Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Cytotoxicity (8)
- Turkey (6)
- 1 (5)
- 3 (5)
- Molecular docking (4)
-
- Antibacterial (3)
- New records (3)
- Reproduction (3)
- Synthesis (3)
- Taxonomy (3)
- ADMET (2)
- Acetylcholinesterase (2)
- Antibacterial activity (2)
- Antifungal (2)
- Antimicrobial activity (2)
- Antioxidant (2)
- Antioxidant activity (2)
- Baculovirus (2)
- Biological studies (2)
- In silico (2)
- In vitro (2)
- Malacosoma neustria NPV (2)
- Molecular modeling (2)
- Pharmacokinetics (2)
- Spectroscopy (2)
- Virus replication (2)
- X-ray structure (2)
- 16SrRNA (1)
- 2-a]pyrimidine (1)
- 3-aminopyridine (1)
- Publication Year
Articles 1 - 30 of 131
Full-Text Articles in Entire DC Network
Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇
Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇
Turkish Journal of Chemistry
Cancer therapy is often limited by the systemic toxicity and dose-dependent adverse effects of conventional chemotherapeutic agents such as doxorubicin (DOX). In this study, a folic acid-functionalized molecularly imprinted polymeric complex based on poly(HEMA) crosslinked with ethylene glycol dimethacrylate was synthesized for the controlled release of DOX in combination with quercetin (QUE), a flavonoid known for its antioxidant and chemosensitizing properties. The aim of this work was to develop and physicochemically characterize a preliminary targeted drug delivery platform at a material-design level. The polymeric complex was synthesized via free-radical polymerization following a DOX–QUE precomplex formation step. Structural characterization was performed …
From Introduction To Biomass Dominance: The Invasive Fish Striped Piggy (Pomadasys Stridens) Reshaping Demersal Assemblages In The Eastern Mediterranean, Mehmet Cengi̇z Deval
From Introduction To Biomass Dominance: The Invasive Fish Striped Piggy (Pomadasys Stridens) Reshaping Demersal Assemblages In The Eastern Mediterranean, Mehmet Cengi̇z Deval
Turkish Journal of Zoology
Rapid increases in the abundance and biomass of nonindigenous species have the potential to profoundly reshape demersal fish assemblages in the Eastern Mediterranean Sea, yet quantitative evidence from long-term standardized surveys remains scarce. In the present study, temporal changes in biomass dynamics and community structure were assessed using fishery-independent trawl surveys conducted on the continental shelf of Antalya Bay (GSA 24) during two periods a decade apart (2009–2010 and 2020–2021), with particular focus on the Lessepsian striped piggy Pomadasys stridens. Based on the second survey, in which both daytime and nocturnal sampling were conducted, the biomass index (BI) differed significantly …
Investigating The Structure And Bioactivity Of Lanthanum Coordination Compounds, Shantanu Kadam, Bhushan Dhale, Bapu Yamgar, Swaminath Bhattar
Investigating The Structure And Bioactivity Of Lanthanum Coordination Compounds, Shantanu Kadam, Bhushan Dhale, Bapu Yamgar, Swaminath Bhattar
Turkish Journal of Chemistry
Lanthanum metal complexes were synthesized using a classical condensation method by reacting lanthanum nitrate salts with a bidentate ligand in a 1:2:1 molar ratio (M:L:L). The formation and structure of the resulting complexes were confirmed through a combination of analytical techniques, including Fourier transformation infrared spectroscopy, thermal gravimetric analysis, X-ray diffraction, elemental microanalysis, and scanning electron microscopy. The lanthanum complexes synthesized exhibited strong in vitro antimicrobial activity. Antibacterial screening showed inhibition zones of 18–26 mm against Staphylococcus aureus and Escherichia coli, surpassing those of the reference drug ciprofloxacin (16–20 mm). Antifungal studies demonstrated inhibition zones of 15–23 mm against Candida …
Cytotoxic And Genotoxic Effects Of Minor Temperature Changes And Zinc Oxide Nanoparticles Synthesized Using Plantago Major On Oncorhynchus Mykiss Gonadal Cells, Semra Çi̇çek, Sevda Işik
Cytotoxic And Genotoxic Effects Of Minor Temperature Changes And Zinc Oxide Nanoparticles Synthesized Using Plantago Major On Oncorhynchus Mykiss Gonadal Cells, Semra Çi̇çek, Sevda Işik
Turkish Journal of Zoology
Temperature changes and nanoparticle exposure have emerged as critical environmental stressors with potential cytotoxic and genotoxic effects on aquatic species. This study investigates the impact of zinc oxide nanoparticles (ZnO NPs), synthesized using Plantago major leaves, on Oncorhynchus mykiss gonadal (RTG-2) cells under different temperature conditions (23 °C, 24 °C, and 25 °C). RTG-2 cells were exposed to hexagonal ZnO NPs (≤100 nm) at concentrations of 6.25, 12.5, 25, 50, 75, and 100 μg/mL for 24 and 48 h. Cytotoxicity was assessed using the sulforhodamine B assay, and genotoxicity was evaluated via the comet assay. Results demonstrated that both temperature …
Discovery And Characterization Of Selective Lipase-Inhibiting Polyheterocyclic Derivatives: A Combined In Silico And In Vitro Study, Madjda Benguechoua, Mebarka Imane Benguechoua, Khedidja Benarous, Houssem Boulebd, Ibtissem Kadi, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka, Mohamed Yousfi
Discovery And Characterization Of Selective Lipase-Inhibiting Polyheterocyclic Derivatives: A Combined In Silico And In Vitro Study, Madjda Benguechoua, Mebarka Imane Benguechoua, Khedidja Benarous, Houssem Boulebd, Ibtissem Kadi, Ari̇f Mermer, Yakup Şi̇ri̇n, Alaeddine Kaouka, Mohamed Yousfi
Turkish Journal of Biology
Background/aim: Obesity has become a global health crisis with an increasing prevalence, necessitating the search for effective therapies. Schiff base derivatives, known for their broad pharmacological activities, have gained attention as potential antiobesity agents. This study aimed to investigate the lipase inhibitory potential of novel Schiff base derivatives and assess their drug-like properties through in vitro assays and in silico methods. Materials and methods: The lipase inhibitory activity of synthesized Schiff base derivatives was evaluated using in vitro assays, with IC50 values determined for each compound. Additionally, in silico ADMET predictions (absorption, distribution, metabolism, excretion, and toxicity), molecular docking studies, …
1,3,4-Thiadiazole Derivatives As Pi3ks Inhibitor: Design, In Silico Studies, Synthesis, Characterization, And Antimicrobial Evaluation, Dharmvir Singh, Pankaj Kumar, Anoop Kumar, Vivek V. Bhosale, Kalicharan Sharma, Deepak Kumar, Ramchander Khatri, Tanuj Hooda, Amit Lather
1,3,4-Thiadiazole Derivatives As Pi3ks Inhibitor: Design, In Silico Studies, Synthesis, Characterization, And Antimicrobial Evaluation, Dharmvir Singh, Pankaj Kumar, Anoop Kumar, Vivek V. Bhosale, Kalicharan Sharma, Deepak Kumar, Ramchander Khatri, Tanuj Hooda, Amit Lather
Turkish Journal of Chemistry
Since PI3Ks are targeted by a variety of bacterial pathogens, they represent a promising target for host-directed immune therapy and may be beneficial in managing persistent bacterial infections. In the present study, computational studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives for phosphoinositide-3-kinases (PI3Ks) inhibitors were carried out using dock scores, Glide scores, and the MMGBSA dG method, with comparison to standard drugs (ofloxacin and fluconazole). A series of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives (D1-D17) were synthesized and evaluated for their in vitro antimicrobial activity against both gram-positive and gram-negative bacterial strains, as well as fungal strains, using the tube dilution method. The synthesized compounds were characterized …
Bibliometric Analysis Of Colchicine In Cardiovascular Health: Trends, Key Contributors, And Global Collaborations, Meltem Sertbaş, Özlem Özaydin, Habi̇p Yilmaz, Abdullah Emre Güner, Özden Güdük, Nalan Okuroğlu, Ali̇ Özdemir, Yaşar Sertbaş
Bibliometric Analysis Of Colchicine In Cardiovascular Health: Trends, Key Contributors, And Global Collaborations, Meltem Sertbaş, Özlem Özaydin, Habi̇p Yilmaz, Abdullah Emre Güner, Özden Güdük, Nalan Okuroğlu, Ali̇ Özdemir, Yaşar Sertbaş
Turkish Journal of Medical Sciences
Background/aim: The study aims to systematically analyze the body of literature concerning the effects of colchicine on the cardiovascular system, providing a comprehensive evaluation of the current knowledge and highlighting the clinical and scientific relevance of colchicine in this field.
Materials and methods: Data were obtained from the Web of Science Core Collection database on November 17, 2024. The search terms included “Colchicine” AND "Cardiovascular effects" OR "Cardiovascular diseases" OR "Heart diseases" OR "Coronary artery disease" OR "Myocarditis" OR "Pericarditis" OR "Atherosclerosis" OR "Heart failure" OR "Myocardial infarction." No restrictions were applied regarding publication date or language, ensuring the comprehensive …
A New Water-Soluble Silicon Phthalocyanine That Catalyzes The Photodegradation Of Pollutant Dyes, Damla Nur Kaya, Behi̇ce Sebnem Sesalan
A New Water-Soluble Silicon Phthalocyanine That Catalyzes The Photodegradation Of Pollutant Dyes, Damla Nur Kaya, Behi̇ce Sebnem Sesalan
Turkish Journal of Chemistry
The removal of color arising from water-soluble dyes in wastewaters is necessary to counter the threat to health. Because of thedifficulty in elimination of these dyes by conventional methods, their photodegradation using photosensitizers such as phthalocyanines(Pcs) has been employed recently. When compared to peripherally substituted derivatives, silicon Pcs are reported to be morebiocompatible with low toxicity. Thus a new silicon Pc substituted with two quaternized dimethylamino phenoxy units (compound 1)and its quaternized derivative (compound 2) were synthesized to test its photocatalytic ability employing the dyes methylene blue (MB),eosin B (EB), erythrosine (ERB), sulforhodamine B (SRB), and brilliant blue FCF (BRB), …
The Effects Of Active Substances Of Clinically Important Drugs On The Survival, Development, And Some Adult Traits Of Drosophila Melanogaster Meigen (Diptera: Drosophilidae), Gökçe Üstündağ, Kemal Büyükgüzel, Ender Büyükgüzel
The Effects Of Active Substances Of Clinically Important Drugs On The Survival, Development, And Some Adult Traits Of Drosophila Melanogaster Meigen (Diptera: Drosophilidae), Gökçe Üstündağ, Kemal Büyükgüzel, Ender Büyükgüzel
Turkish Journal of Zoology
Drosophila melanogaster Meigen (Diptera: Drosophilidae) was used as a model organism and fed on an artificial diet with different clinically important drugs under laboratory conditions. The effects of fluconazole, acyclovir, and piperazine on the survivorship, development, adult longevity, fecundity, and hatching rate of the insect were investigated. The results showed that the highest concentration of fluconazole (1250 mg/L) significantly decreased both the rate of larvae reaching the 3rd instar and the rate of pupation from 93.00 ± 2.95% to 11.00 ± 2.59% (χ2 = 134.696; df = 1; p = 0.0001). The highest concentration of acyclovir (200 mg/L) significantly reduced …
Diversity And Evenness Of Birds During Seasonal Paddy Farming Practice In Southwestern Sarawak, Ivana Berlinda Bilang, Mohamad Fizl Sidq Ramji, Siti Nurlydia Sazali, Andrew Alek Tuen, Wan Nurainie Wan Ismail
Diversity And Evenness Of Birds During Seasonal Paddy Farming Practice In Southwestern Sarawak, Ivana Berlinda Bilang, Mohamad Fizl Sidq Ramji, Siti Nurlydia Sazali, Andrew Alek Tuen, Wan Nurainie Wan Ismail
Turkish Journal of Zoology
The influence of seasonal paddy farming activities on the paddy field environment and its composition of birds could be visually observed but has yet to be systematically studied and is still relatively understudied in Malaysian Borneo. Earlier research relied solely on point counts and not using line transects or mist nets for data collection could have resulted in missing and biased findings. Thus, this study aims to evaluate and compare species diversity and evenness of birds in different paddy stages in southwestern Sarawak with previous studies conducted in the region. We reported a higher species richness than previous reports from …
New Imidazolidindionedioximes And Their Pt(Ii) Complexes: Synthesis And Investigation Of Their Antitumoral Activities On Breast Cancer Cells, Emrah Karahan, Tuğba Gençoğlu Katmerli̇kaya, Emel Önal, Aydan Dağ, Ayşe Gül Gürek, Vefa Ahsen
New Imidazolidindionedioximes And Their Pt(Ii) Complexes: Synthesis And Investigation Of Their Antitumoral Activities On Breast Cancer Cells, Emrah Karahan, Tuğba Gençoğlu Katmerli̇kaya, Emel Önal, Aydan Dağ, Ayşe Gül Gürek, Vefa Ahsen
Turkish Journal of Chemistry
Breast cancer is one of the most common types of cancer worldwide and has the most lethality ratio for females among all cancers. Although current cancer therapeutics have made considerable advancements, there is still room for improvement in terms of efficacy. Many anticancer drugs have a risk of causing serious adverse effects due to their non-specific cytotoxic effects on both tumor and healthy cells. New therapeutics might have a greater ability to kill cancer cells, reduce the volume of tumors, and improve overall therapy response rates. Herein, we report the efficient synthesis and characterization of three amphi vic-dioximes and their …
Synthesis And Characterization Of New Hexahydroquinoline Derivatives, Evaluation Of Their Cytotoxicity, Intracellular Ros Production And Inhibitory Effects On Inflammatory Mediators, Ezgi̇ Pehli̇vanlar, Deni̇z Arca Çakir, Sonia Sanajou, Hülya Tezel Yalçin, Terken Baydar, Pinar Erkekoğlu, Hani̇fe Avci, Rahi̇me Şi̇mşek
Synthesis And Characterization Of New Hexahydroquinoline Derivatives, Evaluation Of Their Cytotoxicity, Intracellular Ros Production And Inhibitory Effects On Inflammatory Mediators, Ezgi̇ Pehli̇vanlar, Deni̇z Arca Çakir, Sonia Sanajou, Hülya Tezel Yalçin, Terken Baydar, Pinar Erkekoğlu, Hani̇fe Avci, Rahi̇me Şi̇mşek
Turkish Journal of Chemistry
Inflammation is a response to injury and infection in the organism. It can be categorized as acute and chronic inflammation. Chronic inflammation is the underlying cause of many diseases such as Alzheimer's, diabetes, rheumatoid arthritis, atherosclerosis and cardiovascular diseases. Recent studies have proven the anti-inflammatory properties of 1,4-dihydropyridines (1,4-DHPs) and its derivatives, which have many biological properties including calcium channel blockers. The structures of the synthesized compounds were elucidated by IR, 1H-NMR, 13C-NMR and HRMS methods. The cytotoxic properties of the compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method in 3T3 cell line. Among the 15 compounds, the three compounds …
Antiviral And Cytotoxic Activities And Chemical Profiles Of Two Species Of Abies Nordmanniana From Türkiye, Nazli Sarikahya, Gaye Sümer Okkali, Furkan Ozan Çöven, Sevda Zeinali̇, Gülce Gucur, Ayşe Di̇la Çağlar, Ece Uyar, Ahmet Ceyhan Gören, Ayşe Nalbantsoy
Antiviral And Cytotoxic Activities And Chemical Profiles Of Two Species Of Abies Nordmanniana From Türkiye, Nazli Sarikahya, Gaye Sümer Okkali, Furkan Ozan Çöven, Sevda Zeinali̇, Gülce Gucur, Ayşe Di̇la Çağlar, Ece Uyar, Ahmet Ceyhan Gören, Ayşe Nalbantsoy
Turkish Journal of Chemistry
Abies is an important genus of the family Pinaceae, with about 50 species found in the highlands of Asia, Europe, North Africa, and North and Central America. The principal aim of the present work was to investigate the chemical content and biological potential of the resin and cone from Abies nordmanniana subsp. bornmulleriana and Abies nordmanniana subsp. equi-trojani, respectively. The flavonoid and phenolic contents of the resin and cones were evaluated using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Additionally, the essential oil and fatty acid compositions were analyzed using gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC-FID).. Cytotoxicity …
Antioxidant Properties And Aldose Reductase Inhibitory Potency Of Viscum Album L. Extracts: Experimental And Computational Insights, Bilal Akyüz, Bülent Şengül
Antioxidant Properties And Aldose Reductase Inhibitory Potency Of Viscum Album L. Extracts: Experimental And Computational Insights, Bilal Akyüz, Bülent Şengül
Turkish Journal of Agriculture and Forestry
This study systematically investigates the antioxidant capacity and inhibitory impact of Viscum album L. plant extracts on the aldose reductase (AR) enzyme through a combined approach of in vitro and in silico methods. Various sections derived from distinct plant parts were examined, revealing potent inhibitory potential. Notably, the methanol extract sourced from the plant's stem displayed remarkable efficacy with an IC50 value of 0.156 µM. Total phenolic content and antioxidant capacity analyses were conducted, highlighting variations across plant parts and solvent types. Qualitative and quantitative phenolic compounds content in the extracts was also elucidated by LC-MS/MS analysis and it was …
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Classification Of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines, Necla Koçhan, Baris Emre Dayanc
Turkish Journal of Biology
Background/aim: The molecular heterogeneity of colon cancer has made classification of tumors a requirement for effective treatment. One of the approaches for molecular subtyping of colon cancer patients is the Consensus Molecular Subtypes (CMS) developed by the Colorectal Cancer Subtyping Consortium (CRCSC). CMS-specific RNA-Seq dependent classification approaches are recent with relatively low sensitivity and specificity. In this study, we aimed to classify patients into CMS groups using RNA-seq profiles. Materials and methods: We first identified subtype specific and survival associated genes using Fuzzy C-Means (FCM) algorithm and log-rank test. Then we classified patients using Support Vector Machines with Backward Elimination …
Combination Of Smartphone Digital Image Colorimetry And Uv-Vis Spectrophotometry As Detection Systems With Solidified Floating Organic Drop Microextraction As Preconcentration Method For The Quantification Of Methyl Red In Wastewater Samples, Mi̇ray Bombom, Ayça Gi̇rgi̇n, Buse Tuğba Zaman, Fatma Turak, Sezgi̇n Bakirdere
Combination Of Smartphone Digital Image Colorimetry And Uv-Vis Spectrophotometry As Detection Systems With Solidified Floating Organic Drop Microextraction As Preconcentration Method For The Quantification Of Methyl Red In Wastewater Samples, Mi̇ray Bombom, Ayça Gi̇rgi̇n, Buse Tuğba Zaman, Fatma Turak, Sezgi̇n Bakirdere
Turkish Journal of Chemistry
In this study, a portable smartphone-based digital image colorimetric system (SDIC) was designed and integrated with a solidified floating organic drop microextraction method (SFODME) for the quantification of methyl red in textile wastewater samples. The RGB (red, green, and blue) data were evaluated for each captured image, and the green channel was selected for quantification due to its linear response for the analyte. Under optimal conditions, an acceptable linear range was recorded for the analyte. The proposed method recorded a limit of detection (LOD) value of 0.046 mg/L. The developed microextraction method was also combined with UVVis spectrophotometry, which recorded …
Phytochemical Analysis And Molecular Docking Studies Of Two Endemic Varieties Of Salvia Sericeotomentosa, Gülbahar Özge Ali̇m Toraman, Halil Şenol, Seçi̇l Yazici Tütüni̇ş, Nur Tan, Gülaçti Topçu
Phytochemical Analysis And Molecular Docking Studies Of Two Endemic Varieties Of Salvia Sericeotomentosa, Gülbahar Özge Ali̇m Toraman, Halil Şenol, Seçi̇l Yazici Tütüni̇ş, Nur Tan, Gülaçti Topçu
Turkish Journal of Chemistry
The use of medicinal plants for treating various diseases dates back thousands of years and has been a part of many cultures around the world. Various parts of plants, including roots, leaves, and flowers, and their extracts have been used to develop remedies to cure different ailments like fever, pain, inflammation, infections, among others. In this research, the aerial parts of both Salvia varieties were extracted with ethanol and water to obtain infusion and decoction, separately. S. sericeotomentosa var. hatayica Celep & Doğan (SH) and Salvia sericeotomentosa Rech. f. var. sericeotomentosa (ST) plants were chemically analyzed for polar compounds using …
Increasing Temperatures Can Pose An Opportunity To Recover Endemic And Endangered Oriental Sweetgum Tree (Liquidambar Orientalis Mill.) From Extinction, Okan Ürker, Nurbahar Usta Baykal, Eren Ada
Increasing Temperatures Can Pose An Opportunity To Recover Endemic And Endangered Oriental Sweetgum Tree (Liquidambar Orientalis Mill.) From Extinction, Okan Ürker, Nurbahar Usta Baykal, Eren Ada
Turkish Journal of Botany
Evidence suggests that past climatic oscillations caused many species to drastically change their distribution range and had significant impacts on their survival capabilities. There is significant evidence suggesting that today's changing climate threatens many species to face a rapid extinction period in the coming decades and centuries. Understanding the changing range patterns provides significant input on biodiversity and conservation biology studies. However, warming climatic conditions may also present an opportunity for some species to expand their habitats?particularly those adapted to warmer environments. In this study, we asked how near-future climate change will affect the distribution range of the oriental sweetgum …
Investigating The Effect Of Poly (Ε-Caprolactone) Nanofibers Scaffolds With Random, Unidirectionally, And Radially Aligned Morphologies On The Fibroblast Cell?S Attachment And Growth Behavior, Saeed Nezari, Mohammadamin Sarli, Ahmad Hivechi, Hajir Bahrami, Peiman B. Milan, Noorahmad Latifi, Fatemeh Latifi, Tayyeb Ghadimi, S. Mohammad Amin Haramshahi, Soheila Naderi Gharahgheshlagh
Investigating The Effect Of Poly (Ε-Caprolactone) Nanofibers Scaffolds With Random, Unidirectionally, And Radially Aligned Morphologies On The Fibroblast Cell?S Attachment And Growth Behavior, Saeed Nezari, Mohammadamin Sarli, Ahmad Hivechi, Hajir Bahrami, Peiman B. Milan, Noorahmad Latifi, Fatemeh Latifi, Tayyeb Ghadimi, S. Mohammad Amin Haramshahi, Soheila Naderi Gharahgheshlagh
Turkish Journal of Chemistry
In the last decade, significant progress in tissue engineering, repairing, and replacing organs has been achieved. The design and production of scaffolds for tissue engineering are one of the main areas which have attracted the researcher's interest. In this regard, electrospinning is one of the most popular methods of nanoscale scaffold similar to extracellular matrix production. This paper reports the fabrication of scaffolds consisting of radially aligned PCL nanofibers by utilizing a collector composed of a central point electrode and a peripheral ring electrode. The chemical and physical properties were compared using SEM, FTIR, XRD, and DSC experiments, as well …
Methionine Restriction And Cancer Treatment: A Systems Biology Study Of Yeast To Investigate The Possible Key Players, Esra Börklü
Methionine Restriction And Cancer Treatment: A Systems Biology Study Of Yeast To Investigate The Possible Key Players, Esra Börklü
Turkish Journal of Biology
Background/aim: Dietary restriction, mainly carbon and/or methionine restriction are among the upcoming supporting interventions along with chemotherapy in various cancers. Although dietary restriction has been proven to be beneficial, the main cellular machineries affected by its administration lacks deeper information considerably, a notable pitfall in its use as a personalized nutritional approach. Materials and methods: In this study, cellular effects of methionine restriction on a yeast model are explored via systems biology approaches. The methionine biosynthesis network, constructed by integrating interaction data with gene ontology terms, was analysed topologically, and proved to be informative about the intertwined relationship of methionine …
Clerodendrum Serratum Extract Attenuates Production Of Inflammatory Mediators Inovalbumin-Induced Asthma In Rats, Poonam Arora, Shahid Hamid Ansari, Lalit Mohan Nainwal
Clerodendrum Serratum Extract Attenuates Production Of Inflammatory Mediators Inovalbumin-Induced Asthma In Rats, Poonam Arora, Shahid Hamid Ansari, Lalit Mohan Nainwal
Turkish Journal of Chemistry
In the present study, ethanolic extract of Clerodendrum serratum roots was investigated for its potential to reverse some features of bronchial asthma in ovalbumin-induced murine model of asthma. Clerodendrum serratum commonly called bharangi, (family Solanaceae) is a well-known anti-allergic drug in Asian folk system of medicines. In the present work, pharmacological studies are done to provide scientific evidence for therapeutic potential of plant in allergic asthma. Asthma was induced in experimental rats with allergen suspension of ovalbumin and aluminum hydroxide followed by treatment with dexamethasone (2.5 mg/kg, po) or C. serratum root extract (0.53 and 5.3 mg/kg, b. w., po). …
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Fluorometric Determination Of Ornidazole By Using Bsa Coated Copper Nanoclusters As A Novel Turn Off Sensor, Mehmetcan Bi̇lkay, Hayri̇ye Eda Şatana Kara
Turkish Journal of Chemistry
A fluorescent probe based on bovine serum albumin stabilized copper nanoclusters (BSA-CuNCs) was developed for the selective and sensitive determination of ornidazole (ORN). The nanoclusters were synthesized via a one-pot hydrothermal process in basic media. The synthesized and characterized BSA-CuNCs have less than 3 nm particle size and exhibited blue emission at 405 nm when excited at 325 nm. Synthesized and characterized nanoclusters were successfully applied as a turn-off fluorescent probe for the determination of ORN in pharmaceutical dosage forms. The quenching mechanism created an was inner filter effect (IFE). The method was linear in the concentration range of 0.52-13.56 …
Synthesis, Antioxidant Activity, Molecular Docking And Adme Studies Of Novel Pyrrolebenzimidazolederivatives, Fi̇kri̇ye Zengi̇n Karadayi, Rahman Başaran, Mehmet Murat Kişla, Bi̇nay Eke, Zeynep Alagöz
Synthesis, Antioxidant Activity, Molecular Docking And Adme Studies Of Novel Pyrrolebenzimidazolederivatives, Fi̇kri̇ye Zengi̇n Karadayi, Rahman Başaran, Mehmet Murat Kişla, Bi̇nay Eke, Zeynep Alagöz
Turkish Journal of Chemistry
Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays. Docking analysis with Human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough information about these compounds that have antioxidant activities. Moreover, their molecular descriptors and ADME properties were calculated using the SwissADME online program. As a result, most of our compounds possessed better affinity and created ample interactions with NQO1. The most potent compound 5j had LP inhibition value of 3.73 nmol/mg/min. Other compounds exhibited moderate activity on LP levels comparing to standard butylated hydroxy toluene (BHT). However, …
Synthesis, Characterization, And Antimicrobial Evaluation Of Polyvinylalcohol-Osthol Composite Films, Ishrat Gowsia, Feroz Mir, Javid Banday
Synthesis, Characterization, And Antimicrobial Evaluation Of Polyvinylalcohol-Osthol Composite Films, Ishrat Gowsia, Feroz Mir, Javid Banday
Turkish Journal of Chemistry
Although poly-vinyl alcohol (PVA) has certain mechanical drawbacks such as a weak barrier, it has widely been used in food packaging over the last many years. To increase the suitability of PVA (C2H4O)n and render it ideal for food packaging, a diversity of studies have already been carried out. In the below-mentioned script, we, for the first time, report the use of natural product osthol in making a new composite with PVA for enhancing thermal, physicochemical, and antimicrobial properties. The significant aim of the report is the insertion of osthol (C15H16O3 …
Encapsulation Of Halocadmate Anion Via Hydrogen Bonding: Synthesis And Characterization Of Bis(Diethylenetriamine)Cobalt(Iii) Complex Containing Hexabromocadmate Anion, Vinit Prakash, Ritu Bala, Amrinder Kaur, Daron E. Janzen
Encapsulation Of Halocadmate Anion Via Hydrogen Bonding: Synthesis And Characterization Of Bis(Diethylenetriamine)Cobalt(Iii) Complex Containing Hexabromocadmate Anion, Vinit Prakash, Ritu Bala, Amrinder Kaur, Daron E. Janzen
Turkish Journal of Chemistry
In this work, the encapsulation of [CdBr6]4- by six cations, [Co(dien)2]3+ has been described with the help of single crystal X-ray structural study in the complex, mer-[Co(dien)2]2[CdBr6]Br2. The complex anion, [CdBr6]4- has been obtained through solution method while attempting to synthesize complex dianion, [CdBr4]2-. This newly synthesized complex has been initially characterized by elemental analyses and spectroscopic studies (IR, NMR and UV-Visible). IR and NMR studies have been used for the isomeric identification of [Co(dien)2]3+ …
Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu
Scaffolds From Medical Grade Chitosan: A Good Choice For 3d Cultivation Of Mesenchymal Stem Cells, Merve Çapkin Yurtsever, Özge Eki̇n Akdere, Menemşe Gümüşdereli̇oğlu
Turkish Journal of Biology
Chitosan has high biocompatibility, supports proliferation of many cells, and can be a good carrier for various growth factors. However, low attachment ratio and spheroid formation of several stem cell types on plain chitosan scaffolds/films is still a problem. In this study, it was aimed to obtain 3D scaffolds using medical grade chitosan (MC) with a high deacetylation degree (DD ≥ 92.6%) to overcome the spheroid formation of rat adipose tissue derived mesenchymal stem cells (rAdMSCs) on control chitosan (C, DD = 75%-85%) scaffolds. Genipin was used as a biological chemical crosslinker, and glycerol phosphate salt was used both as …
Comparison Of M, Mm And Lts Estimators In Linear Regression In The Presence Of Outlier, Cem Tirink, Hasan Önder
Comparison Of M, Mm And Lts Estimators In Linear Regression In The Presence Of Outlier, Cem Tirink, Hasan Önder
Turkish Journal of Veterinary & Animal Sciences
In this study, it was aimed to evaluate the performance of different estimators that will be used in regression analysis, which is one of the multivariate statistical methods in the presence of outliers in the data set. Sixth month live weight was estimated with various body measurements for Saanen kids taken from a private farm. In the data set, the use and performance of robust estimators were evaluated because the least squares method did not provide reliable results in the case of outliers. M (for Huber and Tukey bisquare) estimator, MM estimator and LTS estimator were used as robust used …
Determination Of Acrylamide Using The Immuno-Enzymatic Method In Commercial Dog And Cat Foods, Ni̇met Kiliç, Bi̇lal Cem Li̇man
Determination Of Acrylamide Using The Immuno-Enzymatic Method In Commercial Dog And Cat Foods, Ni̇met Kiliç, Bi̇lal Cem Li̇man
Turkish Journal of Veterinary & Animal Sciences
Pet animals raised by humans do not have the chance to choose their own food. Therefore, mistakes made by humans in feeding dogs and cats will adversely affect the health of the animal. There are applications at high temperatures at various stages during the production of dog and cat foods. It is predicted that acrylamide (AA) can be formed as a result of a possible Maillard reaction since the cat and dog foods contain starch in its structure. The aim of this study is to determine the AA residue immuno-enzymatically in dry cat and dog feeds from different companies available …
Interspecific And Intraspecific Size And Shape Variation In Skull Of Two Closely Relatedspecies Bufo Bufo (Linnaeus, 1758) And Bufo Verrucosissimus (Pallas, 1814) From Turkey, Nazan Üzüm, Nurhayat Özdemi̇r, Canteki̇n Dursun, Bi̇lal Kutrup, Serkan Gül
Interspecific And Intraspecific Size And Shape Variation In Skull Of Two Closely Relatedspecies Bufo Bufo (Linnaeus, 1758) And Bufo Verrucosissimus (Pallas, 1814) From Turkey, Nazan Üzüm, Nurhayat Özdemi̇r, Canteki̇n Dursun, Bi̇lal Kutrup, Serkan Gül
Turkish Journal of Zoology
Anurans are the most suitable vertebrate group to see the development and also evolution in the skull, compared to other terrestrial vertebrates as they show highly derived morphology. For this reason, the cranium of anurans has been widely used for analyzing e.g., development and integration, evolutionary history, phylogenetic relationships, sexual dimorphism; and for taxon determination. We applied geometric morphometric techniques and then multivariate statistical analyses to see the skull size and shape variations in closely related Bufo species (B. bufo and B. verrucosissimus) inhabiting Turkey. Females have larger skull than males for both species. Ventral skull size of males differed …