capabilities, and experiences that will make it up for the next evolution of the Internet. Several researchers have already surveyed the literature on artificial intelligence (AI) and wireless communications in realizing the Metaverse. However, due to the rapid emergence and continuous evolution of technologies, there is a need for a comprehensive and in-depth survey of the role …

Hygrothermal Risk Assessment Of External Wall Insulation Retrofit To Non-Traditional Wall Types In An Irish Context, Using The Glaser Method And A Heat, Air And Moisture Transient Model, Gareth Mcdonnell, Joseph Little

Articles

The Climate Action Plan 2019 targets the low-energy retrofit of 500,000 existing Irish homes before 2030.1 Up to 80 per cent of building failures can be attributed to moisture risks.2 The literature indicated that external wall insulation (EWI, ETICS) failures are mostly due to moisture ingress at junctions and interfaces. A hygrothermal risk assessment of EWI on three walls with rendered concrete/concrete blockwork/cavity walls in Dublin, Belfast and Belmullet was undertaken using transient numerical simulation and the Glaser method. The guidance, common practice indicates a preference for Glaser. The initial simulation results were compared to assess the appropriateness of Glaser. …

Exploring The Impact Of Design Professionals On The Energy Retrofit Of Dwellings In Ireland: A Qualitative Methodology, Olivia Golden

Conference papers

A qualitative approach was taken to investigate the role of design professionals in the energy retrofit of external wall insulation to dwellings in Ireland. The research method combines document analysis with semi structured interviews. Document analysis is used to both inform the questions for the interviews and for validation. The SEAI One Stop Shop grant scheme and PAS 2035 framework were selected for detailed document analysis to gain an understanding of the context in which design professionals are working in Ireland and compare it to the energy retrofit framework in the United Kingdom. This was investigated by mapping the data …

An Investigation Of The Physical And Thermal Properties Of Irish Hemp Fibres As A Loose-Fill Insulation Product, Killian Markey, Sameer Mehra Dr., David Palmer, David Knight, Timothy O'Leary

Conference papers

Construction and built environment sectors account for approximately 37% of Ireland’s carbon emissions. Of this 37%, 14% of the emissions consist of embodied carbon emissions from the construction materials from the production to the end-of-disposal of buildings. The construction industry can reduce its embodied carbon by using materials with a lower embodied carbon. Hemp fibre batt insulation is an example of a bio-based material and a lower embodied carbon alternative to conventional insulations. The existing hemp fibre batt insulation is typically composed of hemp fibres with a polyester binder. These polyester binders have higher embodied carbon while also being a …

The Post-Brexit Security Field On The Island Of Ireland: The Role Of Civil Society In Everyday Security Workshop Summary Report From Event At The Carrickdale Hotel On 28 June 2023, Allely Albert, Matt Bowden, Chloe Carragher, Amanda Kramer

Reports

This report documents the discussions of participants during a workshop at the Carrickdale Hotel, County Louth, that was held on June 28th 2023. The purpose of the workshop was to introduce the BORDEX project, learn about safety and security in local communities, and to learn about the organisations involved in producing and maintaining security, often in an informal way. In addition, the purpose of the event was to develop new connections and provide networking opportunities.

The BORDEX team provided an overview of the project and there were a number of break-out sessions to discuss particular topics. The first session addressed …

Exploring The Conceptual Structure And Perspectives Of Religious-Spiritual And Wellness Tourism Research From The Destination Community: A Bibliometric Review, Priyanka Babu N, Sherry Abraham

International Journal of Religious Tourism and Pilgrimage

The conceptualisation of specific holistic tourism components (religious-spiritual-wellness tourism) and their influence on community well-being in contemporary literature appears complex and needs to be more specific. This research traces critical developments in religious-spiritual-wellness tourism and their relationship with community by reviewing published literature in the Scopus database from 1990 to 2020 using bibliometric analysis. The literature review includes three sub-areas: descriptive analysis, reference publication year spectroscopy, and network analysis. In demonstrating the trends and evolution, the study focuses on the social, conceptual, and intellectual structures in religious-spiritual-wellness tourism (RSWT) and community. The key findings indicate that the RSWT community is …

Kinetic Modelling Of The Cellular Metabolic Responses Underpinning In Vitro Glycolysis Assays, Nitin Patil, Zohreh Mirveis, Hugh Byrne

Articles

This study aims to demonstrate the benefits of augmenting commercially available, real-time, in vitro glycolysis assays with phenomenological rate equation-based kinetic models, describing the contributions of the underpinning metabolic pathways. To this end, a commercially available glycolysis assay, sensitive to changes in extracellular acidification (extracellular pH), was used to derive the glycolysis pathway kinetics. The pathway was numerically modelled using a series of ordinary differential rate equations, to simulate the obtained experimental results. The sensitivity of the model to the key equation parameters was also explored. The cellular glycolysis pathway kinetics were determined for three different cell-lines, under nonmodulated and …

Embedding Development Education And International Service-Learning In Undergraduate Stem Programmes To Address Sustainable Development Goal Target 4.7, Ciaran O'Leary, Claire M. Mcdonnell

Irish Journal of Academic Practice

Development education and international service-learning are approaches to education that have the potential to offer students an opportunity to develop their understanding and appreciation of global issues such as poverty and inequality. In this regard, both approaches are aligned with Global Citizenship, Education for Sustainable Development (ESD) and Sustainable Development Goal (SDG) target 4.7. In this paper, the experiences of eight students who participated in an international service-learning project between 2011 and 2013 are evaluated using a survey and a thematic analysis. By undertaking the evaluation a decade following the running of the module, the analysis benefits from the pivot …

Embedding Sustainability In Food Degrees: A Case-Study Of Service-Learning As A Signature Pedagogy For Developing Food Sustainability Competencies, Julie L. Dunne, Catherine Barry-Ryan, Cormac H. Macmahon

Irish Journal of Academic Practice

Food production and consumption are emblematic of challenges to operate within planetary boundaries, whilst providing minimum access for all. They draw on natural and human resources and are de facto drivers of land-use. Moreover, their recognition in the United Nations Sustainable Development Goals has spurred growing awareness of food system fragility reflected in dietary orientation, waste streams and food security. Education is a key lever in transformation for food system resilience. Yet, food sustainability competencies and their signature pedagogies are in their infancy. This paper offers a reflection of their development at TU Dublin’s School of Food Science & Environmental …

Exploring The Intention Of Religious Tourists To Use Travel Apps: The Moderating Role Of Digital Privacy, Saumya Chandel, Neerja Rai, Srishti Chaubey, Kushendra Mishra

International Journal of Religious Tourism and Pilgrimage

Travel applications (apps) are essential tools for contemporary travel activities in the digital age. These are being used more frequently by religious tourists to access information and carry out travel and tourism-related tasks. So, it is essential for businesses associated with the travel sector to understand the intention of religious tourists towards using mobile travel applications. However, there are only a few empirical studies focusing on the factors that may influence tourists to use mobile travel apps. A research framework based on the technology acceptance model (TAM) has been proposed in this study to examine how and to what extent …

Forecasting Foreign Tourist Arrivals In India: A Strategic Analysis For Sustainable Religious Tourism Growth, Vishwajeet Singh, Dr. Taruna, Tarushree Bari, Subhash Kumar Yadav

International Journal of Religious Tourism and Pilgrimage

The exponential growth of the tourism industry in India significantly impacts the nation’s economic landscape. This study presents an analysis of tourism arrival trends from 2000 to 2019 to forecast foreign tourist arrivals, aligning with the broader scope of religious tourism and pilgrimage. Employing the Box-Jenkins methodology, the research aims to project short-term forecasts for inbound tourism. Diverse modelling techniques are explored to capture the nuances of the time series data, including the assessment of stationarity using the Dickey-Fuller Test to discern underlying trends. The study culminates in identifying the A.R.I.M.A (0, 1, 1) model with drift as the most …

An Analysis Of The Environmental Attitudes Of Undergraduate Construction Management Students Using The New Ecological Paradigm Scale, Jan Gottsche, Mark Kelly, Mary Mc Grath

Irish Journal of Academic Practice

Institutions generally lack formal processes to identify the impact that environmental initiatives may have on students, but one possible solution is the use of the New Ecological Paradigm (NEP) scale to monitor these potential changes. The aim of this study is to evaluate the change (if any) in environmental attitudes of undergraduate year two BSc. in Construction Management students following the completion of one semester of the Environmental Management module at the Atlantic Technological University (ATU) in 2021/2022. The research methodology employed a bounded case-study, which included the dissemination of two questionnaires (pre and post the module delivery in semester …