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Articles 1801 - 1830 of 23216
Full-Text Articles in Entire DC Network
Density Boosts Everything: A One-Stop Strategy For Improving Performance, Robustness, And Sustainability Of Malware Detectors, Jianwen Tian, Wei Kong, Debin Gao, Tong Wang, Taotao Gu, Kefan Qiu, Zhi Wang, Xiaohui Kuang
Density Boosts Everything: A One-Stop Strategy For Improving Performance, Robustness, And Sustainability Of Malware Detectors, Jianwen Tian, Wei Kong, Debin Gao, Tong Wang, Taotao Gu, Kefan Qiu, Zhi Wang, Xiaohui Kuang
Research Collection School Of Computing and Information Systems
In the contemporary landscape of cybersecurity, AI-driven detectors have emerged as pivotal in the realm of malware detection. However, existing AI-driven detectors encounter a myriad of challenges, including poisoning attacks, evasion attacks, and concept drift, which stem from the inherent characteristics of AI methodologies. While numerous solutions have been proposed to address these issues, they often concentrate on isolated problems, neglecting the broader implications for other facets of malware detection. This paper diverges from the conventional approach by not targeting a singular issue but instead identifying one of the fundamental causes of these challenges, sparsity. Sparsity refers to a scenario …
A Commitment Rule For Insolvency Forum, Anthony J. Casey, Aurelio Gurrea-Martinez, Robert K. Rasmussen
A Commitment Rule For Insolvency Forum, Anthony J. Casey, Aurelio Gurrea-Martinez, Robert K. Rasmussen
Research Collection Yong Pung How School Of Law
In this Article, we propose a new rule for determining the proper forum for insolvency proceedings. Currently, the Model Law on Cross-Border Insolvency (Model Law)—promulgated by the United Nations Commission on International Trade Law (UNCITRAL)—looks to a debtor’s center of main interest (COMI) to determine the proper forum for a foreign main insolvency proceeding. This rule is flawed. It is both inflexible and manipulable. It is also indeterminate and neither requires nor allows advance commitment by debtors. As a result, it leads to uncertainty, increases litigation costs, and opens the door to opportunistic manipulation by debtors. These costs, in turn, …
Negotiating With Gpt-4: Digital Doormat Or Skilful Counterpart?, Dorcas Quek Anderson
Negotiating With Gpt-4: Digital Doormat Or Skilful Counterpart?, Dorcas Quek Anderson
Research Collection Yong Pung How School Of Law
Large language models (LLMs) such as GPT-4 have been creatively harnessed in the conflict resolution arena as dialogue agents interacting with humans within negotiations, due to their capacity for in-context learning and giving human-like responses. In light of the burgeoning use of LLMs in conflict resolution training, a pilot study was conducted to ascertain the desirability of using dialogue agents built on GPT-4 in conducting simulations for students learning negotiation skills. This article discusses insights gained from the study on the reliability of LLM agents in following prompts for negotiation simulations; notable negotiation behaviour of the LLM agent; the degree …
Managed Diversity Along The Legal Silk Road: The Asean-Asia Relationship In International Arbitration, Mark Mclaughlin
Managed Diversity Along The Legal Silk Road: The Asean-Asia Relationship In International Arbitration, Mark Mclaughlin
Research Collection Yong Pung How School Of Law
Efforts to foster closer economic integration often focus on the alignment of standards with respect to goods and services. The harmonization of substantive regulations mitigates the inevitable friction caused by moving assets from one jurisdiction to another. In this chapter, it is argued that interna- tional arbitration plays a similar function in the Association of Southeast Asian Nations (ASEAN)-Asia relationship. By providing a neutral and reliable forum for dispute resolution, international arbitration helps manage legal diversity by creating a ‘Legal Silk Road’ on which commercial parties can engage with a familiar dispute resolution process without having to engage the local …
Information Spillover And Corporate Policies: The Case Of Listed Options, Gennaro Bernile, Jianfeng Hu, Guangzhong Li, Roni Michaely
Information Spillover And Corporate Policies: The Case Of Listed Options, Gennaro Bernile, Jianfeng Hu, Guangzhong Li, Roni Michaely
Research Collection Lee Kong Chian School Of Business
Information production associated with derivatives markets is not a sideshow; rather, it has significantly positive spillover effects on an array of corporate decisions of underlying firms. Using a regression-discontinuity design based on exogenous variation in options availability as an instrument for changes in the information environment, we show that options introductions have causal effects on corporate policies on both sides of the balance sheet. Through improved information efficiency, options availability reduces the need for debt and payout, increases efficient investment, and yields superior innovation. We conduct two independent experiments demonstrating that our instrument s impact is not derived from alternative …
Retirement And Organizations: Advocating Organizational Responsibility For Retirement In Practice And Scholarship, Valerie Caines, Gokhan Ertug, Prashant Bordia, Deidra J. Schleicher
Retirement And Organizations: Advocating Organizational Responsibility For Retirement In Practice And Scholarship, Valerie Caines, Gokhan Ertug, Prashant Bordia, Deidra J. Schleicher
Research Collection Lee Kong Chian School Of Business
In this editorial we discuss organizations’ role in the process of retirement. We argue that organizations have abdicated their moral obligation to older workers, thereby negatively impacting older workers’ wellbeing and their successful transition to retirement. We also note that organizational studies scholars have not paid adequate attention to that negligence, or its alternatives. We suggest that, among other reasons, this oversight can be a result of the comparatively privileged socioeconomic positions of faculty in business schools vis-à-vis older workers in many other occupations, as well as to a discord between traditional human capital and human resource management theories and …
The Boundaries Of The Law: Can Us Private Enforcement Discipline Foreign Firms?, Massimo Massa, Xiaoqiao Wang, Bohui Zhang, Hong Zhang
The Boundaries Of The Law: Can Us Private Enforcement Discipline Foreign Firms?, Massimo Massa, Xiaoqiao Wang, Bohui Zhang, Hong Zhang
Research Collection Lee Kong Chian School Of Business
Existing studies tend to focus on how a legal system reinforces the efficiency of its domestic firms or foreign companies that are subject to its domestic jurisdiction (e.g., via cross-listing). Our study provides critical normative implications in the era of financial globalization by showing that the influence of a country’s legal institutions extend beyond its territorial boundaries. We examine whether US shareholder-initiated class action lawsuits can discipline non-US firms. Using an international sample of firms over the period 1994–2019, we find that a US class action lawsuit against a non-US firm cross-listed in the US negatively affects the value of …
Coevolution Of Soes And The Chinese Economy: The Roles Of Soe Heterogeneity From The Institutional, Strategic, And Organizational Perspectives, Kenneth G. Huang, Runtian Jing, Jun Xia, Man Zhang, Weiguo Zhong, David Zhu
Coevolution Of Soes And The Chinese Economy: The Roles Of Soe Heterogeneity From The Institutional, Strategic, And Organizational Perspectives, Kenneth G. Huang, Runtian Jing, Jun Xia, Man Zhang, Weiguo Zhong, David Zhu
Research Collection Lee Kong Chian School Of Business
State-owned enterprises (SOEs) in China play a critical role in national economic development and the country's positioning on the global stage. Chinese SOEs have undergone substantial transformations from traditional government-run entities to a variety of corporate forms exhibiting different levels of state involvement. Despite their substantial influence, the internal diversity of SOEs – from wholly state-owned to mixed-ownership – has not been thoroughly examined. This paper provides an overview of SOEs' critical roles in the Chinese economy, the relationship between SOEs and privately owned enterprises (POEs), and the challenges of SOEs in different stages of Chinese economic development. It then …
Something In The Air: Does Air Pollution Affect Fund Managers’ Carbon Divestment?, Thanh Huynh, Frank Weikai Li, Ying Xia
Something In The Air: Does Air Pollution Affect Fund Managers’ Carbon Divestment?, Thanh Huynh, Frank Weikai Li, Ying Xia
Research Collection Lee Kong Chian School Of Business
We examine whether fund managers overestimate carbon risk when they are exposed to local air pollution. We find that air pollution causes managers to underweight stocks of high-emission firms. The effects are stronger for less salient scopes of carbon emissions, among managers located in pro-environmental states, and among those likely to be surprised by air pollution—consistent with the idea that managers revise their beliefs about climate-transition risk following their exposure to air pollution. Carbon-intensive stocks sold by managers who are exposed to air pollution subsequently outperform stocks that they buy, suggesting that such underweighting is costly to fund investors.
Technology-Enhanced Personalized Learning: Lessons From Online Teaching At Three South-East Asian Universities, Kiran Kaur, Rohaida Mohd Saat, Lieven Demeester, Magdeleine Lew, Wei Leng Neo, Nopphol Pausawasdi, Thasaneeya Ratanaroutai Nopparatjamjomras
Technology-Enhanced Personalized Learning: Lessons From Online Teaching At Three South-East Asian Universities, Kiran Kaur, Rohaida Mohd Saat, Lieven Demeester, Magdeleine Lew, Wei Leng Neo, Nopphol Pausawasdi, Thasaneeya Ratanaroutai Nopparatjamjomras
Research Collection Lee Kong Chian School Of Business
Online teaching during the COVID-19 pandemic compelled many instructors to seek efficient and effective ways to stay connected with their students and improve the learning experience by using a wide range of available technologies. This multiple-case study, in three South-East Asian universities, investigated whether the use of technology in university teaching and learning during that period influenced personalized learning, and if so, how. The study also explored the kinds of institutional support for teachers and learners that led to increased technology-enhanced personalized learning (TEPL). Using a qualitative approach, the study analyzed 23 individual interviews and 3 document analyses (circulars, announcements, …
Effects Of Applicants' Use Of Generative Ai In Personnel Selection: Towards A More Nuanced View?, Filip Lievens, Patrick D. Dunlop
Effects Of Applicants' Use Of Generative Ai In Personnel Selection: Towards A More Nuanced View?, Filip Lievens, Patrick D. Dunlop
Research Collection Lee Kong Chian School Of Business
Generative AI (GenAI) has made rapid inroads in assessment, as a growing number of applicants rely on it as a coach in unproctored assessments of various selection procedures. This had led to assertions that applicants' GenAI use undermines key assumptions of the predictive model underlying selection and is thus disruptive for organizations' current unproctored assessments, thereby invoking various strategies of organizations to deter and detect its use. In this provocation article, we present a more nuanced view. To this end, we start by reviewing the recent research related to the effects of applicants' use of GenAI in assessment and discuss …
Star Inventors, Knowledge Complexity And Collaborative Ties: What Drives Deference In Invention Teams?, Metin Onal Vural, Simon J.D. Schillebeeckx
Star Inventors, Knowledge Complexity And Collaborative Ties: What Drives Deference In Invention Teams?, Metin Onal Vural, Simon J.D. Schillebeeckx
Research Collection Lee Kong Chian School Of Business
This paper provides an empirical investigation of factors that drive deference in an invention team setting. Drawing on innovation literature, we hypothesise and test the distinct factors that determine the extent of deference an inventor receives in an invention team. Using patent data from U.S. semiconductor industry, we show that star inventors command deference among their peers and that this effect is moderated by stars’ embeddedness in knowledge, social and geographical context. Deference is amplified when stars have complex knowledge, but not necessarily when they have strong ties. When the stars are geographically distant from their peers, the amount of …
Singapore Management University Report To Stakeholders 2024/25, Singapore Management University
Singapore Management University Report To Stakeholders 2024/25, Singapore Management University
Report to Stakeholders
Titled “SMU at 25: Celebrating Innovation and Impact”, this year’s report marks the University’s 25th anniversary alongside Singapore’s 60th year of independence. It showcases SMU’s progress in education, research, innovation and societal engagement, and how the University continues to shape meaningful impact in Singapore and across Asia.
Interfaces, Social Information Processing, And Diversity Cascades: How Board Diversity Influences Invention Output, Daniel Z. Mack, Guoli Chen, Po-Hsuan Hsu, Yen Teik Lee, Gerard George
Interfaces, Social Information Processing, And Diversity Cascades: How Board Diversity Influences Invention Output, Daniel Z. Mack, Guoli Chen, Po-Hsuan Hsu, Yen Teik Lee, Gerard George
Research Collection Lee Kong Chian School Of Business
Although recent studies report a positive relationship between board diversity and firms' invention output, less is known about the mechanisms by which they operate, given that boards are typically far removed from on-the-ground invention activities. Drawing from research on interfaces and social information processing, we propose a theory of diversity cascades across the organizational hierarchy. Specifically, we posit that board diversity has a positive––albeit indirect––influence on firms' invention output. This relationship is mediated by the diversity of top management teams and inventor diversity, as board diversity cascades from the top to lower ranks of an organization. This indirect effect is …
The Effect Of Computer Monitoring On Employees’ Productivity In Telecommuting Arrangements, Yea Hee Ko, In Gyun Baek
The Effect Of Computer Monitoring On Employees’ Productivity In Telecommuting Arrangements, Yea Hee Ko, In Gyun Baek
Research Collection Lee Kong Chian School Of Business
When employees work from home, organizations have traditionally placed a stronger reliance on output-based controls because of the inability to physically observe its employees. Because of recent advances in technology, however, many organizations now use input-based controls. One such input-based control is computer monitoring, which records the number of hours spent working and leaves out any time in which an employee does not perform work activities. On the one hand, computer monitoring may provide productivity-enhancing benefits by reducing the likelihood of employees experiencing self-control problems, such as procrastination. On the other hand, computer monitoring may motivate reduced effort by decreasing …
Anatomical Depiction: How Showing A Product's Inner Structure Shapes Product Valuations, Seo Yoon Kang, Junghan Kim, Arun Lakshmanan
Anatomical Depiction: How Showing A Product's Inner Structure Shapes Product Valuations, Seo Yoon Kang, Junghan Kim, Arun Lakshmanan
Research Collection Lee Kong Chian School Of Business
Anatomical depiction is a technique where the product is decomposed into components that are spatially arranged in a layer-by-layer manner to visually explicate its inner structure. The authors demonstrate that anatomical depiction, compared to non-anatomical depiction, enhances product valuation. This effect occurs because anatomical depiction elicits a ‘coming together’ of the inner components in consumers’ minds thereby evoking a gestalt image of the product – a process labeled simulated assemblage. The elicitation of simulated assemblage in turn boosts their confidence in the product’s performance. Two field experiments first demonstrate that anatomical depiction leads to greater engagement in online settings such …
Why Some Companies Weather Trade Was Better Than Others?, Di Fan, Daphne W. Yiu, Pengcheng Ma, Lin Cui
Why Some Companies Weather Trade Was Better Than Others?, Di Fan, Daphne W. Yiu, Pengcheng Ma, Lin Cui
Research Collection Lee Kong Chian School Of Business
In 2018, the U.S. government levied tariffs affecting more than $250 billion of Chinese products. As a result, many American buyers began turning to alternative suppliers to avoid the significant new costs associated with purchasing from China. Recent research found that transactions between U.S. buyers and Chinese suppliers fell by more than 18% immediately following the start of the trade war. However, the study also found that not all companies were affected equally: Chinese firms that were more innovative or more socially responsible were more likely to retain their U.S. buyers, while buyers were more likely to distance themselves from …
Natural Capital Credit Risk Assessment In Agricultural Lending: An Approach Based On The Natural Capital Protocol, Francisco Ascui, Theodor Florian Cojoianu
Natural Capital Credit Risk Assessment In Agricultural Lending: An Approach Based On The Natural Capital Protocol, Francisco Ascui, Theodor Florian Cojoianu
Research Collection College of Integrative Studies
It is increasingly recognised that financial institutions have significant impacts and dependencies on natural capital – defined as the stock of the world’s renewable and non-renewable natural resources and ecosystems that yield flows of environmental goods and services, which directly and indirectly underpin the global economy and human wellbeing. Historically, many of these impacts and dependencies have been overlooked. The value of goods and services that nature provides ‘for free’ has often been ignored, and resources have typically been priced at their cost of extraction, rather than the cost of their replacement or substitution, which would promote more sustainable long-term …
Meteorology, Weather And War In South East Asia: Malaya C. 1940-1960, Fiona Williamson
Meteorology, Weather And War In South East Asia: Malaya C. 1940-1960, Fiona Williamson
Research Collection College of Integrative Studies
This article interrogates the positioning of British colonial meteorology in Malaysia and Singapore from the 1940s to 1960. This period spanned a global conflict and an internecine war, effecting profound sociopolitical changes from which neither Malaysia nor Singapore would emerge the same. The meteorological services were essential to Britain's armed conflicts, providing vital weather information to the army, navy and, especially, the air forces, as well as supporting the aviation and shipping industry often in difficult and dangerous circumstances. This article argues that British military policy in South East Asia and the specific concerns of the colonial government in Malaya …
Automated Program Refinement: Guide And Verify Code Large Language Model With Refinement Calculus, Yufan Cai, Zhe Hou, David Sanan, Xiaokun Luan, Yun Lin, Jun Sun, Jin Song Dong
Automated Program Refinement: Guide And Verify Code Large Language Model With Refinement Calculus, Yufan Cai, Zhe Hou, David Sanan, Xiaokun Luan, Yun Lin, Jun Sun, Jin Song Dong
Research Collection School Of Computing and Information Systems
Recently, the rise of code-centric large language models (LLMs) appears to have reshaped the software engineering world with low-barrier tools like Copilot that can generate code easily. However, there is no correctness guarantee for the code generated by LLMs, which suffer from the hallucination problem, and their output is fraught with risks. Besides, the end-to-end process from specification to code through LLMs is a non-transparent and uncontrolled black box. This opacity makes it difficult for users to understand and trust the generated code. Addressing these challenges is both necessary and critical. In contrast, program refinement transforms high-level specification statements into …
Recdreamer: Consistent Text-To-3d Generation Via Uniform Score Distillation, Chenxi Zheng, Yihong Lin, Bangzhen Liu, Xuemiao Xu, Yongwei Nie, Shengfeng He
Recdreamer: Consistent Text-To-3d Generation Via Uniform Score Distillation, Chenxi Zheng, Yihong Lin, Bangzhen Liu, Xuemiao Xu, Yongwei Nie, Shengfeng He
Research Collection School Of Computing and Information Systems
Current text-to-3D generation methods based on score distillation often suffer from geometric inconsistencies, leading to repeated patterns across different poses of 3D assets. This issue, known as the Multi-Face Janus problem, arises because existing methods struggle to maintain consistency across varying poses and are biased toward a canonical pose. While recent work has improved pose control and approximation, these efforts are still limited by this inherent bias, which skews the guidance during generation. To address this, we propose a solution called RecDreamer, which reshapes the underlying data distribution to achieve more consistent pose representation. The core idea behind our method …
Technology As The Sovereign: A Dual-Path Model Of Managers’ Prioritization Of Technical Tasks, Hesheng Huang
Technology As The Sovereign: A Dual-Path Model Of Managers’ Prioritization Of Technical Tasks, Hesheng Huang
Dissertations and Theses Collection (Open Access)
Competitive pressures challenge managers to navigate a multitude of responsibilities. On the basis of Vancouver and colleagues’ (Vancouver et al., 2010; Ballard et al., 2016) multiple-task pursuit framework, Sherf, Venkataramani, and Gejendran (2019) theorized that when faced with competition between technical tasks (e.g., getting things done, meeting assigned goals, promoting quality or accuracy of work, satisfying customer demands, and fulfilling technical responsibilities) and justice tasks (e.g., evaluating employees’ performance, recognizing employees’ achievements, and allocating rewards), managers tend to prioritize technical tasks over justice tasks under high workload demands. On this basis, I aim to examine a model that encompasses the …
Smu At 25: Celebrating A Legacy Of Innovation And A Bold Vision For The Future, Singapore Management University
Smu At 25: Celebrating A Legacy Of Innovation And A Bold Vision For The Future, Singapore Management University
SMU Press Releases and News
Twenty-five years ago, Singapore Management University (SMU) started out as a bold experiment in transforming the higher education in Singapore. Today, it has already gained the recognition of being a globally recognized institution at the forefront of transformative education and cutting-edge research, shaping future leaders in Asia and beyond. As SMU marks this milestone, the university is not just reflecting on its achievements but charting a path forward with renewed purpose.
Smu Announces New Leadership Appointments: Mr Kuok Khoon Ean And Justice Judith Prakash, As Pro-Chancellors, Singapore Management University
Smu Announces New Leadership Appointments: Mr Kuok Khoon Ean And Justice Judith Prakash, As Pro-Chancellors, Singapore Management University
SMU Press Releases and News
Singapore Management University (SMU) is pleased to announce key leadership appointments that will further strengthen its governance and strategic direction. These appointments underscore SMU’s commitment to delivering excellence in education, research, and community engagement. Effective 1 January 2025, SMU welcomes two distinguished individuals, Mr Kuok Khoon Ean and Justice Judith Prakash, as Pro-Chancellors.
Merchant Guild Culture And Companies’ Sustainable Development: An Empirical Investigation Based On Esg Performance, Yi Wang
Dissertations and Theses Collection (Open Access)
In the context of global economic growth and growing emphasis on sustainable development, this study focuses on the impact of merchant guild culture, an important part of traditional Chinese culture, on the sustainable development of enterprises. Through an in-depth exploration of the historical evolution and cultural connotations of merchant guild culture, this paper systematically analyzes its potential influence on corporate behavior and sustainable development. Using a sample of A-share listed companies and applying regression analysis and other empirical research methods, this study finds that merchant guild culture facilitates the sustainable development of enterprises. Mechanism analysis reveals that merchant guild culture …
Partner Performance Evaluation, Disclosure Of Key Audit Matters, And Audit Quality, Shenghua Chen
Partner Performance Evaluation, Disclosure Of Key Audit Matters, And Audit Quality, Shenghua Chen
Dissertations and Theses Collection (Open Access)
Transparency of information and audit quality are crucial for the efficiency and stability of the market. The disclosure of key audit matters has become an essential part of audit reports, yet there remains widespread debate regarding the role of key audit matters. This study finds a significant positive correlation between the extent of key audit matter disclosures and audit quality. Detailed disclosures can enhance information transparency, strengthen auditors’ sense of responsibility, and reduce information asymmetry. However, over-templating may have negative effects on audit quality, leading to a lack of personalized judgment by auditors. Additionally, this paper suggests that the partner …
Impact Assessment Of Uniqlo’S Neighbours Helping Neighbours, Weng Lin Ng, Dalvin Sidhu
Impact Assessment Of Uniqlo’S Neighbours Helping Neighbours, Weng Lin Ng, Dalvin Sidhu
Lien Centre for Social Innovation: Research
The UNIQLO Neighbours Helping Neighbours (NHN) is a pilot programme that redistributes recycled UNIQLO products to those in need. Preloved UNIQLO clothing in good condition are collected, washed and pressed, and then redistributed to partnered social service organisations and family service centres for donation to their core beneficiaries.
The objective of the current study is to document and evaluate the impact of the NHN programme on its beneficiaries and present evidence-based recommendations that will aid UNIQLO’s efforts to improve and scale subsequent iterations of this programme.
This report will present results obtained from the following data sources: (1) a quantitative …
Digital Infrastructure Development Through Digital Infrastructuring Work: An Institutional Work Perspective, Adrian Yeow, Wee-Kiat Lim, Samer Faraj
Digital Infrastructure Development Through Digital Infrastructuring Work: An Institutional Work Perspective, Adrian Yeow, Wee-Kiat Lim, Samer Faraj
CCX Research
Being able to understand and characterize the digital infrastructure development (DID) process has become even more pressing today due to the rapid advent and implementation of new digital infrastructure (DI) in organizations as well as since the COVID-19 crisis. While information systems (IS) research has begun to recognize the institutional nature of such digital infrastructures, there remains a gap in our understanding of how such developments unfold from an institutional perspective. Through our field study of a digital infrastructure development project involving the implementation of an enterprise-wide electronic medical record system at a large US medical facility, we show how …
Privacy-Preserving User Recruitment With Sensing Quality Evaluation In Mobile Crowdsensing, Jieying An, Yanbing Ren, Xinghua Li, Man Zhang, Bin Luo, Yinbin Miao, Ximeng Liu, Deng, Robert H.
Privacy-Preserving User Recruitment With Sensing Quality Evaluation In Mobile Crowdsensing, Jieying An, Yanbing Ren, Xinghua Li, Man Zhang, Bin Luo, Yinbin Miao, Ximeng Liu, Deng, Robert H.
Research Collection School Of Computing and Information Systems
Recruiting users in mobile crowdsensing (MCS) can make the platform obtain high-quality data to provide better services. Although the privacy leakage during the process of user recruitment has received a lot of research attention, none of the existing work considers the evaluation of the sensing quality of privacy-preserving data submitted by users, which makes the platform incapable of recruiting users suitably to obtain high-quality sensing data, thereby reducing the reliability of MCS services. To solve this problem, we first propose a sensing quality evaluation method based on the deviation and variance of sensing data. According to it, the platform can …
Gnnsynergy: A Multi-View Graph Neural Network For Predicting Anti-Cancer Drug Synergy, Zhifeng Hao, Jianming Zhan, Yuan Fang, Min Wu, Ruichu Cai
Gnnsynergy: A Multi-View Graph Neural Network For Predicting Anti-Cancer Drug Synergy, Zhifeng Hao, Jianming Zhan, Yuan Fang, Min Wu, Ruichu Cai
Research Collection School Of Computing and Information Systems
Drug combinations play very important roles in cancer therapy, as they can enhance curative efficacy and overcome drug resistance. Due to the increasing size of combinatorial space, experimental screening for all the drug combinations becomes infeasible in practice. Therefore, there is a great need to develop accurate computational approaches that can predict potential drug combinations to direct the experimental screening. In this paper, we propose a novel method called GNNSynergy to learn drug embeddings for drug synergy prediction. Given a specific cancer cell line, we propose a multi-view graph neural network framework which considers the current cell line as main …