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Chaetocin Enhances Callus Induction By Decreasing The Expression Of Major Leaf Polarity Genes In Nicotiana Tabacum, Ayyub Ebrahimi, Nagi̇han Özsoy, Saadet Deni̇z Gürle, Baki̇ Yaman, Şule Ari
Chaetocin Enhances Callus Induction By Decreasing The Expression Of Major Leaf Polarity Genes In Nicotiana Tabacum, Ayyub Ebrahimi, Nagi̇han Özsoy, Saadet Deni̇z Gürle, Baki̇ Yaman, Şule Ari
Turkish Journal of Botany
Using chemicals known as inhibitors of chromatin remodeling enzymes is a useful approach in understanding the regulation machinery that contributes to the maintenance of or conversion to a pluri- and totipotent states of the cells in multicellular organisms. They can serve as tools to reveal the molecular and cellular mechanisms required for reprogramming. A deeper understanding of reprogramming pathways that drive the cell into a dedifferentiated state might help us enhance plant micropropagation and green biotechnology applications. Chaetocin is one of the histone methyltransferase inhibitors known as key drivers in several cellular processes. It was shown that chaetocin enhanced the …
Synthesis Of Intracellular And Extracellular Gold Nanoparticles With A Green Machine And Its Antifungal Activity, Nurbanu Gürsoy, Betül Yilmaz Öztürk, İlknur Dağ
Synthesis Of Intracellular And Extracellular Gold Nanoparticles With A Green Machine And Its Antifungal Activity, Nurbanu Gürsoy, Betül Yilmaz Öztürk, İlknur Dağ
Turkish Journal of Biology
Green synthesis method is being increasingly used in the development of safe, stable, and eco-friendly nanostructures with biological resources. In this study, extracellular and intracellular synthesis of gold nanoparticles (AuNPs) was carried out using green algae Chlorella sorokiniana Shihira & R.W. Fresh algae were isolated and identified from Musaözü Pond located in the province of Eskişehir and then extraction process were performed. Optimization studies were studied using pH value, metal salt concentration, and time parameters for extracellular synthesis and using only time parameter for intrasellular synthesis. Since more controlled and optimum conditions can be achieved in the production of AuNPs …
Il-1r1 Deficiency Impairs Liver Regeneration After 2/3 Partial Hepatectomy In Aged Mice, Deming Li, Ze Wang, Chunyan Zhang, Cunshuan Xu
Il-1r1 Deficiency Impairs Liver Regeneration After 2/3 Partial Hepatectomy In Aged Mice, Deming Li, Ze Wang, Chunyan Zhang, Cunshuan Xu
Turkish Journal of Biology
Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment was to determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) and the IL-1R1 knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation. Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative realtime polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient …
Lipase From New Isolate Bacillus Cereus Ata179: Optimization Of Production Conditions, Partial Purification, Characterization And Its Potential In The Detergent Industry, Eli̇f Demi̇rkan, Aynur Aybey Çeti̇nkaya, Maoulida Abdou
Lipase From New Isolate Bacillus Cereus Ata179: Optimization Of Production Conditions, Partial Purification, Characterization And Its Potential In The Detergent Industry, Eli̇f Demi̇rkan, Aynur Aybey Çeti̇nkaya, Maoulida Abdou
Turkish Journal of Biology
In this study, 341 Bacillus sp. strains were isolated from agricultural soils of Turkey. The potent extracellular lipase producer was selected. It was identified by 16S rRNA, named as Bacillus cereus ATA179. Optimal nutritional and physical parameters for lipase production were determined. Sucrose as the carbon source, (NH4)2HPO4 as the nitrogen source, CaCl2 as the metal ion were obtained. The best results of physical parameters were stated at 45°C, pH 7.0, shaking rate 50 rpm, inoculation amount 7% and inoculum age 24 h. ATA179 strain showed a 51% increase in enzyme production in the modified medium created by optimizing nutritional …
Characteristics And Clinical Significance Of Cd163+/Cd206+M2 Mono-Macrophage In The Bladder Cancer Microenvironment, Xiangjie Kong, Ming Zhu, Zhirong Wang, Zhuoqun Xu, Jianfeng Shao
Characteristics And Clinical Significance Of Cd163+/Cd206+M2 Mono-Macrophage In The Bladder Cancer Microenvironment, Xiangjie Kong, Ming Zhu, Zhirong Wang, Zhuoqun Xu, Jianfeng Shao
Turkish Journal of Biology
The tumor microenvironment may recruit monocytes, with a protumoral macrophage phenotype (M2) that plays an important role in solid tumor progression and metastasis. Therefore, it is necessary to understand the characteristics of these cells for cancer prevention and treatment. Bladder cancer tissue samples and paracarcinoma tissues samples were collected, and the expression of CD163+ cells in tumor tissues was observed. Then, we observed the expression of infiltrating CD45+CD14+CD163+ cell subset and analyzed the molecular expressions related to immunity and angiogenesis. C57/BL6 mice were inoculated subcutaneously, and dynamic changes of CD11b+F4/80+CD206+ mononuclear macrophages expression for tumor-bearing mice were detected. The results …
Investigation Of Neuro-Inflammatory Parameters In A Cuprizone Induced Mouse Model Of Multiple Sclerosis, Ti̇muçi̇n Avşar, Gökçe Erdem, Gökhan Terzi̇oğlu, Eda Tahi̇r Turanli
Investigation Of Neuro-Inflammatory Parameters In A Cuprizone Induced Mouse Model Of Multiple Sclerosis, Ti̇muçi̇n Avşar, Gökçe Erdem, Gökhan Terzi̇oğlu, Eda Tahi̇r Turanli
Turkish Journal of Biology
Cuprizone, copper chelator, treatment of mouse is a toxic model of multiple sclerosis (MS) in which oligodendrocyte death, demyelination and remyelination can be observed. Understanding T and B cell subset as well as their cytokines involved in MS pathogenesis still requires further scrutiny to better understand immune component of MS. The study presented here, aimed to evaluate relevant cytokines, lymphocytes, and gene expressions profiles during demyelination and remyelination in the cuprizone mouse model of MS. Eighty male C57BL/6J mice fed with 0.2% cuprizone for eight weeks. Cuprizone has been removed from the diet in the following eight weeks. Cuprizone treated …
Classification Of Bladder Cancer Cell Lines According To Regulon Activity, Aleyna Eray, Serap Erkek Özhan
Classification Of Bladder Cancer Cell Lines According To Regulon Activity, Aleyna Eray, Serap Erkek Özhan
Turkish Journal of Biology
Bladder cancer is one of the most frequent cancers and causes more than 150.000 deaths each year. During the last decade, several studies provided important aspects about genomic characterization, consensus subgroup definition, and transcriptional regulation of bladder cancer. Still, much more research needs to be done to characterize molecular signatures of this cancer in depth. At this point, the use of bladder cancer cell lines is quite useful for the identification and test of new signatures. In this study, we classified the bladder cancer cell lines according to the activities of regulons implicated in the regulation of primary bladder tumors. …
Fluid Shear Stress And Endothelial Cells Synergistically Promote Osteogenesis Of Mesenchymal Stem Cells Via Integrin Ss1-Fak-Erk1/2 Pathway, Mingli Jiang, Qihua Shen, Yi Zhou, Wenxia Ren, Miaomiao Chai, Yan Zhou, Wen-Song Tan
Fluid Shear Stress And Endothelial Cells Synergistically Promote Osteogenesis Of Mesenchymal Stem Cells Via Integrin Ss1-Fak-Erk1/2 Pathway, Mingli Jiang, Qihua Shen, Yi Zhou, Wenxia Ren, Miaomiao Chai, Yan Zhou, Wen-Song Tan
Turkish Journal of Biology
Prevascularization and mechanical stimulation have been reported as effective methods for the construction of functional bone tissue. However, their combined effects on osteogenic differentiation and its mechanism remain to be explored. Here, the effects of fluid shear stress (FSS) on osteogenic differentiation of rat bone-marrow-derived mesenchymal stem cells (BMSCs) when cocultured with human umbilical vein endothelial cells (HUVECs) were investigated, and underlying signaling mechanisms were further explored. FSS stimulation for 1-4 h/day increased alkaline phosphatase (ALP) activity and calcium deposition in coculture systems and promoted the proliferation of cocultured cells. FSS stimulation for 2 h/day was selected as the optimized …
A Cytoplasmic Escapee: Desmin Is Going Nuclear, Ecem Kural Mangit, Ni̇lüfer Düz, Pervi̇n Ruki̇ye Di̇nçer
A Cytoplasmic Escapee: Desmin Is Going Nuclear, Ecem Kural Mangit, Ni̇lüfer Düz, Pervi̇n Ruki̇ye Di̇nçer
Turkish Journal of Biology
It has been a long time since researchers have focused on the cytoskeletal proteins' unconventional functions in the nucleus. Subcellular localization of a protein not only affects its functions but also determines the accessibility for cellular processes. Desmin is a muscle-specific, cytoplasmic intermediate filament protein, the cytoplasmic roles of which are defined. Yet, there is some evidence pointing out nuclear functions for desmin. In silico and wet lab analysis shows that desmin can enter and function in the nucleus. Furthermore, the candidate nuclear partners of desmin support the notion that desmin can serve as a transcriptional regulator inside the nucleus. …
Effects Of Bradykinin On Proliferation, Apoptosis, And Cycle Of Glomerular Mesangial Cells Via The Tgf-Ss1/Smad Signaling Pathway, Ji Dong, Li Ding, Liuwei Wang, Zijun Yang, Yulin Wang, Ying Zang, Xuexia Cao, Lin Tang
Effects Of Bradykinin On Proliferation, Apoptosis, And Cycle Of Glomerular Mesangial Cells Via The Tgf-Ss1/Smad Signaling Pathway, Ji Dong, Li Ding, Liuwei Wang, Zijun Yang, Yulin Wang, Ying Zang, Xuexia Cao, Lin Tang
Turkish Journal of Biology
We aimed to assess the effects of bradykinin (BK) on the proliferation, apoptosis, and cycle of glomerular mesangial cells via the transforming growth factor-ß 1 (TGF-ß1)/Smad signaling pathway. Rat glomerular mesangial cells, HBZY-1, were divided into normal group (untreated), model group (5 ng/L TGF-ß1), BK group (5 ng/L TGF-ß1 + 1 ng/L BK), and inhibitor group [5 ng/L TGF-ß1 + 1 ng/L LY2109761 (TGF-ß1-specific inhibitor)]. The cell proliferation, cycle, apoptosis, expression of type I collagen (Col-1), and protein expressions of Col-1, TGF-ß1, and phosphorylated Smad2 (p-Smad2) were detected by EdU labeling, flow cytometry, acridine orange/ethidium bromide (AO/EB) dual staining, immunofluorescence …
Increased Ribonuclease Activity In Solanum Tuberosum L. Transformed With Heterologous Genes Of Apoplastic Ribonucleases As A Putative Approach For Production Of Virus Resistant Plants, Andrii Potrokhov, Daria Sosnovska, Olga Ovcharenko, Irena Budzanivska, Volodymyr Rudas, Mykola Kuchuk
Increased Ribonuclease Activity In Solanum Tuberosum L. Transformed With Heterologous Genes Of Apoplastic Ribonucleases As A Putative Approach For Production Of Virus Resistant Plants, Andrii Potrokhov, Daria Sosnovska, Olga Ovcharenko, Irena Budzanivska, Volodymyr Rudas, Mykola Kuchuk
Turkish Journal of Biology
Viral pathogens seriously decrease the yield of potato (Solanum tuberosum L.) -an important agricultural crop. Therefore, there is a demand for potato cultivars resistant to multiple viruses. Ribonucleases (RNases) are supposed to be engaged to antiviral response in plants. Heterologous RNase gene expression provides a tool for production of cultivars with multiple resistance to viruses and viroids. Transgenic potato cultivars Luhivs'ka and Lasynak with heterologous genes bov and ZRNase II of apoplastic RNases from Bos taurus and Zinnia elegans respectively were obtained via Agrobacterium-mediated transformation. The presence of bov and ZRNase II transgenes was confirmed by PCR analysis. RNase activity …
An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk
An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk
Turkish Journal of Biology
Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B 1.351, P.1, and B.1.617 lineages or variants of …
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Turkish Journal of Biology
Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate that gut-lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which, in turn, can affect distal organs such as the brain. Moreover, gut microbiota …
Targeting Cov-2 Spike Rbd And Ace-2 Interaction With Flavonoids Of Anatolian Propolis By In Silico And In Vitro Studies In Terms Of Possible Covid-19 Therapeutics, Hali̇l İbrahi̇m Güler, Fulya Ay Şal, Zehra Can, Yakup Kara, Oktay Yildiz, Ali̇ Osman Beldüz, Sabri̇ye Çanakçi, Sevgi̇ Kolayli
Targeting Cov-2 Spike Rbd And Ace-2 Interaction With Flavonoids Of Anatolian Propolis By In Silico And In Vitro Studies In Terms Of Possible Covid-19 Therapeutics, Hali̇l İbrahi̇m Güler, Fulya Ay Şal, Zehra Can, Yakup Kara, Oktay Yildiz, Ali̇ Osman Beldüz, Sabri̇ye Çanakçi, Sevgi̇ Kolayli
Turkish Journal of Biology
Propolis is a multi-functional bee product rich in polyphenols. In this study, the inhibitory effect of Anatolian propolis against SARS-coronavirus-2 (SARS-CoV-2) was investigated in vitro and in silico. Raw and commercial propolis samples were used, and both samples were found to be rich in caffeic acid, p-coumaric acid, ferulic acid, t-cinnamic acid, hesperetin, chrysin, pinocembrin, and caffeic acid phenethyl ester (CAPE) at HPLC-UV analysis. Ethanolic propolis extracts (EPE) were used in the ELISA screening test against the spike S1 protein (SARS-CoV-2): ACE-2 interaction for in vitro study. The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 …
The Potential Use Of Drosophila As An In Vivo Model Organism For Covid-19-Related Research: A Review, Eşref Demi̇r
The Potential Use Of Drosophila As An In Vivo Model Organism For Covid-19-Related Research: A Review, Eşref Demi̇r
Turkish Journal of Biology
The world urgently needs effective antiviral approaches against emerging viruses, as shown by the coronavirus disease 2019 (COVID-19) pandemic, which has become an exponentially growing health crisis. Scientists from diverse backgrounds have directed their efforts towards identifying key features of SARS-CoV-2 and clinical manifestations of COVID-19 infection. Reports of more transmissible variants of SARS-CoV-2 also raise concerns over the possibility of an explosive trajectory of the pandemic, so scientific attention should focus on developing new weapons to help win the fight against coronaviruses that may undergo further mutations in the future. Drosophila melanogaster offers a powerful and potential in vivo …
Determination Of The Interaction Between The Receptor Binding Domain Of 2019-Ncov Spike Protein, Tmprss2, Cathepsin B And Cathepsin L And Glycosidic And Aglycon Forms Of Some Flavonols, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Paulo Augusto Netz, Cengi̇z Sarikürkcü, İbrahi̇m Hali̇l Kiliç, Bektaş Tepe
Determination Of The Interaction Between The Receptor Binding Domain Of 2019-Ncov Spike Protein, Tmprss2, Cathepsin B And Cathepsin L And Glycosidic And Aglycon Forms Of Some Flavonols, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Paulo Augusto Netz, Cengi̇z Sarikürkcü, İbrahi̇m Hali̇l Kiliç, Bektaş Tepe
Turkish Journal of Biology
The novel coronavirus (COVID-19, SARS-CoV-2) is a rapidly spreading disease with a high mortality. In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane protease, serine 2 (TMPRSS2), and cathepsins (CatB and CatL) were analyzed. According to the relative binding capacity index (RBCI) calculated based on the free energy of binding and calculated inhibition constants, it was determined that robinin (ROB) and gossypetin (GOS) were the most effective flavonols on all targets. While the binding free energy of ROB with the spike glycoprotein RBD, TMPRSS2, CatB, and CatL were -5.02, -7.57, -10.10, and -6.11 …
Cannabinoids For Sars-Cov-2 And Is There Evidence Of Their Therapeutic Efficacy?, Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmai̇l Yener, Mustafa Abdullah Yilmaz, Emi̇ne Ayaz Ti̇lkat, Remzi̇ Eki̇nci̇, Nesri̇n Bozhan, Sevgi̇ İrtegün
Cannabinoids For Sars-Cov-2 And Is There Evidence Of Their Therapeutic Efficacy?, Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmai̇l Yener, Mustafa Abdullah Yilmaz, Emi̇ne Ayaz Ti̇lkat, Remzi̇ Eki̇nci̇, Nesri̇n Bozhan, Sevgi̇ İrtegün
Turkish Journal of Biology
To combat the coronaviruses and their novel variants, therapeutic drugs and the development of vaccines that are to be effective throughout human life are urgently needed. The endocannabinoid system (ECS) acts as a modulator in the activation of the microcirculation, immune system, and autonomic nervous system, along with controlling pharmacological functions such as emotional responses, homeostasis, motor functions, cognition, and motivation. The ECS contains endogenous cannabinoids, cannabinoid receptor (CBRs), and enzymes that regulate their biosynthesis, transport, and degradation. Moreover, phytocannabinoids and synthetic cannabinoids that mimic the action of endocannabinoids also play an essential role in the modulation of the ECS. …
Ant Fauna (Hymenoptera: Formicidae) Of Central Anatolian Region Of Turkey, Kadri̇ Kiran, Celal Karaman
Ant Fauna (Hymenoptera: Formicidae) Of Central Anatolian Region Of Turkey, Kadri̇ Kiran, Celal Karaman
Turkish Journal of Zoology
The Central Anatolian part of Turkey was investigated with the aim of determining its Formicidae fauna. Specimens were collected by hand sampling and pitfall traps in 24 habitats in 383 different localities in Central Anatolia Region during 2001-2016. As a result, 137 species belonging to 34 genera were determined. Messor incorruptus Kuznetsov-Ugamsky, 1929 and Ponera testacea Emery, 1895 are new records for Turkish ant fauna. We excluded four species, Camponotus sylvaticus (Oliver, 1792), Messor meridionalis (André, 1883), Proformica striaticeps (Forel, 1911) and Tapinoma nigerrimum (Nylander, 1856), from Turkish ant fauna due to recent taxonomic data and distribution pattern. With these …
Capoeta Kosswigi Karaman, 1969 A Junior Synonym Of Capoeta Damascina(Valenciennes, 1842) (Teleostei: Cyprinidae), Erdoğan Çi̇çek, Soheil Eagderi, Burak Seçer, Sevi̇l Sungur
Capoeta Kosswigi Karaman, 1969 A Junior Synonym Of Capoeta Damascina(Valenciennes, 1842) (Teleostei: Cyprinidae), Erdoğan Çi̇çek, Soheil Eagderi, Burak Seçer, Sevi̇l Sungur
Turkish Journal of Zoology
Capoeta kosswigi was described from Lake Van basin, Turkey, being close to C. damascina and C. umbla. It is distinguished from them by a pointed snout and a small horseshoe-shaped mouth, and differing from C. damascina by having smaller scales, and from the C. umbla by processing larger scales. In this study, we tested the suggested synonymy hypothesis of C. kosswigi and C. damascina by comparing the morphometric and meristic data. The results revealed that all morphometric and meristic characters of C. kosswigi overlap with those of C. damascina. In line with previous molecular studies that COI, cytb and 16S …
Development, Validity And Reliability Study Of A Compliance Scale For The Covid-19 Outbreak Prevention Recommendations, Eli̇f Köse, Esra Yazici, Ahmet Bülent Yazici, Abdülkadi̇r Aydin, Hasan Çeti̇n Ekerbi̇çer, Oğuz Karabay
Development, Validity And Reliability Study Of A Compliance Scale For The Covid-19 Outbreak Prevention Recommendations, Eli̇f Köse, Esra Yazici, Ahmet Bülent Yazici, Abdülkadi̇r Aydin, Hasan Çeti̇n Ekerbi̇çer, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: During the intense periods of the COVID-19 pandemic, legal measures were taken for its containment. However, since legal precautions cannot be implemented continuously, hand washing, mask usage and obeying social distance rules are important in combating the pandemic. Complying with these rules is mostly individual decisions. The behavior of individuals has a prominent place in the course of the pandemic. In this study, we aimed to develop a scale which could measure compliance with outbreak measures. Materials and methods: This study was conducted in two stages after evaluation of the content validity of the item pool formed by the …
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
Turkish Journal of Medical Sciences
Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter. Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with …
Wnt Signaling Pathway Activities May Be Altered In Primary Sjogren's Syndrome, Ahmet Karataş, Zühal Ömerci̇koğlu, Burak Öz, Adi̇le Ferda Dağli, Onur Çatak, Fazi̇let Erman, Kazim Şahi̇n, Nevzat Gözel, Süleyman Serdar Koca
Wnt Signaling Pathway Activities May Be Altered In Primary Sjogren's Syndrome, Ahmet Karataş, Zühal Ömerci̇koğlu, Burak Öz, Adi̇le Ferda Dağli, Onur Çatak, Fazi̇let Erman, Kazim Şahi̇n, Nevzat Gözel, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: Sjögren's syndrome (SS) is an autoimmune disease and its pathogenesis is still not completely clear. The wingless (Wnt)/ß-catenin pathway has recently been shown to play an important role in inflammation. This study aims to determine the serum and saliva levels of Dickkopf (DKK)1 and sclerostin and to evaluate Wnt-1 and Wnt-3a expression in the salivary gland in patients with primary SS. Materials and methods: This study included 30 patients diagnosed with SS, 30 patients diagnosed with systemic lupus erythematosus (SLE), and 29 healthy controls. Serum and saliva levels of DKK1 and sclerostin were measured and the expressions of Wnt1 …
Allergic Diseases In The Elderly Population: A Single-Center Experience, Eray Yildiz, Fati̇h Çölkesen, Şevket Arslan, Recep Evcen, Fi̇li̇z Sadi̇ Aykan, Mehmet Kilinç, Gökhan Ayteki̇n
Allergic Diseases In The Elderly Population: A Single-Center Experience, Eray Yildiz, Fati̇h Çölkesen, Şevket Arslan, Recep Evcen, Fi̇li̇z Sadi̇ Aykan, Mehmet Kilinç, Gökhan Ayteki̇n
Turkish Journal of Medical Sciences
Background/aim: Although allergic diseases are generally considered to be diseases of childhood and youth, the first symptoms of allergic diseases can be seen in old age sometimes. The aim of this study was to determine the prevalence and characteristics of allergic diseases in the elderly population admitted to the allergy unit on an outpatient basis. Materials and methods: The files of the patients who applied to our clinic's allergy unit during the 8-year period were retrospectively analyzed. The data of patients aged ≥ 65 years were obtained from the files of our allergy unit archive. Results: A total of 1272 …
Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k
Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Guided bone regeneration (GBR) is commonly performed to repair bone defects, and rigid occlusive titanium barriers play a vital role in bone formation in regions with no prior bone tissue. The statin, rosuvastatin (RSV), strongly affects bone apposition when applied locally. Here, we aimed to evaluate the anabolic effects of locally applied RSV with a xenograft placed on rabbit calvaria. Materials and methods: Two rigid occlusive titanium caps were used in 16 rabbits after decorticating the calvarial bone. In the control group, the area under the cap was filled with a xenograft, while in the RSV group, a xenograft …
Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu
Perspectives For Immune Plasma Treatment Of Covid-19, Başak Sayinalp, Olgu Erki̇n Çinar, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim: The SARS-CoV-2 infection was declared as a pandemic by the World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already surpassed that of many previous epidemics. A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. This study aims to explain the background of convalescent plasma (CP) treatment and its relations with COVID-19 immunity, to define ideal treatment procedures, and to reveal present and future perspectives in the light of the rapidly growing data. Immunological basis …
The Effect Of Ankaferd Blood Stopper On Liver Damage In Experimental Obstructivejaundice, Koray Koşmaz, Abdullah Durhan, Marlen Süleyman, Yilmaz Ünal, Mustafa Taner Bostanci, Tuğba Yi̇ği̇t Haskaraca, Can Ersak, Mehmet Şeneş, İlknur Alkan Kuşabbi̇, Eylem Pinar Eser, Sema Hücümenoğlu
The Effect Of Ankaferd Blood Stopper On Liver Damage In Experimental Obstructivejaundice, Koray Koşmaz, Abdullah Durhan, Marlen Süleyman, Yilmaz Ünal, Mustafa Taner Bostanci, Tuğba Yi̇ği̇t Haskaraca, Can Ersak, Mehmet Şeneş, İlknur Alkan Kuşabbi̇, Eylem Pinar Eser, Sema Hücümenoğlu
Turkish Journal of Medical Sciences
Background/aims: To evaluate the potential protective effects of Ankaferd blood stopper (ABS) in an experimental obstructive jaundice (OJ) model. Materials and methods: The study included 26 female rats, which were divided into 3 groups. The sham group, consisting of 10 rats, (group 1) only received solely laparotomy. In the control group, consisting of 8 rats, (group 2), ligation was applied to the biliary tract and no treatment was implemented. In the treatment group, consisting of 8 rats, (group 3), following ligation of biliary tract, 0.5 mL/day ABS was given for 10 days. Liver tissue and blood samples were taken for …
New Additions To Turkish Mycota From Ankara, Balıkesir, And Kütahya Provinces, Deni̇z Altuntaş, Fuat Bozok, Hatira Taşkin, Şanli Kabaktepe, Hakan Alli, Ilgaz Akata
New Additions To Turkish Mycota From Ankara, Balıkesir, And Kütahya Provinces, Deni̇z Altuntaş, Fuat Bozok, Hatira Taşkin, Şanli Kabaktepe, Hakan Alli, Ilgaz Akata
Turkish Journal of Botany
The current research was conducted on the fungal materials collected from Ankara, Balıkesir, and Kütahya provinces between 2015 and 2019. As a result of the field and laboratory studies, Conocybe dentatomarginata, Entoloma lampropus, Lactarius lilacinus, Otidea nannfeldtii and Sarcopeziza sicula are reported for the first time from Turkey based on macro- and micromorphological studies and internal transcribed spacer (ITS) rDNA-based molecular phylogeny. Descriptions of new records are provided together with photos showing their macro and micro-morphology.
Optimal Directional Overcurrent Relay Coordination Based On Computationalintelligence Technique: A Review, Suzana Pil Ramli, Muhammad Usama, Hazlie Mokhlis, Wei Ru Wong, Muhamad Hatta Hussain, Munir Azam Muhammad, Nurulafiqah Nadzirah Mansor
Optimal Directional Overcurrent Relay Coordination Based On Computationalintelligence Technique: A Review, Suzana Pil Ramli, Muhammad Usama, Hazlie Mokhlis, Wei Ru Wong, Muhamad Hatta Hussain, Munir Azam Muhammad, Nurulafiqah Nadzirah Mansor
Turkish Journal of Electrical Engineering and Computer Sciences
An exponential increase in diverse load demand in the last decade has influenced the integration of more power plants into the power system. This increases the fault current due to the bidirectional flow of current, resulting in unwanted tripping of the relays if not properly coordinated. Therefore, it is imperative to ensure the installation of relays in the grid being able to sense the fault current from any direction (i.e. upstream or downstream). This can be accomplished by introducing an optimal directional overcurrent relay (DOCR) coordination scheme into the system. This paper presents an in-depth review of the applications of …
Design And Planning Of A Distribution System Using Renewable Technologies In Arural Area Of Pakistan, Abdur Rehman Yousaf, Ghulam Mujtaba, Muhammad Amjad, Zeeshan Rashid
Design And Planning Of A Distribution System Using Renewable Technologies In Arural Area Of Pakistan, Abdur Rehman Yousaf, Ghulam Mujtaba, Muhammad Amjad, Zeeshan Rashid
Turkish Journal of Electrical Engineering and Computer Sciences
The inclusion of renewable energy sources in a distribution system to form a dispersed or decentralized generation network has gained tremendous progress in recent years. The architecture of the distribution system has the potential to serve as a microgrid during an islanding operation connected directly to the load center while excited fully by renewable technologies. This paper deals with planning and designing of a medium voltage power distribution system in a rural area of Pakistan affluent with abundant reserves of renewable sources of electricity. Two types of distribution system architectures, namely radial and ring systems, are simulated using a power …
New Normal: Cooperative Paradigm For Covid-19 Timely Detection Andcontainment Using Internet Of Things And Deep Learning, Farooque Hassan Kumbhar, Ali Hassan Syed, Soo Young Shin
New Normal: Cooperative Paradigm For Covid-19 Timely Detection Andcontainment Using Internet Of Things And Deep Learning, Farooque Hassan Kumbhar, Ali Hassan Syed, Soo Young Shin
Turkish Journal of Electrical Engineering and Computer Sciences
The spread of the novel coronavirus (COVID-19) has caused trillions of dollars of damages to the governments and health authorities by affecting the global economies. It is essential to identify, track and trace COVID-19 spread at its earliest detection. Timely action can not only reduce further spread but also help in providing an efficient medical response. Existing schemes rely on volunteer participation, and/or mobile traceability, which leads to delays in containing the spread. There is a need for an autonomous, connected, and centralized paradigm that can identify, trace and inform connected personals. We propose a novel connected Internet of Things …