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Boswellia Serrata Gum Resin Aqueous Extract Upregulatesbdnf But Not Creb Expression In Adult Male Rat Hippocampus, Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
Boswellia Serrata Gum Resin Aqueous Extract Upregulatesbdnf But Not Creb Expression In Adult Male Rat Hippocampus, Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
Turkish Journal of Medical Sciences
Background/aim: Boswellia from the family Burseraceae has been proposed for prevention of amnesia; however, the molecular mechanism by which it affects memory is not clear. To reveal the potential molecular mechanism, the effects of boswellia on the expression of two memory related genes, CREB and BDNF, were investigated. Materials and methods: Twenty-one male rats were randomly divided into 3 groups (n = 7): the control group received distilled water and the treatment groups received two doses of aqueous extract of Boswellia serrata gum resin (boswellia) (50 and 100 mg/kg) every day for 4 weeks. The animals were tested by the …
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Effects Of Crocin On Experimental Obesity And Type-2 Diabetes, Ömer Hazman, Laçi̇ne Aksoy, Ahmet Büyükben
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to scrutinize the effects of crocin on obesity and type-2 diabetes, with an approach that takes oxidative stress and inflammatory parameters into account. Materials and methods: The experimental obesity model was created by utilizing a 10-week-long high-fat diet (HFD). An experimental type-2 diabetes model was created by injecting multiple low-dose streptozocin (STZ) injections into rats that were fed with the HFD. The treatment groups were administered a daily crocin dose of 150 mg/kg for 6 weeks via gavage. Results: Findings of the study demonstrated that crocin could be effective in relieving the symptoms …
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Isolation Of Virulent Rhodococcus Equi From Arabian Horses In Şanlıurfa, Turkey, Osman Yaşar Tel, Oktay Keski̇n, Sevi̇l Erdenli̇ğ Gürbi̇lek
Turkish Journal of Veterinary & Animal Sciences
The purposes of this study were to investigate plasmid profiles of the isolated virulent (VapA positive) agents by RFLP and to determine the quantitative aspects of Rhodococcus equi in the feces of adult horses and foals, as well as in soil. The frequency of detection of R. equi and virulent R. equi in fecal samples and soil was studied from 20 farms in the Şanlıurfa region. A total of 315 samples were examined. Nasal swabs from 25 foals with pneumonia were also analyzed. R. equi was isolated and identified from 263 (83.4%) samples originating from 15 out of 20 farms. …
Effect Of Different Extenders On Motility And Some Sperm Kinematics Parameters In Norduz Goat Semen, Koray Teki̇n, Ali̇ Daşkin
Effect Of Different Extenders On Motility And Some Sperm Kinematics Parameters In Norduz Goat Semen, Koray Teki̇n, Ali̇ Daşkin
Turkish Journal of Veterinary & Animal Sciences
Use of computer-assisted sperm analyzers (CASAs) to evaluate sperm fertilizing ability has great importance for the artificial insemination industry. For motility evaluation, different CASA systems and diluents are being used. These assays are poor in predicting sperm fertility, because only the samples with markedly poor quality can be detected. However, there is not a unitary extender worldwide. Therefore, we aimed to evaluate the postthaw kinetic parameters of curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP) with two different extenders (skim milk, SM; Tris, TS). Semen was collected twice a week with an artificial vagina from four adult Norduz …
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
The Role Of Porcine Reproductive And Respiratory Syndrome Virus As A Risk Factor In The Outbreak Of Porcine Epidemic Diarrhea In Immunized Swine Herds, Mei-Zhou Huang, Hui Wang, Sheng-Yi Wang, Dong-An Cui, Xin Tuo, Yong-Ming Liu
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to investigate the relation between porcine epidemic diarrhea (PED) and porcine reproductive and respiratory syndrome virus (PRRSV). Here, we constructed a dynamic clinical experimental model in which sows were infected with PRRSV. The stability of the experimental model was surveyed by detecting the levels of antibodies against classical swine fever virus (CSFV) or PRRSV, respectively. In both group A (infected group) and group B (healthy group), the CSFV antibody level was not significantly different (P > 0.05). In group B, the PRRSV antibody level was also not significantly different (P > 0.05) at the three times …
The Effect Of Packaging Method And Dietary Vitamin D3 Supplementation On The Quality Of Beef In Rectus Femoris, Gluteus Medius, And Adductor Femoris Beef Muscles, Aleksandra Lipinska, Andrzej Póltorak, Agnieszka Wierzbicka, Jaroslaw Wyrwisz
The Effect Of Packaging Method And Dietary Vitamin D3 Supplementation On The Quality Of Beef In Rectus Femoris, Gluteus Medius, And Adductor Femoris Beef Muscles, Aleksandra Lipinska, Andrzej Póltorak, Agnieszka Wierzbicka, Jaroslaw Wyrwisz
Turkish Journal of Veterinary & Animal Sciences
The goal of the study was to assess the impact of packaging methods and doses of vitamin D3 fed to animals (with feed) in the last days of finishing on selected indicators of beef quality. The parameters studied include the measurement of CIE L*, a*, and b* colour spaces and the Warner?Bratzler shear force. The muscles used in the study were the m. rectus femoris, m. gluteus medius, and m. adductor femoris, which were packed in two variants of modified atmosphere (MAP1, 80% O2:20% CO2 and MAP2, 60% O2:40% CO2) and in skin-pack technology; they were later aged for 10 …
The Effect Of Live Saccharomyces Cerevisiae Yeast In The Diet Of Rams On The Digestibility Of Nutrients, Nitrogen And Mineral Retention, And Blood Serum Biochemical Parameters, Barbara Kowalik, Jacek Skomial, Renata Miltko, Malgorzata Majewska
The Effect Of Live Saccharomyces Cerevisiae Yeast In The Diet Of Rams On The Digestibility Of Nutrients, Nitrogen And Mineral Retention, And Blood Serum Biochemical Parameters, Barbara Kowalik, Jacek Skomial, Renata Miltko, Malgorzata Majewska
Turkish Journal of Veterinary & Animal Sciences
The effect of live Saccharomyces cerevisiae yeast added to the diet of rams on the digestibility of carbohydrates and protein in the total tract, retention of nitrogen and mineral elements, and concentration of biochemical parameters in blood serum was examined. The experiment was carried out on 12 Corriedale rams allocated to 2 groups of 6 animals each. The control group was fed meadow hay (45.4%), concentrate (53.2%), and a vitamin?mineral mixture (1.4%), while the second group was fed the same diet supplemented with 2 g day-1 live S. cerevisiae. Adaptation to feeding lasted 21 days; the sampling period lasted 7 …
Pharmacokinetics And Bioavailability Of Three Promising Tilmicosin-Loaded Lipid Nanoparticles In Comparison With Tilmicosin Phosphate Following Oral Administration In Broiler Chickens, Ali Rassouli, Alwan Al-Qushawi, Fatemeh Atyabi, Seyed Mostafa Peighambari, Mehdi Esfandyari-Manesh, Gholam Reza Shams
Pharmacokinetics And Bioavailability Of Three Promising Tilmicosin-Loaded Lipid Nanoparticles In Comparison With Tilmicosin Phosphate Following Oral Administration In Broiler Chickens, Ali Rassouli, Alwan Al-Qushawi, Fatemeh Atyabi, Seyed Mostafa Peighambari, Mehdi Esfandyari-Manesh, Gholam Reza Shams
Turkish Journal of Veterinary & Animal Sciences
Tilmicosin (TLM) is a semisynthetic antimicrobial agent used mainly in poultry and cattle, but it has relatively poor oral bioavailability. This study was conducted to compare the bioavailability (BA) and main pharmacokinetic (PK) parameters of TLM after oral administration of tilmicosin phosphate (TLM-PH) and three newly prepared lipid nanoparticles (LNPs) of TLM including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and lipid-core nanocapsules (LNCs). Sixty broiler chickens were divided into eight groups. In four treatment groups (n = 10), each bird was given a single oral dose (20 mg/kg) of a TLM formulation after overnight fasting, and in four …
Hemopoiesis In The Pronephros Of Tench, Tinca Tinca, Linnaeus 1758(Teleostei, Cyprinidae): Cytochemical Identification And Cell Morphology, Andi Alijagic, Damir Suljevic
Hemopoiesis In The Pronephros Of Tench, Tinca Tinca, Linnaeus 1758(Teleostei, Cyprinidae): Cytochemical Identification And Cell Morphology, Andi Alijagic, Damir Suljevic
Turkish Journal of Veterinary & Animal Sciences
Hemopoiesis in the tench (Tinca tinca: Teleostei, Cyprinidae), a cyprinid fish that can be found within the entire territory of Eurasia, from France in the west to the Yenisei River in the east, has not yet been described. The aim of this research was analysis of hemopoiesis lineages in the pronephros of Tinca tinca (sampled from the Jablanicko Reservoir). Identification and cells measurements were done by using a light microscope (Olympus BX41) and an Olympus DP12 camera. Hemopoietic cells of the tench are divided into five different series that include erythropoietic, granulopoietic, lymphopoietic, thrombopoietic, and monopoietic cell series. Erythropoietic series …
Differences In Drone Sperm Morphometry And Activity At The Beginning And End Of The Season, Aldona Gontarz, Dorota Banaszewska, Magdalena Gryzinska, Katarzyna Andraszek
Differences In Drone Sperm Morphometry And Activity At The Beginning And End Of The Season, Aldona Gontarz, Dorota Banaszewska, Magdalena Gryzinska, Katarzyna Andraszek
Turkish Journal of Veterinary & Animal Sciences
The sperm cells of the honey bee, like the sperm of most invertebrates, belong to the modified type of spermatozoa. In our own research, differences have been observed in the activity of sperm cells isolated from drones at the beginning and end of the season. On the basis of these observations, research was undertaken to determine whether the changes in drone activity are associated with morphological changes. The sperm cells collected from drones at the beginning of the mating season are longer than the sperm cells from the end of the season. Moreover, sperm cells from the beginning of the …
Investigation Of The Promoter Polymorphisms Of The Growth Hormone (Gh1), Growth Hormone Receptor (Ghr), Insulin-Like Growth Factor (Igf-I), And Prolactin (Prl) Genes And The Correlation Between Gene Expression And Milk Yields In Holstein Cattle Raised In Central Anatolia, Korhan Arslan, Serpi̇l Taheri̇, Eli̇f Funda Şener, Bi̇lal Akyüz, Aytaç Akçay, Yusuf Özkul, Kaan Muhsi̇n İşcan
Investigation Of The Promoter Polymorphisms Of The Growth Hormone (Gh1), Growth Hormone Receptor (Ghr), Insulin-Like Growth Factor (Igf-I), And Prolactin (Prl) Genes And The Correlation Between Gene Expression And Milk Yields In Holstein Cattle Raised In Central Anatolia, Korhan Arslan, Serpi̇l Taheri̇, Eli̇f Funda Şener, Bi̇lal Akyüz, Aytaç Akçay, Yusuf Özkul, Kaan Muhsi̇n İşcan
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes, and the correlation of the expression levels of these genes with lactation and daily milk yields in Holstein cattle. A total of 154 lactating Holstein cows raised in the Central Anatolia Region of Turkey, with a mean age of 5.4 years and a mean body weight of 571.7 kg, constituted the study material. Each blood sample was examined by real-time PCR for mRNA expression levels and the promoter polymorphisms of the GH1, …
Molecular And Seroprevalence Of Canine Visceral Leishmaniasis In West Anatolia, Turkey, Serkan Bakirci, Hüseyi̇n Bi̇lgi̇n Bi̇lgi̇ç, Onur Köse, Ayça Aksulu, Seli̇n Hacilarlioğlu, Hasan Erdoğan, Tüli̇n Karagenç
Molecular And Seroprevalence Of Canine Visceral Leishmaniasis In West Anatolia, Turkey, Serkan Bakirci, Hüseyi̇n Bi̇lgi̇n Bi̇lgi̇ç, Onur Köse, Ayça Aksulu, Seli̇n Hacilarlioğlu, Hasan Erdoğan, Tüli̇n Karagenç
Turkish Journal of Veterinary & Animal Sciences
Canine leishmaniasis (CanL) is a protozoal disease caused by Leishmania species. Dogs play an important role as a reservoir. The aim of this study is to determine the prevalence of CanL by molecular and serological techniques among stray dogs living in kennels in Aydın, Manisa, and İzmir, located in western Turkey. Blood samples were collected from a total of 191 dogs and analyzed using indirect immunofluorescence antibody test (IFAT) and polymerase chain reaction (PCR). The isolates that tested positive using PCR were further analyzed by real-time PCR for species identification and confirmation. A total of 21 (10.99%) dogs were found …
Ovine Coccidiosis: Prevalence And Associated Risk Factors Inand Around Addis-Zemen, Northwest Ethiopia, Abinet Lakew, Zewdu Seyoum
Ovine Coccidiosis: Prevalence And Associated Risk Factors Inand Around Addis-Zemen, Northwest Ethiopia, Abinet Lakew, Zewdu Seyoum
Turkish Journal of Veterinary & Animal Sciences
This cross-sectional study was conducted in and around Addis-Zemen from November 2014 to April 2015 to determine the prevalence of ovine coccidiosis and to identify associated risk factors. Faecal samples were collected directly from the rectum of 384 randomly selected animals. A centrifugal faecal flotation technique using saturated salt solution was used to detect Eimeria oocysts. Out of 384 samples, only 88 were found to contain Eimeria oocysts. Eimeria infection was recorded in all age and sex groups of the study animals. A strong significant association was observed (P < 0.05) between Eimeria infection and the faecal consistency, production system, hygienic status, age, and body condition of the sampled animals. However, an insignificant (P > 0.05) association was recorded between Eimeria infection and the origins and …
The Effects Of Carvacrol And/Or Thymol On The Performance, Blood And Rumen Parameters, And Carcass Traits Of Merino Sheep, Hakan Bi̇ri̇ci̇k, Hülya Hanoğlu Oral, Ali̇ Mehmet Taluğ, Şeri̇fe Şule Cengi̇z, Mehmet Koyuncu, Serdal Di̇kmen
The Effects Of Carvacrol And/Or Thymol On The Performance, Blood And Rumen Parameters, And Carcass Traits Of Merino Sheep, Hakan Bi̇ri̇ci̇k, Hülya Hanoğlu Oral, Ali̇ Mehmet Taluğ, Şeri̇fe Şule Cengi̇z, Mehmet Koyuncu, Serdal Di̇kmen
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to investigate the effects of increasing doses of carvacrol (C) and/or thymol (T) on the performance, rumen fermentation, and blood and carcass parameters of Merino sheep. Eighty-four 12-week-old male Merino lambs were randomly assigned to 7 treatment groups. The sheep were fed with the same concentrate mixtures including a control diet, carvacrol 100 mg/kg (C100), carvacrol 300 mg/kg (C300), thymol 100 mg/kg (T100), thymol 300 mg/kg (T300), carvacrol+thymol 100 mg/kg (C50+T50), and carvacrol+thymol 300 mg/kg (C150+T150). The C and/or T supplementation did not affect the feed conversion. The lambs fed with C and/or T …
The Determination Of In Vitro Gas Production And Metabolizable Energy Value Of Rice Straw Treated With Exogenous Fibrolytic Enzymes, Zehra Selçuk, Nurcan Çeti̇nkaya, Mustafa Salman, Buğra Genç
The Determination Of In Vitro Gas Production And Metabolizable Energy Value Of Rice Straw Treated With Exogenous Fibrolytic Enzymes, Zehra Selçuk, Nurcan Çeti̇nkaya, Mustafa Salman, Buğra Genç
Turkish Journal of Veterinary & Animal Sciences
This study was conducted to determine the effects of cellulase and xylanase treatments on in vitro 24-h gas production (GP), organic matter digestibility (OMD), and metabolizable energy (ME) values of rice straw (RS). Rice straws were treated with cellulase and xylanase at the levels of 0% (C1), 0.5% (RS+CEL0.5), 1% (RS+CEL1), 1.5% (RS+CEL1.5), and 2% (RS+CEL2) and 0% (C2), 0.5% (RS+XYL0.5), 1% (RS+XYL1), 1.5% (RS+XYL1.5), and 2% (RS+XYL2), respectively. Rice straws treated with each level of cellulase and xylanase were ensiled in 6 glass jars. For each level of cellulase and xylanase treatment, 3 glass jars were incubated at room …
Effects Of Dietary Chicken Grill And Sunflower Seed Oils On Performance, Egg Yolk Cholesterol Level, Biochemical Parameters, And Oxidant/Antioxidant Status Of Laying Hens, Mustafa Numan Oğuz, Fatma Karakaş Oğuz, Tülay Büyükoğlu
Effects Of Dietary Chicken Grill And Sunflower Seed Oils On Performance, Egg Yolk Cholesterol Level, Biochemical Parameters, And Oxidant/Antioxidant Status Of Laying Hens, Mustafa Numan Oğuz, Fatma Karakaş Oğuz, Tülay Büyükoğlu
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to investigate the effects of dietary chicken grill oil (CGO) and sunflower seed oil (SO) on performance, some serum and egg yolk biochemical parameters, and blood and liver oxidant/antioxidant status of laying hens. Fifty-four 19-week-old Lohmann laying hens were randomly assigned to three groups. The groups were fed experimental diets containing 5% SO, 5% CGO1, or 7.5% CGO2, respectively. Diets and water were provided ad libitum over 17 weeks. The feed efficiency ratios and cholesterol content in egg yolks with cholesterol and the triglyceride levels in serum were not affected by the diets. However, …
Occurrence Of Arcobacter In Dogs And Cats In Selangor,Malaysia, And Associated Risk Factors, Dauda Mohammed Goni, Saleha Abdulaziz, Gurmeet Kaur Dhaliwa, Zunita Zakaria, Ibrahim Jalo Muhammad, Mohamed Abdelrahman Mohamed, Abdulrasheed Aliyu Bello, Asinamai Athliamai Bitrus
Occurrence Of Arcobacter In Dogs And Cats In Selangor,Malaysia, And Associated Risk Factors, Dauda Mohammed Goni, Saleha Abdulaziz, Gurmeet Kaur Dhaliwa, Zunita Zakaria, Ibrahim Jalo Muhammad, Mohamed Abdelrahman Mohamed, Abdulrasheed Aliyu Bello, Asinamai Athliamai Bitrus
Turkish Journal of Veterinary & Animal Sciences
Arcobacter is widely regarded as an emerging foodborne pathogen because of its increasing occurrence in food production causing gastroenteritis in humans. In addition, it is also reported as a potential zoonosis. The objectives of this study were to determine the occurrence of Arcobacter in dogs and cats and the associated risk factors. Rectal and buccal cavity swab samples were taken from dogs (n = 40) and cats (n = 40) owned by individuals who brought the animals to a university teaching hospital and stray dogs (n = 61) and cats (n = 46). Suspected colonies of Arcobacter were subjected to …
Mechanisms Of Mrna Polyadenylation, Hizlan Hincal Ağuş, Ayşe Eli̇f Erson Bensan
Mechanisms Of Mrna Polyadenylation, Hizlan Hincal Ağuş, Ayşe Eli̇f Erson Bensan
Turkish Journal of Biology
mRNA 3'-end processing involves the addition of a poly(A) tail based on the recognition of the poly(A) signal and subsequent cleavage of the mRNA at the poly(A) site. Alternative polyadenylation (APA) is emerging as a novel mechanism of gene expression regulation in normal and in disease states. APA results from the recognition of less canonical proximal or distal poly(A) signals leading to changes in the 3' untranslated region (UTR) lengths and even in some cases changes in the coding sequence of the distal part of the transcript. Consequently, RNA-binding proteins and/or microRNAs may differentially bind to shorter or longer isoforms. …
Epigenetic Regulation Of Brca1 Expression And Its Role Inbreast Cancer Stem Cell Development, Elena Shestakova
Epigenetic Regulation Of Brca1 Expression And Its Role Inbreast Cancer Stem Cell Development, Elena Shestakova
Turkish Journal of Biology
The tumor suppressor breast cancer 1, early onset (BRCA1) plays an important role in maintaining the genome integrity, actively participating in DNA repair via homologous recombination. The level of functional final BRCA1 protein is precisely regulated in cells. Epigenetic regulation of BRCA1 gene expression is one of the most important mechanisms for BRCA1 level fine-tuning. In this review the main epigenetic mechanisms of BRCA1 expression regulation are presented, including DNA methylation, histone covalent modifications, and regulation with transcription factors. Another important function of BRCA1 emerging in recent years is its role in the regulation of breast cancer stem cell development. …
Induced Pluripotent Stem Cells: Methods, Disease Modeling, And Microenvironment For Drug Discovery And Screening, Suresh Palamadai Krishnan
Induced Pluripotent Stem Cells: Methods, Disease Modeling, And Microenvironment For Drug Discovery And Screening, Suresh Palamadai Krishnan
Turkish Journal of Biology
The raging ethical, religious, moral, political, and safety issues pertaining to the use of embryonic stem cells for therapy and research have prompted researchers to develop possibly better alternatives that are more efficacious and serve multiple purposes. Induced pluripotent stem cells (iPSCs) developed by multiple methods provide an unparalleled source of cells that could be differentiated into progeny cells. In cell-based disease models the progeny cells mimic, at least in part, the pathology of the studied disease and are used to improve the mechanistic understanding of the pathology. Furthermore, these cells could be used to test the efficacy and safety …
Current Status Of Stem Cell Therapy: Opportunities And Limitations, Elena Rusu, Laura Georgiana Necula, Ana Iulia Neagu, Mihail Alecu, Cristian Stan, Radu Albulescu, Cristiana Pistol Tanase
Current Status Of Stem Cell Therapy: Opportunities And Limitations, Elena Rusu, Laura Georgiana Necula, Ana Iulia Neagu, Mihail Alecu, Cristian Stan, Radu Albulescu, Cristiana Pistol Tanase
Turkish Journal of Biology
Over recent years stem cells have stood out as a promising tool for regenerative medicine, providing alternative therapeutic solutions for a large number of diseases. Many clinical trials using stem cells or induced pluripotent stem cells are focused on the repair and regeneration of various tissues and organs in degenerative diseases, whose current treatment only succeeds in slowing down the progression of the disease. Although the preliminary results are interesting, further studies are required in order to evaluate the safety and benefits of stem cell therapy, considering the teratoma development and ethical considerations in embryonic stem cell cases or reprogramming-induced …
Epigenetic Regulation Of Specific Transcription Factors In Osteogenicdifferentiation Of Mesenchymal Stem Cells, Milad Zadi Heydarabad, Mousa Vatanmakanian, Mina Nikasa, Majid Farshdousti Hagh
Epigenetic Regulation Of Specific Transcription Factors In Osteogenicdifferentiation Of Mesenchymal Stem Cells, Milad Zadi Heydarabad, Mousa Vatanmakanian, Mina Nikasa, Majid Farshdousti Hagh
Turkish Journal of Biology
An abundance of experiments have been performed to clarify the differentiation process of mesenchymal stem cells (MSCs). Osteogenic differentiation and in vitro conditions favoring these cell lineages have attracted the attention of many researchers. Moreover, the gene expression profile during MSC differentiation toward its main specialized cells (bone, cartilage, and adipose cells) has been mostly understood. In the last decades another layer of investigation has attempted to clarify the epigenetic mechanisms underlying MSC differentiation into its specialized cells. It has been shown that as MSCs progress through the differentiation process, more nonspecific genes undergo DNA methylation to prevent differentiation into …
The Heart Of The Matter: Cardiac Stem Cells, Esra Çağavi̇, Arzuhan Koç, Sevi̇lay Şahoğlu Göktaş
The Heart Of The Matter: Cardiac Stem Cells, Esra Çağavi̇, Arzuhan Koç, Sevi̇lay Şahoğlu Göktaş
Turkish Journal of Biology
Cardiovascular diseases are the primary cause of death in the world. Pharmacological and surgical approaches are the main treatment options for heart disease; however, heart transplantation may be the only option for advanced heart failure patients despite its limited nature. Recent advances enabled stem cell-based therapies to become a promising treatment approach for injured or weakened cardiac tissue. With the identification of resident and heart-specific stem cells in early 2000, new avenues of research have been opened to understand heart development, disease, and regeneration. In this review article, different cardiac stem cell subpopulations are classified and defined based on the …
Myelin Disorders And Stem Cells: As Therapies And Models, Fatmagül İlayda Aydinli, Eşref Çeli̇k, Burcu Kurt Vatandaşlar, Bi̇lal Ersen Kerman
Myelin Disorders And Stem Cells: As Therapies And Models, Fatmagül İlayda Aydinli, Eşref Çeli̇k, Burcu Kurt Vatandaşlar, Bi̇lal Ersen Kerman
Turkish Journal of Biology
Myelin disorders burden millions of people around the world, yet existing therapies are inadequate to cure them. Current remedies commonly treat the symptoms with minimal to no effect on the actual cause of the disorder. The basis and/or the mechanism of demyelination is not known for many of the disorders either. In recent years, stem cells of variable origin have been used in clinical trials as transplant agents to restore the defective biochemical process or the damaged tissue. We summarize the outcomes of these trials for demyelination disorders. The capability of reprograming mature cells into stem cells equips researchers with …
Comparison Of The Osteogenic Differentiation Capacity Of Adipose Tissuederived Mesenchymal Stem Cells From Humans And Rats, Seçi̇l Erden Tayhan, Şeyma Taşdemi̇r, Sai̇me İsmet Deli̇loğlu Gürhan, Erol Mi̇r
Comparison Of The Osteogenic Differentiation Capacity Of Adipose Tissuederived Mesenchymal Stem Cells From Humans And Rats, Seçi̇l Erden Tayhan, Şeyma Taşdemi̇r, Sai̇me İsmet Deli̇loğlu Gürhan, Erol Mi̇r
Turkish Journal of Biology
Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they are quite promising for orthopedic clinical trials. The present study aimed to compare the osteogenic differentiation conditions of MSCs from human adipose tissue (hADMSC) and those of MSCs from rat adipose tissue (rADMSC). Therefore, …
Baculoviral Vector Loaded Mesenchymal Stem Cells As Efficient Gene Therapy Tools For Cancer Treatment, Sedef Hande Aktaş, Hakan Akbulut, Ayşe Eser Elçi̇n, Mahmut Parmaksiz, Arzu Keski̇n Aktan, Arzu Çöleri̇ Ci̇han, Yaşar Murat Elçi̇n, Fi̇kri̇ İçli̇
Baculoviral Vector Loaded Mesenchymal Stem Cells As Efficient Gene Therapy Tools For Cancer Treatment, Sedef Hande Aktaş, Hakan Akbulut, Ayşe Eser Elçi̇n, Mahmut Parmaksiz, Arzu Keski̇n Aktan, Arzu Çöleri̇ Ci̇han, Yaşar Murat Elçi̇n, Fi̇kri̇ İçli̇
Turkish Journal of Biology
Insufficient targeting of the therapeutic genes to tumor cells is one of the major reasons for failure in cancer gene therapy. Mesenchymal stem cells (MSCs) seem to be a good candidate as a carrier for gene therapy because of its selective tumor tissue-homing properties. In the current study, we constructed baculoviral vectors (BVs) carrying cytosine deaminase (CD) (BV-CD) or green fluorescence protein (GFP) genes (BV-GFP) and tested the transduction efficiency of the vectors in tumor and mesenchymal stem cells. We also tested the in vivo efficacy of the BV-CD vector in a colon cancer model. Our results showed that the …
Mediterranean Water Shrew (Neomys Anomalus): Range Expansion Northward, Linas Balciauskas, Laima Balciauskiene, Uudo Timm
Mediterranean Water Shrew (Neomys Anomalus): Range Expansion Northward, Linas Balciauskas, Laima Balciauskiene, Uudo Timm
Turkish Journal of Zoology
We identified three individuals of the Mediterranean water shrew (Neomys anomalus) in Estonia, expanding the known distribution range of the species to the north by 500 km from the most northern location in Lithuania and over 700 km from Poland. The identification of the species in Estonia, the most northern known locality, was based on the position of mental foramen, height of coronoid process (>4.3 mm), and Libois index (
A New Record Of The Genus Camerotrombidium Thor, 1936(Acari: Microtrombidiidae) From Turkey, İbrahi̇m Karakurt, Sevgi̇ Sevsay
A New Record Of The Genus Camerotrombidium Thor, 1936(Acari: Microtrombidiidae) From Turkey, İbrahi̇m Karakurt, Sevgi̇ Sevsay
Turkish Journal of Zoology
A newly recorded species for the Turkish fauna, Camerotrombidium rasum Berlese, 1910, is given based on adult females and larvae obtained from an adult female by experimental rearing in the laboratory. The genus Camerotrombidium is recorded for the first time from Turkey.
Comparison Of Rdna Regions (Its, Lsu, And Ssu) Of Some Aspergillus, Penicillium, And Talaromyces Spp., Rasi̇me Demi̇rel
Comparison Of Rdna Regions (Its, Lsu, And Ssu) Of Some Aspergillus, Penicillium, And Talaromyces Spp., Rasi̇me Demi̇rel
Turkish Journal of Botany
Aspergillus, Penicillium, and Talaromyces spp. are commonly found worldwide and include industrially and medicinally important members. These genera are deeply related with life from soil to health hazards via their industrial products, surface proteins, biodiversity, food spoilage, mycotoxins, etc. These three genera progressively encounter important taxonomic revisions, such as the one fungus-one name concept, and various methods are available to establish their evolutionary and phylogenetic relationships. Besides morphological, microscopic, and extrolite analyses, nucleotide sequence analysis is the most preferred method. In particular, rDNA regions, such as the internal transcribed spacer (ITS), large subunit (LSU), and small subunit (SSU), are commonly …
Genetic Differentiation And Polyploid Formation Within The Cryptogramma Crispa Complex (Polypodiales: Pteridaceae), Jordan Metzgar, Mackenzie Stamey, Stefanie Ickert-Bond
Genetic Differentiation And Polyploid Formation Within The Cryptogramma Crispa Complex (Polypodiales: Pteridaceae), Jordan Metzgar, Mackenzie Stamey, Stefanie Ickert-Bond
Turkish Journal of Botany
The tetraploid fern Cryptogramma crispa (L.) R.Br. Ex Hook. İs distributed across alpine and high latitude regions of Europe and western Asia and is sympatric with the recently described octoploid C. Bithynica S.Jess., L.Lehm. And Bujnoch in north-central Turkey. Our analysis of a 6-region plastid DNA sequence dataset comprising 39 accessions of Cryptogramma R.Br., including 14 accessions of C. Crispa and one accession of C. Bithynica, revealed a deep genetic division between the accessions of C. Crispa from western, northern, and central Europe and the accessions of C. Crispa and C. Bithynica from Turkey and the Caucasus Mountains. This legacy …