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Improved Oscillation Criteria For A Class Of Neutral Differential Equations In The Canonical Case, Abdulaziz Khalid Alsharidi, Ali Muhib

Turkish Journal of Mathematics

This paper develops an analytical framework based on comparison with first-order equations to derive new oscillation criteria for all solutions of a class of second-order differential equations with multiple delays. These criteria extend and improve upon previously published results. Illustrative examples are provided to validate the theoretical findings and to demonstrate the significance and applicability of the proposed criteria.

Oscillation Properties Of First-Order Difference Equations With Nonmonotone Delays: New Insights And Criteria, Emad Attia, George Chatzarakis

Turkish Journal of Mathematics

In this paper, we examine the oscillatory behavior of the first-order linear delay difference equation Δy(n) + p(n) y(τ(n)) = 0, n ∈ ℕ₀. It is known in the literature that, for any C > 0, the condition lim sup_n→∞ ∑_i=τ(n)ⁿ p(i) > C, with τ(n) nonmonotone, is not, in general, sufficient to establish the oscillation of the difference equation. We prove that, for certain classes of difference equations, the aforementioned condition is sufficient to ensure the …

On The Number Of Exact Factorization Of Finite Groups, Jesus Alonso Ochoa Arango, Maria Angelica Umbarila Martin

Turkish Journal of Mathematics

In this work, the function f2(G), which counts the number of exact factorizations of a finite group G, is studied. The value of  f2(G) is computed for several well-known families of finite groups, and an asymptotic expression is derived for the number of exact factorizations of the alternating group A2n .

Genetic Variation In Crops Of The Second Millennium Bce Revealed By Ancient Dna Analysis, Asi̇ye Uluğ, Funda Özdemi̇r Deği̇rmenci̇, Çi̇ğdem Kansu, Christina Luke, Christopher H. Roosevelt, Zeki̇ Kaya

Turkish Journal of Botany

For millennia, the Anatolian plateau has functioned as a major migratory corridor between Africa, Asia, and Europe and has subsequently been shaped by shifting settlement patterns, ranging from small communities to complex urban and imperial systems. These processes were closely associated with the development and diversification of agricultural practices. Archaeobotanical investigations at Kaymakçı, a Middle and Late Bronze Age (ca. 3500 years BP) site located in the middle Gediz Valley of western Anatolia, have provided substantial evidence of crop cultivation in the region. In this study, genetic variation in barley (Hordeum vulgare L.), chickpea (Cicer arietinum L.), bitter vetch (Vicia …

Improved Nutritional Value Of Spinach (Spinacia Oleracea L.) Through Moderate Salinity-Induced Regulation Of Vitamin C And Folate Pathways, Laleh Ahmadi, Hanieh Mohajjel Shoja, Elham Mohajel Kazemi, Maryam Kolahi

Turkish Journal of Botany

Soil salinity is a major abiotic stress affecting over 20% of cultivated and 33% of irrigated lands worldwide, significantly limiting crop productivity and nutrient biosynthesis. Vitamin C and folate are crucial antioxidants in plant stress tolerance and human nutrition; however, their regulation under salt stress remains unclear, particularly in leafy vegetables. This study evaluated the effects of different salinity levels (0, 50, 150, 250, and 350 mM NaCl) on physiological traits, antioxidant activity, vitamin C and folate accumulation, and the expression of related biosynthetic genes in spinach (Spinacia oleracea L.). High salinity (250–350 mM) reduced growth, leaf area, and pigment …

Identification Of Qtls And Molecular Markers Associated With Gray Mold Resistance In Grape, İlknur Polat, İbrahi̇m Çeli̇k, Onur Ergönül, Asli Polat, İlker Kurbetli̇, Görkem Sülü, Ayfer Daldal, Hali̇l İbrahi̇m Uzun

Turkish Journal of Botany

Grape (Vitis vinifera L.) is an economically important fruit that is both consumed fresh from the vine and used in the production of raisins, wine, and vinegar. One of the main factors limiting grape production is gray mold, caused by the fungal pathogen Botrytis cinerea. The cultivation of mold-resistant grape cultivars represents the most effective strategy for disease management; however, molecular tools to aid in the breeding of B. cinerea-resistant grapes remain limited. The present study maps the quantitative trait loci (QTLs) associated with B. cinerea resistance in grape using an F1 population derived from a reciprocal cross between the …

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Turkish Journal of Chemistry

No abstract provided.

Vanadium’S Journey From Essential Trace Metal To Emerging Environmental Pollutant In The Anthropocene Era, Tanu Arora, Nivedita Agnihotri, Mohammad Azam

Turkish Journal of Chemistry

Vanadium, previously considered a minor trace element, is gaining global environmental attention due to its expanding applications in metallurgy, energy storage, catalysis, and agriculture. With this rise in its industrial and technological uses, however, anthropogenic emissions of vanadium into the atmosphere, soils, and water bodies have also escalated. Unlike many heavy metals, vanadium exhibits complex redox behavior, primarily existing as V(IV) and V(V) species, which significantly impacts its environmental mobility, bioavailability, and toxicity. Vanadium exhibits complex behavior that necessitates an integrated research approach to better understand its various roles in scientific fields. This review summarizes the current knowledge on vanadium’s …

Computational And Experimental Analysis Of Oleanolic Acid As An Allosteric Activator Of Sirt1, Emrah Sariyer, Eda Dokumacioğlu, Hati̇ce İskender

Turkish Journal of Chemistry

Sirtuin 1 (SIRT1) is a member of the sirtuin protein family and the biological effects of SIRT1 encompass various areas such as the ageing process, metabolism regulation, and cellular stress response. SIRT1 activators are compounds that enhance the activity of SIRT1 enzyme. These activators can be natural or synthetic compounds and have the potential to provide health benefits by augmenting the biological effects of SIRT1. Oleanolic acid (OA) is a triterpenoid compound that has antiinflammatory, antioxidant, and glucose and lipid metabolism-regulating properties naturally found in many plants. The aim of the present study was to investigate the effect of OA …

Synthesis Of Werner- And Werner-Like-Type Clathrates, Their Characterization, And Theoretical Calculation Of Their Properties, Zari̇fe Si̇bel Şahi̇n, Zeki̇ Kartal

Turkish Journal of Chemistry

In this paper, the synthesis and structural characterization of three new coordination compounds in crystal structure consisting of a nickel atom, varying numbers of 3-aminopyridine molecules, and two isothiocyanate ion ligands are presented. The crystal structures of these compounds were determined by single crystal X-ray diffraction. Consequently, the explicit formulas and shorthand notations of the compounds are [Ni(NCS)2(C5H6N2)2(H2O)]·(H2O) (1), [Ni(NCS)2(C5H6N2)3]·(C2H6) (2), and [Ni(NCS)2(C5H6N2)4]·2(C5H6N2) (3). The consistency of the crystal structure data was confirmed by elemental analysis and infrared spectroscopy. These coordination compounds are Werner-like-type clathrates containing water, ethane, and 3-aminopyridine molecules as guest molecules in their structures, respectively. According to …

Investigation Of The Enzyme-Inhibitory, Antibacterial, And Anticancer Properties Of Metal Phthalocyanines, Meryem Topal, Fevzi̇ Topal, Firat Yilmaz, Esra Bulut Atalay, Ümi̇t Muhammet Koçyi̇ği̇t, Emre Güzel

Turkish Journal of Chemistry

In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was …

Templating Effect Of Neutral Dithiane Ligands On The Self-Assembly Of Cationic Au(I)-Phosphine Units, Farzane Osanlou, Abdollah Neshat, Mohammad Reza Yousefshahi, Vaclav Eigner, Michal Dusek, Shahram Seidi

Turkish Journal of Chemistry

The interactions between the dinuclear Au(I) precursor (dppm)Au2Cl2 and neutral sulfur-containing dithianes (specifically 1,3- and 1,4-dithiane) were examined in the presence of NH₄PF₆. Although these sulfur-based ligands were initially employed to facilitate the formation of mixed phosphine/sulfur Au(I) complexes, single-crystal X-ray diffraction analysis revealed the unexpected generation of multinuclear Au(I) assemblies exclusively coordinated by phosphine ligands. When 1,3-dithiane was present, a trinuclear Au(I) complex was isolated, characterized by a central four-coordinate Au(I) center exhibiting a distorted see-saw geometry, flanked by two terminal Au(I) centers with T-shaped coordination environments. Importantly, the dithiane ligand did not coordinate directly to the gold centers …

Nucleophilic Cyclization Of N-Propargylated Pyrazole-5-Carboxylates: Synthesis Of Pyrazolo[1,5-A]Pyrazin-4(5h)-One Derivatives, Meli̇k Firat Mengeş, Meltem Tan Uygun

Turkish Journal of Chemistry

Cyclization reactions are among the most important and widely used methods for synthesizing biologically active fused heterocyclic compounds. In the present study, pyrazolopyrazinone derivatives (10a–i) were synthesized from N-propargylated pyrazoles via nucleophilic cyclization with hydrazine hydrate under a nitrogen atmosphere. Nuclear magnetic resonance (NMR) spectral analyses confirmed that ring closure proceeded in a manner consistent with the formation of a six-membered pyrazinone moiety. In addition, the pyrazolotriazepinone derivative 15c was synthesized using an alternative approach. In this method, substitution with chloroacetone was first carried out, followed by ring closure with hydrazine hydrate, affording a seven-membered triazepinone system. Comparison of the …

Sensitive Stripping Voltammetric Determination Of An Anthracene–Isatin Schiff Base In Biological Samples, Gökçe Öztürk, İrem Gökgöz, Emi̇ne Arslan, Eli̇f Şi̇şman, İnci̇ Seli̇n Doğan, Di̇lek Kul, Fatma Ağin

Turkish Journal of Chemistry

​In the present study, the electrochemical behavior and quantitative determination of the Schiff base 3-[(anthracen-2-yl)imino]-5-nitro-1,3-dihydro-2H-indol-2-one (ANT) were investigated for the first time using voltammetric techniques at a glassy carbon electrode. The effects of solvent composition, pH, and scan rate on the redox behavior of ANT were systematically evaluated. The compound exhibited an irreversible oxidation process governed by adsorption-controlled kinetics. Quantitative analysis was conducted using differential pulse stripping voltammetry (AdS-DPV) and square-wave stripping voltammetry (AdS-SWV) under optimized conditions. Both methods exhibited linear responses over the concentration range of 0.2–8.0 μM, with limits of detection of 0.0366 μM and 0.0433 μM for …

Influence Of Precursor Synthesis Temperature And Hydrothermal Alkaline Medium On Agglomeration And Crystal Phase Of Barium Titanate Nanoparticles, Murat Özen

Turkish Journal of Chemistry

Phase‑pure, cube‑like barium titanate (BaTiO3) nanoparticles were synthesized via hydrothermal treatment of a single‑source barium-titanium peroxo-hydroxide precursor. Precursor solutions prepared at room temperature, 0 °C, and –10 °C with various storage times exhibited Ba/Ti molar ratios ranging from 0.66 to 1.05 as determined by X-ray fluorescence. Cooling the precursor solution to –10 °C effectively suppressed the polymerization of Ti-O-Ti, yielding near‑ideal stoichiometry and finer precursor particles. Subsequent hydrothermal processing in NH4OH, KOH, and NaOH (0.5–10 M, 100–200 °C) revealed the strong dependence of agglomeration and morphology on the alkaline medium. While NH4OH and KOH resulted in severe agglomeration and the …

​Spectrophotometric Detection Of Food Additives And Pesticides By Magnetite Cross-Linked Tyrosinase Aggregates (Mcltas)​, İlker Polatoğlu

Turkish Journal of Agriculture and Forestry

In this study, tyrosinase enzyme was cross-linked with glutaraldehyde to form aggregates on the surface of activated magnetite nanoparticles, without the need for a separate support matrix. For the first time, this novel aggregate was employed for the spectroscopic detection of ascorbic acid (AA) and diazinon, as model food additives and pesticides, respectively. This technique, developed as an alternative to optical sensors, not only eliminates their drawbacks but also facilitates the recovery of cross-linked enzyme aggregates (CLEA) from the reaction medium using the incorporated magnetite nanoparticles. A spectrophotometric technique was used to measure the enzyme activity of the aggregates to …

Effect Of Some Organic Fertilizers On Yield And Quality Of Olive Oil In Semiarid Conditions, İshak Bayyi̇ği̇t, Ebru Sakar

Turkish Journal of Agriculture and Forestry

This two-year field experiment evaluated the effects of different organic fertilizers on olive oil quality of the Gemlik cultivar grown under semiarid conditions in Mardin, Türkiye. Treatments of olive pomace (P1: 4, P2: 8, P3: 12 kg tree⁻¹), leonardite (L1: 1.5, L2: 3.0, L3: 4.5 kg tree⁻¹), and vermicompost (SG1: 3, SG2: 6, SG3: 9 kg tree⁻¹) were applied in a randomized complete block design with three replicates. Oils were analyzed for free acidity (FA), peroxide value, and phenolic profile using high-pressure liquid chromatography. FA ranged from 0.27% to 0.42% (as oleic acid), remaining well below the International Olive Council …

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …

Ankrd2 May Alleviate Denervation-Induced Skeletal Muscle Atrophy By Inhibiting Inflammation, Yalin Zhang, Lin Zhang, Li Li, Liqin Zhang, Li Zeng, Jiaying Qiu, Zhengrong Xi, Wenwen Wang

Turkish Journal of Biology

Background/aim: Sciatic nerve injury causes a loss of skeletal muscle innervation, reduced motor function, and eventual muscle atrophy. Inflammation and increased protein degradation are key factors contributing to muscle atrophy. Inflammation is activated early during muscle atrophy and can be modulated by various factors. However, the precise role of inflammation in denervation-induced muscle atrophy remains unclear. Materials and methods: Transcriptome sequencing was used to determine that the inflammatory response occurs early during denervation-induced muscle atrophy. RT-qPCR validation of several inflammatory factors showed rapid upregulation at early stages, followed by gradual downregulation. Weighted gene coexpression network analysis of differentially expressed genes …

Analysis Of Agricultural Remote Sensing Data Driven By Artificial Intelligence On Crop Growth Patterns And Economic Benefits Of Grain, Yang Wang

Turkish Journal of Agriculture and Forestry

To address the shortcomings of conventional agricultural statistical and monitoring methods on a regional scale, this paper proposes the use of artificial intelligence-driven remote sensing data for analysing crop growth patterns and the economic benefits of grain. Winter wheat data from three stations in a single province from 2011 to 2020 was used, with the leaf area index (LAI) used as the key crop growth indicator value. The simulated annealing algorithm was used to assimilate the LAI and remote sensing leaf area index (MODIS-LAI), simulated by the World Food Study (WOFOST) simulation model, to carry out simulation analysis of winter …

Nitrogen Transport Patterns And Vegetation Community Optimization In Urban Green Space Soils Using Multifactor Coupling Analysis, Shujian Yang, Baoxi Yu, Zheng He, Baochang Liu, Chang Liu

Turkish Journal of Agriculture and Forestry

As vital components of urban ecosystems, urban green spaces directly affect soil fertility and plant growth through nitrogen transport dynamics. This study addresses the existing methodological gaps in understanding nitrogen cycling within urban green spaces, particularly the unclear interaction mechanisms between vegetation structure and soil physicochemical characteristics. The study was conducted in the Green Expo Park located in Nanjing, China. Using a stratified sampling approach, physicochemical indicators of soil layers were measured and combined with community parameters—including leaf area index, vegetation coverage, and plant density—to identify key drivers through correlation and multiple regression analyses. The regulatory mechanisms of soil physicochemical …

Mitigation Of Salinity Stress In Carnation Plants Through Zinc Oxide Nanoparticles: Growth, Physiological, And Biochemical Responses, Adel A. Rezk, Ishtiaq Ahmad, Maryam, Muhammad Saleem, Othman Al-Dossary, Hossam S. El-Beltagi, Mohammed Aldaej, Bader Y. Alsubaie, Hati̇ce Gülen, Tarek Shalaby, Riaz Ahmad

Turkish Journal of Agriculture and Forestry

Carnation (Dianthus caryophyllus L.) growth and floral yield are severely reduced when grown in soils with excessive salinity. Mitigation of adverse effects from salinity-induced stress is necessary for sustainable carnation cultivation. Although various approaches have been developed, the use of zinc oxide nanoparticles (ZnO-NPs) to ameliorate these effects remains scarcely explored. The current study explored the potential of ZnO-NPs to alleviate salinity-induced stress by examining their effects on morphophysiological and biochemical traits. A controlled pot experiment was conducted using a factorial design with three concentrations of sodium chloride (0, 50, and 100 mM) and three of ZnO-NPs (0, 50, and …

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …

Effects Of Gnrh And Hcg Administration On Conception Rate And The Subsequent Estrous Cycle On Day 12 Following Artificial Insemination In Holstein Cows, Mustafa Hi̇lmi̇ Yaranoğlu, Hüseyi̇n Erdem

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin administration on the conception rate of cows 12 days after artificial insemination (AI). Included in the study were 150 high milkyielding Holstein cows housed under the same husbandry and feeding conditions. All had calved at least once between the ages of 2.5 and 6 years, and were between 90 and 220 days in milk. In accordance with the farm’s reproductive management approach, a controlled internal drug release (CIDR) device was inserted into the vagina concurrent with a GnRH injection (day 0), and the device was removed …

Effects Of Preslaughter Fasting On Ph And Bacterial Contamination In Akkaraman And Anatolian Merino Sheep, Sai̇m Boztepe, Özcan Şahi̇n, Talha Demi̇rci̇, Gi̇zem Coşkun, İbrahi̇m Ayteki̇n, İsmai̇l Keski̇n

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of the preslaughter fasting on pH and bacterial contamination in Akkaraman and Anatolian Merino sheep. Included in the study were 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that were fasted for 24 h prior to slaughter, and a further 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that continued to be fed until slaughter as a control group. The total mesophilic aerobic bacteria (TMAB) measured at 0 and 24 h in the fasting Akkaraman and Anatolian Merino sheep were 4.87/4.79 and 4.75/5.57 log CFU/g, respectively, and the corresponding Enterobacteriaceae …

Comparative Efficacy Of Repetitive Peripheral Magnetic Stimulation And Transcutaneous Electrical Nerve Stimulation In Upper Trapezius Myofascial Pain Syndrome ​, Shahri̇yar Kalbi̇yev, Şehi̇m Kutlay, Ati̇lla Hali̇l Elhan, Yeşi̇m Kurtai̇ş Aytür, Aysun Genç

Turkish Journal of Medical Sciences

Background/aim: In this prospective, randomized, single-blind study, the effects of repetitive peripheral magnetic stimulation (rPMS) and transcutaneous electrical nerve stimulation (TENS) on pain intensity, functional status, and tissue elasticity were evaluated in patients with upper trapezius myofascial pain syndrome (MPS).

Materials and methods: A total of 75 female patients were randomly allocated to three groups: rPMS, TENS, and sham rPMS. All participants were provided with an exercise program consisting of cervical range-of-motion (ROM), stretching, and strengthening exercises. Outcome measures included pain intensity assessed using the visual analog scale, pressure pain threshold (PPT), the Neck Disability Index, cervical ROM, SF-36 subscale …

Res-Mnd: Motor Neuron Disease Detection Using Res4net–Convolutional Block Attention Module ​, Shuriya Balusamy, Rakesh Sivalingam, Shobana Rooben, Sony Helen

Turkish Journal of Medical Sciences

Background/aim: Motor neuron diseases (MNDs) are progressive neurological disorders that cause muscle weakness and wasting as a result of ongoing neurodegeneration. MNDs require comprehensive diagnostic approaches that integrate clinical symptoms, laboratory findings, and multimodal imaging data.

Materials and methods: In this study, a novel residual network for motor neuron disease detection (RES-MND) framework is proposed for detecting MNDs using multimodal imaging data. Initially, the input multimodal images, including MRI, CT, PET, and DTI, are preprocessed using adaptive dynamic histogram equalization and the total variation bilateral filter. The preprocessed multimodal images are processed through Res4Net-CBAM for feature extraction to enhance image …

Association Between Superstition Levels On Sports-Specific Success Motivation In Active Athletes: A Study In Ankara Province ​, Canan Sayin Temur

Turkish Journal of Medical Sciences

Background/aim: When athletes perceive themselves as strong, they may seek to maintain their motivation through the control of random external factors. The present study examines the effect of superstitions on sports-specific success motivation among active athletes.

Materials and methods: The research population consisted of licensed athletes in the athletics branch, while the sample comprised licensed and active athletes based in Ankara. A total of 408 athletes participated in the research, including 201 women, and 207 men. The participants completed a three-part questionnaire consisting of a Personal Information Form, the Motivation in Sports Scale, and the Superstitious Beliefs and Behaviors in …

Sun-Macerated Hypericum Perforatum Oleates In Fixed Oils: Analytical Characterization And Comparative Wound-Healing Activity, Ci̇han Çapar, Esra Akkol, Ayli̇n Yaba, Ayhan Parmaksiz, Engi̇n Sümer, Erdem Yeşi̇lada

Turkish Journal of Medical Sciences

Background/aim: Hypericum perforatum L. oleates prepared in fixed oils have long been used for wound management due to their anti-inflammatory, antibacterial, and tissue-regenerative properties. The bioactivity of these oleates is mainly attributed to hypericin, hyperforin, and pseudohypericin. This study aimed to comparatively evaluate the wound-healing potential of H. perforatum oleates prepared in different fixed oils, including Olea europaea L. (olive), Sesamum indicum L. (sesame), Helianthus annuus L. (sunflower), and Nigella sativa L. (black seed).Materials and methodsFixed oils were characterized by GC–MS, while oleuropein in olive oil and thymoquinone in black seed oil were quantified by HPLC, and sesamin and sesamol …

Artificial Intelligence-Assisted Neuropharmacology: Reshaping Drug Discovery And Translational Strategies For Neurological Diseases ​, Pri̇yanka Rathee, Suni̇thi̇ Lohan, Sari̇ta Khatkar, Neelam Mali̇k, Esra Akkol, Renu Sehrawat, Pooja Rathee, Anurag Khatkar

Turkish Journal of Medical Sciences

The rapid expansion of data-driven technologies, particularly machine learning (ML) and artificial intelligence (AI), has substantially influenced biomedical research and drug discovery. In neuropharmacology, the availability of large-scale genomic, proteomic, chemical, and clinical datasets has stimulated the adoption of AI-based approaches to address persistent challenges in neurological drug development, including high attrition rates and the scarcity of disease-modifying therapies. Unlike prior reviews that broadly discuss AI applications in drug discovery or neurology, this narrative review focuses specifically on neuropharmacology, with an emphasis on translational relevance, disease-oriented examples, and real-world constraints. We critically examine the application of AI and ML across …