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Articles 661 - 690 of 1022
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Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to determine the reference ranges of 25-hydroxyvitamin D3 (25(OH)vitD3) by an indirect method using data obtained from patients over the course of 3 years. Materials and methods: The 25(OH)vitD3 test results of the patients who applied to the medical biochemistry laboratory of Balıkesir State Hospital between the years of 2010 and 2014 were analyzed. Patient data were retrospectively taken from the laboratory information system. The 25(OH)vitD3 levels of patients were examined after exclusion of outliers. Patients were divided into subgroups according to season, sex, and age. The central 95% reference intervals were calculated …
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
Turkish Journal of Medical Sciences
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The Utility Of Ebus-Tbna In Mediastinal Or Hilar Lymph Node Evaluation In Extrapulmonary Malignancy, Onur Fevzi̇ Erer, Ceyda Anar, Serhat Erol, Seri̇r Özkan
The Utility Of Ebus-Tbna In Mediastinal Or Hilar Lymph Node Evaluation In Extrapulmonary Malignancy, Onur Fevzi̇ Erer, Ceyda Anar, Serhat Erol, Seri̇r Özkan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of mediastinal and hilar lymph nodes (LNs) in patients with known extrapulmonary malignancy. Materials and methods: Between March 2011 and August 2013, 378 EBUS-TBNA procedures were performed. Sixty-three (16.6%) of these were performed on known extrapulmonary malignancy patients. Results: There were 28 male and 35 female patients, with median ages of 65 years (min-max: 53-87) and 57 years (min-max: 39-76), respectively. From the 63 cases, 138 lymph nodes (LNs) were sampled with EBUS-TBNA (median: 2 LNs/patient; min-max: 1-4). …
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …
The Clinical And Laboratory Characteristics, Treatments, And Outcomes Of Patients With Brucella Epididymo-Orchitis (Beo) Compared To Those Without Beo*, Hasan Naz, Pinar Korkmaz, Fi̇gen Çevi̇k, Nevi̇l Aykin
The Clinical And Laboratory Characteristics, Treatments, And Outcomes Of Patients With Brucella Epididymo-Orchitis (Beo) Compared To Those Without Beo*, Hasan Naz, Pinar Korkmaz, Fi̇gen Çevi̇k, Nevi̇l Aykin
Turkish Journal of Medical Sciences
Background/aim: We aim to describe the clinical and laboratory characteristics, treatment, and outcomes of 21 patients with Brucella epididymo-orchitis (BEO) from Eskişehir Yunus Emre State Hospital, Turkey. Materials and methods: A total of 21 patients with BEO who were diagnosed and followed in the Infectious Diseases Clinic between June 2001 and June 2013 were evaluated retrospectively. Results: One hundred and twenty-eight of 192 patients evaluated throughout the study were male and BEO was determined in 21 (16.4%) patients. A total of 18 (85.7%) patients had a titer of ≥1:160 in standard agglutination test (STA). Three patients with STA
An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed
An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed
Turkish Journal of Medical Sciences
Background/aim: The prevalences of Plasmodium falciparum and Plasmodium vivax are increasing rapidly in Pakistan, but recent data on the epidemiology of malaria are not properly reported with scarce diagnostic methods for quick diagnosis. This study was designed to determine the current prevalence and distribution of Plasmodium species in the vicinity of Rawalpindi and Islamabad and report on the validity of the immunochromatographic test (ICT) in diagnosing malarial infections. Materials and methods: A total of 1500 blood samples obtained from a local hospital were screened during the course of this study via microscopic examination and ICT. Results: It was seen that …
Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani
Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani
Turkish Journal of Medical Sciences
Background/aim: T-helper cell type 1 (Th1)/Th2 cytokine balance is involved in the resistance or susceptibility to Brucella infection. The analysis of cytokine levels is valuable to determine the role of the immune system in Brucella prognosis. The aim of this study was to investigate the levels of serum interleukin-17 (IL-17) and transforming growth factor beta (TGF-β) and their alterations with treatment in patients with acute brucellosis. Materials and methods: TGF-β was tested in 33 acute brucellosis patients and 19 controls and IL-17 was analyzed in 40 patients and 12 controls. Cytokine levels were tested in controls and patients before and …
The Efficacy Of Oral Ribavirin On Clinical And Laboratory Parameters Incrimean?Congo Hemorrhagic Fever: An Observational Study From Turkey*, Günay Ertem, Meli̇ha Çağla Sönmezer, Fati̇h Temoçi̇n, Çi̇ğdem Ataman Hati̇poğlu, Necla Tülek, Behi̇ç Oral
The Efficacy Of Oral Ribavirin On Clinical And Laboratory Parameters Incrimean?Congo Hemorrhagic Fever: An Observational Study From Turkey*, Günay Ertem, Meli̇ha Çağla Sönmezer, Fati̇h Temoçi̇n, Çi̇ğdem Ataman Hati̇poğlu, Necla Tülek, Behi̇ç Oral
Turkish Journal of Medical Sciences
Background/aim: In this observational study, the effects of oral ribavirin on clinical and laboratory parameters and blood products use in patients with Crimean-Congo hemorrhagic fever (CCHF) were evaluated. Materials and methods: CCHF patients (n = 100) who were hospitalized between 2007 and 2010 were included. Oral ribavirin was administered to 56 patients with symptom duration less than 5 days. Forty-four patients did not receive ribavirin (control group). The patients that received ribavirin in the first 3 days following the initiation of symptoms were designated as Group 1 (n = 29) and the others were designated as Group 2. Results: Ribavirin-treated …
Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun
Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun
Turkish Journal of Medical Sciences
Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 …
Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r
Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to characterize strains genotypically, to determine their phylogenetic relationships, to investigate the presence of the papG gene, and to compare their antibiotic susceptibility test results. Materials and methods: Seventy pathogenic E. coli strains were isolated from both urine and blood cultures of patients with the preliminary diagnosis of urosepsis who were referred to the Ege University Faculty of Medicine, Bacteriology Laboratory of Medical Microbiology Department in İzmir. All of these strains were examined for the papG gene and phylogenetic groups with the multiplex polymerase chain reaction technique. Pulsed-field gel electrophoresis and multilocus sequence …
Distribution Of Hepatitis C Virus Genotypes Among Intravenous Drug Users In The Çukurova Region Of Turkey, Enver Üçbi̇lek, Bahri̇ Abayli, Mahmut Bakir Koyuncu, Durdane Midikli, Süveyda Gözüküçük, Alper Akdağ, Osman Özdoğan, Engi̇n Altintaş, Orhan Sezgi̇n
Distribution Of Hepatitis C Virus Genotypes Among Intravenous Drug Users In The Çukurova Region Of Turkey, Enver Üçbi̇lek, Bahri̇ Abayli, Mahmut Bakir Koyuncu, Durdane Midikli, Süveyda Gözüküçük, Alper Akdağ, Osman Özdoğan, Engi̇n Altintaş, Orhan Sezgi̇n
Turkish Journal of Medical Sciences
Background/aim: The most common hepatitis C virus (HCV) genotype in Turkey is genotype 1. However, there has not been a study about the distribution of HCV genotypes among intravenous drug users (IVDUs) in the Çukurova region of Turkey. This study was planned to understand if there is a difference between IVDUs and the normal population. Materials and methods: Between May 2010 and May 2014, anti-HCV positive IVDUs who applied to the 6 hospitals in the Çukurova region of Turkey were included in this study. Their HCV genotypes were studied. Results: Ninety-seven anti-HCV positive IVDUs were screened in terms of HCV …
Cytomegalovirus Hepatitis In 49 Pediatric Patients With Normal Immunity, Hasan Tezer, Sali̇ha Kanik Yüksek, Belgi̇n Gülhan, Asli Nur Özkaya Parlakay, Ceyda Tuna Kirsaçlioğlu
Cytomegalovirus Hepatitis In 49 Pediatric Patients With Normal Immunity, Hasan Tezer, Sali̇ha Kanik Yüksek, Belgi̇n Gülhan, Asli Nur Özkaya Parlakay, Ceyda Tuna Kirsaçlioğlu
Turkish Journal of Medical Sciences
Background/aim: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. Materials and methods: A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. Results: The median age of the patients was 5.81 ± 6.49 months and 57.1% were female. Complaints were prolonged jaundice, vomiting, diarrhea, and abdominal distension. Seventeen patients (34.6%) had congenital or probable congenital CMV infection, while 32/49 (65.3%) had perinatal CMV infection. CMV …
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of balneotherapy on acute, process-related, and cumulative peripheral cardiac responses and pulmonary functions in patients with musculoskeletal disorders. Materials and methods: Ninety-eight patients with musculoskeletal disorders referred to physiotherapy with balneotherapy were recruited. The patients received balneotherapy for 20 min 5 times per week for 2 weeks. Blood pressure and pulse were measured at the 0th, 5th, 10th, 20th, and 30th minutes during the 1st and 10th sessions. All patients were subjected to pulmonary function testing before balneotherapy and after the 10th session. Results: It was found that systolic blood pressure decreased …
Evaluation Of Epidemiological Characteristics And Risk Factors Affecting Mortality In Patients With Candidemia, Fatma Yilmaz Karadağ, Pinar Ergen, Özlem Aydin, Arzu Doğru, Berri̇n Tanidir, Mustafa Haluk Vahaboğlu
Evaluation Of Epidemiological Characteristics And Risk Factors Affecting Mortality In Patients With Candidemia, Fatma Yilmaz Karadağ, Pinar Ergen, Özlem Aydin, Arzu Doğru, Berri̇n Tanidir, Mustafa Haluk Vahaboğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine epidemiologic characters of patients with candidemia and to evaluate risk factors that can affect mortality rates among these patients. Materials and methods: Patients admitted to the İstanbul Medeniyet University Göztepe Training Hospital between 2009 and 2011 who had a positive blood culture for Candida spp. during hospitalization were studied retrospectively for demographic characteristics and risk factors. Statistical comparisons were estimated with the Stata 12 package. Independent variables associated with mortality were estimated by Cox regression analyses. Results: A total of 89 patients were identified with a positive blood culture. Of the …
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Turkish Journal of Medical Sciences
Background/aim: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. Materials and methods: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. Results: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain …
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Materials and methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Results: The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen …
Treatment Efficacy And Superinfection Rates In Complicated Urinarytract Infections Treated With Ertapenem Or Piperacillin Tazobactam, Murat Di̇zbay, Hasan Selçuk Özger, Ömer Karaşahi̇n, Emi̇ne Füsun Karaşahi̇n
Treatment Efficacy And Superinfection Rates In Complicated Urinarytract Infections Treated With Ertapenem Or Piperacillin Tazobactam, Murat Di̇zbay, Hasan Selçuk Özger, Ömer Karaşahi̇n, Emi̇ne Füsun Karaşahi̇n
Turkish Journal of Medical Sciences
Background/aim: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. Materials and methods: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. Results: In both groups, urine cultures after 48 h were negative for the initial uropathogen. The frequency of superinfection was 29.4% in the ertapenem group and 8.3% in the piperacillin-tazobactam group over the duration of treatment (P < 0.05). Urinary catheterization increased the superinfection risk 2.88-fold in the ertapenem group and diabetes mellitus increased the risk 8.50-fold in the piperacillin-tazobactam group (CI: 1.44-5.76 and 1.16-62.09, respectively, P < 0.05). The main pathogen isolated from superinfection in the ertapenem group after 48 h was Enterococcus spp. (71.4%). Conclusion: Both ertapenem and piperacillin-tazobactam were effective in the treatment of cUTIs caused by ESBL-producing microorganisms. A high frequency of superinfection in the ertapenem group was the result of Enterococcus and Pseudomonas spp., against which ertapenem is not active. In the presence of urinary catheterization, diabetes mellitus, and urological intervention, patients should be closely monitored for the development of a superinfection, especially patients receiving ertapenem.
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Turkish Journal of Medical Sciences
Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were recruited and treated with nevirapine-based antiretroviral therapy. Plasma nevirapine and metabolite concentrations were assayed using high-performance liquid chromatography via liquid-liquid extraction. Results: Thirty-nine (34.8%) of the patients had no 3-OH NVP detected …
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA58, and NDM-1 was investigated by PCR. Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% …
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results. Materials and methods: In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used. Results: Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results …
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Turkish Journal of Medical Sciences
Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics. Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician. Results: A total of 1906 specialists from 20 cities in Turkey participated …
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to evaluate nosocomial infections occurring in our hospital intensive care units (ICUs) and the risk factors for these, and to determine the effect of these infections on mortality and cost. Materials and methods: This retrospective study was performed via infection control committee surveillance data, ICU records, and information processing data between 1 January and 31 December 2013 at the Kanuni Education and Research Hospital. Results: A total of 309 nosocomial infections were observed in 205 out of 566 patients. The density of nosocomial infections was 25.4 in 1000 patient days. Hospitalization was prolonged, …
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = …
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Turkish Journal of Veterinary & Animal Sciences
The purposes of this study were to investigate plasmid profiles of the isolated virulent (VapA positive) agents by RFLP and to determine the quantitative aspects of Rhodococcus equi in the feces of adult horses and foals, as well as in soil. The frequency of detection of R. equi and virulent R. equi in fecal samples and soil was studied from 20 farms in the Şanlıurfa region. A total of 315 samples were examined. Nasal swabs from 25 foals with pneumonia were also analyzed. R. equi was isolated and identified from 263 (83.4%) samples originating from 15 out of 20 farms. …
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to investigate the relation between porcine epidemic diarrhea (PED) and porcine reproductive and respiratory syndrome virus (PRRSV). Here, we constructed a dynamic clinical experimental model in which sows were infected with PRRSV. The stability of the experimental model was surveyed by detecting the levels of antibodies against classical swine fever virus (CSFV) or PRRSV, respectively. In both group A (infected group) and group B (healthy group), the CSFV antibody level was not significantly different (P > 0.05). In group B, the PRRSV antibody level was also not significantly different (P > 0.05) at the three times …
Mucormycosis: A 10-Year Experience At A Tertiary Care Center In Turkey, Süheyla Kömür, Ayşe Seza İnal, Behi̇ce Kurtaran, Aslihan Ulu, Aysun Uğuz, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova
Mucormycosis: A 10-Year Experience At A Tertiary Care Center In Turkey, Süheyla Kömür, Ayşe Seza İnal, Behi̇ce Kurtaran, Aslihan Ulu, Aysun Uğuz, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova
Turkish Journal of Medical Sciences
Background/aim: Mucormycosis is a rare invasive fungal infection most commonly encountered in the immunocompromised host. We analyzed 51 adult patients treated for mucormycosis between 2003 and 2013 and recorded at a tertiary university hospital in Turkey. Materials and methods: We examined the following data for all patients: age, sex, predisposing disease, symptoms, treatment, surgical procedure, concomitant infections, intensive care requirement, and outcomes. Results: During the study period 51 cases of mucormycosis were documented; 54.9% of the patients were female. The mean age was 44.2 ± 18.2 years. Rhinocerebral presentation was reported in 94.1% of patients. Almost all patients (88.2%) had …
In Ovo Feeding With Ss-Hydroxy Ss-Methylbutyrate And Broilerperformance, Intestinal Health, And Immunity Status, Ömer Hakan Muğlali, Mustafa Salman, Ayhan Gacar, Fi̇li̇z Akdağ, Mustafa Yavuz Gülbahar, Alper Çi̇ftçi̇, Ertan Emek Onuk, Fi̇li̇z Karadaş, Hüseyi̇n Eseceli̇
In Ovo Feeding With Ss-Hydroxy Ss-Methylbutyrate And Broilerperformance, Intestinal Health, And Immunity Status, Ömer Hakan Muğlali, Mustafa Salman, Ayhan Gacar, Fi̇li̇z Akdağ, Mustafa Yavuz Gülbahar, Alper Çi̇ftçi̇, Ertan Emek Onuk, Fi̇li̇z Karadaş, Hüseyi̇n Eseceli̇
Turkish Journal of Veterinary & Animal Sciences
The effects of in ovo administration of β-hydroxy-β-methylbutyrate (HMB) on broiler performance, intestinal health, and immunity were investigated. At day 18 of incubation, fertile eggs were divided into negative (no injection) and positive (physiologic serum injection) controls and three HMB treatment groups. HMB solution was injected at 0.1% (Group 1), 0.2% (Group 2), and 0.3% (Group 3) concentrations. There were no significant differences between the groups for live weight gain, feed conversion rate, and hot carcass, breast meat, liver, and heart weight. However, the gizzard weight in Group 1 was significantly higher than those in the other groups (P < 0.05). Although the intestinal villi lengths in the treatment Groups 1 and 3 on day 20 were greater than those in the control groups (P < 0.01), at the end of the experiment there were no significant differences among the groups. For antibody levels, the differences between groups on days 4 and 42 were highly significant (P < 0.01), and the antibody levels in Group 2 were higher than those in the other groups. Separately, growth performance and antibody levels were positively correlated with the length of villi in Group 2 (HMB 0.2%).
Purification Of Avian Influenza Virus (H9n2) From Allantoic Fluidby Size-Exclusion Chromatography, Ali Nazari Shirvan, Maedeh Samianifard, Naser Ghodsian
Purification Of Avian Influenza Virus (H9n2) From Allantoic Fluidby Size-Exclusion Chromatography, Ali Nazari Shirvan, Maedeh Samianifard, Naser Ghodsian
Turkish Journal of Veterinary & Animal Sciences
Avian influenza viruses represent a rising threat of pandemic influenza. Allantoic fluid including influenza virus H9N2 was run on downstream processing to purify the virus. To do this, allantoic fluid was clarified and concentrated. It was applied to size exclusion chromatography. Different parameters such as ovalbumin, protein content, and hemagglutinin activity were determined to confirm the purity. The results may suggest that this method is quite efficient for achieving a purified H9N2 influenza virus and further reveal that size-exclusion chromatography is a practical method for purifying avian influenza viruses. In conclusion, this procedure can be used in vaccine production and …
The Efficacy Of Kaolin Clay In Reducing The Duration And Severity Of `Heat' Diarrhea In Foals, Magdalena Pieszka, Jaroslaw Luszczynski, Magdalena Hedrzak, Katerina Goncharova, Stefan G. Pierzynowski
The Efficacy Of Kaolin Clay In Reducing The Duration And Severity Of `Heat' Diarrhea In Foals, Magdalena Pieszka, Jaroslaw Luszczynski, Magdalena Hedrzak, Katerina Goncharova, Stefan G. Pierzynowski
Turkish Journal of Veterinary & Animal Sciences
'Heat' diarrhea in foals is an onerous but not life-threatening ailment, which indicates that it may be of osmotic origin. This was confirmed by a successful attempt, presented in this paper, to alleviate the severity and duration of foal heat diarrhea with the use of a typical absorbent, kaolin clay, as a feed additive, usually applied in feed production as an anticaking agent. Based on the present results, it can be concluded that treatment of foals maintained on different stud farms with a kaolin paste reduced the duration of heat diarrhea and alleviated its severity (P < 0.05 and P = 0.001). The observed action of kaolin clay, an excellent absorbent, suggests that the so-called heat diarrhea can be caused by disturbances in the intestinal osmotic balance at this specific age of foals. The use of this preparation can reduce the risk of secondary pathological viral or bacterial diarrhea and the requirement for veterinary intervention in foal management. It can also shorten the care period and increase foal well-being, essential for the normal development of a young horse. In addition, prophylactic application of an antidiarrheal preparation based on an industrial by-product, i.e. A cheap component, will reduce the costs of foal care.
Seroepidemiological Survey Of Bovine Tick-Borne Infections In Theblack Sea Region Of Turkey, Mustafa Açici, Cenk Soner Bölükbaş, Gökmen Zafer Pekmezci̇, Ali̇ Tümay Gürler, Şi̇nasi̇ Umur, Kadri̇ Zafer Karaer, Ayşe Çakmak, Ayşe Serpi̇l Nalbantoğlu, Cevat Ni̇sbet
Seroepidemiological Survey Of Bovine Tick-Borne Infections In Theblack Sea Region Of Turkey, Mustafa Açici, Cenk Soner Bölükbaş, Gökmen Zafer Pekmezci̇, Ali̇ Tümay Gürler, Şi̇nasi̇ Umur, Kadri̇ Zafer Karaer, Ayşe Çakmak, Ayşe Serpi̇l Nalbantoğlu, Cevat Ni̇sbet
Turkish Journal of Veterinary & Animal Sciences
Babesiosis, theileriosis, and anaplasmosis are the tick-borne diseases of cattle in most of the tropical areas and Turkey. A total of 270 cattle were randomly selected from 27 villages and 77 farms in the Black Sea Region of Turkey for the determination of infections by Babesia bigemina and Anaplasma marginale by using the indirect fluorescent antibody (IFA) test and the competitive enzyme-linked immunosorbent assay (cELISA). Of those, 242 and 256 sera were also analyzed for antibodies against Theileria annulata and Babesia bovis infections using the IFA test, respectively, during the period of June 2006 to June 2007. Of the 256 …