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Protonation Behavior Of Dextran Amino Acid Esters, Konrad Hotzel, Lidjia Fras Zemljic, Matej Bracic, Thomas Heinze
Protonation Behavior Of Dextran Amino Acid Esters, Konrad Hotzel, Lidjia Fras Zemljic, Matej Bracic, Thomas Heinze
Turkish Journal of Chemistry
Dextran esters of different amino acids (glycine, $\beta $-alanine, L-ornithine, L-lysine) are investigated regarding their pK$_{a}$ values by potentiometric titration. The pK$_{a}$ values of the dextran derivatives are generally dependent on the position of the amino group in relation to the ester group, i.e. the nearer they are located in the molecule, the lower the resulting pK$_{a}$ values are, L-ornithine ester being the exception. An influence of the polymer backbone is ruled out. Stability against hydrolysis at different pH values and over longer periods at constant pH value is measured by potentiometric and polyelectrolyte titration. The $\beta $-alanine ester shows …
Bisbenzoxazole Derivatives Had An Antiinflammatory Effect On In Vitro Stimulated Macrophages, Furkan Ayaz, Rusmeenee Kheeree, Qadar Ahmed Isse, Ronak Haj Ersan, Özteki̇n Algül
Bisbenzoxazole Derivatives Had An Antiinflammatory Effect On In Vitro Stimulated Macrophages, Furkan Ayaz, Rusmeenee Kheeree, Qadar Ahmed Isse, Ronak Haj Ersan, Özteki̇n Algül
Turkish Journal of Chemistry
Benzoxazoles are DNA base bioisosteres and studies suggest that their derivatives have antiproliferative activities. Based on their antiproliferative activities they have been mostly studied as new generation anticancer drugs. In our study we exploited their antiproliferative effect, aiming to delineate bisbenzoxazole derivatives' (RHE 231 and RHE 238) potential antiinflammatory effect on mouse macrophages that are activated in vitro through danger signal LPS stimulation. RAW 267.4 mammalian macrophages were activated in the presence of our derivatives with or without danger mimic E. coli derived LPS. We present data that support the strong antiinflammatory activity of the bisbenzoxazole derivatives RHE 231 and …
Sensitive Biological Detection Based On Langmuir--Blodgett Films Prepared From Diluted Silica Suspensions, Numan Gözübenli̇
Sensitive Biological Detection Based On Langmuir--Blodgett Films Prepared From Diluted Silica Suspensions, Numan Gözübenli̇
Turkish Journal of Chemistry
Self-assembled three-dimensional (3-D) colloidal crystals have been extensively utilized in nanolithography for fabricating a wide spectrum of functional periodic nanostructures for important technological applications. Here a simple and versatile way is reported using silica colloids to prepare close-packed particle multilayers by the Langmuir--Blodgett technique to create highly ordered 3-D colloidal crystals with unusual nanoarrays on a large variety of substrates. Successive deposition of monolayers using amphiphilic molecules in this approach allows control of the layer thickness, particle size, and especially packing structure of them in each layer. It has been demonstrated that the Langmuir--Blodgett film's transparency and high antiglare optical …
Naphthoxazoles And Heterobenzoxazoles: Cholinesterase Inhibition And Antioxidant Activity, Ivana Sagud, Irena Skoric, Franko Burcul
Naphthoxazoles And Heterobenzoxazoles: Cholinesterase Inhibition And Antioxidant Activity, Ivana Sagud, Irena Skoric, Franko Burcul
Turkish Journal of Chemistry
Finding novel cholinesterase inhibitors that would be able to cross the blood--brain barrier, have favorable pharmacokinetic parameters, and reduce hepatotoxicity along with other side effects has been the main focus of investigations dealing with Alzheimer disease. In this study we evaluated cholinesterase inhibitory and antioxidant activity of seven oxazole derivatives. These compounds have been efficiently and sustainably prepared by photochemical electrocyclization reaction. Various naphthoxazoles have been previously investigated as potential antibacterial, antituberculosis, and anticancer agents. They have also been tested for antioxidant activity, but never for cholinesterase inhibitory activity. Among the tested oxazole derivatives, fused heterobenzoxazole compounds with pyridine and …
Novel "Turn Off-On" Sensors For Detection Of Dna-Acrylamide Interaction Using Zns Quantum Dots As A Phosphorescent Probe, Hayri̇ye Eda Şatana Kara
Novel "Turn Off-On" Sensors For Detection Of Dna-Acrylamide Interaction Using Zns Quantum Dots As A Phosphorescent Probe, Hayri̇ye Eda Şatana Kara
Turkish Journal of Chemistry
A novel "turn off-on" sensor for detection of interaction between DNA and acrylamide (ACR) was developed. In this method, L-cysteine capped Mn-doped ZnS quantum dots (QDs) were used as room temperature phosphorescent probes. In the ``turn-off'' mode, ACR was absorbed onto the surface of QDs via electrostatic interaction, which caused a quenching effect of room-temperature phosphorescence signal by photoinduced electron-transfer mechanism. ACR was removed from the QDs' surface with the addition of DNA. Thus, the phosphorescence emission of QDs was recovered and the system was turned to the ``turn-on'' mode. The quenching mechanism of QDs by ACR was collisional (dynamic) …
3d-Qsar/Hqsar-Based Analysis Of Bioconcentration And Molecular Modification Of Monophenyl Aromatic Compounds, Qing Li, Wenwen Gu, Yu Li
3d-Qsar/Hqsar-Based Analysis Of Bioconcentration And Molecular Modification Of Monophenyl Aromatic Compounds, Qing Li, Wenwen Gu, Yu Li
Turkish Journal of Chemistry
Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of three-dimensional quantitative structure-activity relationship (3D-QSAR) models were conducted using 36 aromatic compound congeners as the training set and eight aromatic compound congeners as the test set. Logarithms of experimental bioconcentration data (logBCF) were used as dependent variables and the physicochemical properties of the aromatic compound congeners were used as independent variables. Furthermore, the molecular holographic quantitative structure--activity relationship (HQSAR) model constructed by the HQSAR module in Sybyl software was used to establish a method to find molecular activity substitution sites of bioconcentration potential by coupling the molecule …
Computational Investigation Of Influenza A Virus M2 Protein Inhibition Mechanism By Ion Channel Blockers, Mehmet Özbi̇l
Computational Investigation Of Influenza A Virus M2 Protein Inhibition Mechanism By Ion Channel Blockers, Mehmet Özbi̇l
Turkish Journal of Chemistry
The M2 protein of the influenza A virus, responsible for flu, is a homotetramer transmembrane protein, forming a transmembrane ion channel, where His 37s act as pH sensors and Trp 41s and Asp 44s act as channel gates. Opening of this channel leads to transfer of virus RNA into the human host. Thus, blocking this transfer is an important pharmaceutical strategy to stop infection. As a result of viral drug resistance, commercially available channel inhibitors, rimantadine (RIM) and amantadine (AMA), are not as effective as they used to be. Understanding binding sites and outcomes of binding will lead to new …
Synthesis Of Novel Azo Linkage-Based Schiff Bases Including Anthranilic Acid And Hexanoic Acid Moieties: Investigation Of Azo-Hydrazone And Phenol-Keto Tautomerism, Solvatochromism, And Ionochromism, Özlem Özdemi̇r
Turkish Journal of Chemistry
Two new azo-Schiff base receptors (L$_{{1}}$ and L$_{{2}})$ containing azo and azomethine groups with a conjugated group (benzyl ring of anthranilic acid, in L$_{{1}})$ and electron-donating group (alkyl chain of hexanoic acid, in L$_{{2}})$ were synthesized and characterized. Azo-hydrazone/phenol-keto tautomerism and solvatochromism were investigated. Studying their sensing ability towards cations (Co$^{2+}$, Cu$^{2+}$, Zn$^{2+}$, Ni$^{2+}$, Pb$^{2+}$, Cd$^{2+}$, Mn$^{2+}$, Fe$^{3+}$, Cr$^{3+}$, and Al$^{3+})$, high sensitivity and selectivity were recorded for Fe$^{3+}$ by naked eye and UV-Vis spectra in DMF-aqueous HEPES buffer (v:v, 1:1, pH 6.8). The color of L$_{{1}}$ and L$_{{2}})$ solutions instantly changed from yellow to deep orange and pale orange. …
Stability Improvement By Crosslinking Of Previously Immobilized Glucose Oxidase On Carbon Nanotube-Based Bioanode, Tahsi̇n Bahar
Stability Improvement By Crosslinking Of Previously Immobilized Glucose Oxidase On Carbon Nanotube-Based Bioanode, Tahsi̇n Bahar
Turkish Journal of Chemistry
Bioanode stability with glucose oxidase was enhanced significantly by covalent crosslinking without substantial enzymatic activity and affinity loss. Initially, glucose oxidase was immobilized by aldehyde groups on the electrode that was developed using ferrocenecarboxaldehyde, polyethyleneimine, multiwall carbon nanotubes, and carbon cloth for biofuel cell applications. The glucose oxidase half-life was extended by more than 4 times, from 27.2 to 124.7 h, after the electrode was crosslinked. Enzymatic kinetic parameters were determined for the crosslinked enzyme and they were compared to the noncrosslinked immobilized enzyme parameters on the electrode. The apparent substrate affinity of the crosslinked enzyme electrode was decreased (i.e. …
Attempts To Save A Spanish Endemism Astragalus Devesae Talavera, A. González & G. López (Fabaceae) From Extinction, Karoline Aparecida Felix Ribeiro, José Ángel Sánchez Agudo, Silvia Sánchez Durán, Ester Vega Elices, José Sánchez Sánchez
Attempts To Save A Spanish Endemism Astragalus Devesae Talavera, A. González & G. López (Fabaceae) From Extinction, Karoline Aparecida Felix Ribeiro, José Ángel Sánchez Agudo, Silvia Sánchez Durán, Ester Vega Elices, José Sánchez Sánchez
Turkish Journal of Botany
Astragalus devesae Talavera, A. González & G. López (Fabaceae) is a threatened Hispanic endemic species whose distribution is restricted to the center of Spain (the province of Ávila). It is classified as ?Critically Endangered? in the 2010 List of Threatened Spanish Vascular Flora and as ?Endangered? in the ?Decree 63/2007? of Castile and Leon (administrative region in which Ávila is included). In this study, censuses of three existing populations were carried out and one of these that was found along the course of this work, was ecologically characterized. High interpopulation variability (0%, 26%, and 73%) was observed with respect to …
Moderate Level Of Toxic Boron Causes Differential Regulation Of Micrornas Related To Jasmonate And Ethylene Metabolisms In Arabidopsis Thaliana, Doğa Seli̇n Kayihan, Ceyhun Kayihan, Yelda Özden Çi̇ftçi̇
Moderate Level Of Toxic Boron Causes Differential Regulation Of Micrornas Related To Jasmonate And Ethylene Metabolisms In Arabidopsis Thaliana, Doğa Seli̇n Kayihan, Ceyhun Kayihan, Yelda Özden Çi̇ftçi̇
Turkish Journal of Botany
Earlier our colleagues detected that the genes related to jasmonate (JA), ethylene, and cell wall modification were significantly regulated under boron (B) toxicity in wheat. Determination of regulation mechanisms of these novel genes under B toxicity is very important in Arabidopsis thaliana as a model plant. As key regulators, the microRNAs (miRNAs) regulate gene expression at the posttranscriptional level and respond to numerous abiotic stresses in plants. In this study, expression levels of miRNAs such as miR159, miR172, miR319, and miR394 targeting JA and ethylene-related transcription factors and also miR397 targeting laccase were determined in Arabidopsis thaliana under toxic B …
G-Quadruplex Enrichment Analysis Reveals Their Role As Intronic Regulatory Elements In Plants, Osman Doluca
G-Quadruplex Enrichment Analysis Reveals Their Role As Intronic Regulatory Elements In Plants, Osman Doluca
Turkish Journal of Botany
G-Quadruplexes, a class of noncanonical but highly stable nucleic acid structures, have the potential to be part of the regulatory mechanism of cells. They can form in the genome where the double-stranded helix is unwound to facilitate formation of a G-quadruplex. The biological significance of these structures is yet to be understood entirely. This work presents a novel approach and investigates common characteristics in the distribution of G-quadruplexes relative to genes in plants through analysis of genomes and gene expressions. The results indicate that G-quadruplex distribution has gone through significant changes with the evolution of higher plants and, for the …
Assessing Impacts Of Climate Change On Campanula Yaltirikii H.Duman (Campanulaceae), A Critically Endangered Endemic Species In Turkey, Canan Dülgeroğlu, Ahmet Aksoy
Assessing Impacts Of Climate Change On Campanula Yaltirikii H.Duman (Campanulaceae), A Critically Endangered Endemic Species In Turkey, Canan Dülgeroğlu, Ahmet Aksoy
Turkish Journal of Botany
Ecological niche models (ENMs) provide information to assess the effects of environmental and climatic conditions on species distribution. The purpose of this study was to predict the impact of climate change on a critically endangered species, Campanula yaltirikii H.Duman. It is a local endemic chasmophyte from Mt Çığlıkara (Antalya, Turkey), restricted to cracks in calcareous rocks and threatened by goat overgrazing. Current and future ENMs of C. yaltirikii were predicted with a maximum entropy (Maxent) algorithm. The MIROC5 (Model for Interdisciplinary Research on Climate) climate change scenario for the year 2070 was used for projecting the future ENM of the …
A Contribution To The Taxonomy Of Zoegea (Asteraceae, Cardueae?Centaureinae), Kazem Negaresh, Mohammad Reza Rahiminejad
A Contribution To The Taxonomy Of Zoegea (Asteraceae, Cardueae?Centaureinae), Kazem Negaresh, Mohammad Reza Rahiminejad
Turkish Journal of Botany
A worldwide taxonomic revision and the relevant lectotypifications of Zoegea L. (Asteraceae) are presented. The recognized taxa, the relevant synonyms, type details, images of the type specimen, examined specimen lists, and a taxonomic key are provided for this genus. The geographic distribution of all recognized taxa is presented and tabulated. Zoegea leptaurea L. subsp. leptaurea for the floras of Iran and Saudi Arabia and also Z. purpurea Fresen. for the flora of Iraq are reported as new here.
Identification And Functional Analysis Of Soybean Gmsbh1 Gene Promoter Conferring High Temperature- And Humidity-Induced Expression, Ming Chen, Peipei Qian, Zhankui Wang, Yingjie Shu, Yuan Tao, Liyan Huang, Yilong Wang, Haihong Zhao, Hao Ma
Identification And Functional Analysis Of Soybean Gmsbh1 Gene Promoter Conferring High Temperature- And Humidity-Induced Expression, Ming Chen, Peipei Qian, Zhankui Wang, Yingjie Shu, Yuan Tao, Liyan Huang, Yilong Wang, Haihong Zhao, Hao Ma
Turkish Journal of Botany
Soybean homeobox gene GmSBH1 has previously been proven to be involved in response to high temperature and humidity (HTH) stress. To investigate its expression patterns and active cis-elements, a 2040-bp 5'-upstream genomic DNA fragment of GmSBH1,named GmSBH1P, was isolated by PCR walking and characterized. Sequence analysis revealed that the fragment contains a series of cis-acting elements related to stress responses. The transient expression assay in the leaves of Nicotiana benthamiana and in the cotyledonary nodes of soybean indicated that the GmSBH1P strongly and rapidly mediates the induction of GUS expression under HTH stress. Deletion and mutation analysis of the promoter …
Two Pronounced Chlorella Strains For Efficient Biodiesel Feedstock Production, İlhami̇ Tüzün, Zeynep Eli̇bol Çakmak, Emmanuel Young, Turgay Çakmak
Two Pronounced Chlorella Strains For Efficient Biodiesel Feedstock Production, İlhami̇ Tüzün, Zeynep Eli̇bol Çakmak, Emmanuel Young, Turgay Çakmak
Turkish Journal of Botany
In this study, two indigenous Chlorella strains were evaluated for triacylglycerol (TAG) production and related parameters during 10 days of N-deprivation. The strains were identified based on morphological characteristics and genomic information, named as Chlorella sp. IMU12 and Chlorella sp. IMU17. Time-dependent reduction of growth was accompanied by decreased chlorophyll content, reduced oxygen evolution ratio, and elevated carotenoid content of both strains cultivated in N-free Bold's basal medium. Nitrogen deprivation induced total lipid and neutral lipid content in both strains, supported by FTIR measurement of TAGs. Chlorella sp. IMU17 showed higher production of TAGs as a response to N-deprivation. Strikingly, …
Colostrum Immunoglobulins And Oxidative Capacity May Be Affected By Infant Sex And Maternal Age And Parity, Davut Si̇nan Kaplan, Cahi̇t Bağci, Mustafa Örkmez, Özge Kömürcü Karuserci̇, Seyhun Sucu, Haki̇m Çeli̇k, Seyi̇than Taysi
Colostrum Immunoglobulins And Oxidative Capacity May Be Affected By Infant Sex And Maternal Age And Parity, Davut Si̇nan Kaplan, Cahi̇t Bağci, Mustafa Örkmez, Özge Kömürcü Karuserci̇, Seyhun Sucu, Haki̇m Çeli̇k, Seyi̇than Taysi
Turkish Journal of Medical Sciences
The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age, maternal parity, and infant sex. Materials and methods: The analysis was performed in serum samples of colostrum which were collected from 90 mothers on the first day of lactation between 10:00 and 12:00 AM.Results: The measurements established that no significant association existed between the TAS level of colostrum and parity, maternal age, or …
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi
Turkish Journal of Medical Sciences
Background: Conventionalmethods of detecting Brucella spp. suffer from technical and biological complications. Besides, newly characterized species of the genus Brucella could be neglected by previously designed polymerase chain reaction (PCR) tests. Therefore, a more accurate PCR-based test seems to be imminently needed. Materials and methods: Blood samples were collected from 39 patients diagnosed with brucellosis and 25 healthy controls. Multiple sequence alignments (MSA) were performed on 500 Omp2-related protein and gene sequences. Thereafter, specific primers were designed and synthesized for the regions with highest conservancy. The collected samples were assessed by PCR test. To overcome the cross-reactivity issue, PCR thermal …
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia, Rana Hasanato
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia, Rana Hasanato
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA.Materials and methods: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument.Results: The median serum Cu levels among SCA patients (1.3 -g/mL) were …
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Turkish Journal of Medical Sciences
Background/aim: Hemophagocytic lymphohistiocytosis (HLH) is a clinical, biological, and pathological entity that is rare but has certain morbidity that may be life-threatening. This work aims to establish a focus on the hemophagocytic lymphohistiocytosis and analyze different aspects of diagnosis while emphasizing the biological data.Materials and methods: We report the results of a retrospective study conducted in the hematology department of Avicenna Hospital in Marrakesh. Thirty-one patients with hemophagocytic lymphohistiocytosis were enrolled.Results: The clinical presentation was dominated by fever and deterioration of the general state for almost all our patients. Splenomegaly was objectified in 90% of the patients. Hepatomegaly, lymphadenopathy, and …
Neutrophil To Lymphocyte Ratio As A Predictor Of Treatment Response And Mortality In Septic Shock Patients In The Intensive Care Unit, Rabi̇a Sari, Zühal Karakurt, Mustafa Ay, Muhammed Emi̇n Çeli̇k, Ülgen Yalaz Tekan, Fulya Çi̇yi̇ltepe, Feyza Kargin, Cüneyt Saltürk, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Nalan Adigüzel
Neutrophil To Lymphocyte Ratio As A Predictor Of Treatment Response And Mortality In Septic Shock Patients In The Intensive Care Unit, Rabi̇a Sari, Zühal Karakurt, Mustafa Ay, Muhammed Emi̇n Çeli̇k, Ülgen Yalaz Tekan, Fulya Çi̇yi̇ltepe, Feyza Kargin, Cüneyt Saltürk, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Nalan Adigüzel
Turkish Journal of Medical Sciences
Background/aim: While C-reactive protein (CRP) is a well-studied marker for predicting treatment response and mortality in sepsis, it was aimed to assess the efficacy of the neutrophil lymphocyte ratio (NLR) as a predictor of mortality and treatment response in sepsis patients in the intensive care unit (ICU). Materials and methods: In this retrospective cross-sectional study, sepsis patients were divided according to the presence of septic shock on the 1st day of ICU stay, and then subgrouped according to mortality. Patient demographics, acute physiologic and chronic health evaluation II and sequential organ failure assessment scores, NLR and CRP (on the 1st, …
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Changes in collagen metabolism and fibroblastic activity may play a role in the pathogenesis of brucellosis. The prolidase enzyme plays an important role in collagen synthesis. We aimed to investigate the association of prolidase levels with brucellosis.Materials and methods: Serum prolidase levels in 20 patients newly diagnosed with brucellosis were compared with levels in 30 healthy control subjects. Patients with brucellosis were reassessed 3 months later for prolidase, other laboratory measurements, and response to treatment. Results: The levels of serum prolidase were significantly higher in brucellosis patients compared with those of healthy controls. Prolidase, sedimentation, and C-reactive protein levels …
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Turkish Journal of Medical Sciences
Background/aim: We evaluate whether transrectal ultrasonography (TRUS)-guided prostate biopsy might lead to spillage of tumor cells into peripheral blood as a result of disruption of the epithelial barrier and ultimately result in metastasis. Materials and methods: Eighty-eight patients underwent TRUS-guided prostate needle biopsy due to prostate-specific antigen (PSA) increase or abnormal digital rectal examination at the Samsun Research and Training Hospital (Samsun, Turkey) between April 2016 and September 2018. Approximately 10 mL of whole blood was collected from patients before, 1 week after, and 1 month after biopsy. Samples were analyzed for CD117 positivity and prostate-specific membrane antigen (PSMA) levels …
Is The Asymmetry Between The Vertebral Arteries Related To Cerebral Dominance?, Ahmet Vural, Esma Esi̇n Deri̇n Çi̇çek
Is The Asymmetry Between The Vertebral Arteries Related To Cerebral Dominance?, Ahmet Vural, Esma Esi̇n Deri̇n Çi̇çek
Turkish Journal of Medical Sciences
Background/aim: The two vertebral arteries (VAs) are usually unequal in size; the left one is generally larger than the right one. It was hypothesized that the asymmetry results from the need of the dominant cerebral hemisphere for more glucose and oxygen, i.e. more blood supply. In this study, we aimed to test this hypothesis in patients by evaluating their arterial diameter and hand preference, as it is the most common criterion to determine the dominance of the hemisphere. Materials and methods: The study was performed with 844 participants who consented to participate in the study. We identified the dominant cerebral …
Synthesis And Characterization Of Polycaprolactone-Based Segmented Polyurethanes, Aysun Güney, Aysel Kiziltay, Nesri̇n Hasirci, Tuğba Endoğan Tanir
Synthesis And Characterization Of Polycaprolactone-Based Segmented Polyurethanes, Aysun Güney, Aysel Kiziltay, Nesri̇n Hasirci, Tuğba Endoğan Tanir
Turkish Journal of Chemistry
Segmented polyurethanes were synthesized by the reactions of poly($\varepsilon $-caprolactone) (PCL)-diol and 1,6-hexamethylene diisocyanate through bulk polymerization without using solvent, initiator, or catalyst. Phase separation and hydrogen bond formation between hard segments or between hard and soft segments were examined by Fourier transform infrared spectroscopy (FTIR)-ATR and X-ray diffraction (XRD), while physical and mechanical properties were studied by atomic force microscope, differential scanning calorimeter, dynamic mechanical analysis, and tensile tester. When the diisocyanate content was increased, deconvolution results of FTIR-ATR in C$=$O and N-H regions demonstrated better miscibility of the segments and XRD results showed a significant decrease in the …
Tricholoma (Fr.) Staude In The Aegean Region Of Turkey, İsmai̇l Şen, Hakan Alli
Tricholoma (Fr.) Staude In The Aegean Region Of Turkey, İsmai̇l Şen, Hakan Alli
Turkish Journal of Botany
The Tricholoma biodiversity of the Aegean region of Turkey has been determined and reported in this study. As a consequence of field and laboratory studies, 31 Tricholoma species have been identified, and five of them (T. filamentosum, T. frondosae, T. quercetorum, T. rufenum, and T. sudum) have been reported for the first time from Turkey. The identification key of the determined taxa is given with this study.
Design, Synthesis, Biological Evaluation And Molecular Docking Of Novel Molecules To Parp-1 Enzyme, Fati̇h Tok, Bedi̇a Kaymakçioğlu, Recep İlhan, Si̇nem Yilmaz, Petek Ballar Kirmizibayrak, Tuğba Taşkin Tok
Design, Synthesis, Biological Evaluation And Molecular Docking Of Novel Molecules To Parp-1 Enzyme, Fati̇h Tok, Bedi̇a Kaymakçioğlu, Recep İlhan, Si̇nem Yilmaz, Petek Ballar Kirmizibayrak, Tuğba Taşkin Tok
Turkish Journal of Chemistry
Poly (ADP-ribose) polymerase (PARP) enzyme catalyzes the transfer of ADP-ribose into target proteins. Therefore, PARP is responsible for DNA repair, cell proliferation, and cell death. In this study, potential PARP enzyme inhibitors were designed and synthesized. The synthesized compounds were elucidated by Fourier-transform infrared spectroscopy, $^{1}$H NMR, $^{13}$C NMR, heteronuclear single-quantum correlation, and mass spectrometry, and their purity was checked via thin-layer chromatography, high-performance liquid chromatography, and elemental analysis. A total of 63 newly synthesized compounds were screened in terms of PARP inhibition by cellular PARylation assay in the HeLa cell line. It was found that 19 compounds significantly inhibited …
Natural Diterpenoid Alysine A Isolated From Teucrium Alyssifolium Exerts Antidiabetic Effect Via Enhanced Glucose Uptake And Suppressed Glucose Absorption, Alaatti̇n Şen, Buket Ayar, Anil Yilmaz, Özden Özgün Acar, Gurbet Çeli̇k Turgut, Gülaçti Topçu
Natural Diterpenoid Alysine A Isolated From Teucrium Alyssifolium Exerts Antidiabetic Effect Via Enhanced Glucose Uptake And Suppressed Glucose Absorption, Alaatti̇n Şen, Buket Ayar, Anil Yilmaz, Özden Özgün Acar, Gurbet Çeli̇k Turgut, Gülaçti Topçu
Turkish Journal of Chemistry
Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium. The lactate dehydrogenase (LDH) cytotoxicity assay, glucose uptake test, glucose utilization (glycogen content) test, glucose transport test, glucose absorption ($\alpha $-glucosidase activity) test, insulin secretion test, RNA isolation and cDNA synthesis assay, qPCR quantification assays, and statistical analyses were carried out in the present study. Alysine A exerted the following effects at non-cytotoxic doses: . Enhanced the glucose uptake, as much as the insulin in …
Anticancer And Antiangiogenesis Activities Of Novel Synthesized 2-Substituted Benzimidazoles Molecules, Adem Güner, Eli̇fsu Polatli, Tamer Akkan, Hakan Bektaş, Canan Albay
Anticancer And Antiangiogenesis Activities Of Novel Synthesized 2-Substituted Benzimidazoles Molecules, Adem Güner, Eli̇fsu Polatli, Tamer Akkan, Hakan Bektaş, Canan Albay
Turkish Journal of Chemistry
In this study, novel 2-substituted benzimidazoles molecules having triazole, thiadiazole, and oxadiazole rings were synthesized and were evaluated by anticancer, antioxidant/oxidant status, genotoxicity, and antiangiogenesis assays. Anticancer activity of the compounds was determined by MTT (0.5, 5, and 50 $\mu $g/mL) and lactate dehydrogenase (LDH) release assays against human prostate and breast cancer cells. Oxidative status of cells was elicited by total oxidative stress and total antioxidant capacity methods. Chick chorioallantoic membrane assay was used to evaluate the antiangiogenic activity. Genotoxicity was evaluated by the sister chromatid exchange (SCE) and micronucleus (MN) tests in lymphocyte cultured human blood. Our results …