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Investigation Of The Efficiency And Safety Of Tilmicosin Phosphate In Treating Experimentalmycoplasmal Infections In Pigs, Xiaohui Zhang, Jinzhe Pan, Ning Wu, Shu Tang, Xiangdong Lei, Yangyang Sun, Joerg Hartung, Endong Bao
Investigation Of The Efficiency And Safety Of Tilmicosin Phosphate In Treating Experimentalmycoplasmal Infections In Pigs, Xiaohui Zhang, Jinzhe Pan, Ning Wu, Shu Tang, Xiangdong Lei, Yangyang Sun, Joerg Hartung, Endong Bao
Turkish Journal of Veterinary & Animal Sciences
In order to evaluate the in vivo therapeutic effect of oral administration of tilmicosin phosphate on mycoplasmal pneumonia in swine and its safety for the infected swine, the model of mycoplasmal pneumonia disease in swine was established by artificial infection, and indices such as efficiency, cure rate, death rate, the score of lung lesion, and the routine blood tests, blood biochemistry, and routine urine tests of tested swine were determined. The results showed that all of the dosage groups of 100 mg/L, 80 mg/L, 60 mg/L of 10% tilmicosin phosphate soluble powder demonstrated distinct therapeutic effects on mycoplasmal pneumonia in …
Effects Of The Supplementation Of Lamb Rations With Oregano Essential Oil On Theantimicrobial And Antioxidant Metabolism In Meat, Hali̇t İmi̇k, Sevda Urçar, Meryem Aydemi̇r Atasever, Recep Gümüş, Hayrunni̇sa Özlü
Effects Of The Supplementation Of Lamb Rations With Oregano Essential Oil On Theantimicrobial And Antioxidant Metabolism In Meat, Hali̇t İmi̇k, Sevda Urçar, Meryem Aydemi̇r Atasever, Recep Gümüş, Hayrunni̇sa Özlü
Turkish Journal of Veterinary & Animal Sciences
Although oregano essential oil has common use in the cosmetics, pharmaceutical, and food sectors, information on its effects on meat quality and shelf life, when incorporated into lamb feed rations, is scarce. In this study, the effects of oregano essential oil (OEO) in feed on the water activity, pH, lipid peroxidation, color parameters, and microbial counts of the Musculus longissimus dorsi (MLD) were investigated. The control group was fed a basal ration and the OEO1 and OEO2 groups were fed a basal ration supplemented with 200 mg/kg and 400 mg/kg OEO, respectively. Akkaraman lambs were fed experimental rations for a …
A Stereological Study On Calculation Of Volume Values Of The Cervical Spinalsegments In Ducks, Gamze Çakmak, Hüseyi̇n Karadağ, Zafer Soygüder, Murat Çeti̇n Rağbetli̇, Serkan Yildirim, Haci Keleş
A Stereological Study On Calculation Of Volume Values Of The Cervical Spinalsegments In Ducks, Gamze Çakmak, Hüseyi̇n Karadağ, Zafer Soygüder, Murat Çeti̇n Rağbetli̇, Serkan Yildirim, Haci Keleş
Turkish Journal of Veterinary & Animal Sciences
In the present study, volume values of the cervical segments in the spinal cords of adult ducks weighing 3-4 kg were investigated. Volume values of the grey matter and white matter in the cervical segment of the spinal cord of the ducks were examined stereologically. Ten ducks (genus Anas) without regarding the sex of the animals. All animals were perfused using 10% formaldehyde. The animals were kept in 10% formaldehyde for 1 week to ensure fixation. The ducks were then dissected. The cervical segments were uncovered by removing the cervical vertebrae. Tissue samples were obtained from each of the cervical …
Chronic Diarrhea Due To Lymphosarcoma In An Adult Cow: A Sporadic Clinical Report, Nuzhat Hassan, Charanjit Singh Randhawa, Swaran Singh Randhawa, Deepti Narang
Chronic Diarrhea Due To Lymphosarcoma In An Adult Cow: A Sporadic Clinical Report, Nuzhat Hassan, Charanjit Singh Randhawa, Swaran Singh Randhawa, Deepti Narang
Turkish Journal of Veterinary & Animal Sciences
The present clinical report describes a rare sporadic clinical case of chronic diarrhea due to lymphosarcoma in a 7-yearold crossbred Holstein?Friesian cattle. Diarrhea occurred due to intestinal lymphoid tissue involvement. The clinical diagnosis of lymphosarcoma was derived from peritoneal fluid aspirate, lymph node enlargement, and absence of serological and fecal evidence of any parasitic or bacterial infection. Reactive proliferative mesothelial hyperplasia in peritoneal fluid examination confirmed lymphosarcoma. The cells form numerous 3-dimensional clusters in mesothelial lymphosarcoma. Postmortem examinations confirmed visceral lymph node enlargements. A hematological examination revealed leukocytosis and a marked decrease in hemoglobin level, which reflected a severe degree …
Cover And Contents
Turkish Journal of Veterinary & Animal Sciences
No abstract provided.
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an …
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess expression changes of serum sPD-1 levels in HBeAg-positive chronic hepatitis B patients with entecavir treatment and explore the correlation with the curative effect. Materials and methods: A total of 220 HBeAg-positive CHB patients and 207 healthy individuals were included. sPD-1 levels and virological and biochemical responses were assessed at baseline and at 12, 24, and 48 weeks in CHB patients a er antiviral therapy. Results: sPD-1 levels in HBeAg-positive CHB patients before treatment were signi cantly lower than those of healthy controls. After entecavir treatment, sPD-1 levels increased gradually over time. At 48 weeks …
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Turkish Journal of Medical Sciences
Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Turkish Journal of Medical Sciences
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method. Results: At 10% ABS successfully inhibited the biofilm formation of the tested microorganisms. Enzyme inhibition analysis revealed that …
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Materials and methods: This prospective study enrolled all consecutive patients from two tertiary hospitals who underwent diagnostic or therapeutic thoracentesis. In a cohort of 149 subjects with pleural effusion, including transudates and malignant (MPE), tuberculous (TPE), and parapneumonic effusion (PPE), serum and pleural effusion PTX-3 concentration measurements were performed using ELISA. Serum and pleural effusion protein, lactate dehydrogenase, C-reactive protein …
The Effect Of Generalized Seizure Activity On Ischemia-Induced Cardiac Arrhythmias And Myocardial Injury With Histopathological Evaluation In Anesthetized Rats, Ersöz Gonca, Fi̇gen Barut, Deni̇z Şahi̇n
The Effect Of Generalized Seizure Activity On Ischemia-Induced Cardiac Arrhythmias And Myocardial Injury With Histopathological Evaluation In Anesthetized Rats, Ersöz Gonca, Fi̇gen Barut, Deni̇z Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in anesthetized rats for …
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Turkish Journal of Medical Sciences
Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats. Materials and methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Whole blood, liver, and lung samples were obtained from rats of 3 groups (n = 10 for each group, n total = 30: control as a wild-type group, laparotomy group (LAP), and CLP). Gene expression of MPO and CD177 in targeted …
Comparative Diet Of Hedgehogs (Atelerix Algirus) In Two Localities In Kabylia, Algeria, Dalila Djennoune, Faiza Marniche, Mansour Amroun, Raphaël Boulay
Comparative Diet Of Hedgehogs (Atelerix Algirus) In Two Localities In Kabylia, Algeria, Dalila Djennoune, Faiza Marniche, Mansour Amroun, Raphaël Boulay
Turkish Journal of Zoology
The present study is the first qualitative and quantitative analysis of the diet of Algerian hedgehogs (Atelerix algirus) in Kabylia, Algeria. The study was carried out between May and October 2014 and covered two different sites, Yakouren (a forested site) and Tizi-Rached (an agricultural site). In Yakouren, the analysis of droppings allowed us to identify 12,050 items grouped into 16 categories of eaten preys, while in Tizi-Rached, 13,543 items grouped into 13 categories of preys were identified. In both locations, the Hymenoptera category is the most eaten type of prey at a rate of 93% in Yakouren and 98% in …
Overexpression Of The Alfalfa Dnaj-Like Protein (Msdjlp) Gene Enhancestolerance To Chilling And Heat Stresses In Transgenic Tobacco Plants, Ki-Won Lee, Md. Atikur Rahman, Ki-Yong Kim, Gi Jun Choi, Joon-Yung Cha, Mi Sun Cheong, Abdullah Mohammad Shohael, Chris Jones, Sang Hoon Lee
Overexpression Of The Alfalfa Dnaj-Like Protein (Msdjlp) Gene Enhancestolerance To Chilling And Heat Stresses In Transgenic Tobacco Plants, Ki-Won Lee, Md. Atikur Rahman, Ki-Yong Kim, Gi Jun Choi, Joon-Yung Cha, Mi Sun Cheong, Abdullah Mohammad Shohael, Chris Jones, Sang Hoon Lee
Turkish Journal of Biology
n plant development and abiotic stress response processes. In this study, we examined the role of a HSP, the Medicago sativa DnaJ-like protein (MsDJLP), in alfalfa and its potential application for the development of abiotic stress tolerance in plants. We found that expression of the MsDJLP gene was induced by chilling (4 °C) and heat (42 °C), but not by cadmium (500 µM) or arsenic (500 µM) stresses. We then cloned the MsDJLP gene downstream of the strong constitutive CaMV 35S promoter and transformed it into tobacco plants. Ectopic expression of MsDJLP conferred enhanced tolerance to both chilling and heat …
Ultrasound-Enhanced Gene Delivery To Alfalfa Cells By Hpamam Dendrimer Nanoparticles, Amin Amani, Nasser Zare, Asadollah Asadi, Rasool Asghari Zakaria
Ultrasound-Enhanced Gene Delivery To Alfalfa Cells By Hpamam Dendrimer Nanoparticles, Amin Amani, Nasser Zare, Asadollah Asadi, Rasool Asghari Zakaria
Turkish Journal of Biology
Cationic polyamidoamine (PAMAM) dendrimers are highly branched nanoparticles with unique molecular properties, which make them promising nanocarriers for gene delivery into cells. This research evaluated the ability of hyperbranched PAMAM (hPAMAM)-G2 with a diethylenetriamine core to interact with DNA, its protection from ultrasonic damage, and delivery to alfalfa cells. Additionally, the effects of ultrasound on the efficacy of hPAMAM-G2 for the delivery and expression of the gusA gene in the alfalfa cells were investigated. The electrophoresis retardation of plasmid DNA occurred at an N/P ratio (where N is the number of hPAMAM nitrogen atoms and P is the number of …
Deep Sequencing Reveals Two Jurkat Subpopulations With Distinct Mirna Profiles During Camptothecin-Induced Apoptosis, İpek Erdoğan, Mehmet İlyas Coşacak, Ayten Nalbant Aldanmaz, Bünyami̇n Akgül
Deep Sequencing Reveals Two Jurkat Subpopulations With Distinct Mirna Profiles During Camptothecin-Induced Apoptosis, İpek Erdoğan, Mehmet İlyas Coşacak, Ayten Nalbant Aldanmaz, Bünyami̇n Akgül
Turkish Journal of Biology
MicroRNAs (miRNAs) are small noncoding RNAs of about 19-25 nt that regulate gene expression posttranscriptionally under various cellular conditions, including apoptosis. The miRNAs involved in modulation of apoptotic events in T cells are partially known. However, heterogeneity associated with cell lines makes it difficult to interpret gene expression signatures, especially in cancer-related cell lines. Treatment of the Jurkat T-cell leukemia cell line with the universal apoptotic drug, camptothecin, resulted in identification of two Jurkat subpopulations: one that is sensitive to camptothecin and another that is rather intrinsically resistant. We sorted apoptotic Jurkat cells from nonapoptotic ones prior to profiling miRNAs …
Recombinant Outer Membrane Protein Q And Putative Lipoprotein From Bordetella Pertussis Inducing Strong Humoral Response Were Not Protective Alone In The Murine Lung Colonization Model, Çi̇ğdem Yilmaz, Erkan Özcengi̇z, Gülay Özcengi̇z
Recombinant Outer Membrane Protein Q And Putative Lipoprotein From Bordetella Pertussis Inducing Strong Humoral Response Were Not Protective Alone In The Murine Lung Colonization Model, Çi̇ğdem Yilmaz, Erkan Özcengi̇z, Gülay Özcengi̇z
Turkish Journal of Biology
Despite high vaccination coverage after introduction of whole cell (wP) and acellular pertussis (aP) vaccines, pertussis resurgence has been reported in many countries. aP vaccines are commonly preferred due to side effects of wP vaccines and formulated with aluminum hydroxide (Alum), which is not an effective adjuvant to eliminate Bordetella pertussis. Low efficiency of current aP vaccines is thought to be the main reason for the resurgence for which newer generation aP vaccines are needed. In the present study, immunogenicity and protective efficacy of outer membrane protein Q (OmpQ) and a putative lipoprotein (Lpp) from B. pertussis were investigated in …
Polyphenolic Contents Of Teucrium Polium L. And Teucrium Scordium L. Associated With Their Protective Effects Against Mmc-Induced Chromosomal Damage In Cultured Human Peripheral Blood Lymphocytes, Olivera Milosevic Djordjevic, Marina Radovic Jakovljevic, Aleksandra Markovic, Milan Stankovic, Andrija Ciric, Dragoslav Marinkovic, Darko Grujicic
Polyphenolic Contents Of Teucrium Polium L. And Teucrium Scordium L. Associated With Their Protective Effects Against Mmc-Induced Chromosomal Damage In Cultured Human Peripheral Blood Lymphocytes, Olivera Milosevic Djordjevic, Marina Radovic Jakovljevic, Aleksandra Markovic, Milan Stankovic, Andrija Ciric, Dragoslav Marinkovic, Darko Grujicic
Turkish Journal of Biology
Teucrium species have been used in traditional medicine for treatment of different diseases. The aim of this study was to investigate polyphenolic contents by high-performance liquid chromatography (HPLC), and the genotoxic effect of methanolic extracts of Teucrium polium and Teucrium scordium using the cytokinesis-block micronucleus (CBMN) assay on human peripheral blood lymphocytes (PBLs) from healthy donors. The HPLC analysis showed that extracts consist of phenolic acid (gallic, vanillic, caffeic, chlorogenic, p-coumaric, sinapic) and flavonoids (catechin, rutin, myricetin, luteolin, quercetin and apigenin). Cultures were treated with extracts of both plants separately and in combinations with mitomycin C (MMC). In separate treatments, …
Evaluation Of The Lifespan Extension Effects Of Several Turkish Medicinal Plants In Caenorhabditiselegans, Nuri̇ Ergen, Sanem Hoşbaş Coşkun, Di̇dem Deli̇orman Orhan, Mustafa Aslan, Ekrem Sezi̇k, Arzu Atalay
Evaluation Of The Lifespan Extension Effects Of Several Turkish Medicinal Plants In Caenorhabditiselegans, Nuri̇ Ergen, Sanem Hoşbaş Coşkun, Di̇dem Deli̇orman Orhan, Mustafa Aslan, Ekrem Sezi̇k, Arzu Atalay
Turkish Journal of Biology
Research on longevity is important to both prolong lifespan and support healthy aging. Natural products are widely being utilized and used as new resources for drug molecules. Caenorhabditis elegans is an advantageous organism for longevity research and age-related diseases. In this study, we tested a number of plant extracts for their effects on C. elegans longevity. In lifespan assays, age- synchronized wild-type C. elegans specimens were treated with different concentrations of plant extracts. Plant extracts were prepared as either infusions or decoctions, similar to their traditional utilization. Hedera helix L. (Araliaceae) extended lifespan in worms in a concentration-dependent manner. The …
Age- And Sex-Dependent Alteration Of Functions And Epigenetic Modifications Ofvessel And Endothelium Related Biomarkers, Sevtap Han, Muammer Merve Aydin, Serdar Akansel, Suzan Emel Usanmaz, Kami̇l Can Akçali, Meci̇t Orhan Uludağ, Emi̇ne Demi̇rel Yilmaz
Age- And Sex-Dependent Alteration Of Functions And Epigenetic Modifications Ofvessel And Endothelium Related Biomarkers, Sevtap Han, Muammer Merve Aydin, Serdar Akansel, Suzan Emel Usanmaz, Kami̇l Can Akçali, Meci̇t Orhan Uludağ, Emi̇ne Demi̇rel Yilmaz
Turkish Journal of Biology
Aging is a main risk factor for development of cardiovascular diseases associated with the impairment of endothelial function in both sexes. In the present study, age-related changes in vascular responsiveness, epigenetic modifications of vessel wall, and blood biomarkers related to endothelial functions were examined in an age- and sex-dependent manner. Acetylcholine (ACh)-induced relaxations of the aorta were decreased in 3-, 6-, and 12-month-old rats compared to those in 1-month-old female rats. In males, maximum relaxations related to ACh were higher in 1- and 6-month-old rats than in 3- and 12-month-old rats. Plasma levels of nitric oxide (NO) and asymmetric dimethylarginine …
Evaluation Of Antiproliferative And Protective Effects Of Eupatorium Cannabinum L. Extracts, Alice Grigore, Georgeta Neagu, Nicoleta Dobre, Adrian Albulescu, Lucian Ionita, Carmen Ionita, Radu Albulescu
Evaluation Of Antiproliferative And Protective Effects Of Eupatorium Cannabinum L. Extracts, Alice Grigore, Georgeta Neagu, Nicoleta Dobre, Adrian Albulescu, Lucian Ionita, Carmen Ionita, Radu Albulescu
Turkish Journal of Biology
Eupatorium cannabinum L. (Asteraceae) has been used for a long time for medicinal purposes due to its various pharmacological effects and richness in active compounds such as phenolics, sesquiterpenes, pyrrolizidine alkaloids, and polysaccharides. Despite the high content of compounds that have important roles in medicinal plants, there are still limited literature data regarding this valuable species. The plant was fractioned using chloroform (EC) and distilled water (EA) and HPLC analysis revealed the presence of eupatorin, eupatilin, and quercetin in EC and caffeic acid and rutin in EA. The antiproliferative potential on BT-20, HepG2, Caco-2, and Jurkat cancer cell lines was …
A Minimally Invasive Transfer Method Of Mesenchymal Stem Cells To The Intactperiodontal Ligament Of Rat Teeth: A Preliminary Study, Ni̇sa Gül Amuk, Gokmen Kurt, Melis Kartal Yandim, Aysun Adan, Yusuf Baran
A Minimally Invasive Transfer Method Of Mesenchymal Stem Cells To The Intactperiodontal Ligament Of Rat Teeth: A Preliminary Study, Ni̇sa Gül Amuk, Gokmen Kurt, Melis Kartal Yandim, Aysun Adan, Yusuf Baran
Turkish Journal of Biology
The aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and …
In Vitro Evaluation Of The Effects Of Capsaicin On Normal And Cancerouscells Of Human Cartilage, Nagi̇han Helvaci, Sabahatti̇n Cömertpay
In Vitro Evaluation Of The Effects Of Capsaicin On Normal And Cancerouscells Of Human Cartilage, Nagi̇han Helvaci, Sabahatti̇n Cömertpay
Turkish Journal of Biology
Chondrosarcoma is a common form of bone cancer which affects the fibrous connective tissue around a joint. It most commonly develops in legs, arms, shoulder blades, rib cage, and pelvis. Capsaicin is an active bitter compound found in red pepper, the fruit of the species Capsicum annuum, and it has been shown to have a lethal effect on different types of cancer. However, to date, investigation of its effect on human chondrosarcoma cells has remained limited. In the study presented here, we determined IC50 values of capsaicin for chondrosarcoma and chondrocyte cells in both fetal bovine serum (FBS)-containing and FBS-deprived …
Oxidative Stress Upregulates The Transcription Of Genes Involved In Thiaminemetabolism, Burcu Kartal, Ahmet Akçay, Bedi̇a Palabiyik
Oxidative Stress Upregulates The Transcription Of Genes Involved In Thiaminemetabolism, Burcu Kartal, Ahmet Akçay, Bedi̇a Palabiyik
Turkish Journal of Biology
Thiamine is a major vitamin that acts as a cofactor in energy metabolism in all organisms, as well as in lipid and amino acid metabolisms, and is associated with many diseases. It is known that glucose starvation decreases the intracellular thiamine pool while increasing oxidative stress tolerance. Earlier, in whole genome analysis, we detected major differences in the expression of genes related to thiamine pathway against oxidative stress in Schizosaccharomyces pombe. We investigated the effects of oxidative stress and glucose repression to thiamine pathway in S. pombe by comparing some genes encoding key enzymes of each related pathway at the …
Peptidomic Characterization And Bioactivity Of Protoiurus Kraepelini(Scorpiones: Iuridae) Venom, Tuğba Doğan, Naşi̇t İğci̇, Ayşenur Bi̇ber, Seli̇n Gerekci̇, Hepşen Hazal Hüsnügi̇l, Afi̇fe İzbirak, Can Özen
Peptidomic Characterization And Bioactivity Of Protoiurus Kraepelini(Scorpiones: Iuridae) Venom, Tuğba Doğan, Naşi̇t İğci̇, Ayşenur Bi̇ber, Seli̇n Gerekci̇, Hepşen Hazal Hüsnügi̇l, Afi̇fe İzbirak, Can Özen
Turkish Journal of Biology
Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a protein distribution from 2 to 130 kDa. MALDI-TOF MS analysis of the venom peptide fraction yielded 27 peptides between 1059 and 4623 Da in mass. Several ion channelblocking and antimicrobial peptides were identified by peptide mass fingerprinting analysis. Cytotoxic and antimicrobial effects of the venom were also demonstrated on Jurkat cells and Escherichia coli, respectively. As the first peptidomic characterization study on P. …
Effect Of Long-Term Administration Of Cinnamomum Cassia Silver Nanoparticles On Organs (Kidneys And Liver) Of Sprague-Dawley Rats, Koffi Kouame, Aniekan Peter, Edidiong Akang, Mistura Adana, Roshila Moodlay, Edwin C. Naidu, Onyemaechi Azu
Effect Of Long-Term Administration Of Cinnamomum Cassia Silver Nanoparticles On Organs (Kidneys And Liver) Of Sprague-Dawley Rats, Koffi Kouame, Aniekan Peter, Edidiong Akang, Mistura Adana, Roshila Moodlay, Edwin C. Naidu, Onyemaechi Azu
Turkish Journal of Biology
This study investigated the toxic effects of silver on the kidneys and livers of Sprague-Dawley rats after administering multiple doses of silver nanoparticles synthesized using extracts of Cinnamomum cassia (CcAgNPs). Twenty-four Sprague-Dawley rats (250 ± 20 g) were randomly assigned to four groups (A-D) of six animals per group and treated for 8 weeks. Group A was administered 200 mg/kg of Cinnamon Cassia extract (Cc), group B 5 mg/kg of CcAgNPs, group C 10 mg/kg of CcAgNPs, and group D normal saline. Body weight was measured weekly and fasting blood glucose was measured fortnightly. At the end of the experiment, …
Discriminant-Based Study Of The Shell Morphometric Relationships Of Patella Caerulea (Gastropoda: Prosobranchia) Of The Western Mediterranean Sea, Zoheir Bouzaza, Karim Mezali
Discriminant-Based Study Of The Shell Morphometric Relationships Of Patella Caerulea (Gastropoda: Prosobranchia) Of The Western Mediterranean Sea, Zoheir Bouzaza, Karim Mezali
Turkish Journal of Zoology
Our work is a contribution to the study of the morphometric dissimilarity of the limpet Patella caerulea (Linnaeus, 1758) inhabiting the seashore of the western Mediterranean Sea. For this study, 438 individuals of this species were sampled in 24 stations and separated into 2 groups of individuals: the first group (G1) originating from the upper infralittoral and the lower mediolittoral areas, and the second group (G2) originating from the upper mediolittoral area. The biometry of P. caerulea has been studied by considering the total length (L), the total width (W), and the total height (H) of the shell. These parameters …
Bioremoval Of Toxic Dye By Using Different Marine Macroalgae, Hanan Omar, Adel El-Gendy, Khairia Al-Ahmary
Bioremoval Of Toxic Dye By Using Different Marine Macroalgae, Hanan Omar, Adel El-Gendy, Khairia Al-Ahmary
Turkish Journal of Botany
The removal of malachite green dye from aqueous solution by Ulva lactuca, Sargassum crassifolium, and Gracilaria corticata has been demonstrated in order to examine their potential use as low-cost adsorbents. The optimum pH (8.0), temperature (25 °C), contact time (150 min), and biomass (2.0 g) for removal of dye by algae are reported. The maximum removal percentage of the dye ranged between 95.6% and 98.3% by using Sargassum crassifolium at the optimal conditions. Minimum removal of dye by algae (69%-77.1%) was observed with the high dye concentration of 35 mg L-1 at the optimal conditions. Adsorption of the dye by …
Cloning And Functional Assessment Of The Protein Disulfide Isomerase (Pdi-V) Gene And Its Promoter Sequences From Haynaldia Villosa, Muhammad Faheem, Muhammad Arshad, Jin Xiao, Haiyan Wang, Yingbo Li, Xiue Wang
Cloning And Functional Assessment Of The Protein Disulfide Isomerase (Pdi-V) Gene And Its Promoter Sequences From Haynaldia Villosa, Muhammad Faheem, Muhammad Arshad, Jin Xiao, Haiyan Wang, Yingbo Li, Xiue Wang
Turkish Journal of Botany
Protein disulfide isomerase (PDI) and PDI-like genes encode key foldase enzymes that play an important role in disulfide bond formation, isomerization, and many other metabolic functions in plants. Our previous results indicate that the PDI-V expression is tissue-specific and that it is upregulated by powdery mildew and other abiotic stress treatments. In the current study, the complete PDI-V gene and its promoter sequence were cloned to identify gene structure and the important cis-regulating motifs responsible for various genes' activities. Sequence analysis revealed the size of the cloned genomic sequence and promoter region as 5728 bp and 2086 bp, respectively. The …