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Intermolecular Complexes Of Halocyclopropenone Derivatives With The Hypohalous Acids Hof, Hocl, Hobr, And Hoi, Dariush Mirzaei, Abedien Zabardasti, Yaghoub Mansourpanah
Intermolecular Complexes Of Halocyclopropenone Derivatives With The Hypohalous Acids Hof, Hocl, Hobr, And Hoi, Dariush Mirzaei, Abedien Zabardasti, Yaghoub Mansourpanah
Turkish Journal of Chemistry
The intermolecular interactions between halocyclopropenone derivatives (HC$_{3}$OX; X $=$ I, Br, Cl, and F) and hypohalous acids (HOY; Y $=$ I, Br, Cl, and F) were studied via the MP2 method utilizing the aug-cc-pVTZ and aug-cc-pVTZ(-PP) basis sets. The three types of complexes were hydrogen bonds, halogen bonds, and complexes containing both hydrogen and halogen bonds. The results obtained indicated that interactions in the Type 1 complexes were stronger than those in Types 2 and 3. The H-O bonds revealed red shifts with complex formation in Types 1 and 2. The O-Y bonds displayed red shifts in the Type 3 …
Synthesis And Antitumor Activities Of 2-(Piperidin-4-Yl)-Thiazole-4-Carboxamides Analogues Of Tubulysins, Xiangfu Peng, Mingsha Shao, Shuchao Ma, Lei Yao
Synthesis And Antitumor Activities Of 2-(Piperidin-4-Yl)-Thiazole-4-Carboxamides Analogues Of Tubulysins, Xiangfu Peng, Mingsha Shao, Shuchao Ma, Lei Yao
Turkish Journal of Chemistry
}Tubulysins are a family of natural products that exhibit potent antitumor activities, which have attracted much attention from synthetic and medicinal chemists. Previous attempts to aromatize the Tuv part of tubulysin analogues led to a loss in antitumor activity, which suggested that the Ile and Tuv fragments of these analogues were adopting different conformations than the natural products. In this study, a series of 2-(piperidin-4-yl)-thiazole-4-carboxamides have been prepared to investigate whether an intramolecular H-bond between key NH and OH groups is responsible for the conformational control. The antitumor activities of these analogues have been screened using MDA-MB-231-breast, Siha-cervical, MCF7-breast, and …
Electrochemical Oxidation Of Curcuminoids: An Experimental And Computational Investigation, Zeynep Kalaycioğlu, Nurgül Karadaş, Mehmet Emi̇n Çinar, Si̇bel Ayşil Özkan, Duri̇şehvar Özer Ünal, Ayşegül Gölcü, Fatma Bedi̇a Eri̇m
Electrochemical Oxidation Of Curcuminoids: An Experimental And Computational Investigation, Zeynep Kalaycioğlu, Nurgül Karadaş, Mehmet Emi̇n Çinar, Si̇bel Ayşil Özkan, Duri̇şehvar Özer Ünal, Ayşegül Gölcü, Fatma Bedi̇a Eri̇m
Turkish Journal of Chemistry
Curcuminoids, reported to have important biological properties, such as antioxidant, anti-Alzheimer, and antidiabetic properties, comprise curcumin (CRM; 1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and its derivatives demethoxycurcumin (DMC; (E,6E)-1-(3,4-dimethoxy-cyclohexyl)-7-(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione) and bisdemethoxycurcumin (BDMC; 1,7-bis[4-hydroxyphenyl]-1,6-heptadiene-3,5-dione). Their electrochemical oxidations are thoroughly explored by applying cyclic and differential pulse voltammetric techniques. The dependence of current intensities and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The outcome is supported by density functional theory computations indicating the transfer of 4-e$^{-}$/H$^{+}$, 6-e$^{-}$/H$^{+}$, and 8-e$^{-}$/H$^{+}$ couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formation of the same oxidized product.
Determination Of N-Acetylcysteine In The Presence Of Ciprofloxacin Or Levofloxacin In Microparticulate Dry Powder Inhalers, Yağmur Akdağ Çayli, Selma Şahi̇n, Emi̇rhan Nemutlu, Levent Öner
Determination Of N-Acetylcysteine In The Presence Of Ciprofloxacin Or Levofloxacin In Microparticulate Dry Powder Inhalers, Yağmur Akdağ Çayli, Selma Şahi̇n, Emi̇rhan Nemutlu, Levent Öner
Turkish Journal of Chemistry
A fast and easy method was validated for simultaneous determination of ciprofloxacin hydrochloride monohydrate (CP), levofloxacin hemihydrate (LV), and N-acetylcysteine (NAC) in samples. The analysis was performed on a C$_{18}$ column (250 x 4.6 mm, 5 μm) (Inertsil ODS-3V) using an isocratic elution method with a mobile phase composed of 25 mM KH$_{2}$PO$_{4}$ (pH 3.0) and methanol (72:28, v/v) at a flow rate of 1 mL/min. UV detection was performed at 214 nm for NAC and 293 nm for CP and LV. The method was validated for linearity, accuracy, precision (repeatability and reproducibility), specificity, sensitivity, and stability. The calibration study …
Methyl-Substituted 2-Aminothiazole--Based Cobalt(Ii) And Silver(I) Complexes: Synthesis, X-Ray Structures, And Biological Activities, Ezzat Khan, Tufail Ahmad, Zarif Gul, Farhat Ullah, Muhammad Nawaz Tahir, Awal Noor
Methyl-Substituted 2-Aminothiazole--Based Cobalt(Ii) And Silver(I) Complexes: Synthesis, X-Ray Structures, And Biological Activities, Ezzat Khan, Tufail Ahmad, Zarif Gul, Farhat Ullah, Muhammad Nawaz Tahir, Awal Noor
Turkish Journal of Chemistry
2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic N, exocyclic NH$_{2}$, and S atom in the ring system. In addition to these centers there are $\pi$-electrons in the ring system which can also expectedly be involved in some sort of coordination. To the best of our knowledge the solid state coordination chemistry of such ligands has not been fully presented in the literature. These ligands (2-amino-4-methylthiazole and 2-amino-5-methylthiazole) were coupled with CoCl$_{2}$ under aerobic conditions to form tetrahedral complexes, bis(2-amino-4-methylthiazole)dichlorocobalt(II) (1) and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2). Reaction of 2-amino-5-methylthiazole with AgNO$_{3}$ led to an expected two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3) as crystalline material. …
Antioxidant Properties Of Water-Soluble Phthalocyanines Containing Quinoline 5-Sulfonic Acid Groups, Armağan Günsel, Esma Hande Alici, Ahmet Turgut Bi̇lgi̇çli̇, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
Antioxidant Properties Of Water-Soluble Phthalocyanines Containing Quinoline 5-Sulfonic Acid Groups, Armağan Günsel, Esma Hande Alici, Ahmet Turgut Bi̇lgi̇çli̇, Gülnur Arabaci, Meryem Ni̇lüfer Yaraşir
Turkish Journal of Chemistry
In the present study, the antioxidant properties of peripherally and nonperipherally water-soluble tetra (quinoline 5-sulfonic acid) substituted metal-free (1,2), Zn(II) (3, 4), Co(II) (5, 6), and Mn(III)Cl (7, 8) phthalocyanine (Pc) derivatives were reported. In order to determine the antioxidant properties of the Pc compounds, three different commonly known antioxidant methods were used: DPPH ($\alpha $,$\alpha $-diphenyl-$\beta $-picrylhydrazyl) radical scavenging, ferrous ion chelating, and reducing power assays. Compound \textbf{6} showed the best DPPH activity among the other tested compounds except for the standards. The ferrous ion chelating IC$_{50\, }$value of compound 7 was nearly as good as that of the …
Molecular Dynamics Simulations Of Adsorption Of Long Pyrene-Peg Chains On A Thin Carbon Nanotube, Peli̇n Deni̇z Akkuş, Ayşe Özge Kürkçüoğlu Levi̇tas
Molecular Dynamics Simulations Of Adsorption Of Long Pyrene-Peg Chains On A Thin Carbon Nanotube, Peli̇n Deni̇z Akkuş, Ayşe Özge Kürkçüoğlu Levi̇tas
Turkish Journal of Chemistry
Carbon nanotubes have emerged as highly promising theranostic agents due to their unique structural/physical features, high surface area, and high drug-loading capacity. The high cytotoxicity of carbon nanotubes can be eliminated by noncovalent coating using hydrophilic polymers. We investigated the adsorption of long pyrene functionalized polyethylene glycol (PEG) chains, PEG$_{2000}$ and PEG$_{5000}$, on a single-walled carbon nanotube (SWNT) from a crowded solution. Full-atom molecular dynamics simulations in explicit water were used to mimic the experimental conditions of noncovalent PEGylation with a stoichiometry of one SWNT to ten pyrene-PEG. Although the diffusional behavior of the pyrene molecules still attached to the …
Primary Report Of First Documentation Of Mammal Footprints From The Late Oligocene Inthe Sivas Basin, Turkey, Beki̇r Levent Mesci̇, Ahmet Cem Erkman, Şaki̇r Önder Özkurt
Primary Report Of First Documentation Of Mammal Footprints From The Late Oligocene Inthe Sivas Basin, Turkey, Beki̇r Levent Mesci̇, Ahmet Cem Erkman, Şaki̇r Önder Özkurt
Turkish Journal of Earth Sciences
The footprints in this study, which were considered to have been made by ungulates, were discovered on mudstone that was approximately 5 cm thick, near an abundant mud-cracked plane located on the stratigraphic subsurface of the late Oligocene Karayün Formation, which crops out over wide areas in southern Sivas (Turkey) and has terrestrial, fluvial sediment characteristics. These ungulate footprints documented from the late Oligocene of the Karayün Formation in southern Sivas represent the first reported vertebrates in Anatolia. The footprints of three different species of ungulates were identified. The shapes, depth, and widths of the footprints provided some basic ichnotaxonomic …
Investigation Of The Relationship Between Ischemic Stroke And Endothelial Nitric Oxide Synthase Gene Polymorphisms [G894t, Intron 4 Vntr And T786c], Süleyman Ömer Anliaçik, Osman Serhat Tokgöz, Ayşegül Zamani̇, Mahmut Selman Yildirim, Mehmet Si̇nan İyi̇soy
Investigation Of The Relationship Between Ischemic Stroke And Endothelial Nitric Oxide Synthase Gene Polymorphisms [G894t, Intron 4 Vntr And T786c], Süleyman Ömer Anliaçik, Osman Serhat Tokgöz, Ayşegül Zamani̇, Mahmut Selman Yildirim, Mehmet Si̇nan İyi̇soy
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the associations between endothelial nitric oxide synthase(eNOS) gene polymorphisms [G894T (rs1799983)], intron 4 (27-bpTR) variable number tandem repeat (VNTR) and T786C (rs2070744), and ischemic stroke in the Anatolian population.Materials and methods: This case-control study included 112 patients with "stroke of undetermined etiology" and 160 controls. Real-time polymerase chain reaction (RT-PCR) analysis was used to analyze these polymorphisms. Between-group frequencies of alleles and genotypes were compared using binary logistic regression analysis.Results: No significant difference was observed between the two groups in terms of the genotype and allele distributions of the eNOS G894T (rs1799983) polymorphism (P > 0.05). …
Results Of Home-Based Modified Combined Decongestive Therapy In Patients With Lower Extremity Lymphedema, Ali̇s Kostanoğlu, Meltem Ramoğlu, Ethem Güneren
Results Of Home-Based Modified Combined Decongestive Therapy In Patients With Lower Extremity Lymphedema, Ali̇s Kostanoğlu, Meltem Ramoğlu, Ethem Güneren
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to present the results of modified combined decongestive therapy (CDT) in patients with lower extremity lymphedema (LEL). Materials and methods: We retrospectively reviewed 95 patients aged 55.84 ± 15.70 years who had been diagnosed with LEL between May 2015 and May 2017. The patients were treated for 4 weeks with modified CDT, including self-manual lymphatic drainage, self-bandaging, decongestive exercises, and skin care.Results: The mean reduction amounts of edema volume before and after treatment were 296.05, 784.92, and 1038.50 mL for stages 1, 2, and 3 respectively (P = 0.001). There were significant differences …
Antibiotic Resistance Pattern And Spa Types Of Staphylococcus Aureus Strains Isolated From Food Business And Hospital Kitchen Employees In Çanakkale, Turkey, Nesri̇n Çakici, Alper Akçali, Nükhet Ni̇lüfer Zorba
Antibiotic Resistance Pattern And Spa Types Of Staphylococcus Aureus Strains Isolated From Food Business And Hospital Kitchen Employees In Çanakkale, Turkey, Nesri̇n Çakici, Alper Akçali, Nükhet Ni̇lüfer Zorba
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine antibiotic resistance profiles and spa types of Staphylococcus aureus strains isolated from food business employees in Çanakkale, Turkey.Materials and methods:S.aureus isolates were collected from hand and nasal swabs of 300 individuals working in 17 food businesses and 9 hospital kitchens. All S. aureus isolates obtained from each carrier were typed by staphylococcal protein A (spa) typing method.Staphylococcal cassette chromosome mec (SCCmec) and multilocus sequence typing (MLST) of MRSA were performed by sequencing method.Results: Of the 300 individuals, 125 (41.6%) were found to be carriers of S. aureus, 215 isolates of which …
Is Nocturnal Enuresis A Predisposing Factor For The Overactive Bladder?, Nicolaie Suditu, Irina Negru, Adelina Miron, Bogdan Novac, Catalin Ciuta
Is Nocturnal Enuresis A Predisposing Factor For The Overactive Bladder?, Nicolaie Suditu, Irina Negru, Adelina Miron, Bogdan Novac, Catalin Ciuta
Turkish Journal of Medical Sciences
Background/aim: This study aimed to perform a limited observational study to ascertain whether there is statistical support that nocturnal enuresis (NE) is a predisposing factor in the development of overactive bladder (OAB).Materials and methods: The authors recruited patients diagnosed with OAB over a period of twelve months, and those who declared a history of NE were asked additional questions regarding the features of their NE.Results: A total of 285 patients were diagnosed with overactive bladder, and 98 (34.38%) of them had previously displayed NE symptoms that had diminished before reaching the median age of 9.83. Separation of patients by sex …
A Pilot Study On The Beneficial Effects Of Additional Selenium Supplementation To Methimazole For Treating Patients With Graves' Disease, Bin Xu, Di Wu, Hong Ying, Ying Zhang
A Pilot Study On The Beneficial Effects Of Additional Selenium Supplementation To Methimazole For Treating Patients With Graves' Disease, Bin Xu, Di Wu, Hong Ying, Ying Zhang
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the effect of a combination use of methimazole (MMI) and selenium (Se) in the treatment of Graves' disease (GD). Materials and methods: A total of 103 newly diagnosed hyperthyroidism patients were randomized to MMI and MMI + Se combination groups. After treatment for 6 months, the levels of triiodothyronine (FT3), free thyroxine (FT4), thyrotropin receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) were observed. An in vitro culture model of thyroid cells was established and the protein expression and mRNA levels of TRAb, TPOAb, and TGAb were determined …
Can Apelin Play A Role In The Etiology Of Tinnitus?, Nuray Ensari̇, Özer Erdem Gür, Ni̇lgün Gür, Ömer Tarik Selçuk, Levent Renda, Mustafa Deni̇z Yilmaz, Mehmet Türker Öztürk, Yeşi̇m Çeki̇n
Can Apelin Play A Role In The Etiology Of Tinnitus?, Nuray Ensari̇, Özer Erdem Gür, Ni̇lgün Gür, Ömer Tarik Selçuk, Levent Renda, Mustafa Deni̇z Yilmaz, Mehmet Türker Öztürk, Yeşi̇m Çeki̇n
Turkish Journal of Medical Sciences
Background/aim: Tinnitus is seen in 15% of the general population; in 1%-6% of this number, the quality of life is seriously affected by this chronic condition. Chemical, oxidative, and emotional stressors are important in terms of the clinical course of tinnitus. Apelin is an endogenous peptide which is an oxidative stress mediator. It has been shown that the apelin/APJ (apelin junction receptor) system plays various roles in the physiology and pathophysiology of many organs. However, the role of the apelin/APJ system as an oxidative stress mediator in tinnitus is unknown. We investigated the level of apelin in patients with normal …
Use Of Traditional And Complementary Medicine For Musculoskeletal Diseases, Güli̇s Kavadar, Sali̇ha Eroğlu Demi̇r, Ebru Ayteki̇n, Yildiz Akbal
Use Of Traditional And Complementary Medicine For Musculoskeletal Diseases, Güli̇s Kavadar, Sali̇ha Eroğlu Demi̇r, Ebru Ayteki̇n, Yildiz Akbal
Turkish Journal of Medical Sciences
Background/aim: We aimedto determine the prevalence of traditional and complementary medicine (TCM) use among patients with musculoskeletal disorders (MSDs) and to examine the methods used, frequency, and experienced benefits of therapies; the reasons for using TCM; and the sources of information about therapies. We also compared demographic characteristics of users and nonusers of TCM.Materials and methods: The descriptive study was conducted with 839 patients who attended the physical therapy and rehabilitation units of 3 public hospitals between September 2014 and March 2015. A self-administered questionnaire including demographic characteristics, medical history, and details of TCM use was applied. Results: Of the …
Risk Factors For Coronary Artery Disease In Young Patients With Stable Angina Pectoris, Mustafa Duran, Deni̇z Elçi̇k, Sani̇ Namik Murat, Fati̇h Öksüz, İbrahi̇m Etem Çeli̇k
Risk Factors For Coronary Artery Disease In Young Patients With Stable Angina Pectoris, Mustafa Duran, Deni̇z Elçi̇k, Sani̇ Namik Murat, Fati̇h Öksüz, İbrahi̇m Etem Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in a young population with stable angina pectoris (SAP).Materials and methods: A total of571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain and referred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemical parameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individuals were divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis …
Prognostic Importance Of Pten, Egfr, Her-2, And Igf-1r In Gastric Cancer Patients Treated With Postoperative Chemoradiation, Berri̇n Benli̇ Yavuz, Mehmet Koç, Sümeyye Kozacioğlu, Gül Kanyilmaz, Meryem Aktan
Prognostic Importance Of Pten, Egfr, Her-2, And Igf-1r In Gastric Cancer Patients Treated With Postoperative Chemoradiation, Berri̇n Benli̇ Yavuz, Mehmet Koç, Sümeyye Kozacioğlu, Gül Kanyilmaz, Meryem Aktan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to describe the prognostic importance of epidermal growth factor (EGFR), phosphatase and tensin homolog (PTEN), human EGF receptor-2 (HER-2), and insulin-like growth factor 1 receptor (IGF-1R) in gastric cancer patients treated with postoperative chemoradiation therapy. Materials and methods: Sixty-nine patients treated with adjuvant chemoradiation therapy were retrospectively evaluated. Tumor samples were stained immunohistochemically. Results: All patients were treated with 3D conformal radiation therapy with concomitant and adjuvant chemotherapy. Perineural invasion (PNI) (P = 0.042), prechemoradiation therapy albumin levels below 3.5 mg/dL (P = 0.011), and EGFR positivity (P = 0.008) had negative effects on overall survival …
Effect Of 4 Weeks Of Frankincense Consumption On Explicit Motor Memory And Serum Bdnf In Elderly Men, Elham Asadi, Mohammad Reza Shahabi Kaseb, Rasool Zeidabadi, Mohammad Reza Hamedinia
Effect Of 4 Weeks Of Frankincense Consumption On Explicit Motor Memory And Serum Bdnf In Elderly Men, Elham Asadi, Mohammad Reza Shahabi Kaseb, Rasool Zeidabadi, Mohammad Reza Hamedinia
Turkish Journal of Medical Sciences
Background/aim: Memory is a mechanism for coding, storing, and recalling information. Weak memory and learning disability are common psychological problems in the elderly. The aim of this study was to investigate the effect of 4 weeks of frankincense consumption on explicit motor memory and serum BDNF in the elderly.Materials and methods: Twenty elderly men (mean age of 60.2 ± 1.7 years) were randomly divided into two groups: experimental (n = 12) and placebo (n = 8). The first blood samples were collected 24 h before the pretest. Then both groups participated in a 4-week exercise program based on the protocol …
Anticipatory Effect Of Execution On Observation: An Approach Using Exopinch Finger Robot, Kutluk Bi̇lge Arikan, Hassan Gol Mohammad Zadeh, Ali̇ Emre Turgut, Murat Zi̇nnuroğlu, Gözde Bayer, Zafer Günendi̇, Bülent Cengi̇z
Anticipatory Effect Of Execution On Observation: An Approach Using Exopinch Finger Robot, Kutluk Bi̇lge Arikan, Hassan Gol Mohammad Zadeh, Ali̇ Emre Turgut, Murat Zi̇nnuroğlu, Gözde Bayer, Zafer Günendi̇, Bülent Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: This study aims to explore the mirror neuron system (MNS) involvement using mu (8?12 Hz)/beta (15?25 Hz) band suppression in an action observation-execution paradigm. Materials and methods: Electrophysiological (EEG) data from 16 electrodes were recorded while 8 participants observed video clips of a hand squeezing a spring. Specifically, the effect of anticipated execution on observation was studied. For this purpose, a fully actuated finger exoskeleton robot was utilized to synchronize observation and execution and to control the execution condition for the partici-pants. Anticipatory effect was created with a randomized robot accompany session. Results: The results showed that the observational …
Relationship Between Sirt1 Gene Expression Level And Disease In Age-Related Cataract Cases, Ni̇hat Buğra Ağaoğlu, Nuray Varol, Sali̇ha Handan Yildiz, Cem Karaosmanoğlu, Rahmi̇ Duman, Müjgan Özdemi̇r Erdoğan, Mustafa Solak
Relationship Between Sirt1 Gene Expression Level And Disease In Age-Related Cataract Cases, Ni̇hat Buğra Ağaoğlu, Nuray Varol, Sali̇ha Handan Yildiz, Cem Karaosmanoğlu, Rahmi̇ Duman, Müjgan Özdemi̇r Erdoğan, Mustafa Solak
Turkish Journal of Medical Sciences
Background/aim: Age-related cataract is the most important visual impairment all over the world. Epigenetic modifications, especially overexpression of histone deacetylases, have become the focus of interest for cataract development in recent years. Sirtuin 1 (SIRT1), a class II histone deacetylase and a member of the sirtuin family, is one of the best-characterized histone deacetylases and has a pivotal role in age-related diseases. However, the association of SIRT1 with age-related cataracts has not yet been fully elucidated. Therefore, we aimed to determine the expression of SIRT1 in age-related cataract patients.Materials and methods: Expressions of SIRT1 were evaluated by quantitative polymerase chain …
Conventional Versus Endoscopic Components Separation Technique: New Anthropometric Calculation For Selection Of Surgical Approach, Yaşar Subutay Peker, Oğuz Hançerli̇oğullari, Mehmet Fati̇h Can, Sezai̇ Demi̇rbaş
Conventional Versus Endoscopic Components Separation Technique: New Anthropometric Calculation For Selection Of Surgical Approach, Yaşar Subutay Peker, Oğuz Hançerli̇oğullari, Mehmet Fati̇h Can, Sezai̇ Demi̇rbaş
Turkish Journal of Medical Sciences
Background/aim: Giant ventral incisional hernias (GVIHs) are hard to manage for surgeons. This problem was resolved in 1990 with the components separation technique (CST). We aimed to compare endoscopic and conventional CST for GVIHs and find a new anthropometric calculation.Materials and methods: In this prospective nonrandomized clinical trial, 21 patients were treated with endoscopic or conventional CST between 2012 and 2016. Eight patients (38.1%) were operated endoscopically and 13 (61.9%) conventionally on the basis of preoperative tomography results, hernia surface area (HSA), number of recent abdominal operations, comorbidities, and the presence or history of ostomy. Groups in which prosthetic material …
Determination Of Liver Fibrosis Stages In Egyptian Chronic Hepatitis B Patients By A Noninvasive Tool, Waleed Serag, Magdy Mahmoud, Basem Eysa, Sara Mahmoud
Determination Of Liver Fibrosis Stages In Egyptian Chronic Hepatitis B Patients By A Noninvasive Tool, Waleed Serag, Magdy Mahmoud, Basem Eysa, Sara Mahmoud
Turkish Journal of Medical Sciences
Background/aim: Hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF). The prognosis and management of patients with chronic hepatitis B virus depend on the amount and progression of liver fibrosis. Angiopoietin-like protein 2 (Angptl2) is not only a chronic inflammatory mediator, but also a tissue-remodeling factor. The aim of this study is to explore the predictive value of Angptl2 in different fibrosis stages in patients chronically infected with HBV. Materials and methods: Eighty patients with chronic HBV infection undergoing Fibroscan were included. Serum concentrations of Angptl2 were detected using a commercial ELISA kit.Results: Angptl2 levels were …
Optical Characterization Of Salt-Induced Swelling Behavior Of Poly($N$-Isopropylacrylamide) Terpolymer Hydrogel Layers, İlke Anaç, Anil Bozdoğan
Optical Characterization Of Salt-Induced Swelling Behavior Of Poly($N$-Isopropylacrylamide) Terpolymer Hydrogel Layers, İlke Anaç, Anil Bozdoğan
Turkish Journal of Chemistry
This study reports for the first time the effect of different sodium halide salts (NaClO$_{4}$, NaI, and Na$_{2}$CO$_{3})$ in the low concentration range (in the range of 10$^{-7}$-1 M) on the swelling behavior of photo-crosslinked, surface-immobilized poly($N$-isopropyl acrylamide) (PNIPAAm) terpolymer layers. PNIPAAm terpolymer (consisting of $N$-isopropylacrylamide, methacrylic acid, and 4-methacryloxybenzophenone) was synthesized via free radical polymerization. The PNIPAAm terpolymer layers were prepared on gold substrates via spin coating and crosslinked and surface attached via UV radiation. The swelling behavior of the layers in monovalent (NaClO$_{4}$ and NaI) and divalent (Na$_{2}$CO$_{3})$ solutions was monitored by surface plasmon/optical waveguide spectroscopy. The terpolymer …
Targeting Human Telomeric Dna With Azacyanines, Ayça Küçükakdağ Doğu, Özgül Persi̇l Çeti̇nkol
Targeting Human Telomeric Dna With Azacyanines, Ayça Küçükakdağ Doğu, Özgül Persi̇l Çeti̇nkol
Turkish Journal of Chemistry
Small molecules targeting telomeric DNA or its interactions with telomerase have been an active area of cancer research. In the present study, we investigated the interactions of six benzimidazole compounds, called azacyanines, differing from each other in alkyl chain length and branching in the benzimidazole ring (azamethyl, azaethyl, azapropyl, azaisopropyl, azabutyl, and azaisobutyl) with human telomeric DNA (tel24) in 1:1 and 1:6 ratio (tel24:azacyanine) using UV-Vis, circular dichroism (CD), and fluorescence spectroscopy. All the compounds were binding to tel24 as indicated by the formation of the weak induced CD band between 320 nm and 360 nm. A substantial red shift …
Acetyl- And Butyrylcholinesterase Inhibitory Activity Of Selected Photochemically Synthesized Polycycles, Ivana Sagud, Irena Skoric, Dragana Vuk, Ana Ratkovic, Franko Burcul
Acetyl- And Butyrylcholinesterase Inhibitory Activity Of Selected Photochemically Synthesized Polycycles, Ivana Sagud, Irena Skoric, Dragana Vuk, Ana Ratkovic, Franko Burcul
Turkish Journal of Chemistry
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia in the elderly population. Since the treatment of AD has been associated with the activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), their inhibitors remain the main focus of AD investigations. In this study we evaluated cholinesterase inhibitory activity of 14 bicyclo[3.2.1]octene/octadiene derivatives and naturally occurring sesquiterpene alcohol cedrol. These 14 compounds have been efficiently and ecologically prepared by a photochemical approach in batch photochemical reactors. Various compounds with the bicyclo[3.2.1]octene skeleton have already been successfully evaluated for treatment of central nervous system disorders and AD. Among …
In Silico And In Vitro Evaluation Of The Biological Activity Of Some Organic Sulfur-Containing Compounds, Victoria Osipova, Maria Polovinkina, Anastasia Osipova, Yulia Gracheva, Andrey Okhlobystin
In Silico And In Vitro Evaluation Of The Biological Activity Of Some Organic Sulfur-Containing Compounds, Victoria Osipova, Maria Polovinkina, Anastasia Osipova, Yulia Gracheva, Andrey Okhlobystin
Turkish Journal of Chemistry
It was predicted, using the Prediction of Activity Spectra for Substances online software, that organic sulfur-containing compounds 2,6-di-tert-butyl-4-mercaptophenol (1), 2,6-di-tert-butyl-4-(3-mercaptopropyl)phenol (2), bis-3-[3,5-di-tert-butyl-4-hydroxyphenyl)propyl] sulfide (3), bis(3,5-di-tert- butyl-4-hydroxyphenyl) disulfide (4), diphenyl disulfide (5), dibenzyl disulfide (6), dibutyl disulfide (7), di-tert-butyl disulfide (8), diallyl disulfide (9), and methyl propyl trisulfide (10) could possess antioxidant activity and act as active scavengers of oxygen metabolites. The antiradical activity of these species was analyzed and it was shown that they were able to react with electrochemically generated the superoxide anion radical. The rate constants for reactions of 1-10 with the superoxide anion radical were calculated. The …
One-Pot Synthesis Of Quinazolin-4(3$H$)-Ones And 2,3-Dihydroquinazolin-4(1$H$)-Ones Utilizing $N$-(2-Aminobenzoyl)Benzotriazoles, İlbi̇lge Merve Şenol, İlhami̇ Çeli̇k, İlker Avan
One-Pot Synthesis Of Quinazolin-4(3$H$)-Ones And 2,3-Dihydroquinazolin-4(1$H$)-Ones Utilizing $N$-(2-Aminobenzoyl)Benzotriazoles, İlbi̇lge Merve Şenol, İlhami̇ Çeli̇k, İlker Avan
Turkish Journal of Chemistry
A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3$H)$-ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3$H)$-ones, and 2,3-dihydroquinazolin-4(1$H)$-ones were obtained at yields of 46% to 95% by a one-pot reaction of $N$-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.
Characterization And Purification Of 1,2,4-Triazole-Containing Phthalocyanines Synthesized By Microwave Method And Structure Elucidation By Spectroscopic Techniques, Asi̇ye Nas, Ümi̇t Demi̇rbaş, Nurhan Gümrükçüoğlu, Hali̇t Kanteki̇n
Characterization And Purification Of 1,2,4-Triazole-Containing Phthalocyanines Synthesized By Microwave Method And Structure Elucidation By Spectroscopic Techniques, Asi̇ye Nas, Ümi̇t Demi̇rbaş, Nurhan Gümrükçüoğlu, Hali̇t Kanteki̇n
Turkish Journal of Chemistry
The complexes of peripherally tetra-substituted metal-free (8), lead(II) 9), and zinc(II) (10) phthalocyanine derivatives were synthesized for the first time in this work. The structures of these new complex compounds have been elucidated using many spectral methods such as electronic absorption, FT-IR, $^{1}$H NMR, $^{13}$C NMR, elemental analysis, and mass spectra. The thermogravimetric behavior of compounds 8-10 was determined by thermogravimetric analysis method in addition to these spectral methods.
Determination Of Triacylglycerols And Fatty Acid Composition Of Chilopsis Linearis Seed Oil By Reverse-Phase High-Performance Liquid Chromatography, Anh Van Nguyen, Victor Ivanovic Deineka, Lyudmila Aleksandrovna Deineka, Anh Thi Ngoc Vu
Determination Of Triacylglycerols And Fatty Acid Composition Of Chilopsis Linearis Seed Oil By Reverse-Phase High-Performance Liquid Chromatography, Anh Van Nguyen, Victor Ivanovic Deineka, Lyudmila Aleksandrovna Deineka, Anh Thi Ngoc Vu
Turkish Journal of Chemistry
In the present work, the compositions of the 27 triacylglycerols (TAGs) as well as fatty acid composition of Chilopsis linearis seed oil were determined by reverse-phase high-performance liquid chromatography (RP-HPLC) with diode array and mass spectrometric detections. It was shown that the main conjugated acid in the seed oil is a catalpic acid, (9E,11E,13Z)-octadeca-9,11,13-trienoic acid, while two unusual fatty acids have the parameters satisfying the literature data for (10E,12E)-octadeca-10,12-dienoic and (9E,12E)-octadeca-9,12-dienoic acids. For the two conjugated acid substituents the isosbestic point (at 234 nm) was found and was used to calculate the ratios of TAGs with different chromophores in the …
Preparation Of Epoxidized Sunflower Oil Metal Soap Derivatives And Their Use As Heat Stabilizers For Polyvinyl Chloride, Ouassila Chelil, Naima Belhaneche-Bensemra, Daniel Lopez Garcia, Marta Fernandez-Garcia, Mohamed Tahar Benaniba
Preparation Of Epoxidized Sunflower Oil Metal Soap Derivatives And Their Use As Heat Stabilizers For Polyvinyl Chloride, Ouassila Chelil, Naima Belhaneche-Bensemra, Daniel Lopez Garcia, Marta Fernandez-Garcia, Mohamed Tahar Benaniba
Turkish Journal of Chemistry
The aim of this work was to prepare metal soaps of epoxidized sunflower oil (ESO) and use them as thermal stabilizers for polyvinyl chloride (PVC). For that purpose, commercial sunflower oil was first epoxidized and then used to prepare (Ba, Zn, Pb, and Cd) metal soap derivatives, which were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The prepared metal soaps derivatives of ESO were used as thermal stabilizers for plasticized PVC. Discoloration, residual thermal stability at 200 $^{\circ}$C , and rheological properties of PVC samples were tested. The structural modifications were investigated …